1 1.5792 SUB158 >= 3 any ring size 5 1 1.5792 PF01126 Heme oxygenase 2 1.5630 SUB387 C(:C)(:C)(:N) 2 1.5630 PF00042 Globin 3 1.3732 SUB840 CC1CC(C)CC1 3 1.3732 PF00191 Annexin 4 1.2767 SUB414 S(~C)(~H) 4 1.2767 PF01124 MAPEG family 5 1.2402 SUB32 >= 2 P 5 1.2402 PF00025 ADP-ribosylation factor family 6 1.1032 SUB32 >= 2 P 6 1.1032 PF01370 NAD dependent epimerase/dehydratase family 7 1.0937 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 7 1.0937 PF00020 TNFR/NGFR cysteine-rich region 8 1.0861 SUB410 O(:C)(:C) 8 1.0861 PF00001 7 transmembrane receptor (rhodopsin family), 9 1.0802 SUB670 Cl-C:C-C=O 9 1.0802 PF00069 Protein kinase domain 10 1.0793 SUB778 CC1CCC(O)CC1 10 1.0793 PF12497 Estrogen receptor beta 11 1.0608 SUB706 O=C-C-C-C-C(O)-C 11 1.0608 PF01391 Collagen triple helix repeat (20 copies), 12 1.0525 SUB503 N-C=C-[#1] 12 1.0525 PF00069 Protein kinase domain 13 1.0413 SUB17 >= 4 N 13 1.0413 PF01916 Deoxyhypusine synthase 14 1.0341 SUB409 O(~H)(~S) 14 1.0341 PF00167 Fibroblast growth factor 15 1.0209 SUB656 O-C-C-C:C 15 1.0209 PF00497 Bacterial extracellular solute-binding proteins, family 3 16 1.0204 SUB414 S(~C)(~H) 16 1.0204 PF00255 Glutathione peroxidase 17 1.0178 SUB32 >= 2 P 17 1.0178 PF00334 Nucleoside diphosphate kinase 18 1.0170 SUB840 CC1CC(C)CC1 18 1.0170 PF01735 Lysophospholipase catalytic domain 19 1.0113 SUB360 C(~C)(:N)(:N) 19 1.0113 PF05761 5" nucleotidase family 20 1.0006 SUB193 >= 3 any ring size 6 20 1.0006 PF09396 Thrombin light chain 21 1.0005 SUB364 C(~F)(~F) 21 1.0005 PF00654 Voltage gated chloride channel 22 0.9958 SUB704 O-C-C-C-C-C(N)-C 22 0.9958 PF00214 Calcitonin / CGRP / IAPP family 23 0.9904 SUB657 C-C-N-C-C 23 0.9904 PF07562 Nine Cysteines Domain of family 3 GPCR 24 0.9790 SUB38 >= 1 Cl 24 0.9790 PF08403 Amino acid permease N-terminal 25 0.9686 SUB498 O-C:C:N 25 0.9686 PF01053 Cys/Met metabolism PLP-dependent enzyme 26 0.9578 SUB537 O=C-C-N 26 0.9578 PF00375 Sodium:dicarboxylate symporter family 27 0.9464 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 27 0.9464 PF00656 Caspase domain 28 0.9424 SUB369 C(~H)(~S) 28 0.9424 PF01770 Reduced folate carrier 29 0.9382 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 29 0.9382 PF01429 Methyl-CpG binding domain 30 0.9277 SUB687 O=C-C-C-C-O 30 0.9277 PF03171 2OG-Fe(II), oxygenase superfamily 31 0.9255 SUB537 O=C-C-N 31 0.9255 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 32 0.9235 SUB720 Oc1ccc(O)cc1 32 0.9235 PF00079 Serpin (serine protease inhibitor), 33 0.8892 SUB32 >= 2 P 33 0.8892 PF00348 Polyprenyl synthetase 34 0.8825 SUB414 S(~C)(~H) 34 0.8825 PF00462 Glutaredoxin 35 0.8729 SUB706 O=C-C-C-C-C(O)-C 35 0.8729 PF00079 Serpin (serine protease inhibitor), 36 0.8717 SUB339 C(~C)(~C)(~H)(~N) 36 0.8717 PF00128 Alpha amylase, catalytic domain 37 0.8707 SUB337 C(~C)(~C)(~C)(~N) 37 0.8707 PF00497 Bacterial extracellular solute-binding proteins, family 3 38 0.8648 SUB686 O=C-C-C-C-N 38 0.8648 PF02798 Glutathione S-transferase, N-terminal domain 39 0.8648 SUB387 C(:C)(:C)(:N) 39 0.8648 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 40 0.8538 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 40 0.8538 PF01039 Carboxyl transferase domain 41 0.8494 SUB4 >= 32 H 41 0.8494 PF00625 Guanylate kinase 42 0.8485 SUB309 O-H 42 0.8485 PF00102 Protein-tyrosine phosphatase 43 0.8426 SUB567 O-C-C-N 43 0.8426 PF00464 Serine hydroxymethyltransferase 44 0.8365 SUB687 O=C-C-C-C-O 44 0.8365 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 45 0.8333 SUB348 C(~C)(~H)(~O)(~O) 45 0.8333 PF00143 Interferon alpha/beta domain 46 0.8333 SUB5 >= 1 Li 46 0.8333 PF00459 Inositol monophosphatase family 47 0.8284 SUB172 >= 5 any ring size 5 47 0.8284 PF07645 Calcium-binding EGF domain 48 0.8000 SUB680 C-C-C-C-C-C 48 0.8000 PF08718 Glycolipid transfer protein (GLTP), 49 0.7968 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 49 0.7968 PF00071 Ras family 50 0.7906 SUB398 N(~C)(:C)(:C) 50 0.7906 PF02525 Flavodoxin-like fold 51 0.7896 SUB306 N-S 51 0.7896 PF00194 Eukaryotic-type carbonic anhydrase 52 0.7886 SUB529 [#1]-N-C-[#1] 52 0.7886 PF00709 Adenylosuccinate synthetase 53 0.7884 SUB681 O-C-C-C-C-C 53 0.7884 PF00023 Ankyrin repeat 54 0.7878 SUB664 O-C-C-O-[#1] 54 0.7878 PF00728 Glycosyl hydrolase family 20, catalytic domain 55 0.7876 SUB695 O=C-C-C-C-C=O 55 0.7876 PF00551 Formyl transferase 56 0.7850 SUB706 O=C-C-C-C-C(O)-C 56 0.7850 PF00229 TNF(Tumour Necrosis Factor), family 57 0.7846 SUB629 C-N-C-C:C 57 0.7846 PF00248 Aldo/keto reductase family 58 0.7804 SUB424 N=O 58 0.7804 PF00211 Adenylate and Guanylate cyclase catalytic domain 59 0.7802 SUB703 O-C-C-C-C-C-N-C 59 0.7802 PF00233 3"5"-cyclic nucleotide phosphodiesterase 60 0.7753 SUB691 O-C-C-C-C-C-O 60 0.7753 PF02806 Alpha amylase, C-terminal all-beta domain 61 0.7736 SUB722 Oc1ccc(N)cc1 61 0.7736 PF00068 Phospholipase A2 62 0.7734 SUB506 Cl-C:C-O 62 0.7734 PF00069 Protein kinase domain 63 0.7597 SUB17 >= 4 N 63 0.7597 PF00186 Dihydrofolate reductase 64 0.7574 SUB330 C(~Br)(~H) 64 0.7574 PF00001 7 transmembrane receptor (rhodopsin family), 65 0.7500 SUB414 S(~C)(~H) 65 0.7500 PF01406 tRNA synthetases class I (C), catalytic domain 66 0.7500 SUB330 C(~Br)(~H) 66 0.7500 PF01007 Inward rectifier potassium channel 67 0.7468 SUB208 >= 5 saturated or aromatic carbon-only ring size 6 67 0.7468 PF01160 Vertebrate endogenous opioids neuropeptide 68 0.7438 SUB695 O=C-C-C-C-C=O 68 0.7438 PF08240 Alcohol dehydrogenase GroES-like domain 69 0.7429 SUB336 C(~C)(~C)(~C)(~H) 69 0.7429 PF00133 tRNA synthetases class I (I, L, M and V), 70 0.7374 SUB389 C(:C)(:N)(:N) 70 0.7374 PF00106 short chain dehydrogenase 71 0.7307 SUB702 O-C-C-C-C-C(O)-C 71 0.7307 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 72 0.7302 SUB449 C(-H)(=O) 72 0.7302 PF00107 Zinc-binding dehydrogenase 73 0.7300 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 73 0.7300 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 74 0.7294 SUB407 O(~C)(~H) 74 0.7294 PF00303 Thymidylate synthase 75 0.7279 SUB16 >= 2 N 75 0.7279 PF00194 Eukaryotic-type carbonic anhydrase 76 0.7260 SUB338 C(~C)(~C)(~C)(~O) 76 0.7260 PF00557 Metallopeptidase family M24 77 0.7195 SUB246 >= 1 unsaturated non-aromatic carbon-only ring size 9 77 0.7195 PF00071 Ras family 78 0.7182 SUB398 N(~C)(:C)(:C) 78 0.7182 PF00067 Cytochrome P450 79 0.7152 SUB364 C(~F)(~F) 79 0.7152 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 80 0.7149 SUB441 C(-C)(-O)(=O) 80 0.7149 PF00324 Amino acid permease 81 0.7131 SUB618 C-C-C-O-[#1] 81 0.7131 PF02155 Glucocorticoid receptor 82 0.7130 SUB694 O=C-C-C-C-C-O 82 0.7130 PF07654 Immunoglobulin C1-set domain 83 0.7125 SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 83 0.7125 PF00854 POT family 84 0.7104 SUB682 O-C-C-C-C-O 84 0.7104 PF01532 Glycosyl hydrolase family 47 85 0.7094 SUB414 S(~C)(~H) 85 0.7094 PF00656 Caspase domain 86 0.7083 SUB629 C-N-C-C:C 86 0.7083 PF00225 Kinesin motor domain 87 0.7061 SUB360 C(~C)(:N)(:N) 87 0.7061 PF00074 Pancreatic ribonuclease 88 0.7051 SUB242 >= 1 any ring size 9 88 0.7051 PF01048 Phosphorylase superfamily 89 0.7030 SUB515 O-N-C-C 89 0.7030 PF00305 Lipoxygenase 90 0.6983 SUB309 O-H 90 0.6983 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 91 0.6964 SUB499 O-C=C-C 91 0.6964 PF00069 Protein kinase domain 92 0.6963 SUB49 >= 4 I 92 0.6963 PF02423 Ornithine cyclodeaminase/mu-crystallin family 93 0.6909 SUB541 C-N-C-[#1] 93 0.6909 PF00755 Choline/Carnitine o-acyltransferase 94 0.6893 SUB433 C(-C)(-C)(=O) 94 0.6893 PF07884 Vitamin K epoxide reductase family 95 0.6875 SUB448 C(-H)(=N) 95 0.6875 PF02267 ADP-ribosyl cyclase 96 0.6793 SUB674 O=C-C=C-N 96 0.6793 PF00303 Thymidylate synthase 97 0.6788 SUB288 C-F 97 0.6788 PF03477 ATP cone domain 98 0.6786 SUB706 O=C-C-C-C-C(O)-C 98 0.6786 PF03062 MBOAT family 99 0.6759 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 99 0.6759 PF00069 Protein kinase domain 100 0.6757 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 100 0.6757 PF01180 Dihydroorotate dehydrogenase 101 0.6742 SUB622 N-C:C:C:N 101 0.6742 PF00175 Oxidoreductase NAD-binding domain 102 0.6738 SUB42 >= 1 K 102 0.6738 PF00324 Amino acid permease 103 0.6708 SUB695 O=C-C-C-C-C=O 103 0.6708 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 104 0.6701 SUB216 >= 1 saturated or aromatic nitrogen-containing ring size 7 104 0.6701 PF00069 Protein kinase domain 105 0.6700 SUB519 O=C-N-N 105 0.6700 PF00209 Sodium:neurotransmitter symporter family 106 0.6653 SUB613 N-C-O-C-C 106 0.6653 PF02223 Thymidylate kinase 107 0.6620 SUB536 O=C-C-C 107 0.6620 PF07690 Major Facilitator Superfamily 108 0.6570 SUB398 N(~C)(:C)(:C) 108 0.6570 PF00071 Ras family 109 0.6548 SUB640 O-C-C-C-O 109 0.6548 PF00343 Carbohydrate phosphorylase 110 0.6534 SUB631 O-C:C-O-C 110 0.6534 PF07690 Major Facilitator Superfamily 111 0.6525 SUB277 B-O 111 0.6525 PF00227 Proteasome subunit 112 0.6502 SUB20 >= 2 O 112 0.6502 PF00821 Phosphoenolpyruvate carboxykinase 113 0.6491 SUB414 S(~C)(~H) 113 0.6491 PF07686 Immunoglobulin V-set domain 114 0.6489 SUB687 O=C-C-C-C-O 114 0.6489 PF00939 Sodium:sulfate symporter transmembrane region 115 0.6473 SUB379 C(~N)(:C)(:N) 115 0.6473 PF00186 Dihydrofolate reductase 116 0.6441 SUB640 O-C-C-C-O 116 0.6441 PF00341 Platelet-derived growth factor (PDGF), 117 0.6430 SUB306 N-S 117 0.6430 PF01007 Inward rectifier potassium channel 118 0.6425 SUB618 C-C-C-O-[#1] 118 0.6425 PF00310 Glutamine amidotransferases class-II 119 0.6415 SUB457 P(-O)(=O) 119 0.6415 PF01852 START domain 120 0.6389 SUB433 C(-C)(-C)(=O) 120 0.6389 PF00648 Calpain family cysteine protease 121 0.6385 SUB567 O-C-C-N 121 0.6385 PF00155 Aminotransferase class I and II 122 0.6377 SUB656 O-C-C-C:C 122 0.6377 PF00576 HIUase/Transthyretin family 123 0.6373 SUB18 >= 8 N 123 0.6373 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 124 0.6357 SUB7 >= 1 B 124 0.6357 PF00227 Proteasome subunit 125 0.6328 SUB644 [#1]-C-C-N-[#1] 125 0.6328 PF01536 Adenosylmethionine decarboxylase 126 0.6317 SUB537 O=C-C-N 126 0.6317 PF00579 tRNA synthetases class I (W and Y), 127 0.6289 SUB713 C-C(C)-C(C)-C 127 0.6289 PF00341 Platelet-derived growth factor (PDGF), 128 0.6269 SUB392 N(~C)(~C)(~C) 128 0.6269 PF08674 Acetylcholinesterase tetramerisation domain 129 0.6268 SUB536 O=C-C-C 129 0.6268 PF00264 Common central domain of tyrosinase 130 0.6245 SUB14 >= 32 C 130 0.6245 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 131 0.6236 SUB594 N-C-C-C-N 131 0.6236 PF00583 Acetyltransferase (GNAT), family 132 0.6225 SUB691 O-C-C-C-C-C-O 132 0.6225 PF01094 Receptor family ligand binding region 133 0.6224 SUB96 >= 1 Hg 133 0.6224 PF00194 Eukaryotic-type carbonic anhydrase 134 0.6207 SUB408 O(~C)(~P) 134 0.6207 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 135 0.6197 SUB757 Cc1c(O)cccc1 135 0.6197 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 136 0.6197 SUB200 >= 4 any ring size 6 136 0.6197 PF00520 Ion transport protein 137 0.6185 SUB437 C(-C)(-H)(=O) 137 0.6185 PF00089 Trypsin 138 0.6183 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 138 0.6183 PF00069 Protein kinase domain 139 0.6148 SUB692 O-C-C-C-C-C-N 139 0.6148 PF01168 Alanine racemase, N-terminal domain 140 0.6140 SUB460 S(=O)(=O) 140 0.6140 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 141 0.6135 SUB633 C-C-O-C:C 141 0.6135 PF08441 Integrin alpha 142 0.6107 SUB302 N-O 142 0.6107 PF00850 Histone deacetylase domain 143 0.6082 SUB759 Cc1c(N)cccc1 143 0.6082 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 144 0.6060 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 144 0.6060 PF00676 Dehydrogenase E1 component 145 0.6055 SUB348 C(~C)(~H)(~O)(~O) 145 0.6055 PF03414 Glycosyltransferase family 6 146 0.6052 SUB603 O=C-C-N-C 146 0.6052 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 147 0.6044 SUB642 O-C-C-C=C 147 0.6044 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 148 0.6021 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 148 0.6021 PF00183 Hsp90 protein 149 0.6010 SUB576 O-C-C:C-O 149 0.6010 PF00171 Aldehyde dehydrogenase family 150 0.6007 SUB498 O-C:C:N 150 0.6007 PF00155 Aminotransferase class I and II 151 0.6001 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 151 0.6001 PF00432 Prenyltransferase and squalene oxidase repeat 152 0.5997 SUB484 N-S-C:C 152 0.5997 PF00324 Amino acid permease 153 0.5992 SUB548 N-C:C-N 153 0.5992 PF01687 Riboflavin kinase 154 0.5970 SUB341 C(~C)(~C)(~N) 154 0.5970 PF00291 Pyridoxal-phosphate dependent enzyme 155 0.5966 SUB698 C-C-C-C-C-C(C)-C 155 0.5966 PF00149 Calcineurin-like phosphoesterase 156 0.5959 SUB727 Sc1ccc(Cl)cc1 156 0.5959 PF00067 Cytochrome P450 157 0.5953 SUB520 N=C-N-C 157 0.5953 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 158 0.5948 SUB444 C(-C)(=O) 158 0.5948 PF02166 Androgen receptor 159 0.5928 SUB408 O(~C)(~P) 159 0.5928 PF00069 Protein kinase domain 160 0.5921 SUB606 O=C-C-O-C 160 0.5921 PF00354 Pentaxin family 161 0.5915 SUB554 O=C-C=C 161 0.5915 PF00464 Serine hydroxymethyltransferase 162 0.5910 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 162 0.5910 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 163 0.5906 SUB814 NC1CC(Cl)CCC1 163 0.5906 PF00043 Glutathione S-transferase, C-terminal domain 164 0.5890 SUB13 >= 16 C 164 0.5890 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 165 0.5886 SUB14 >= 32 C 165 0.5886 PF00493 MCM2/3/5 family 166 0.5884 SUB694 O=C-C-C-C-C-O 166 0.5884 PF07722 Peptidase C26 167 0.5865 SUB598 O=C-C-C:C 167 0.5865 PF06512 Sodium ion transport-associated 168 0.5852 SUB674 O=C-C=C-N 168 0.5852 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 169 0.5850 SUB588 N-C:C-O-[#1] 169 0.5850 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 170 0.5828 SUB622 N-C:C:C:N 170 0.5828 PF08240 Alcohol dehydrogenase GroES-like domain 171 0.5824 SUB695 O=C-C-C-C-C=O 171 0.5824 PF04389 Peptidase family M28 172 0.5823 SUB674 O=C-C=C-N 172 0.5823 PF02219 Methylenetetrahydrofolate reductase 173 0.5817 SUB433 C(-C)(-C)(=O) 173 0.5817 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 174 0.5810 SUB841 CC1CC(O)CC1 174 0.5810 PF00001 7 transmembrane receptor (rhodopsin family), 175 0.5806 SUB408 O(~C)(~P) 175 0.5806 PF00168 C2 domain 176 0.5787 SUB537 O=C-C-N 176 0.5787 PF00282 Pyridoxal-dependent decarboxylase conserved domain 177 0.5780 SUB688 O=C-C-C-C=O 177 0.5780 PF00549 CoA-ligase 178 0.5770 SUB386 C(:C)(:C)(:C) 178 0.5770 PF01387 Synuclein 179 0.5759 SUB572 [#1]-C-O-[#1] 179 0.5759 PF00342 Phosphoglucose isomerase 180 0.5755 SUB346 C(~C)(~H)(~N) 180 0.5755 PF00209 Sodium:neurotransmitter symporter family 181 0.5736 SUB413 S(~C)(~C) 181 0.5736 PF04321 RmlD substrate binding domain 182 0.5729 SUB688 O=C-C-C-C=O 182 0.5729 PF00271 Helicase conserved C-terminal domain 183 0.5727 SUB799 CC1CC(O)CCC1 183 0.5727 PF00520 Ion transport protein 184 0.5724 SUB688 O=C-C-C-C=O 184 0.5724 PF01144 Coenzyme A transferase 185 0.5692 SUB336 C(~C)(~C)(~C)(~H) 185 0.5692 PF01007 Inward rectifier potassium channel 186 0.5688 SUB588 N-C:C-O-[#1] 186 0.5688 PF00266 Aminotransferase class-V 187 0.5681 SUB469 O=S-C-N 187 0.5681 PF00287 Sodium / potassium ATPase beta chain 188 0.5655 SUB695 O=C-C-C-C-C=O 188 0.5655 PF03951 Glutamine synthetase, beta-Grasp domain 189 0.5652 SUB172 >= 5 any ring size 5 189 0.5652 PF01122 Eukaryotic cobalamin-binding protein 190 0.5642 SUB132 >= 1 saturated or aromatic nitrogen-containing ring size 4 190 0.5642 PF00854 POT family 191 0.5642 SUB365 C(~F)(:C) 191 0.5642 PF00069 Protein kinase domain 192 0.5636 SUB783 OC1CCC(O)CC1 192 0.5636 PF00459 Inositol monophosphatase family 193 0.5635 SUB636 N-N-C-N-[#1] 193 0.5635 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 194 0.5630 SUB422 C=S 194 0.5630 PF07645 Calcium-binding EGF domain 195 0.5630 SUB664 O-C-C-O-[#1] 195 0.5630 PF02065 Melibiase 196 0.5611 SUB715 Cc1ccc(O)cc1 196 0.5611 PF00105 Zinc finger, C4 type (two domains), 197 0.5576 SUB381 C(~O)(~O) 197 0.5576 PF00405 Transferrin 198 0.5561 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 198 0.5561 PF00233 3"5"-cyclic nucleotide phosphodiesterase 199 0.5546 SUB460 S(=O)(=O) 199 0.5546 PF00520 Ion transport protein 200 0.5528 SUB36 >= 4 S 200 0.5528 PF00171 Aldehyde dehydrogenase family 201 0.5520 SUB367 C(~H)(~O) 201 0.5520 PF02214 K+ channel tetramerisation domain 202 0.5518 SUB703 O-C-C-C-C-C-N-C 202 0.5518 PF02159 Oestrogen receptor 203 0.5514 SUB696 O=C-C-C-C-C-N 203 0.5514 PF00026 Eukaryotic aspartyl protease 204 0.5513 SUB694 O=C-C-C-C-C-O 204 0.5513 PF00074 Pancreatic ribonuclease 205 0.5502 SUB535 S-C:C-O 205 0.5502 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 206 0.5500 SUB567 O-C-C-N 206 0.5500 PF00153 Mitochondrial carrier protein 207 0.5485 SUB537 O=C-C-N 207 0.5485 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 208 0.5480 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 208 0.5480 PF00106 short chain dehydrogenase 209 0.5477 SUB660 O-C-C-N-C 209 0.5477 PF01467 Cytidylyltransferase 210 0.5477 SUB714 Cc1ccc(C)cc1 210 0.5477 PF00017 SH2 domain 211 0.5460 SUB18 >= 8 N 211 0.5460 PF07992 Pyridine nucleotide-disulphide oxidoreductase 212 0.5450 SUB708 O=C-C-C-C-C(N)-C 212 0.5450 PF02219 Methylenetetrahydrofolate reductase 213 0.5446 SUB208 >= 5 saturated or aromatic carbon-only ring size 6 213 0.5446 PF00089 Trypsin 214 0.5435 SUB572 [#1]-C-O-[#1] 214 0.5435 PF01066 CDP-alcohol phosphatidyltransferase 215 0.5429 SUB673 O=C-C=C-[#1] 215 0.5429 PF00531 Death domain 216 0.5410 SUB348 C(~C)(~H)(~O)(~O) 216 0.5410 PF00293 NUDIX domain 217 0.5398 SUB834 NC1C(N)CCCC1 217 0.5398 PF01923 Cobalamin adenosyltransferase 218 0.5388 SUB707 O=C-C-C-C-C(=O)-C 218 0.5388 PF02059 Interleukin-3 219 0.5376 SUB664 O-C-C-O-[#1] 219 0.5376 PF00328 Histidine acid phosphatase 220 0.5374 SUB702 O-C-C-C-C-C(O)-C 220 0.5374 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 221 0.5352 SUB686 O=C-C-C-C-N 221 0.5352 PF00060 Ligand-gated ion channel 222 0.5352 SUB201 >= 4 saturated or aromatic carbon-only ring size 6 222 0.5352 PF00001 7 transmembrane receptor (rhodopsin family), 223 0.5350 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 223 0.5350 PF00106 short chain dehydrogenase 224 0.5340 SUB623 O=C-O-C:C 224 0.5340 PF00067 Cytochrome P450 225 0.5339 SUB622 N-C:C:C:N 225 0.5339 PF06628 Catalase-related immune-responsive 226 0.5320 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 226 0.5320 PF00069 Protein kinase domain 227 0.5319 SUB431 C(-C)(-C)(=C) 227 0.5319 PF00171 Aldehyde dehydrogenase family 228 0.5316 SUB356 C(~C)(:C) 228 0.5316 PF00233 3"5"-cyclic nucleotide phosphodiesterase 229 0.5295 SUB516 N-N-C-C 229 0.5295 PF00664 ABC transporter transmembrane region 230 0.5286 SUB694 O=C-C-C-C-C-O 230 0.5286 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 231 0.5282 SUB359 C(~C)(:N) 231 0.5282 PF00001 7 transmembrane receptor (rhodopsin family), 232 0.5272 SUB567 O-C-C-N 232 0.5272 PF03489 Saposin-like type B, region 2 233 0.5269 SUB735 Cc1cc(C)ccc1 233 0.5269 PF01030 Receptor L domain 234 0.5263 SUB682 O-C-C-C-C-O 234 0.5263 PF03360 Glycosyltransferase family 43 235 0.5242 SUB695 O=C-C-C-C-C=O 235 0.5242 PF02059 Interleukin-3 236 0.5235 SUB336 C(~C)(~C)(~C)(~H) 236 0.5235 PF01425 Amidase 237 0.5234 SUB692 O-C-C-C-C-C-N 237 0.5234 PF00085 Thioredoxin 238 0.5226 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 238 0.5226 PF08246 Cathepsin propeptide inhibitor domain (I29), 239 0.5210 SUB664 O-C-C-O-[#1] 239 0.5210 PF00265 Thymidine kinase 240 0.5201 SUB674 O=C-C=C-N 240 0.5201 PF01808 AICARFT/IMPCHase bienzyme 241 0.5189 SUB651 O=C-N-C=O 241 0.5189 PF00520 Ion transport protein 242 0.5173 SUB686 O=C-C-C-C-N 242 0.5173 PF00282 Pyridoxal-dependent decarboxylase conserved domain 243 0.5169 SUB688 O=C-C-C-C=O 243 0.5169 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 244 0.5163 SUB433 C(-C)(-C)(=O) 244 0.5163 PF01067 Calpain large subunit, domain III 245 0.5161 SUB695 O=C-C-C-C-C=O 245 0.5161 PF08763 Voltage gated calcium channel IQ domain 246 0.5144 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 246 0.5144 PF02159 Oestrogen receptor 247 0.5143 SUB364 C(~F)(~F) 247 0.5143 PF00146 NADH dehydrogenase 248 0.5139 SUB629 C-N-C-C:C 248 0.5139 PF02180 Bcl-2 homology region 4 249 0.5138 SUB414 S(~C)(~H) 249 0.5138 PF00149 Calcineurin-like phosphoesterase 250 0.5137 SUB14 >= 32 C 250 0.5137 PF00149 Calcineurin-like phosphoesterase 251 0.5129 SUB408 O(~C)(~P) 251 0.5129 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 252 0.5129 SUB439 C(-C)(-N)(=N) 252 0.5129 PF00406 Adenylate kinase 253 0.5124 SUB799 CC1CC(O)CCC1 253 0.5124 PF00168 C2 domain 254 0.5116 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 254 0.5116 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 255 0.5112 SUB490 N-C-S-C 255 0.5112 PF02189 Immunoreceptor tyrosine-based activation motif 256 0.5105 SUB360 C(~C)(:N)(:N) 256 0.5105 PF00017 SH2 domain 257 0.5103 SUB250 >= 1 saturated or aromatic carbon-only ring size 10 257 0.5103 PF06327 Domain of Unknown Function (DUF1053), 258 0.5099 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 258 0.5099 PF00364 Biotin-requiring enzyme 259 0.5095 SUB4 >= 32 H 259 0.5095 PF08725 Integrin beta cytoplasmic domain 260 0.5081 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 260 0.5081 PF00501 AMP-binding enzyme 261 0.5070 SUB567 O-C-C-N 261 0.5070 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 262 0.5065 SUB705 O=C-C-C-C-C-C-C 262 0.5065 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 263 0.5059 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 263 0.5059 PF03807 NADP oxidoreductase coenzyme F420-dependent 264 0.5051 SUB386 C(:C)(:C)(:C) 264 0.5051 PF01582 TIR domain 265 0.5051 SUB687 O=C-C-C-C-O 265 0.5051 PF01112 Asparaginase 266 0.5037 SUB588 N-C:C-O-[#1] 266 0.5037 PF00001 7 transmembrane receptor (rhodopsin family), 267 0.5029 SUB588 N-C:C-O-[#1] 267 0.5029 PF00294 pfkB family carbohydrate kinase 268 0.5018 SUB350 C(~C)(~H)(~S) 268 0.5018 PF00245 Alkaline phosphatase 269 0.5007 SUB771 Nc1c(N)cccc1 269 0.5007 PF00792 Phosphoinositide 3-kinase C2 270 0.5000 SUB5 >= 1 Li 270 0.5000 PF00514 Armadillo/beta-catenin-like repeat 271 0.5000 SUB783 OC1CCC(O)CC1 271 0.5000 PF00031 Cystatin domain 272 0.5000 SUB52 >= 1 Al 272 0.5000 PF00273 Serum albumin family 273 0.5000 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 273 0.5000 PF03921 Intercellular adhesion molecule (ICAM), , N-terminal domain 274 0.5000 SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 274 0.5000 PF12126 Protein of unknown function (DUF3583), 275 0.5000 SUB348 C(~C)(~H)(~O)(~O) 275 0.5000 PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), 276 0.5000 SUB611 C-O-C-O-C 276 0.5000 PF00403 Heavy-metal-associated domain 277 0.5000 SUB589 O=C-C-C=O 277 0.5000 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), 278 0.5000 SUB158 >= 3 any ring size 5 278 0.5000 PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 279 0.5000 SUB414 S(~C)(~H) 279 0.5000 PF07722 Peptidase C26 280 0.5000 SUB687 O=C-C-C-C-O 280 0.5000 PF05328 CybS 281 0.5000 SUB66 >= 1 As 281 0.5000 PF00170 bZIP transcription factor 282 0.5000 SUB414 S(~C)(~H) 282 0.5000 PF01053 Cys/Met metabolism PLP-dependent enzyme 283 0.5000 SUB330 C(~Br)(~H) 283 0.5000 PF00631 GGL domain 284 0.5000 SUB409 O(~H)(~S) 284 0.5000 PF00188 Cysteine-rich secretory protein family 285 0.5000 SUB215 >= 1 saturated or aromatic carbon-only ring size 7 285 0.5000 PF00717 Peptidase S24-like 286 0.5000 SUB414 S(~C)(~H) 286 0.5000 PF01208 Uroporphyrinogen decarboxylase (URO-D), 287 0.5000 SUB809 SC1CC(S)CCC1 287 0.5000 PF02038 ATP1G1/PLM/MAT8 family 288 0.5000 SUB449 C(-H)(=O) 288 0.5000 PF03453 MoeA N-terminal region (domain I and II), 289 0.5000 SUB32 >= 2 P 289 0.5000 PF00629 MAM domain 290 0.5000 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 290 0.5000 PF02984 Cyclin, C-terminal domain 291 0.5000 SUB66 >= 1 As 291 0.5000 PF07970 Endoplasmic reticulum vesicle transporter 292 0.5000 SUB613 N-C-O-C-C 292 0.5000 PF00012 Hsp70 protein 293 0.5000 SUB695 O=C-C-C-C-C=O 293 0.5000 PF01019 Gamma-glutamyltranspeptidase 294 0.5000 SUB606 O=C-C-O-C 294 0.5000 PF05721 Phytanoyl-CoA dioxygenase (PhyH), 295 0.5000 SUB333 C(~C)(~C) 295 0.5000 PF01227 GTP cyclohydrolase I 296 0.4996 SUB707 O=C-C-C-C-C(=O)-C 296 0.4996 PF00001 7 transmembrane receptor (rhodopsin family), 297 0.4995 SUB762 Oc1c(O)cccc1 297 0.4995 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 298 0.4972 SUB340 C(~C)(~C)(~H)(~O) 298 0.4972 PF01433 Peptidase family M1 299 0.4964 SUB381 C(~O)(~O) 299 0.4964 PF01401 Angiotensin-converting enzyme 300 0.4940 SUB334 C(~C)(~C)(~C) 300 0.4940 PF00248 Aldo/keto reductase family 301 0.4928 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 301 0.4928 PF00702 haloacid dehalogenase-like hydrolase 302 0.4927 SUB23 >= 16 O 302 0.4927 PF00002 7 transmembrane receptor (Secretin family), 303 0.4898 SUB718 Cc1ccc(Cl)cc1 303 0.4898 PF00168 C2 domain 304 0.4889 SUB60 >= 1 Co 304 0.4889 PF01122 Eukaryotic cobalamin-binding protein 305 0.4888 SUB490 N-C-S-C 305 0.4888 PF11628 T-cell surface glycoprotein CD3 zeta chain 306 0.4879 SUB631 O-C:C-O-C 306 0.4879 PF00643 B-box zinc finger 307 0.4873 SUB381 C(~O)(~O) 307 0.4873 PF10420 Cytokine interleukin-12p40 C-terminus 308 0.4853 SUB249 >= 1 any ring size 10 308 0.4853 PF03493 Calcium-activated BK potassium channel alpha subunit 309 0.4850 SUB503 N-C=C-[#1] 309 0.4850 PF00067 Cytochrome P450 310 0.4836 SUB756 Cc1c(C)cccc1 310 0.4836 PF07645 Calcium-binding EGF domain 311 0.4816 SUB261 >= 3 hetero-aromatic rings 311 0.4816 PF01434 Peptidase family M41 312 0.4806 SUB158 >= 3 any ring size 5 312 0.4806 PF08240 Alcohol dehydrogenase GroES-like domain 313 0.4804 SUB441 C(-C)(-O)(=O) 313 0.4804 PF01063 Aminotransferase class IV 314 0.4791 SUB603 O=C-C-N-C 314 0.4791 PF00089 Trypsin 315 0.4791 SUB51 >= 1 Mg 315 0.4791 PF00625 Guanylate kinase 316 0.4788 SUB132 >= 1 saturated or aromatic nitrogen-containing ring size 4 316 0.4788 PF02460 Patched family 317 0.4783 SUB715 Cc1ccc(O)cc1 317 0.4783 PF00017 SH2 domain 318 0.4775 SUB594 N-C-C-C-N 318 0.4775 PF00149 Calcineurin-like phosphoesterase 319 0.4767 SUB730 Nc1ccc(Cl)cc1 319 0.4767 PF00343 Carbohydrate phosphorylase 320 0.4763 SUB719 Cc1ccc(Br)cc1 320 0.4763 PF00432 Prenyltransferase and squalene oxidase repeat 321 0.4761 SUB683 O-C-C-C-C-N 321 0.4761 PF07885 Ion channel 322 0.4750 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 322 0.4750 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 323 0.4749 SUB692 O-C-C-C-C-C-N 323 0.4749 PF00209 Sodium:neurotransmitter symporter family 324 0.4740 SUB4 >= 32 H 324 0.4740 PF03137 Organic Anion Transporter Polypeptide (OATP), family 325 0.4730 SUB736 Cc1cc(O)ccc1 325 0.4730 PF00001 7 transmembrane receptor (rhodopsin family), 326 0.4729 SUB23 >= 16 O 326 0.4729 PF01835 MG2 domain 327 0.4720 SUB38 >= 1 Cl 327 0.4720 PF03630 Fumble 328 0.4717 SUB3 >= 16 H 328 0.4717 PF00005 ABC transporter 329 0.4715 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 329 0.4715 PF00229 TNF(Tumour Necrosis Factor), family 330 0.4708 SUB815 NC1CC(Br)CCC1 330 0.4708 PF00001 7 transmembrane receptor (rhodopsin family), 331 0.4698 SUB32 >= 2 P 331 0.4698 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 332 0.4684 SUB567 O-C-C-N 332 0.4684 PF00557 Metallopeptidase family M24 333 0.4673 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 333 0.4673 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 334 0.4672 SUB287 C-O 334 0.4672 PF00145 C-5 cytosine-specific DNA methylase 335 0.4670 SUB624 O=C-C:C-C 335 0.4670 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 336 0.4669 SUB702 O-C-C-C-C-C(O)-C 336 0.4669 PF02055 O-Glycosyl hydrolase family 30 337 0.4666 SUB23 >= 16 O 337 0.4666 PF07703 Alpha-2-macroglobulin family N-terminal region 338 0.4655 SUB686 O=C-C-C-C-N 338 0.4655 PF00755 Choline/Carnitine o-acyltransferase 339 0.4654 SUB545 O-C:C-O 339 0.4654 PF01596 O-methyltransferase 340 0.4642 SUB338 C(~C)(~C)(~C)(~O) 340 0.4642 PF00149 Calcineurin-like phosphoesterase 341 0.4633 SUB39 >= 2 Cl 341 0.4633 PF00067 Cytochrome P450 342 0.4631 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 342 0.4631 PF00211 Adenylate and Guanylate cyclase catalytic domain 343 0.4627 SUB250 >= 1 saturated or aromatic carbon-only ring size 10 343 0.4627 PF08491 Squalene epoxidase 344 0.4624 SUB158 >= 3 any ring size 5 344 0.4624 PF00067 Cytochrome P450 345 0.4624 SUB691 O-C-C-C-C-C-O 345 0.4624 PF00005 ABC transporter 346 0.4623 SUB336 C(~C)(~C)(~C)(~H) 346 0.4623 PF00005 ABC transporter 347 0.4622 SUB680 C-C-C-C-C-C 347 0.4622 PF08534 Redoxin 348 0.4622 SUB712 C-C(C)(C)-C-C 348 0.4622 PF00104 Ligand-binding domain of nuclear hormone receptor 349 0.4620 SUB59 >= 1 Fe 349 0.4620 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 350 0.4615 SUB409 O(~H)(~S) 350 0.4615 PF00001 7 transmembrane receptor (rhodopsin family), 351 0.4598 SUB702 O-C-C-C-C-C(O)-C 351 0.4598 PF01347 Lipoprotein amino terminal region 352 0.4595 SUB381 C(~O)(~O) 352 0.4595 PF00058 Low-density lipoprotein receptor repeat class B 353 0.4591 SUB13 >= 16 C 353 0.4591 PF00171 Aldehyde dehydrogenase family 354 0.4584 SUB286 C-N 354 0.4584 PF00497 Bacterial extracellular solute-binding proteins, family 3 355 0.4580 SUB158 >= 3 any ring size 5 355 0.4580 PF00106 short chain dehydrogenase 356 0.4578 SUB801 CC1CC(N)CCC1 356 0.4578 PF02394 Interleukin-1 propeptide 357 0.4577 SUB337 C(~C)(~C)(~C)(~N) 357 0.4577 PF00431 CUB domain 358 0.4572 SUB615 C-C-O-C-C 358 0.4572 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 359 0.4571 SUB407 O(~C)(~H) 359 0.4571 PF00079 Serpin (serine protease inhibitor), 360 0.4566 SUB694 O=C-C-C-C-C-O 360 0.4566 PF00229 TNF(Tumour Necrosis Factor), family 361 0.4563 SUB441 C(-C)(-O)(=O) 361 0.4563 PF00092 von Willebrand factor type A domain 362 0.4561 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 362 0.4561 PF00041 Fibronectin type III domain 363 0.4548 SUB696 O=C-C-C-C-C-N 363 0.4548 PF00490 Delta-aminolevulinic acid dehydratase 364 0.4543 SUB686 O=C-C-C-C-N 364 0.4543 PF01094 Receptor family ligand binding region 365 0.4538 SUB349 C(~C)(~H)(~P) 365 0.4538 PF12179 I-kappa-kinase-beta NEMO binding domain 366 0.4537 SUB578 C:C-N-C:C 366 0.4537 PF07686 Immunoglobulin V-set domain 367 0.4536 SUB348 C(~C)(~H)(~O)(~O) 367 0.4536 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 368 0.4535 SUB594 N-C-C-C-N 368 0.4535 PF00089 Trypsin 369 0.4534 SUB23 >= 16 O 369 0.4534 PF02793 Hormone receptor domain 370 0.4533 SUB413 S(~C)(~C) 370 0.4533 PF00186 Dihydrofolate reductase 371 0.4533 SUB708 O=C-C-C-C-C(N)-C 371 0.4533 PF02310 B12 binding domain 372 0.4531 SUB581 O=C-C-C-N 372 0.4531 PF01731 Arylesterase 373 0.4527 SUB567 O-C-C-N 373 0.4527 PF00266 Aminotransferase class-V 374 0.4527 SUB840 CC1CC(C)CC1 374 0.4527 PF00105 Zinc finger, C4 type (two domains), 375 0.4526 SUB580 O=C-C-C-C 375 0.4526 PF00153 Mitochondrial carrier protein 376 0.4516 SUB691 O-C-C-C-C-C-O 376 0.4516 PF00180 Isocitrate/isopropylmalate dehydrogenase 377 0.4509 SUB588 N-C:C-O-[#1] 377 0.4509 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 378 0.4508 SUB207 >= 5 any ring size 6 378 0.4508 PF02932 Neurotransmitter-gated ion-channel transmembrane region 379 0.4507 SUB792 NC1CCC(N)CC1 379 0.4507 PF00001 7 transmembrane receptor (rhodopsin family), 380 0.4507 SUB686 O=C-C-C-C-N 380 0.4507 PF00023 Ankyrin repeat 381 0.4506 SUB421 C=O 381 0.4506 PF00107 Zinc-binding dehydrogenase 382 0.4506 SUB414 S(~C)(~H) 382 0.4506 PF05995 Cysteine dioxygenase type I 383 0.4503 SUB458 S(-C)(=O) 383 0.4503 PF00230 Major intrinsic protein 384 0.4502 SUB782 CC1CCC(Br)CC1 384 0.4502 PF00432 Prenyltransferase and squalene oxidase repeat 385 0.4498 SUB572 [#1]-C-O-[#1] 385 0.4498 PF01607 Chitin binding Peritrophin-A domain 386 0.4497 SUB160 >= 3 saturated or aromatic nitrogen-containing ring size 5 386 0.4497 PF03002 Somatostatin/Cortistatin family 387 0.4497 SUB801 CC1CC(N)CCC1 387 0.4497 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 388 0.4495 SUB66 >= 1 As 388 0.4495 PF00005 ABC transporter 389 0.4486 SUB698 C-C-C-C-C-C(C)-C 389 0.4486 PF00413 Matrixin 390 0.4479 SUB702 O-C-C-C-C-C(O)-C 390 0.4479 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 391 0.4474 SUB456 N(-O)(=O) 391 0.4474 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 392 0.4473 SUB299 C-I 392 0.4473 PF12605 Casein kinase 1 gamma C terminal 393 0.4459 SUB572 [#1]-C-O-[#1] 393 0.4459 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 394 0.4438 SUB313 O-Al 394 0.4438 PF01459 Eukaryotic porin 395 0.4432 SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 395 0.4432 PF02259 FAT domain 396 0.4431 SUB529 [#1]-N-C-[#1] 396 0.4431 PF00117 Glutamine amidotransferase class-I 397 0.4430 SUB459 S(-O)(=O) 397 0.4430 PF01530 Zinc finger, C2HC type 398 0.4425 SUB757 Cc1c(O)cccc1 398 0.4425 PF00005 ABC transporter 399 0.4413 SUB414 S(~C)(~H) 399 0.4413 PF00806 Pumilio-family RNA binding repeat 400 0.4406 SUB186 >= 2 any ring size 6 400 0.4406 PF00067 Cytochrome P450 401 0.4404 SUB688 O=C-C-C-C=O 401 0.4404 PF00229 TNF(Tumour Necrosis Factor), family 402 0.4395 SUB825 OC1C(O)CCCC1 402 0.4395 PF01596 O-methyltransferase 403 0.4389 SUB249 >= 1 any ring size 10 403 0.4389 PF02254 TrkA-N domain 404 0.4385 SUB444 C(-C)(=O) 404 0.4385 PF00202 Aminotransferase class-III 405 0.4384 SUB31 >= 1 P 405 0.4384 PF03770 Inositol polyphosphate kinase 406 0.4384 SUB779 CC1CCC(S)CC1 406 0.4384 PF00005 ABC transporter 407 0.4383 SUB706 O=C-C-C-C-C(O)-C 407 0.4383 PF00104 Ligand-binding domain of nuclear hormone receptor 408 0.4380 SUB295 C-Cl 408 0.4380 PF02888 Calmodulin binding domain 409 0.4370 SUB664 O-C-C-O-[#1] 409 0.4370 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 410 0.4370 SUB414 S(~C)(~H) 410 0.4370 PF03002 Somatostatin/Cortistatin family 411 0.4365 SUB486 N:C:C:N 411 0.4365 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 412 0.4364 SUB793 NC1CCC(Cl)CC1 412 0.4364 PF00343 Carbohydrate phosphorylase 413 0.4363 SUB350 C(~C)(~H)(~S) 413 0.4363 PF02798 Glutathione S-transferase, N-terminal domain 414 0.4357 SUB624 O=C-C:C-C 414 0.4357 PF01347 Lipoprotein amino terminal region 415 0.4354 SUB550 N-C-C:C 415 0.4354 PF00229 TNF(Tumour Necrosis Factor), family 416 0.4353 SUB580 O=C-C-C-C 416 0.4353 PF00106 short chain dehydrogenase 417 0.4350 SUB256 >= 1 aromatic ring 417 0.4350 PF00001 7 transmembrane receptor (rhodopsin family), 418 0.4348 SUB711 C-C-C(C)-C-C 418 0.4348 PF00233 3"5"-cyclic nucleotide phosphodiesterase 419 0.4342 SUB567 O-C-C-N 419 0.4342 PF00282 Pyridoxal-dependent decarboxylase conserved domain 420 0.4342 SUB674 O=C-C=C-N 420 0.4342 PF02142 MGS-like domain 421 0.4337 SUB32 >= 2 P 421 0.4337 PF05347 Complex 1 protein (LYR family), 422 0.4327 SUB588 N-C:C-O-[#1] 422 0.4327 PF00155 Aminotransferase class I and II 423 0.4323 SUB674 O=C-C=C-N 423 0.4323 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 424 0.4321 SUB406 O(~C)(~C) 424 0.4321 PF00122 E1-E2 ATPase 425 0.4312 SUB602 N-C:C:C-N 425 0.4312 PF00069 Protein kinase domain 426 0.4310 SUB606 O=C-C-O-C 426 0.4310 PF00001 7 transmembrane receptor (rhodopsin family), 427 0.4309 SUB751 Nc1cc(Cl)ccc1 427 0.4309 PF00043 Glutathione S-transferase, C-terminal domain 428 0.4308 SUB207 >= 5 any ring size 6 428 0.4308 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 429 0.4304 SUB193 >= 3 any ring size 6 429 0.4304 PF06387 D1 dopamine receptor-interacting protein (calcyon), 430 0.4301 SUB862 CC1C(O)CCC1 430 0.4301 PF00001 7 transmembrane receptor (rhodopsin family), 431 0.4297 SUB547 N-C:C-[#1] 431 0.4297 PF07885 Ion channel 432 0.4295 SUB578 C:C-N-C:C 432 0.4295 PF00343 Carbohydrate phosphorylase 433 0.4287 SUB52 >= 1 Al 433 0.4287 PF00405 Transferrin 434 0.4283 SUB407 O(~C)(~H) 434 0.4283 PF00576 HIUase/Transthyretin family 435 0.4282 SUB242 >= 1 any ring size 9 435 0.4282 PF00212 Atrial natriuretic peptide 436 0.4277 SUB589 O=C-C-C=O 436 0.4277 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 437 0.4272 SUB704 O-C-C-C-C-C(N)-C 437 0.4272 PF00040 Fibronectin type II domain 438 0.4265 SUB447 C(-H)(=C) 438 0.4265 PF03098 Animal haem peroxidase 439 0.4248 SUB594 N-C-C-C-N 439 0.4248 PF01564 Spermine/spermidine synthase 440 0.4232 SUB696 O=C-C-C-C-C-N 440 0.4232 PF02100 Ornithine decarboxylase antizyme 441 0.4229 SUB389 C(:C)(:N)(:N) 441 0.4229 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 442 0.4227 SUB368 C(~H)(~O)(~O) 442 0.4227 PF00090 Thrombospondin type 1 domain 443 0.4225 SUB614 C-N-C-C-C 443 0.4225 PF01007 Inward rectifier potassium channel 444 0.4217 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 444 0.4217 PF00059 Lectin C-type domain 445 0.4203 SUB441 C(-C)(-O)(=O) 445 0.4203 PF00354 Pentaxin family 446 0.4201 SUB275 B-C 446 0.4201 PF00227 Proteasome subunit 447 0.4192 SUB692 O-C-C-C-C-C-N 447 0.4192 PF00491 Arginase family 448 0.4179 SUB629 C-N-C-C:C 448 0.4179 PF00452 Apoptosis regulator proteins, Bcl-2 family 449 0.4173 SUB694 O=C-C-C-C-C-O 449 0.4173 PF05378 Hydantoinase/oxoprolinase N-terminal region 450 0.4169 SUB781 CC1CCC(Cl)CC1 450 0.4169 PF01094 Receptor family ligand binding region 451 0.4168 SUB431 C(-C)(-C)(=C) 451 0.4168 PF01593 Flavin containing amine oxidoreductase 452 0.4152 SUB386 C(:C)(:C)(:C) 452 0.4152 PF00989 PAS fold 453 0.4151 SUB32 >= 2 P 453 0.4151 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 454 0.4144 SUB813 NC1CC(N)CCC1 454 0.4144 PF00754 F5/8 type C domain 455 0.4143 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 455 0.4143 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 456 0.4142 SUB460 S(=O)(=O) 456 0.4142 PF08399 VWA N-terminal 457 0.4139 SUB686 O=C-C-C-C-N 457 0.4139 PF01323 DSBA-like thioredoxin domain 458 0.4137 SUB352 C(~C)(~N) 458 0.4137 PF00001 7 transmembrane receptor (rhodopsin family), 459 0.4135 SUB336 C(~C)(~C)(~C)(~H) 459 0.4135 PF01462 Leucine rich repeat N-terminal domain 460 0.4132 SUB348 C(~C)(~H)(~O)(~O) 460 0.4132 PF04711 Apolipoprotein A-II (ApoA-II), 461 0.4126 SUB690 O-C-C-C-C-C-C 461 0.4126 PF08763 Voltage gated calcium channel IQ domain 462 0.4125 SUB35 >= 2 S 462 0.4125 PF04055 Radical SAM superfamily 463 0.4123 SUB407 O(~C)(~H) 463 0.4123 PF08240 Alcohol dehydrogenase GroES-like domain 464 0.4116 SUB578 C:C-N-C:C 464 0.4116 PF00043 Glutathione S-transferase, C-terminal domain 465 0.4114 SUB440 C(-C)(-N)(=O) 465 0.4114 PF00068 Phospholipase A2 466 0.4100 SUB200 >= 4 any ring size 6 466 0.4100 PF00043 Glutathione S-transferase, C-terminal domain 467 0.4095 SUB339 C(~C)(~C)(~H)(~N) 467 0.4095 PF07690 Major Facilitator Superfamily 468 0.4094 SUB451 C(-N)(=N) 468 0.4094 PF00069 Protein kinase domain 469 0.4092 SUB568 O-C-C-O 469 0.4092 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 470 0.4089 SUB677 N#C-C-C-C 470 0.4089 PF00520 Ion transport protein 471 0.4085 SUB348 C(~C)(~H)(~O)(~O) 471 0.4085 PF07654 Immunoglobulin C1-set domain 472 0.4083 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 472 0.4083 PF02466 Tim17/Tim22/Tim23 family 473 0.4081 SUB158 >= 3 any ring size 5 473 0.4081 PF00170 bZIP transcription factor 474 0.4064 SUB200 >= 4 any ring size 6 474 0.4064 PF00089 Trypsin 475 0.4055 SUB666 N-C:C-C-C 475 0.4055 PF00520 Ion transport protein 476 0.4049 SUB695 O=C-C-C-C-C=O 476 0.4049 PF02934 GatB/GatE catalytic domain 477 0.4049 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 477 0.4049 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 478 0.4043 SUB594 N-C-C-C-N 478 0.4043 PF00026 Eukaryotic aspartyl protease 479 0.4029 SUB406 O(~C)(~C) 479 0.4029 PF00001 7 transmembrane receptor (rhodopsin family), 480 0.4020 SUB486 N:C:C:N 480 0.4020 PF00858 Amiloride-sensitive sodium channel 481 0.4005 SUB691 O-C-C-C-C-C-O 481 0.4005 PF01571 Aminomethyltransferase folate-binding domain 482 0.3984 SUB663 O-C-C-O-C 482 0.3984 PF00089 Trypsin 483 0.3983 SUB441 C(-C)(-O)(=O) 483 0.3983 PF00682 HMGL-like 484 0.3982 SUB389 C(:C)(:N)(:N) 484 0.3982 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 485 0.3982 SUB346 C(~C)(~H)(~N) 485 0.3982 PF02159 Oestrogen receptor 486 0.3980 SUB144 >= 1 any ring size 5 486 0.3980 PF00233 3"5"-cyclic nucleotide phosphodiesterase 487 0.3980 SUB603 O=C-C-N-C 487 0.3980 PF00151 Lipase 488 0.3978 SUB332 C(~Br)(:N) 488 0.3978 PF03002 Somatostatin/Cortistatin family 489 0.3978 SUB349 C(~C)(~H)(~P) 489 0.3978 PF00328 Histidine acid phosphatase 490 0.3973 SUB698 C-C-C-C-C-C(C)-C 490 0.3973 PF00106 short chain dehydrogenase 491 0.3967 SUB196 >= 3 saturated or aromatic heteroatom-containing ring size 6 491 0.3967 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 492 0.3962 SUB756 Cc1c(C)cccc1 492 0.3962 PF11956 Ankyrin-G binding motif of KCNQ2-3 493 0.3952 SUB376 C(~N)(~N) 493 0.3952 PF01007 Inward rectifier potassium channel 494 0.3946 SUB337 C(~C)(~C)(~C)(~N) 494 0.3946 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 495 0.3939 SUB158 >= 3 any ring size 5 495 0.3939 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 496 0.3936 SUB662 O-C-O-C-C 496 0.3936 PF00209 Sodium:neurotransmitter symporter family 497 0.3924 SUB130 >= 1 any ring size 4 497 0.3924 PF00854 POT family 498 0.3907 SUB348 C(~C)(~H)(~O)(~O) 498 0.3907 PF00337 Galactoside-binding lectin 499 0.3896 SUB52 >= 1 Al 499 0.3896 PF01459 Eukaryotic porin 500 0.3891 SUB345 C(~C)(~H) 500 0.3891 PF00045 Hemopexin 501 0.3885 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 501 0.3885 PF00489 Interleukin-6/G-CSF/MGF family 502 0.3883 SUB18 >= 8 N 502 0.3883 PF00184 Neurohypophysial hormones, C-terminal Domain 503 0.3882 SUB95 >= 1 Au 503 0.3882 PF12179 I-kappa-kinase-beta NEMO binding domain 504 0.3878 SUB408 O(~C)(~P) 504 0.3878 PF00070 Pyridine nucleotide-disulphide oxidoreductase 505 0.3871 SUB638 O-C-C-C-C 505 0.3871 PF00764 Arginosuccinate synthase 506 0.3870 SUB543 O-C:C-[#1] 506 0.3870 PF00656 Caspase domain 507 0.3870 SUB340 C(~C)(~C)(~H)(~O) 507 0.3870 PF07686 Immunoglobulin V-set domain 508 0.3868 SUB21 >= 4 O 508 0.3868 PF08246 Cathepsin propeptide inhibitor domain (I29), 509 0.3868 SUB806 OC1CC(N)CCC1 509 0.3868 PF00341 Platelet-derived growth factor (PDGF), 510 0.3866 SUB567 O-C-C-N 510 0.3866 PF00248 Aldo/keto reductase family 511 0.3863 SUB677 N#C-C-C-C 511 0.3863 PF00194 Eukaryotic-type carbonic anhydrase 512 0.3859 SUB228 >= 1 any ring size 8 512 0.3859 PF02932 Neurotransmitter-gated ion-channel transmembrane region 513 0.3859 SUB696 O=C-C-C-C-C-N 513 0.3859 PF00653 Inhibitor of Apoptosis domain 514 0.3856 SUB572 [#1]-C-O-[#1] 514 0.3856 PF04515 Plasma-membrane choline transporter 515 0.3856 SUB369 C(~H)(~S) 515 0.3856 PF00233 3"5"-cyclic nucleotide phosphodiesterase 516 0.3854 SUB12 >= 8 C 516 0.3854 PF01593 Flavin containing amine oxidoreductase 517 0.3850 SUB639 O-C-C-C-N 517 0.3850 PF00040 Fibronectin type II domain 518 0.3848 SUB45 >= 2 Br 518 0.3848 PF00568 WH1 domain 519 0.3845 SUB529 [#1]-N-C-[#1] 519 0.3845 PF01490 Transmembrane amino acid transporter protein 520 0.3844 SUB151 >= 2 any ring size 5 520 0.3844 PF00069 Protein kinase domain 521 0.3841 SUB720 Oc1ccc(O)cc1 521 0.3841 PF00105 Zinc finger, C4 type (two domains), 522 0.3835 SUB537 O=C-C-N 522 0.3835 PF00248 Aldo/keto reductase family 523 0.3833 SUB441 C(-C)(-O)(=O) 523 0.3833 PF00151 Lipase 524 0.3830 SUB697 C-C-C-C-C-C-C-C 524 0.3830 PF00432 Prenyltransferase and squalene oxidase repeat 525 0.3827 SUB703 O-C-C-C-C-C-N-C 525 0.3827 PF01401 Angiotensin-converting enzyme 526 0.3815 SUB494 O=C-C:C 526 0.3815 PF00071 Ras family 527 0.3813 SUB580 O=C-C-C-C 527 0.3813 PF03807 NADP oxidoreductase coenzyme F420-dependent 528 0.3800 SUB645 C-C=N-N-C 528 0.3800 PF00233 3"5"-cyclic nucleotide phosphodiesterase 529 0.3795 SUB412 P(~O)(~O) 529 0.3795 PF00074 Pancreatic ribonuclease 530 0.3795 SUB32 >= 2 P 530 0.3795 PF00153 Mitochondrial carrier protein 531 0.3789 SUB682 O-C-C-C-C-O 531 0.3789 PF00079 Serpin (serine protease inhibitor), 532 0.3785 SUB672 O=C-C=C-C 532 0.3785 PF00069 Protein kinase domain 533 0.3778 SUB441 C(-C)(-O)(=O) 533 0.3778 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 534 0.3774 SUB615 C-C-O-C-C 534 0.3774 PF03137 Organic Anion Transporter Polypeptide (OATP), family 535 0.3773 SUB459 S(-O)(=O) 535 0.3773 PF00822 PMP-22/EMP/MP20/Claudin family 536 0.3767 SUB660 O-C-C-N-C 536 0.3767 PF04515 Plasma-membrane choline transporter 537 0.3764 SUB572 [#1]-C-O-[#1] 537 0.3764 PF07653 Variant SH3 domain 538 0.3759 SUB708 O=C-C-C-C-C(N)-C 538 0.3759 PF01426 BAH domain 539 0.3754 SUB660 O-C-C-N-C 539 0.3754 PF00067 Cytochrome P450 540 0.3746 SUB378 C(~N)(:C)(:C) 540 0.3746 PF00229 TNF(Tumour Necrosis Factor), family 541 0.3743 SUB648 O=C-N-C-N 541 0.3743 PF00692 dUTPase 542 0.3742 SUB769 Sc1c(Cl)cccc1 542 0.3742 PF02060 Slow voltage-gated potassium channel 543 0.3740 SUB802 CC1CC(Cl)CCC1 543 0.3740 PF00243 Nerve growth factor family 544 0.3738 SUB522 C:N-C-[#1] 544 0.3738 PF01731 Arylesterase 545 0.3732 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 545 0.3732 PF00069 Protein kinase domain 546 0.3729 SUB339 C(~C)(~C)(~H)(~N) 546 0.3729 PF07562 Nine Cysteines Domain of family 3 GPCR 547 0.3724 SUB193 >= 3 any ring size 6 547 0.3724 PF04622 ERG2 and Sigma1 receptor like protein 548 0.3720 SUB664 O-C-C-O-[#1] 548 0.3720 PF01370 NAD dependent epimerase/dehydratase family 549 0.3718 SUB353 C(~C)(~O) 549 0.3718 PF00233 3"5"-cyclic nucleotide phosphodiesterase 550 0.3716 SUB343 C(~C)(~Cl) 550 0.3716 PF00084 Sushi domain (SCR repeat), 551 0.3712 SUB25 >= 2 F 551 0.3712 PF00702 haloacid dehalogenase-like hydrolase 552 0.3709 SUB498 O-C:C:N 552 0.3709 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 553 0.3705 SUB151 >= 2 any ring size 5 553 0.3705 PF00170 bZIP transcription factor 554 0.3689 SUB440 C(-C)(-N)(=O) 554 0.3689 PF03073 TspO/MBR family 555 0.3687 SUB674 O=C-C=C-N 555 0.3687 PF00550 Phosphopantetheine attachment site 556 0.3686 SUB647 O=C-N-C-[#1] 556 0.3686 PF01401 Angiotensin-converting enzyme 557 0.3680 SUB757 Cc1c(O)cccc1 557 0.3680 PF00001 7 transmembrane receptor (rhodopsin family), 558 0.3671 SUB503 N-C=C-[#1] 558 0.3671 PF07885 Ion channel 559 0.3671 SUB451 C(-N)(=N) 559 0.3671 PF00001 7 transmembrane receptor (rhodopsin family), 560 0.3662 SUB365 C(~F)(:C) 560 0.3662 PF00493 MCM2/3/5 family 561 0.3661 SUB688 O=C-C-C-C=O 561 0.3661 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 562 0.3659 SUB688 O=C-C-C-C=O 562 0.3659 PF01112 Asparaginase 563 0.3654 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 563 0.3654 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 564 0.3652 SUB638 O-C-C-C-C 564 0.3652 PF00001 7 transmembrane receptor (rhodopsin family), 565 0.3647 SUB646 O=C-N-C-C 565 0.3647 PF00074 Pancreatic ribonuclease 566 0.3643 SUB675 N-C-N-C:C 566 0.3643 PF00001 7 transmembrane receptor (rhodopsin family), 567 0.3638 SUB413 S(~C)(~C) 567 0.3638 PF01625 Peptide methionine sulfoxide reductase 568 0.3637 SUB697 C-C-C-C-C-C-C-C 568 0.3637 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 569 0.3636 SUB52 >= 1 Al 569 0.3636 PF00702 haloacid dehalogenase-like hydrolase 570 0.3636 SUB25 >= 2 F 570 0.3636 PF00689 Cation transporting ATPase, C-terminus 571 0.3634 SUB663 O-C-C-O-C 571 0.3634 PF00454 Phosphatidylinositol 3- and 4-kinase 572 0.3631 SUB621 C:C-O-C-C 572 0.3631 PF00591 Glycosyl transferase family, a/b domain 573 0.3629 SUB735 Cc1cc(C)ccc1 573 0.3629 PF00757 Furin-like cysteine rich region 574 0.3626 SUB340 C(~C)(~C)(~H)(~O) 574 0.3626 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 575 0.3620 SUB158 >= 3 any ring size 5 575 0.3620 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 576 0.3619 SUB621 C:C-O-C-C 576 0.3619 PF01023 S-100/ICaBP type calcium binding domain 577 0.3616 SUB375 C(~H)(~H)(~H) 577 0.3616 PF00135 Carboxylesterase 578 0.3614 SUB379 C(~N)(:C)(:N) 578 0.3614 PF00858 Amiloride-sensitive sodium channel 579 0.3610 SUB632 O-C:C-O-[#1] 579 0.3610 PF01596 O-methyltransferase 580 0.3609 SUB516 N-N-C-C 580 0.3609 PF00079 Serpin (serine protease inhibitor), 581 0.3600 SUB718 Cc1ccc(Cl)cc1 581 0.3600 PF01094 Receptor family ligand binding region 582 0.3596 SUB412 P(~O)(~O) 582 0.3596 PF01652 Eukaryotic initiation factor 4E 583 0.3594 SUB500 N-C:C:N 583 0.3594 PF00962 Adenosine/AMP deaminase 584 0.3592 SUB3 >= 16 H 584 0.3592 PF00001 7 transmembrane receptor (rhodopsin family), 585 0.3575 SUB296 C-As 585 0.3575 PF01161 Phosphatidylethanolamine-binding protein 586 0.3554 SUB14 >= 32 C 586 0.3554 PF08983 Domain of unknown function (DUF1856), 587 0.3549 SUB835 NC1C(Cl)CCCC1 587 0.3549 PF00001 7 transmembrane receptor (rhodopsin family), 588 0.3547 SUB691 O-C-C-C-C-C-O 588 0.3547 PF01230 HIT domain 589 0.3538 SUB369 C(~H)(~S) 589 0.3538 PF00184 Neurohypophysial hormones, C-terminal Domain 590 0.3537 SUB759 Cc1c(N)cccc1 590 0.3537 PF00305 Lipoxygenase 591 0.3537 SUB180 >= 1 saturated or aromatic carbon-only ring size 6 591 0.3537 PF00001 7 transmembrane receptor (rhodopsin family), 592 0.3537 SUB640 O-C-C-C-O 592 0.3537 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 593 0.3536 SUB351 C(~C)(~I) 593 0.3536 PF00233 3"5"-cyclic nucleotide phosphodiesterase 594 0.3530 SUB364 C(~F)(~F) 594 0.3530 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 595 0.3527 SUB32 >= 2 P 595 0.3527 PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 596 0.3521 SUB25 >= 2 F 596 0.3521 PF00146 NADH dehydrogenase 597 0.3520 SUB646 O=C-N-C-C 597 0.3520 PF00005 ABC transporter 598 0.3519 SUB664 O-C-C-O-[#1] 598 0.3519 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 599 0.3519 SUB647 O=C-N-C-[#1] 599 0.3519 PF07686 Immunoglobulin V-set domain 600 0.3514 SUB611 C-O-C-O-C 600 0.3514 PF00884 Sulfatase 601 0.3511 SUB694 O=C-C-C-C-C-O 601 0.3511 PF03024 Folate receptor family 602 0.3510 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 602 0.3510 PF06907 Latexin 603 0.3509 SUB158 >= 3 any ring size 5 603 0.3509 PF08040 MNLL subunit 604 0.3503 SUB356 C(~C)(:C) 604 0.3503 PF00001 7 transmembrane receptor (rhodopsin family), 605 0.3499 SUB683 O-C-C-C-C-N 605 0.3499 PF00225 Kinesin motor domain 606 0.3495 SUB640 O-C-C-C-O 606 0.3495 PF01230 HIT domain 607 0.3490 SUB712 C-C(C)(C)-C-C 607 0.3490 PF03953 Tubulin C-terminal domain 608 0.3489 SUB686 O=C-C-C-C-N 608 0.3489 PF08763 Voltage gated calcium channel IQ domain 609 0.3488 SUB408 O(~C)(~P) 609 0.3488 PF01130 CD36 family 610 0.3487 SUB495 O=C-C:N 610 0.3487 PF01652 Eukaryotic initiation factor 4E 611 0.3486 SUB686 O=C-C-C-C-N 611 0.3486 PF04961 Formiminotransferase-cyclodeaminase 612 0.3485 SUB394 N(~C)(~H) 612 0.3485 PF00186 Dihydrofolate reductase 613 0.3478 SUB486 N:C:C:N 613 0.3478 PF04389 Peptidase family M28 614 0.3477 SUB36 >= 4 S 614 0.3477 PF00089 Trypsin 615 0.3473 SUB517 [#1]-C=C-[#1] 615 0.3473 PF00069 Protein kinase domain 616 0.3473 SUB694 O=C-C-C-C-C-O 616 0.3473 PF00696 Amino acid kinase family 617 0.3457 SUB261 >= 3 hetero-aromatic rings 617 0.3457 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 618 0.3450 SUB644 [#1]-C-C-N-[#1] 618 0.3450 PF02166 Androgen receptor 619 0.3444 SUB560 O-C-N-[#1] 619 0.3444 PF00377 Prion/Doppel alpha-helical domain 620 0.3440 SUB659 C-C-S-C-C 620 0.3440 PF00001 7 transmembrane receptor (rhodopsin family), 621 0.3438 SUB361 C(~Cl)(~Cl) 621 0.3438 PF00153 Mitochondrial carrier protein 622 0.3437 SUB683 O-C-C-C-C-N 622 0.3437 PF01607 Chitin binding Peritrophin-A domain 623 0.3434 SUB685 O=C-C-C-C-C 623 0.3434 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 624 0.3428 SUB96 >= 1 Hg 624 0.3428 PF00171 Aldehyde dehydrogenase family 625 0.3421 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 625 0.3421 PF00180 Isocitrate/isopropylmalate dehydrogenase 626 0.3415 SUB694 O=C-C-C-C-C-O 626 0.3415 PF00749 tRNA synthetases class I (E and Q), , catalytic domain 627 0.3412 SUB407 O(~C)(~H) 627 0.3412 PF00169 PH domain 628 0.3410 SUB716 Cc1ccc(S)cc1 628 0.3410 PF00005 ABC transporter 629 0.3407 SUB345 C(~C)(~H) 629 0.3407 PF00060 Ligand-gated ion channel 630 0.3406 SUB494 O=C-C:C 630 0.3406 PF00017 SH2 domain 631 0.3402 SUB707 O=C-C-C-C-C(=O)-C 631 0.3402 PF00377 Prion/Doppel alpha-helical domain 632 0.3400 SUB625 O=C-C:C-N 632 0.3400 PF00071 Ras family 633 0.3395 SUB158 >= 3 any ring size 5 633 0.3395 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 634 0.3394 SUB340 C(~C)(~C)(~H)(~O) 634 0.3394 PF02898 Nitric oxide synthase, oxygenase domain 635 0.3391 SUB378 C(~N)(:C)(:C) 635 0.3391 PF00850 Histone deacetylase domain 636 0.3389 SUB21 >= 4 O 636 0.3389 PF00413 Matrixin 637 0.3387 SUB756 Cc1c(C)cccc1 637 0.3387 PF00433 Protein kinase C terminal domain 638 0.3384 SUB703 O-C-C-C-C-C-N-C 638 0.3384 PF08527 Protein-arginine deiminase (PAD), middle domain 639 0.3382 SUB621 C:C-O-C-C 639 0.3382 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 640 0.3379 SUB688 O=C-C-C-C=O 640 0.3379 PF01546 Peptidase family M20/M25/M40 641 0.3366 SUB703 O-C-C-C-C-C-N-C 641 0.3366 PF00211 Adenylate and Guanylate cyclase catalytic domain 642 0.3365 SUB694 O=C-C-C-C-C-O 642 0.3365 PF02798 Glutathione S-transferase, N-terminal domain 643 0.3365 SUB23 >= 16 O 643 0.3365 PF00248 Aldo/keto reductase family 644 0.3363 SUB567 O-C-C-N 644 0.3363 PF03917 Eukaryotic glutathione synthase, ATP binding domain 645 0.3359 SUB688 O=C-C-C-C=O 645 0.3359 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 646 0.3356 SUB694 O=C-C-C-C-C-O 646 0.3356 PF01433 Peptidase family M1 647 0.3354 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 647 0.3354 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 648 0.3353 SUB633 C-C-O-C:C 648 0.3353 PF01023 S-100/ICaBP type calcium binding domain 649 0.3353 SUB4 >= 32 H 649 0.3353 PF04051 Transport protein particle (TRAPP), component 650 0.3350 SUB699 O-C-C-C-C-C-C-C 650 0.3350 PF00664 ABC transporter transmembrane region 651 0.3348 SUB647 O=C-N-C-[#1] 651 0.3348 PF00656 Caspase domain 652 0.3333 SUB32 >= 2 P 652 0.3333 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 653 0.3317 SUB613 N-C-O-C-C 653 0.3317 PF01712 Deoxynucleoside kinase 654 0.3297 SUB738 Cc1cc(N)ccc1 654 0.3297 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 655 0.3296 SUB626 O=C-C:C-O 655 0.3296 PF00018 SH3 domain 656 0.3294 SUB825 OC1C(O)CCCC1 656 0.3294 PF03953 Tubulin C-terminal domain 657 0.3294 SUB259 >= 2 hetero-aromatic rings 657 0.3294 PF00520 Ion transport protein 658 0.3285 SUB338 C(~C)(~C)(~C)(~O) 658 0.3285 PF00246 Zinc carboxypeptidase 659 0.3280 SUB498 O-C:C:N 659 0.3280 PF00266 Aminotransferase class-V 660 0.3277 SUB389 C(:C)(:N)(:N) 660 0.3277 PF00136 DNA polymerase family B 661 0.3277 SUB158 >= 3 any ring size 5 661 0.3277 PF09166 Biliverdin reductase, catalytic 662 0.3277 SUB592 Cl-C-C-C-C 662 0.3277 PF03630 Fumble 663 0.3276 SUB379 C(~N)(:C)(:N) 663 0.3276 PF00156 Phosphoribosyl transferase domain 664 0.3275 SUB706 O=C-C-C-C-C(O)-C 664 0.3275 PF00067 Cytochrome P450 665 0.3275 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 665 0.3275 PF00364 Biotin-requiring enzyme 666 0.3274 SUB577 N=C-C:C-[#1] 666 0.3274 PF00106 short chain dehydrogenase 667 0.3273 SUB444 C(-C)(=O) 667 0.3273 PF00266 Aminotransferase class-V 668 0.3271 SUB438 C(-C)(-N)(=C) 668 0.3271 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 669 0.3270 SUB438 C(-C)(-N)(=C) 669 0.3270 PF00520 Ion transport protein 670 0.3270 SUB35 >= 2 S 670 0.3270 PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain 671 0.3267 SUB533 S-C:C-[#1] 671 0.3267 PF00104 Ligand-binding domain of nuclear hormone receptor 672 0.3267 SUB454 N(-C)(=C) 672 0.3267 PF00069 Protein kinase domain 673 0.3266 SUB338 C(~C)(~C)(~C)(~O) 673 0.3266 PF08384 Pro-opiomelanocortin, N-terminal region 674 0.3266 SUB66 >= 1 As 674 0.3266 PF08240 Alcohol dehydrogenase GroES-like domain 675 0.3265 SUB693 O=C-C-C-C-C-C 675 0.3265 PF00089 Trypsin 676 0.3264 SUB694 O=C-C-C-C-C-O 676 0.3264 PF00795 Carbon-nitrogen hydrolase 677 0.3261 SUB578 C:C-N-C:C 677 0.3261 PF00858 Amiloride-sensitive sodium channel 678 0.3255 SUB476 S-C=N-C 678 0.3255 PF00287 Sodium / potassium ATPase beta chain 679 0.3254 SUB489 N-C=N-[#1] 679 0.3254 PF00089 Trypsin 680 0.3253 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 680 0.3253 PF00890 FAD binding domain 681 0.3252 SUB691 O-C-C-C-C-C-O 681 0.3252 PF00229 TNF(Tumour Necrosis Factor), family 682 0.3251 SUB261 >= 3 hetero-aromatic rings 682 0.3251 PF00005 ABC transporter 683 0.3251 SUB708 O=C-C-C-C-C(N)-C 683 0.3251 PF03024 Folate receptor family 684 0.3242 SUB695 O=C-C-C-C-C=O 684 0.3242 PF00795 Carbon-nitrogen hydrolase 685 0.3241 SUB200 >= 4 any ring size 6 685 0.3241 PF00069 Protein kinase domain 686 0.3238 SUB537 O=C-C-N 686 0.3238 PF01490 Transmembrane amino acid transporter protein 687 0.3231 SUB394 N(~C)(~H) 687 0.3231 PF02727 Copper amine oxidase, N2 domain 688 0.3228 SUB712 C-C(C)(C)-C-C 688 0.3228 PF00091 Tubulin/FtsZ family, GTPase domain 689 0.3223 SUB158 >= 3 any ring size 5 689 0.3223 PF00676 Dehydrogenase E1 component 690 0.3219 SUB261 >= 3 hetero-aromatic rings 690 0.3219 PF00018 SH3 domain 691 0.3214 SUB503 N-C=C-[#1] 691 0.3214 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 692 0.3213 SUB413 S(~C)(~C) 692 0.3213 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 693 0.3209 SUB440 C(-C)(-N)(=O) 693 0.3209 PF00079 Serpin (serine protease inhibitor), 694 0.3206 SUB738 Cc1cc(N)ccc1 694 0.3206 PF00324 Amino acid permease 695 0.3195 SUB350 C(~C)(~H)(~S) 695 0.3195 PF09334 tRNA synthetases class I (M), 696 0.3191 SUB350 C(~C)(~H)(~S) 696 0.3191 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 697 0.3190 SUB339 C(~C)(~C)(~H)(~N) 697 0.3190 PF00155 Aminotransferase class I and II 698 0.3190 SUB367 C(~H)(~O) 698 0.3190 PF00107 Zinc-binding dehydrogenase 699 0.3185 SUB683 O-C-C-C-C-N 699 0.3185 PF00266 Aminotransferase class-V 700 0.3181 SUB696 O=C-C-C-C-C-N 700 0.3181 PF05544 Proline racemase 701 0.3180 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 701 0.3180 PF06212 GRIM-19 protein 702 0.3177 SUB315 O-P 702 0.3177 PF00929 Exonuclease 703 0.3176 SUB699 O-C-C-C-C-C-C-C 703 0.3176 PF00579 tRNA synthetases class I (W and Y), 704 0.3172 SUB529 [#1]-N-C-[#1] 704 0.3172 PF00155 Aminotransferase class I and II 705 0.3171 SUB520 N=C-N-C 705 0.3171 PF01048 Phosphorylase superfamily 706 0.3170 SUB708 O=C-C-C-C-C(N)-C 706 0.3170 PF00850 Histone deacetylase domain 707 0.3169 SUB668 C=C-C-O-[#1] 707 0.3169 PF00102 Protein-tyrosine phosphatase 708 0.3168 SUB680 C-C-C-C-C-C 708 0.3168 PF00089 Trypsin 709 0.3166 SUB529 [#1]-N-C-[#1] 709 0.3166 PF00112 Papain family cysteine protease 710 0.3164 SUB738 Cc1cc(N)ccc1 710 0.3164 PF02394 Interleukin-1 propeptide 711 0.3162 SUB695 O=C-C-C-C-C=O 711 0.3162 PF02127 Aminopeptidase I zinc metalloprotease (M18), 712 0.3161 SUB32 >= 2 P 712 0.3161 PF00248 Aldo/keto reductase family 713 0.3156 SUB664 O-C-C-O-[#1] 713 0.3156 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 714 0.3154 SUB581 O=C-C-C-N 714 0.3154 PF01593 Flavin containing amine oxidoreductase 715 0.3152 SUB490 N-C-S-C 715 0.3152 PF01733 Nucleoside transporter 716 0.3152 SUB637 C-N-C-N-C 716 0.3152 PF00225 Kinesin motor domain 717 0.3148 SUB144 >= 1 any ring size 5 717 0.3148 PF02166 Androgen receptor 718 0.3146 SUB683 O-C-C-C-C-N 718 0.3146 PF01063 Aminotransferase class IV 719 0.3141 SUB691 O-C-C-C-C-C-O 719 0.3141 PF00551 Formyl transferase 720 0.3133 SUB531 N:C-C:C 720 0.3133 PF02196 Raf-like Ras-binding domain 721 0.3132 SUB394 N(~C)(~H) 721 0.3132 PF01179 Copper amine oxidase, enzyme domain 722 0.3132 SUB407 O(~C)(~H) 722 0.3132 PF01023 S-100/ICaBP type calcium binding domain 723 0.3129 SUB686 O=C-C-C-C-N 723 0.3129 PF00464 Serine hydroxymethyltransferase 724 0.3127 SUB825 OC1C(O)CCCC1 724 0.3127 PF00091 Tubulin/FtsZ family, GTPase domain 725 0.3120 SUB414 S(~C)(~H) 725 0.3120 PF00619 Caspase recruitment domain 726 0.3116 SUB407 O(~C)(~H) 726 0.3116 PF00041 Fibronectin type III domain 727 0.3115 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 727 0.3115 PF01582 TIR domain 728 0.3113 SUB257 >= 1 hetero-aromatic ring 728 0.3113 PF00067 Cytochrome P450 729 0.3108 SUB259 >= 2 hetero-aromatic rings 729 0.3108 PF00017 SH2 domain 730 0.3107 SUB296 C-As 730 0.3107 PF00105 Zinc finger, C4 type (two domains), 731 0.3102 SUB681 O-C-C-C-C-C 731 0.3102 PF00501 AMP-binding enzyme 732 0.3101 SUB444 C(-C)(=O) 732 0.3101 PF00074 Pancreatic ribonuclease 733 0.3099 SUB288 C-F 733 0.3099 PF07686 Immunoglobulin V-set domain 734 0.3097 SUB18 >= 8 N 734 0.3097 PF00704 Glycosyl hydrolases family 18 735 0.3094 SUB644 [#1]-C-C-N-[#1] 735 0.3094 PF00324 Amino acid permease 736 0.3092 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 736 0.3092 PF03572 Peptidase family S41 737 0.3092 SUB631 O-C:C-O-C 737 0.3092 PF00233 3"5"-cyclic nucleotide phosphodiesterase 738 0.3091 SUB545 O-C:C-O 738 0.3091 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 739 0.3084 SUB822 CC1C(N)CCCC1 739 0.3084 PF02166 Androgen receptor 740 0.3082 SUB548 N-C:C-N 740 0.3082 PF00962 Adenosine/AMP deaminase 741 0.3081 SUB1 >= 4 H 741 0.3081 PF08674 Acetylcholinesterase tetramerisation domain 742 0.3078 SUB387 C(:C)(:C)(:N) 742 0.3078 PF01387 Synuclein 743 0.3077 SUB16 >= 2 N 743 0.3077 PF02898 Nitric oxide synthase, oxygenase domain 744 0.3076 SUB768 Sc1c(N)cccc1 744 0.3076 PF00520 Ion transport protein 745 0.3074 SUB664 O-C-C-O-[#1] 745 0.3074 PF00043 Glutathione S-transferase, C-terminal domain 746 0.3074 SUB537 O=C-C-N 746 0.3074 PF00999 Sodium/hydrogen exchanger family 747 0.3072 SUB153 >= 2 saturated or aromatic nitrogen-containing ring size 5 747 0.3072 PF00028 Cadherin domain 748 0.3072 SUB653 O-C:C:C-N 748 0.3072 PF00123 Peptide hormone 749 0.3071 SUB158 >= 3 any ring size 5 749 0.3071 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 750 0.3071 SUB801 CC1CC(N)CCC1 750 0.3071 PF01122 Eukaryotic cobalamin-binding protein 751 0.3069 SUB389 C(:C)(:N)(:N) 751 0.3069 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 752 0.3066 SUB756 Cc1c(C)cccc1 752 0.3066 PF04756 OST3 / OST6 family 753 0.3062 SUB747 Sc1cc(N)ccc1 753 0.3062 PF03372 Endonuclease/Exonuclease/phosphatase family 754 0.3059 SUB441 C(-C)(-O)(=O) 754 0.3059 PF01433 Peptidase family M1 755 0.3058 SUB683 O-C-C-C-C-N 755 0.3058 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 756 0.3056 SUB682 O-C-C-C-C-O 756 0.3056 PF00478 IMP dehydrogenase / GMP reductase domain 757 0.3056 SUB674 O=C-C=C-N 757 0.3056 PF00111 2Fe-2S iron-sulfur cluster binding domain 758 0.3055 SUB217 >= 1 saturated or aromatic heteroatom-containing ring size 7 758 0.3055 PF00149 Calcineurin-like phosphoesterase 759 0.3053 SUB490 N-C-S-C 759 0.3053 PF04263 Thiamin pyrophosphokinase, catalytic domain 760 0.3046 SUB158 >= 3 any ring size 5 760 0.3046 PF03949 Malic enzyme, NAD binding domain 761 0.3045 SUB48 >= 2 I 761 0.3045 PF00105 Zinc finger, C4 type (two domains), 762 0.3038 SUB158 >= 3 any ring size 5 762 0.3038 PF00180 Isocitrate/isopropylmalate dehydrogenase 763 0.3036 SUB339 C(~C)(~C)(~H)(~N) 763 0.3036 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 764 0.3035 SUB691 O-C-C-C-C-C-O 764 0.3035 PF07654 Immunoglobulin C1-set domain 765 0.3031 SUB674 O=C-C=C-N 765 0.3031 PF00106 short chain dehydrogenase 766 0.3026 SUB633 C-C-O-C:C 766 0.3026 PF00105 Zinc finger, C4 type (two domains), 767 0.3026 SUB450 C(-N)(=C) 767 0.3026 PF01007 Inward rectifier potassium channel 768 0.3024 SUB347 C(~C)(~H)(~O) 768 0.3024 PF00089 Trypsin 769 0.3017 SUB781 CC1CCC(Cl)CC1 769 0.3017 PF00033 Cytochrome b(N-terminal), /b6/petB 770 0.3016 SUB529 [#1]-N-C-[#1] 770 0.3016 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 771 0.3011 SUB414 S(~C)(~H) 771 0.3011 PF00778 DIX domain 772 0.3007 SUB376 C(~N)(~N) 772 0.3007 PF00171 Aldehyde dehydrogenase family 773 0.3006 SUB388 C(:C)(:N) 773 0.3006 PF00001 7 transmembrane receptor (rhodopsin family), 774 0.3005 SUB158 >= 3 any ring size 5 774 0.3005 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 775 0.3003 SUB522 C:N-C-[#1] 775 0.3003 PF00105 Zinc finger, C4 type (two domains), 776 0.3003 SUB520 N=C-N-C 776 0.3003 PF02310 B12 binding domain 777 0.3002 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 777 0.3002 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 778 0.3001 SUB606 O=C-C-O-C 778 0.3001 PF00520 Ion transport protein 779 0.2999 SUB757 Cc1c(O)cccc1 779 0.2999 PF01023 S-100/ICaBP type calcium binding domain 780 0.2998 SUB572 [#1]-C-O-[#1] 780 0.2998 PF00400 WD domain, G-beta repeat 781 0.2995 SUB229 >= 1 saturated or aromatic carbon-only ring size 8 781 0.2995 PF02932 Neurotransmitter-gated ion-channel transmembrane region 782 0.2988 SUB691 O-C-C-C-C-C-O 782 0.2988 PF01187 Macrophage migration inhibitory factor (MIF), 783 0.2988 SUB393 N(~C)(~C)(~H) 783 0.2988 PF07645 Calcium-binding EGF domain 784 0.2981 SUB35 >= 2 S 784 0.2981 PF00001 7 transmembrane receptor (rhodopsin family), 785 0.2980 SUB648 O=C-N-C-N 785 0.2980 PF09303 KCNMB2, ball and chain domain 786 0.2980 SUB660 O-C-C-N-C 786 0.2980 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 787 0.2978 SUB715 Cc1ccc(O)cc1 787 0.2978 PF03062 MBOAT family 788 0.2978 SUB738 Cc1cc(N)ccc1 788 0.2978 PF01122 Eukaryotic cobalamin-binding protein 789 0.2977 SUB375 C(~H)(~H)(~H) 789 0.2977 PF00258 Flavodoxin 790 0.2976 SUB387 C(:C)(:C)(:N) 790 0.2976 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 791 0.2973 SUB696 O=C-C-C-C-C-N 791 0.2973 PF02274 Amidinotransferase 792 0.2972 SUB453 C(-O)(=O) 792 0.2972 PF00194 Eukaryotic-type carbonic anhydrase 793 0.2966 SUB800 CC1CC(S)CCC1 793 0.2966 PF00001 7 transmembrane receptor (rhodopsin family), 794 0.2964 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 794 0.2964 PF00501 AMP-binding enzyme 795 0.2963 SUB683 O-C-C-C-C-N 795 0.2963 PF02743 Cache domain 796 0.2961 SUB621 C:C-O-C-C 796 0.2961 PF01030 Receptor L domain 797 0.2959 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 797 0.2959 PF00688 TGF-beta propeptide 798 0.2958 SUB17 >= 4 N 798 0.2958 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 799 0.2955 SUB602 N-C:C:C-N 799 0.2955 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 800 0.2950 SUB431 C(-C)(-C)(=C) 800 0.2950 PF02525 Flavodoxin-like fold 801 0.2949 SUB324 P-H 801 0.2949 PF12179 I-kappa-kinase-beta NEMO binding domain 802 0.2949 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 802 0.2949 PF00560 Leucine Rich Repeat 803 0.2948 SUB258 >= 2 aromatic rings 803 0.2948 PF00520 Ion transport protein 804 0.2948 SUB499 O-C=C-C 804 0.2948 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 805 0.2945 SUB21 >= 4 O 805 0.2945 PF00106 short chain dehydrogenase 806 0.2945 SUB96 >= 1 Hg 806 0.2945 PF06617 M-phase inducer phosphatase 807 0.2944 SUB684 N-C-C-C-C-C 807 0.2944 PF00001 7 transmembrane receptor (rhodopsin family), 808 0.2939 SUB647 O=C-N-C-[#1] 808 0.2939 PF01431 Peptidase family M13 809 0.2936 SUB369 C(~H)(~S) 809 0.2936 PF00248 Aldo/keto reductase family 810 0.2933 SUB708 O=C-C-C-C-C(N)-C 810 0.2933 PF07690 Major Facilitator Superfamily 811 0.2928 SUB167 >= 4 saturated or aromatic nitrogen-containing ring size 5 811 0.2928 PF00001 7 transmembrane receptor (rhodopsin family), 812 0.2924 SUB336 C(~C)(~C)(~C)(~H) 812 0.2924 PF00051 Kringle domain 813 0.2915 SUB801 CC1CC(N)CCC1 813 0.2915 PF01061 ABC-2 type transporter 814 0.2914 SUB689 C-C-C-C-C-C-C 814 0.2914 PF01593 Flavin containing amine oxidoreductase 815 0.2907 SUB401 N(~H)(:C)(:C) 815 0.2907 PF05790 Immunoglobulin C2-set domain 816 0.2906 SUB215 >= 1 saturated or aromatic carbon-only ring size 7 816 0.2906 PF00135 Carboxylesterase 817 0.2906 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 817 0.2906 PF01094 Receptor family ligand binding region 818 0.2906 SUB660 O-C-C-N-C 818 0.2906 PF00614 Phospholipase D Active site motif 819 0.2905 SUB771 Nc1c(N)cccc1 819 0.2905 PF01687 Riboflavin kinase 820 0.2904 SUB567 O-C-C-N 820 0.2904 PF04072 Leucine carboxyl methyltransferase 821 0.2899 SUB819 CC1C(C)CCCC1 821 0.2899 PF01234 NNMT/PNMT/TEMT family 822 0.2898 SUB695 O=C-C-C-C-C=O 822 0.2898 PF00696 Amino acid kinase family 823 0.2897 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 823 0.2897 PF09166 Biliverdin reductase, catalytic 824 0.2896 SUB640 O-C-C-C-O 824 0.2896 PF00069 Protein kinase domain 825 0.2896 SUB117 >= 1 saturated or aromatic carbon-only ring size 3 825 0.2896 PF01244 Membrane dipeptidase (Peptidase family M19), 826 0.2896 SUB384 C(~S)(:C) 826 0.2896 PF00069 Protein kinase domain 827 0.2896 SUB32 >= 2 P 827 0.2896 PF00373 FERM central domain 828 0.2890 SUB540 N=C-C-[#1] 828 0.2890 PF00005 ABC transporter 829 0.2890 SUB695 O=C-C-C-C-C=O 829 0.2890 PF00067 Cytochrome P450 830 0.2885 SUB544 O-C:C-N 830 0.2885 PF00294 pfkB family carbohydrate kinase 831 0.2884 SUB568 O-C-C-O 831 0.2884 PF00017 SH2 domain 832 0.2881 SUB200 >= 4 any ring size 6 832 0.2881 PF00170 bZIP transcription factor 833 0.2880 SUB785 OC1CCC(N)CC1 833 0.2880 PF07885 Ion channel 834 0.2879 SUB537 O=C-C-N 834 0.2879 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 835 0.2879 SUB691 O-C-C-C-C-C-O 835 0.2879 PF00248 Aldo/keto reductase family 836 0.2876 SUB453 C(-O)(=O) 836 0.2876 PF01369 Sec7 domain 837 0.2875 SUB4 >= 32 H 837 0.2875 PF03765 CRAL/TRIO, N-terminus 838 0.2874 SUB354 C(~C)(~S) 838 0.2874 PF00656 Caspase domain 839 0.2873 SUB664 O-C-C-O-[#1] 839 0.2873 PF01842 ACT domain 840 0.2871 SUB442 C(-C)(=C) 840 0.2871 PF00001 7 transmembrane receptor (rhodopsin family), 841 0.2870 SUB505 N:C:N-C 841 0.2870 PF00005 ABC transporter 842 0.2870 SUB158 >= 3 any ring size 5 842 0.2870 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 843 0.2863 SUB643 O-C-C-C=O 843 0.2863 PF00454 Phosphatidylinositol 3- and 4-kinase 844 0.2861 SUB612 N-C-C-N-C 844 0.2861 PF08246 Cathepsin propeptide inhibitor domain (I29), 845 0.2859 SUB664 O-C-C-O-[#1] 845 0.2859 PF03414 Glycosyltransferase family 6 846 0.2857 SUB572 [#1]-C-O-[#1] 846 0.2857 PF00191 Annexin 847 0.2857 SUB396 N(~C)(~O) 847 0.2857 PF00850 Histone deacetylase domain 848 0.2857 SUB22 >= 8 O 848 0.2857 PF01118 Semialdehyde dehydrogenase, NAD binding domain 849 0.2857 SUB180 >= 1 saturated or aromatic carbon-only ring size 6 849 0.2857 PF00209 Sodium:neurotransmitter symporter family 850 0.2853 SUB700 O-C-C-C-C-C(C)-C 850 0.2853 PF01401 Angiotensin-converting enzyme 851 0.2853 SUB350 C(~C)(~H)(~S) 851 0.2853 PF01641 SelR domain 852 0.2852 SUB519 O=C-N-N 852 0.2852 PF00664 ABC transporter transmembrane region 853 0.2850 SUB348 C(~C)(~H)(~O)(~O) 853 0.2850 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 854 0.2848 SUB675 N-C-N-C:C 854 0.2848 PF00520 Ion transport protein 855 0.2844 SUB691 O-C-C-C-C-C-O 855 0.2844 PF00070 Pyridine nucleotide-disulphide oxidoreductase 856 0.2843 SUB597 N=C-N-C-C 856 0.2843 PF00233 3"5"-cyclic nucleotide phosphodiesterase 857 0.2841 SUB706 O=C-C-C-C-C(O)-C 857 0.2841 PF01347 Lipoprotein amino terminal region 858 0.2841 SUB44 >= 1 Br 858 0.2841 PF00001 7 transmembrane receptor (rhodopsin family), 859 0.2840 SUB339 C(~C)(~C)(~H)(~N) 859 0.2840 PF08246 Cathepsin propeptide inhibitor domain (I29), 860 0.2838 SUB440 C(-C)(-N)(=O) 860 0.2838 PF00337 Galactoside-binding lectin 861 0.2835 SUB350 C(~C)(~H)(~S) 861 0.2835 PF00184 Neurohypophysial hormones, C-terminal Domain 862 0.2830 SUB261 >= 3 hetero-aromatic rings 862 0.2830 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 863 0.2829 SUB441 C(-C)(-O)(=O) 863 0.2829 PF00001 7 transmembrane receptor (rhodopsin family), 864 0.2827 SUB21 >= 4 O 864 0.2827 PF01590 GAF domain 865 0.2825 SUB703 O-C-C-C-C-C-N-C 865 0.2825 PF00069 Protein kinase domain 866 0.2824 SUB738 Cc1cc(N)ccc1 866 0.2824 PF00175 Oxidoreductase NAD-binding domain 867 0.2824 SUB683 O-C-C-C-C-N 867 0.2824 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 868 0.2820 SUB618 C-C-C-O-[#1] 868 0.2820 PF00927 Transglutaminase family, C-terminal ig like domain 869 0.2818 SUB440 C(-C)(-N)(=O) 869 0.2818 PF00868 Transglutaminase family 870 0.2814 SUB488 N-C=N-C 870 0.2814 PF00206 Lyase 871 0.2813 SUB14 >= 32 C 871 0.2813 PF02121 Phosphatidylinositol transfer protein 872 0.2810 SUB309 O-H 872 0.2810 PF00354 Pentaxin family 873 0.2807 SUB730 Nc1ccc(Cl)cc1 873 0.2807 PF02932 Neurotransmitter-gated ion-channel transmembrane region 874 0.2806 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 874 0.2806 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 875 0.2804 SUB392 N(~C)(~C)(~C) 875 0.2804 PF06387 D1 dopamine receptor-interacting protein (calcyon), 876 0.2804 SUB827 OC1C(N)CCCC1 876 0.2804 PF00170 bZIP transcription factor 877 0.2800 SUB583 C-C-C-C-C 877 0.2800 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 878 0.2792 SUB339 C(~C)(~C)(~H)(~N) 878 0.2792 PF01409 tRNA synthetases class II core domain (F), 879 0.2790 SUB440 C(-C)(-N)(=O) 879 0.2790 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 880 0.2780 SUB309 O-H 880 0.2780 PF06079 Apyrase 881 0.2778 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 881 0.2778 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 882 0.2778 SUB2 >= 8 H 882 0.2778 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 883 0.2773 SUB339 C(~C)(~C)(~H)(~N) 883 0.2773 PF01401 Angiotensin-converting enzyme 884 0.2772 SUB407 O(~C)(~H) 884 0.2772 PF02898 Nitric oxide synthase, oxygenase domain 885 0.2772 SUB440 C(-C)(-N)(=O) 885 0.2772 PF00927 Transglutaminase family, C-terminal ig like domain 886 0.2771 SUB379 C(~N)(:C)(:N) 886 0.2771 PF03024 Folate receptor family 887 0.2768 SUB19 >= 1 O 887 0.2768 PF01180 Dihydroorotate dehydrogenase 888 0.2765 SUB572 [#1]-C-O-[#1] 888 0.2765 PF00704 Glycosyl hydrolases family 18 889 0.2761 SUB415 S(~C)(~O) 889 0.2761 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 890 0.2760 SUB602 N-C:C:C-N 890 0.2760 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 891 0.2758 SUB421 C=O 891 0.2758 PF00001 7 transmembrane receptor (rhodopsin family), 892 0.2757 SUB158 >= 3 any ring size 5 892 0.2757 PF00056 lactate/malate dehydrogenase, NAD binding domain 893 0.2750 SUB394 N(~C)(~H) 893 0.2750 PF02008 CXXC zinc finger domain 894 0.2748 SUB336 C(~C)(~C)(~C)(~H) 894 0.2748 PF00089 Trypsin 895 0.2747 SUB702 O-C-C-C-C-C(O)-C 895 0.2747 PF01391 Collagen triple helix repeat (20 copies), 896 0.2746 SUB694 O=C-C-C-C-C-O 896 0.2746 PF04768 Protein of unknown function (DUF619), 897 0.2744 SUB436 C(-C)(-H)(=N) 897 0.2744 PF04389 Peptidase family M28 898 0.2742 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 898 0.2742 PF00561 alpha/beta hydrolase fold 899 0.2742 SUB353 C(~C)(~O) 899 0.2742 PF00194 Eukaryotic-type carbonic anhydrase 900 0.2740 SUB621 C:C-O-C-C 900 0.2740 PF00989 PAS fold 901 0.2739 SUB662 O-C-O-C-C 901 0.2739 PF00860 Permease family 902 0.2739 SUB158 >= 3 any ring size 5 902 0.2739 PF10276 Zinc-finger domain 903 0.2733 SUB664 O-C-C-O-[#1] 903 0.2733 PF00405 Transferrin 904 0.2732 SUB683 O-C-C-C-C-N 904 0.2732 PF01055 Glycosyl hydrolases family 31 905 0.2727 SUB22 >= 8 O 905 0.2727 PF03034 Phosphatidyl serine synthase 906 0.2722 SUB350 C(~C)(~H)(~S) 906 0.2722 PF12497 Estrogen receptor beta 907 0.2718 SUB646 O=C-N-C-C 907 0.2718 PF07686 Immunoglobulin V-set domain 908 0.2717 SUB340 C(~C)(~C)(~H)(~O) 908 0.2717 PF00001 7 transmembrane receptor (rhodopsin family), 909 0.2717 SUB214 >= 1 any ring size 7 909 0.2717 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 910 0.2715 SUB693 O=C-C-C-C-C-C 910 0.2715 PF00059 Lectin C-type domain 911 0.2712 SUB34 >= 1 S 911 0.2712 PF00167 Fibroblast growth factor 912 0.2706 SUB638 O-C-C-C-C 912 0.2706 PF00153 Mitochondrial carrier protein 913 0.2702 SUB465 N-C-C=C 913 0.2702 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 914 0.2700 SUB441 C(-C)(-O)(=O) 914 0.2700 PF06628 Catalase-related immune-responsive 915 0.2698 SUB433 C(-C)(-C)(=O) 915 0.2698 PF00622 SPRY domain 916 0.2697 SUB659 C-C-S-C-C 916 0.2697 PF00378 Enoyl-CoA hydratase/isomerase family 917 0.2695 SUB386 C(:C)(:C)(:C) 917 0.2695 PF08491 Squalene epoxidase 918 0.2694 SUB339 C(~C)(~C)(~H)(~N) 918 0.2694 PF00023 Ankyrin repeat 919 0.2694 SUB738 Cc1cc(N)ccc1 919 0.2694 PF00105 Zinc finger, C4 type (two domains), 920 0.2693 SUB573 N:C:N:C 920 0.2693 PF00821 Phosphoenolpyruvate carboxykinase 921 0.2692 SUB696 O=C-C-C-C-C-N 921 0.2692 PF00491 Arginase family 922 0.2690 SUB433 C(-C)(-C)(=O) 922 0.2690 PF00089 Trypsin 923 0.2684 SUB644 [#1]-C-C-N-[#1] 923 0.2684 PF00074 Pancreatic ribonuclease 924 0.2675 SUB20 >= 2 O 924 0.2675 PF03098 Animal haem peroxidase 925 0.2672 SUB413 S(~C)(~C) 925 0.2672 PF09334 tRNA synthetases class I (M), 926 0.2669 SUB582 O=C-C-C-O 926 0.2669 PF00005 ABC transporter 927 0.2668 SUB369 C(~H)(~S) 927 0.2668 PF00084 Sushi domain (SCR repeat), 928 0.2666 SUB375 C(~H)(~H)(~H) 928 0.2666 PF03781 Formylglycine-generating sulfatase enzyme 929 0.2666 SUB706 O=C-C-C-C-C(O)-C 929 0.2666 PF00071 Ras family 930 0.2666 SUB193 >= 3 any ring size 6 930 0.2666 PF00017 SH2 domain 931 0.2665 SUB673 O=C-C=C-[#1] 931 0.2665 PF00171 Aldehyde dehydrogenase family 932 0.2664 SUB13 >= 16 C 932 0.2664 PF00104 Ligand-binding domain of nuclear hormone receptor 933 0.2661 SUB14 >= 32 C 933 0.2661 PF00105 Zinc finger, C4 type (two domains), 934 0.2661 SUB339 C(~C)(~C)(~H)(~N) 934 0.2661 PF03074 Glutamate-cysteine ligase 935 0.2660 SUB694 O=C-C-C-C-C-O 935 0.2660 PF07690 Major Facilitator Superfamily 936 0.2658 SUB179 >= 1 any ring size 6 936 0.2658 PF00089 Trypsin 937 0.2658 SUB698 C-C-C-C-C-C(C)-C 937 0.2658 PF08127 Peptidase family C1 propeptide 938 0.2657 SUB662 O-C-O-C-C 938 0.2657 PF00021 u-PAR/Ly-6 domain 939 0.2656 SUB341 C(~C)(~C)(~N) 939 0.2656 PF06512 Sodium ion transport-associated 940 0.2655 SUB688 O=C-C-C-C=O 940 0.2655 PF00890 FAD binding domain 941 0.2650 SUB3 >= 16 H 941 0.2650 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 942 0.2649 SUB338 C(~C)(~C)(~C)(~O) 942 0.2649 PF01733 Nucleoside transporter 943 0.2647 SUB579 C-C:C-C:C 943 0.2647 PF00209 Sodium:neurotransmitter symporter family 944 0.2646 SUB249 >= 1 any ring size 10 944 0.2646 PF07690 Major Facilitator Superfamily 945 0.2644 SUB713 C-C(C)-C(C)-C 945 0.2644 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 946 0.2643 SUB626 O=C-C:C-O 946 0.2643 PF00520 Ion transport protein 947 0.2643 SUB682 O-C-C-C-C-O 947 0.2643 PF00349 Hexokinase 948 0.2638 SUB673 O=C-C=C-[#1] 948 0.2638 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 949 0.2636 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 949 0.2636 PF02932 Neurotransmitter-gated ion-channel transmembrane region 950 0.2634 SUB389 C(:C)(:N)(:N) 950 0.2634 PF10531 SLBB domain 951 0.2634 SUB408 O(~C)(~P) 951 0.2634 PF00343 Carbohydrate phosphorylase 952 0.2634 SUB300 N-H 952 0.2634 PF06512 Sodium ion transport-associated 953 0.2625 SUB299 C-I 953 0.2625 PF00233 3"5"-cyclic nucleotide phosphodiesterase 954 0.2624 SUB686 O=C-C-C-C-N 954 0.2624 PF00068 Phospholipase A2 955 0.2621 SUB703 O-C-C-C-C-C-N-C 955 0.2621 PF02223 Thymidylate kinase 956 0.2619 SUB697 C-C-C-C-C-C-C-C 956 0.2619 PF01007 Inward rectifier potassium channel 957 0.2618 SUB22 >= 8 O 957 0.2618 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 958 0.2614 SUB523 C-N-N-[#1] 958 0.2614 PF02025 Interleukin 5 959 0.2613 SUB335 C(~C)(~C)(~C)(~C) 959 0.2613 PF00653 Inhibitor of Apoptosis domain 960 0.2605 SUB529 [#1]-N-C-[#1] 960 0.2605 PF00989 PAS fold 961 0.2604 SUB22 >= 8 O 961 0.2604 PF02779 Transketolase, pyrimidine binding domain 962 0.2604 SUB533 S-C:C-[#1] 962 0.2604 PF00045 Hemopexin 963 0.2603 SUB736 Cc1cc(O)ccc1 963 0.2603 PF02159 Oestrogen receptor 964 0.2601 SUB643 O-C-C-C=O 964 0.2601 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 965 0.2599 SUB589 O=C-C-C=O 965 0.2599 PF00377 Prion/Doppel alpha-helical domain 966 0.2595 SUB489 N-C=N-[#1] 966 0.2595 PF00002 7 transmembrane receptor (Secretin family), 967 0.2594 SUB639 O-C-C-C-N 967 0.2594 PF00088 Trefoil (P-type), domain 968 0.2591 SUB772 Nc1c(Cl)cccc1 968 0.2591 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 969 0.2584 SUB695 O=C-C-C-C-C=O 969 0.2584 PF00749 tRNA synthetases class I (E and Q), , catalytic domain 970 0.2581 SUB436 C(-C)(-H)(=N) 970 0.2581 PF00001 7 transmembrane receptor (rhodopsin family), 971 0.2580 SUB392 N(~C)(~C)(~C) 971 0.2580 PF00001 7 transmembrane receptor (rhodopsin family), 972 0.2575 SUB626 O=C-C:C-O 972 0.2575 PF01007 Inward rectifier potassium channel 973 0.2573 SUB4 >= 32 H 973 0.2573 PF08441 Integrin alpha 974 0.2572 SUB681 O-C-C-C-C-C 974 0.2572 PF00058 Low-density lipoprotein receptor repeat class B 975 0.2568 SUB51 >= 1 Mg 975 0.2568 PF00690 Cation transporter/ATPase, N-terminus 976 0.2566 SUB368 C(~H)(~O)(~O) 976 0.2566 PF00041 Fibronectin type III domain 977 0.2561 SUB657 C-C-N-C-C 977 0.2561 PF00822 PMP-22/EMP/MP20/Claudin family 978 0.2560 SUB618 C-C-C-O-[#1] 978 0.2560 PF00490 Delta-aminolevulinic acid dehydratase 979 0.2554 SUB249 >= 1 any ring size 10 979 0.2554 PF00070 Pyridine nucleotide-disulphide oxidoreductase 980 0.2554 SUB394 N(~C)(~H) 980 0.2554 PF02728 Copper amine oxidase, N3 domain 981 0.2553 SUB710 C-C(C)-C-C-C 981 0.2553 PF00001 7 transmembrane receptor (rhodopsin family), 982 0.2551 SUB479 S-C=N-[#1] 982 0.2551 PF00287 Sodium / potassium ATPase beta chain 983 0.2550 SUB572 [#1]-C-O-[#1] 983 0.2550 PF00145 C-5 cytosine-specific DNA methylase 984 0.2550 SUB32 >= 2 P 984 0.2550 PF00378 Enoyl-CoA hydratase/isomerase family 985 0.2546 SUB394 N(~C)(~H) 985 0.2546 PF00051 Kringle domain 986 0.2545 SUB582 O=C-C-C-O 986 0.2545 PF01187 Macrophage migration inhibitory factor (MIF), 987 0.2543 SUB32 >= 2 P 987 0.2543 PF01363 FYVE zinc finger 988 0.2543 SUB537 O=C-C-N 988 0.2543 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 989 0.2542 SUB262 >= 4 aromatic rings 989 0.2542 PF00089 Trypsin 990 0.2541 SUB17 >= 4 N 990 0.2541 PF00067 Cytochrome P450 991 0.2538 SUB144 >= 1 any ring size 5 991 0.2538 PF00554 Rel homology domain (RHD), 992 0.2538 SUB537 O=C-C-N 992 0.2538 PF00079 Serpin (serine protease inhibitor), 993 0.2537 SUB705 O=C-C-C-C-C-C-C 993 0.2537 PF00092 von Willebrand factor type A domain 994 0.2536 SUB691 O-C-C-C-C-C-O 994 0.2536 PF02310 B12 binding domain 995 0.2535 SUB357 C(~C)(:C)(:C) 995 0.2535 PF00089 Trypsin 996 0.2535 SUB96 >= 1 Hg 996 0.2535 PF00754 F5/8 type C domain 997 0.2534 SUB444 C(-C)(=O) 997 0.2534 PF00413 Matrixin 998 0.2533 SUB457 P(-O)(=O) 998 0.2533 PF00224 Pyruvate kinase, barrel domain 999 0.2532 SUB577 N=C-C:C-[#1] 999 0.2532 PF00089 Trypsin 1000 0.2530 SUB21 >= 4 O 1000 0.2530 PF07562 Nine Cysteines Domain of family 3 GPCR 1001 0.2529 SUB421 C=O 1001 0.2529 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 1002 0.2527 SUB21 >= 4 O 1002 0.2527 PF07992 Pyridine nucleotide-disulphide oxidoreductase 1003 0.2515 SUB3 >= 16 H 1003 0.2515 PF00169 PH domain 1004 0.2513 SUB20 >= 2 O 1004 0.2513 PF00625 Guanylate kinase 1005 0.2512 SUB441 C(-C)(-O)(=O) 1005 0.2512 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 1006 0.2512 SUB756 Cc1c(C)cccc1 1006 0.2512 PF01234 NNMT/PNMT/TEMT family 1007 0.2510 SUB562 Cl-C-C=O 1007 0.2510 PF00591 Glycosyl transferase family, a/b domain 1008 0.2509 SUB24 >= 1 F 1008 0.2509 PF00989 PAS fold 1009 0.2509 SUB437 C(-C)(-H)(=O) 1009 0.2509 PF00702 haloacid dehalogenase-like hydrolase 1010 0.2507 SUB392 N(~C)(~C)(~C) 1010 0.2507 PF00170 bZIP transcription factor 1011 0.2503 SUB158 >= 3 any ring size 5 1011 0.2503 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 1012 0.2500 SUB5 >= 1 Li 1012 0.2500 PF00069 Protein kinase domain 1013 0.2498 SUB419 C=N 1013 0.2498 PF02898 Nitric oxide synthase, oxygenase domain 1014 0.2495 SUB334 C(~C)(~C)(~C) 1014 0.2495 PF02770 Acyl-CoA dehydrogenase, middle domain 1015 0.2495 SUB478 N-N-C:C 1015 0.2495 PF03098 Animal haem peroxidase 1016 0.2492 SUB419 C=N 1016 0.2492 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1017 0.2485 SUB17 >= 4 N 1017 0.2485 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1018 0.2485 SUB686 O=C-C-C-C-N 1018 0.2485 PF07686 Immunoglobulin V-set domain 1019 0.2484 SUB591 C-C:C-O-[#1] 1019 0.2484 PF00282 Pyridoxal-dependent decarboxylase conserved domain 1020 0.2480 SUB735 Cc1cc(C)ccc1 1020 0.2480 PF00105 Zinc finger, C4 type (two domains), 1021 0.2479 SUB406 O(~C)(~C) 1021 0.2479 PF00337 Galactoside-binding lectin 1022 0.2476 SUB338 C(~C)(~C)(~C)(~O) 1022 0.2476 PF02161 Progesterone receptor 1023 0.2476 SUB407 O(~C)(~H) 1023 0.2476 PF00273 Serum albumin family 1024 0.2475 SUB691 O-C-C-C-C-C-O 1024 0.2475 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 1025 0.2472 SUB458 S(-C)(=O) 1025 0.2472 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 1026 0.2472 SUB582 O=C-C-C-O 1026 0.2472 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 1027 0.2472 SUB300 N-H 1027 0.2472 PF00001 7 transmembrane receptor (rhodopsin family), 1028 0.2471 SUB713 C-C(C)-C(C)-C 1028 0.2471 PF00079 Serpin (serine protease inhibitor), 1029 0.2467 SUB686 O=C-C-C-C-N 1029 0.2467 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1030 0.2465 SUB96 >= 1 Hg 1030 0.2465 PF07732 Multicopper oxidase 1031 0.2464 SUB216 >= 1 saturated or aromatic nitrogen-containing ring size 7 1031 0.2464 PF00169 PH domain 1032 0.2462 SUB343 C(~C)(~Cl) 1032 0.2462 PF03493 Calcium-activated BK potassium channel alpha subunit 1033 0.2461 SUB379 C(~N)(:C)(:N) 1033 0.2461 PF01747 ATP-sulfurylase 1034 0.2461 SUB691 O-C-C-C-C-C-O 1034 0.2461 PF03623 Focal adhesion targeting region 1035 0.2460 SUB466 O=S-C-C 1035 0.2460 PF01590 GAF domain 1036 0.2460 SUB350 C(~C)(~H)(~S) 1036 0.2460 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 1037 0.2460 SUB664 O-C-C-O-[#1] 1037 0.2460 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 1038 0.2459 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 1038 0.2459 PF00643 B-box zinc finger 1039 0.2459 SUB463 O-C-C=O 1039 0.2459 PF00557 Metallopeptidase family M24 1040 0.2458 SUB695 O=C-C-C-C-C=O 1040 0.2458 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 1041 0.2457 SUB392 N(~C)(~C)(~C) 1041 0.2457 PF01370 NAD dependent epimerase/dehydratase family 1042 0.2457 SUB783 OC1CCC(O)CC1 1042 0.2457 PF01363 FYVE zinc finger 1043 0.2457 SUB822 CC1C(N)CCCC1 1043 0.2457 PF00653 Inhibitor of Apoptosis domain 1044 0.2456 SUB392 N(~C)(~C)(~C) 1044 0.2456 PF00625 Guanylate kinase 1045 0.2456 SUB39 >= 2 Cl 1045 0.2456 PF00689 Cation transporting ATPase, C-terminus 1046 0.2454 SUB21 >= 4 O 1046 0.2454 PF00822 PMP-22/EMP/MP20/Claudin family 1047 0.2452 SUB675 N-C-N-C:C 1047 0.2452 PF00702 haloacid dehalogenase-like hydrolase 1048 0.2452 SUB158 >= 3 any ring size 5 1048 0.2452 PF00390 Malic enzyme, N-terminal domain 1049 0.2446 SUB430 C(#N)(-C) 1049 0.2446 PF00625 Guanylate kinase 1050 0.2443 SUB523 C-N-N-[#1] 1050 0.2443 PF00001 7 transmembrane receptor (rhodopsin family), 1051 0.2443 SUB369 C(~H)(~S) 1051 0.2443 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 1052 0.2442 SUB825 OC1C(O)CCCC1 1052 0.2442 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1053 0.2442 SUB151 >= 2 any ring size 5 1053 0.2442 PF11555 EGFR receptor inhibitor Mig-6 1054 0.2440 SUB587 C-S-C-C-C 1054 0.2440 PF02772 S-adenosylmethionine synthetase, central domain 1055 0.2440 SUB600 [#1]-C-C=C-[#1] 1055 0.2440 PF00487 Fatty acid desaturase 1056 0.2440 SUB572 [#1]-C-O-[#1] 1056 0.2440 PF01633 Choline/ethanolamine kinase 1057 0.2439 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1057 0.2439 PF00248 Aldo/keto reductase family 1058 0.2433 SUB512 S=C-N-[#1] 1058 0.2433 PF03098 Animal haem peroxidase 1059 0.2433 SUB347 C(~C)(~H)(~O) 1059 0.2433 PF01243 Pyridoxamine 5"-phosphate oxidase 1060 0.2432 SUB379 C(~N)(:C)(:N) 1060 0.2432 PF00962 Adenosine/AMP deaminase 1061 0.2427 SUB408 O(~C)(~P) 1061 0.2427 PF04716 ETC complex I subunit conserved region 1062 0.2427 SUB4 >= 32 H 1062 0.2427 PF00068 Phospholipase A2 1063 0.2426 SUB572 [#1]-C-O-[#1] 1063 0.2426 PF00714 Interferon gamma 1064 0.2426 SUB214 >= 1 any ring size 7 1064 0.2426 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1065 0.2424 SUB686 O=C-C-C-C-N 1065 0.2424 PF02971 Formiminotransferase domain 1066 0.2422 SUB360 C(~C)(:N)(:N) 1066 0.2422 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 1067 0.2420 SUB440 C(-C)(-N)(=O) 1067 0.2420 PF01007 Inward rectifier potassium channel 1068 0.2418 SUB350 C(~C)(~H)(~S) 1068 0.2418 PF00059 Lectin C-type domain 1069 0.2416 SUB179 >= 1 any ring size 6 1069 0.2416 PF00305 Lipoxygenase 1070 0.2415 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 1070 0.2415 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1071 0.2415 SUB640 O-C-C-C-O 1071 0.2415 PF00305 Lipoxygenase 1072 0.2414 SUB153 >= 2 saturated or aromatic nitrogen-containing ring size 5 1072 0.2414 PF01208 Uroporphyrinogen decarboxylase (URO-D), 1073 0.2413 SUB656 O-C-C-C:C 1073 0.2413 PF00001 7 transmembrane receptor (rhodopsin family), 1074 0.2409 SUB712 C-C(C)(C)-C-C 1074 0.2409 PF00001 7 transmembrane receptor (rhodopsin family), 1075 0.2409 SUB394 N(~C)(~H) 1075 0.2409 PF00209 Sodium:neurotransmitter symporter family 1076 0.2409 SUB465 N-C-C=C 1076 0.2409 PF03953 Tubulin C-terminal domain 1077 0.2408 SUB698 C-C-C-C-C-C(C)-C 1077 0.2408 PF00664 ABC transporter transmembrane region 1078 0.2408 SUB572 [#1]-C-O-[#1] 1078 0.2408 PF00167 Fibroblast growth factor 1079 0.2407 SUB668 C=C-C-O-[#1] 1079 0.2407 PF00171 Aldehyde dehydrogenase family 1080 0.2406 SUB430 C(#N)(-C) 1080 0.2406 PF01007 Inward rectifier potassium channel 1081 0.2406 SUB695 O=C-C-C-C-C=O 1081 0.2406 PF00120 Glutamine synthetase, catalytic domain 1082 0.2400 SUB537 O=C-C-N 1082 0.2400 PF00438 S-adenosylmethionine synthetase, N-terminal domain 1083 0.2399 SUB407 O(~C)(~H) 1083 0.2399 PF00225 Kinesin motor domain 1084 0.2397 SUB144 >= 1 any ring size 5 1084 0.2397 PF00079 Serpin (serine protease inhibitor), 1085 0.2397 SUB375 C(~H)(~H)(~H) 1085 0.2397 PF00305 Lipoxygenase 1086 0.2395 SUB389 C(:C)(:N)(:N) 1086 0.2395 PF02770 Acyl-CoA dehydrogenase, middle domain 1087 0.2395 SUB622 N-C:C:C:N 1087 0.2395 PF00056 lactate/malate dehydrogenase, NAD binding domain 1088 0.2394 SUB21 >= 4 O 1088 0.2394 PF00354 Pentaxin family 1089 0.2392 SUB336 C(~C)(~C)(~C)(~H) 1089 0.2392 PF04072 Leucine carboxyl methyltransferase 1090 0.2390 SUB367 C(~H)(~O) 1090 0.2390 PF00069 Protein kinase domain 1091 0.2389 SUB446 C(-H)(-N)(=C) 1091 0.2389 PF00056 lactate/malate dehydrogenase, NAD binding domain 1092 0.2389 SUB31 >= 1 P 1092 0.2389 PF02441 Flavoprotein 1093 0.2386 SUB217 >= 1 saturated or aromatic heteroatom-containing ring size 7 1093 0.2386 PF00001 7 transmembrane receptor (rhodopsin family), 1094 0.2386 SUB477 C-O-C=C 1094 0.2386 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1095 0.2386 SUB16 >= 2 N 1095 0.2386 PF00324 Amino acid permease 1096 0.2386 SUB24 >= 1 F 1096 0.2386 PF00248 Aldo/keto reductase family 1097 0.2385 SUB687 O=C-C-C-C-O 1097 0.2385 PF05193 Peptidase M16 inactive domain 1098 0.2383 SUB608 N-C-C-C:C 1098 0.2383 PF00001 7 transmembrane receptor (rhodopsin family), 1099 0.2383 SUB522 C:N-C-[#1] 1099 0.2383 PF00017 SH2 domain 1100 0.2383 SUB536 O=C-C-C 1100 0.2383 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1101 0.2380 SUB381 C(~O)(~O) 1101 0.2380 PF00224 Pyruvate kinase, barrel domain 1102 0.2379 SUB518 N-N-C-N 1102 0.2379 PF00001 7 transmembrane receptor (rhodopsin family), 1103 0.2378 SUB409 O(~H)(~S) 1103 0.2378 PF10417 C-terminal domain of 1-Cys peroxiredoxin 1104 0.2377 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 1104 0.2377 PF01234 NNMT/PNMT/TEMT family 1105 0.2376 SUB699 O-C-C-C-C-C-C-C 1105 0.2376 PF00005 ABC transporter 1106 0.2375 SUB172 >= 5 any ring size 5 1106 0.2375 PF03308 ArgK protein 1107 0.2372 SUB537 O=C-C-N 1107 0.2372 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1108 0.2370 SUB729 Nc1ccc(N)cc1 1108 0.2370 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 1109 0.2367 SUB610 Cl-C-C-N-C 1109 0.2367 PF00070 Pyridine nucleotide-disulphide oxidoreductase 1110 0.2365 SUB653 O-C:C:C-N 1110 0.2365 PF00001 7 transmembrane receptor (rhodopsin family), 1111 0.2362 SUB694 O=C-C-C-C-C-O 1111 0.2362 PF02127 Aminopeptidase I zinc metalloprotease (M18), 1112 0.2360 SUB260 >= 3 aromatic rings 1112 0.2360 PF00074 Pancreatic ribonuclease 1113 0.2357 SUB339 C(~C)(~C)(~H)(~N) 1113 0.2357 PF00176 SNF2 family N-terminal domain 1114 0.2357 SUB375 C(~H)(~H)(~H) 1114 0.2357 PF00667 FAD binding domain 1115 0.2356 SUB145 >= 1 saturated or aromatic carbon-only ring size 5 1115 0.2356 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1116 0.2356 SUB695 O=C-C-C-C-C=O 1116 0.2356 PF02769 AIR synthase related protein, C-terminal domain 1117 0.2355 SUB629 C-N-C-C:C 1117 0.2355 PF01234 NNMT/PNMT/TEMT family 1118 0.2354 SUB637 C-N-C-N-C 1118 0.2354 PF00115 Cytochrome C and Quinol oxidase polypeptide I 1119 0.2354 SUB533 S-C:C-[#1] 1119 0.2354 PF01471 Putative peptidoglycan binding domain 1120 0.2353 SUB692 O-C-C-C-C-C-N 1120 0.2353 PF03807 NADP oxidoreductase coenzyme F420-dependent 1121 0.2352 SUB186 >= 2 any ring size 6 1121 0.2352 PF01007 Inward rectifier potassium channel 1122 0.2350 SUB432 C(-C)(-C)(=N) 1122 0.2350 PF00069 Protein kinase domain 1123 0.2346 SUB726 Sc1ccc(N)cc1 1123 0.2346 PF00069 Protein kinase domain 1124 0.2344 SUB495 O=C-C:N 1124 0.2344 PF00821 Phosphoenolpyruvate carboxykinase 1125 0.2343 SUB564 O-C-O-C 1125 0.2343 PF00021 u-PAR/Ly-6 domain 1126 0.2340 SUB381 C(~O)(~O) 1126 0.2340 PF00105 Zinc finger, C4 type (two domains), 1127 0.2338 SUB348 C(~C)(~H)(~O)(~O) 1127 0.2338 PF08702 Fibrinogen alpha/beta chain family 1128 0.2335 SUB348 C(~C)(~H)(~O)(~O) 1128 0.2335 PF00200 Disintegrin 1129 0.2333 SUB600 [#1]-C-C=C-[#1] 1129 0.2333 PF00001 7 transmembrane receptor (rhodopsin family), 1130 0.2329 SUB572 [#1]-C-O-[#1] 1130 0.2329 PF00069 Protein kinase domain 1131 0.2329 SUB315 O-P 1131 0.2329 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 1132 0.2328 SUB242 >= 1 any ring size 9 1132 0.2328 PF00478 IMP dehydrogenase / GMP reductase domain 1133 0.2323 SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 1133 0.2323 PF00478 IMP dehydrogenase / GMP reductase domain 1134 0.2323 SUB825 OC1C(O)CCCC1 1134 0.2323 PF00664 ABC transporter transmembrane region 1135 0.2321 SUB32 >= 2 P 1135 0.2321 PF01704 UTP--glucose-1-phosphate uridylyltransferase 1136 0.2321 SUB3 >= 16 H 1136 0.2321 PF00432 Prenyltransferase and squalene oxidase repeat 1137 0.2319 SUB407 O(~C)(~H) 1137 0.2319 PF00018 SH3 domain 1138 0.2316 SUB682 O-C-C-C-C-O 1138 0.2316 PF01259 SAICAR synthetase 1139 0.2314 SUB759 Cc1c(N)cccc1 1139 0.2314 PF01582 TIR domain 1140 0.2314 SUB646 O=C-N-C-C 1140 0.2314 PF01180 Dihydroorotate dehydrogenase 1141 0.2312 SUB567 O-C-C-N 1141 0.2312 PF00664 ABC transporter transmembrane region 1142 0.2307 SUB375 C(~H)(~H)(~H) 1142 0.2307 PF06512 Sodium ion transport-associated 1143 0.2305 SUB710 C-C(C)-C-C-C 1143 0.2305 PF00343 Carbohydrate phosphorylase 1144 0.2305 SUB12 >= 8 C 1144 0.2305 PF06512 Sodium ion transport-associated 1145 0.2304 SUB60 >= 1 Co 1145 0.2304 PF03308 ArgK protein 1146 0.2302 SUB682 O-C-C-C-C-O 1146 0.2302 PF00171 Aldehyde dehydrogenase family 1147 0.2298 SUB137 >= 2 any ring size 4 1147 0.2298 PF00069 Protein kinase domain 1148 0.2298 SUB702 O-C-C-C-C-C(O)-C 1148 0.2298 PF00762 Ferrochelatase 1149 0.2298 SUB441 C(-C)(-O)(=O) 1149 0.2298 PF00762 Ferrochelatase 1150 0.2298 SUB347 C(~C)(~H)(~O) 1150 0.2298 PF00171 Aldehyde dehydrogenase family 1151 0.2297 SUB717 Cc1ccc(N)cc1 1151 0.2297 PF02310 B12 binding domain 1152 0.2296 SUB603 O=C-C-N-C 1152 0.2296 PF03171 2OG-Fe(II), oxygenase superfamily 1153 0.2296 SUB705 O=C-C-C-C-C-C-C 1153 0.2296 PF01431 Peptidase family M13 1154 0.2290 SUB642 O-C-C-C=C 1154 0.2290 PF00989 PAS fold 1155 0.2287 SUB338 C(~C)(~C)(~C)(~O) 1155 0.2287 PF00001 7 transmembrane receptor (rhodopsin family), 1156 0.2286 SUB751 Nc1cc(Cl)ccc1 1156 0.2286 PF00168 C2 domain 1157 0.2286 SUB572 [#1]-C-O-[#1] 1157 0.2286 PF00212 Atrial natriuretic peptide 1158 0.2284 SUB643 O-C-C-C=O 1158 0.2284 PF00405 Transferrin 1159 0.2283 SUB433 C(-C)(-C)(=O) 1159 0.2283 PF07690 Major Facilitator Superfamily 1160 0.2283 SUB692 O-C-C-C-C-C-N 1160 0.2283 PF00337 Galactoside-binding lectin 1161 0.2282 SUB387 C(:C)(:C)(:N) 1161 0.2282 PF00001 7 transmembrane receptor (rhodopsin family), 1162 0.2278 SUB375 C(~H)(~H)(~H) 1162 0.2278 PF06628 Catalase-related immune-responsive 1163 0.2278 SUB495 O=C-C:N 1163 0.2278 PF00149 Calcineurin-like phosphoesterase 1164 0.2277 SUB3 >= 16 H 1164 0.2277 PF08763 Voltage gated calcium channel IQ domain 1165 0.2276 SUB621 C:C-O-C-C 1165 0.2276 PF00105 Zinc finger, C4 type (two domains), 1166 0.2275 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 1166 0.2275 PF03520 KCNQ voltage-gated potassium channel 1167 0.2273 SUB523 C-N-N-[#1] 1167 0.2273 PF04042 DNA polymerase alpha/epsilon subunit B 1168 0.2272 SUB663 O-C-C-O-C 1168 0.2272 PF00135 Carboxylesterase 1169 0.2272 SUB618 C-C-C-O-[#1] 1169 0.2272 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 1170 0.2272 SUB696 O=C-C-C-C-C-N 1170 0.2272 PF08983 Domain of unknown function (DUF1856), 1171 0.2270 SUB261 >= 3 hetero-aromatic rings 1171 0.2270 PF00106 short chain dehydrogenase 1172 0.2270 SUB688 O=C-C-C-C=O 1172 0.2270 PF00005 ABC transporter 1173 0.2269 SUB489 N-C=N-[#1] 1173 0.2269 PF02807 ATP:guanido phosphotransferase, N-terminal domain 1174 0.2266 SUB529 [#1]-N-C-[#1] 1174 0.2266 PF00586 AIR synthase related protein, N-terminal domain 1175 0.2263 SUB587 C-S-C-C-C 1175 0.2263 PF02773 S-adenosylmethionine synthetase, C-terminal domain 1176 0.2262 SUB567 O-C-C-N 1176 0.2262 PF00764 Arginosuccinate synthase 1177 0.2261 SUB564 O-C-O-C 1177 0.2261 PF00860 Permease family 1178 0.2258 SUB600 [#1]-C-C=C-[#1] 1178 0.2258 PF00171 Aldehyde dehydrogenase family 1179 0.2257 SUB13 >= 16 C 1179 0.2257 PF00067 Cytochrome P450 1180 0.2255 SUB640 O-C-C-C-O 1180 0.2255 PF00084 Sushi domain (SCR repeat), 1181 0.2253 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 1181 0.2253 PF00097 Zinc finger, C3HC4 type (RING finger), 1182 0.2252 SUB587 C-S-C-C-C 1182 0.2252 PF00438 S-adenosylmethionine synthetase, N-terminal domain 1183 0.2252 SUB807 OC1CC(Cl)CCC1 1183 0.2252 PF00043 Glutathione S-transferase, C-terminal domain 1184 0.2250 SUB348 C(~C)(~H)(~O)(~O) 1184 0.2250 PF01869 BadF/BadG/BcrA/BcrD ATPase family 1185 0.2250 SUB699 O-C-C-C-C-C-C-C 1185 0.2250 PF03099 Biotin/lipoate A/B protein ligase family 1186 0.2249 SUB643 O-C-C-C=O 1186 0.2249 PF00001 7 transmembrane receptor (rhodopsin family), 1187 0.2248 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 1187 0.2248 PF01401 Angiotensin-converting enzyme 1188 0.2248 SUB339 C(~C)(~C)(~H)(~N) 1188 0.2248 PF00018 SH3 domain 1189 0.2245 SUB603 O=C-C-N-C 1189 0.2245 PF01619 Proline dehydrogenase 1190 0.2240 SUB369 C(~H)(~S) 1190 0.2240 PF00576 HIUase/Transthyretin family 1191 0.2240 SUB369 C(~H)(~S) 1191 0.2240 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 1192 0.2238 SUB407 O(~C)(~H) 1192 0.2238 PF00929 Exonuclease 1193 0.2235 SUB651 O=C-N-C=O 1193 0.2235 PF00343 Carbohydrate phosphorylase 1194 0.2232 SUB369 C(~H)(~S) 1194 0.2232 PF00079 Serpin (serine protease inhibitor), 1195 0.2230 SUB580 O=C-C-C-C 1195 0.2230 PF02574 Homocysteine S-methyltransferase 1196 0.2229 SUB440 C(-C)(-N)(=O) 1196 0.2229 PF01841 Transglutaminase-like superfamily 1197 0.2225 SUB21 >= 4 O 1197 0.2225 PF00531 Death domain 1198 0.2221 SUB642 O-C-C-C=C 1198 0.2221 PF00069 Protein kinase domain 1199 0.2220 SUB653 O-C:C:C-N 1199 0.2220 PF03508 Gap junction alpha-1 protein (Cx43), 1200 0.2218 SUB346 C(~C)(~H)(~N) 1200 0.2218 PF03073 TspO/MBR family 1201 0.2218 SUB736 Cc1cc(O)ccc1 1201 0.2218 PF00225 Kinesin motor domain 1202 0.2217 SUB700 O-C-C-C-C-C(C)-C 1202 0.2217 PF00069 Protein kinase domain 1203 0.2216 SUB759 Cc1c(N)cccc1 1203 0.2216 PF00017 SH2 domain 1204 0.2214 SUB367 C(~H)(~O) 1204 0.2214 PF00574 Clp protease 1205 0.2212 SUB712 C-C(C)(C)-C-C 1205 0.2212 PF00106 short chain dehydrogenase 1206 0.2210 SUB806 OC1CC(N)CCC1 1206 0.2210 PF00029 Connexin 1207 0.2210 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 1207 0.2210 PF00531 Death domain 1208 0.2209 SUB682 O-C-C-C-C-O 1208 0.2209 PF00169 PH domain 1209 0.2208 SUB414 S(~C)(~H) 1209 0.2208 PF07992 Pyridine nucleotide-disulphide oxidoreductase 1210 0.2207 SUB577 N=C-C:C-[#1] 1210 0.2207 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1211 0.2206 SUB660 O-C-C-N-C 1211 0.2206 PF01401 Angiotensin-converting enzyme 1212 0.2203 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 1212 0.2203 PF00493 MCM2/3/5 family 1213 0.2202 SUB572 [#1]-C-O-[#1] 1213 0.2202 PF06888 Putative Phosphatase 1214 0.2200 SUB340 C(~C)(~C)(~H)(~O) 1214 0.2200 PF00341 Platelet-derived growth factor (PDGF), 1215 0.2199 SUB396 N(~C)(~O) 1215 0.2199 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 1216 0.2199 SUB386 C(:C)(:C)(:C) 1216 0.2199 PF00001 7 transmembrane receptor (rhodopsin family), 1217 0.2197 SUB459 S(-O)(=O) 1217 0.2197 PF00089 Trypsin 1218 0.2196 SUB631 O-C:C-O-C 1218 0.2196 PF00918 Gastrin/cholecystokinin family 1219 0.2195 SUB682 O-C-C-C-C-O 1219 0.2195 PF00175 Oxidoreductase NAD-binding domain 1220 0.2195 SUB489 N-C=N-[#1] 1220 0.2195 PF10397 Adenylosuccinate lyase C-terminus 1221 0.2193 SUB695 O=C-C-C-C-C=O 1221 0.2193 PF02793 Hormone receptor domain 1222 0.2193 SUB663 O-C-C-O-C 1222 0.2193 PF00176 SNF2 family N-terminal domain 1223 0.2187 SUB804 OC1CC(O)CCC1 1223 0.2187 PF02121 Phosphatidylinositol transfer protein 1224 0.2187 SUB629 C-N-C-C:C 1224 0.2187 PF00105 Zinc finger, C4 type (two domains), 1225 0.2187 SUB375 C(~H)(~H)(~H) 1225 0.2187 PF03160 Calx-beta domain 1226 0.2185 SUB392 N(~C)(~C)(~C) 1226 0.2185 PF01467 Cytidylyltransferase 1227 0.2183 SUB580 O=C-C-C-C 1227 0.2183 PF00180 Isocitrate/isopropylmalate dehydrogenase 1228 0.2182 SUB350 C(~C)(~H)(~S) 1228 0.2182 PF08725 Integrin beta cytoplasmic domain 1229 0.2182 SUB660 O-C-C-N-C 1229 0.2182 PF00551 Formyl transferase 1230 0.2182 SUB24 >= 1 F 1230 0.2182 PF01180 Dihydroorotate dehydrogenase 1231 0.2181 SUB762 Oc1c(O)cccc1 1231 0.2181 PF01596 O-methyltransferase 1232 0.2180 SUB389 C(:C)(:N)(:N) 1232 0.2180 PF05347 Complex 1 protein (LYR family), 1233 0.2176 SUB783 OC1CCC(O)CC1 1233 0.2176 PF01733 Nucleoside transporter 1234 0.2175 SUB694 O=C-C-C-C-C-O 1234 0.2175 PF00675 Insulinase (Peptidase family M16), 1235 0.2174 SUB347 C(~C)(~H)(~O) 1235 0.2174 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 1236 0.2173 SUB408 O(~C)(~P) 1236 0.2173 PF00459 Inositol monophosphatase family 1237 0.2170 SUB34 >= 1 S 1237 0.2170 PF00273 Serum albumin family 1238 0.2170 SUB572 [#1]-C-O-[#1] 1238 0.2170 PF02065 Melibiase 1239 0.2170 SUB339 C(~C)(~C)(~H)(~N) 1239 0.2170 PF00667 FAD binding domain 1240 0.2168 SUB158 >= 3 any ring size 5 1240 0.2168 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 1241 0.2168 SUB14 >= 32 C 1241 0.2168 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1242 0.2167 SUB494 O=C-C:C 1242 0.2167 PF00354 Pentaxin family 1243 0.2166 SUB285 C-C 1243 0.2166 PF09127 Leukotriene A4 hydrolase, C-terminal 1244 0.2162 SUB360 C(~C)(:N)(:N) 1244 0.2162 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 1245 0.2162 SUB629 C-N-C-C:C 1245 0.2162 PF00001 7 transmembrane receptor (rhodopsin family), 1246 0.2159 SUB16 >= 2 N 1246 0.2159 PF00171 Aldehyde dehydrogenase family 1247 0.2152 SUB647 O=C-N-C-[#1] 1247 0.2152 PF00357 Integrin alpha cytoplasmic region 1248 0.2152 SUB640 O-C-C-C-O 1248 0.2152 PF03781 Formylglycine-generating sulfatase enzyme 1249 0.2148 SUB444 C(-C)(=O) 1249 0.2148 PF00390 Malic enzyme, N-terminal domain 1250 0.2146 SUB3 >= 16 H 1250 0.2146 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 1251 0.2145 SUB581 O=C-C-C-N 1251 0.2145 PF06512 Sodium ion transport-associated 1252 0.2142 SUB686 O=C-C-C-C-N 1252 0.2142 PF00149 Calcineurin-like phosphoesterase 1253 0.2141 SUB348 C(~C)(~H)(~O)(~O) 1253 0.2141 PF01562 Reprolysin family propeptide 1254 0.2141 SUB545 O-C:C-O 1254 0.2141 PF00918 Gastrin/cholecystokinin family 1255 0.2140 SUB13 >= 16 C 1255 0.2140 PF00501 AMP-binding enzyme 1256 0.2134 SUB681 O-C-C-C-C-C 1256 0.2134 PF00107 Zinc-binding dehydrogenase 1257 0.2132 SUB624 O=C-C:C-C 1257 0.2132 PF01467 Cytidylyltransferase 1258 0.2130 SUB406 O(~C)(~C) 1258 0.2130 PF00059 Lectin C-type domain 1259 0.2130 SUB350 C(~C)(~H)(~S) 1259 0.2130 PF01323 DSBA-like thioredoxin domain 1260 0.2128 SUB642 O-C-C-C=C 1260 0.2128 PF00149 Calcineurin-like phosphoesterase 1261 0.2128 SUB441 C(-C)(-O)(=O) 1261 0.2128 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 1262 0.2128 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1262 0.2128 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 1263 0.2127 SUB556 N=C-C=C 1263 0.2127 PF03073 TspO/MBR family 1264 0.2125 SUB389 C(:C)(:N)(:N) 1264 0.2125 PF02493 MORN repeat 1265 0.2125 SUB537 O=C-C-N 1265 0.2125 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 1266 0.2124 SUB158 >= 3 any ring size 5 1266 0.2124 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 1267 0.2124 SUB465 N-C-C=C 1267 0.2124 PF00091 Tubulin/FtsZ family, GTPase domain 1268 0.2124 SUB697 C-C-C-C-C-C-C-C 1268 0.2124 PF00209 Sodium:neurotransmitter symporter family 1269 0.2124 SUB200 >= 4 any ring size 6 1269 0.2124 PF00357 Integrin alpha cytoplasmic region 1270 0.2123 SUB366 C(~H)(~N) 1270 0.2123 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1271 0.2123 SUB806 OC1CC(N)CCC1 1271 0.2123 PF10582 Gap junction channel protein cysteine-rich domain 1272 0.2122 SUB647 O=C-N-C-[#1] 1272 0.2122 PF05649 Peptidase family M13 1273 0.2122 SUB441 C(-C)(-O)(=O) 1273 0.2122 PF01401 Angiotensin-converting enzyme 1274 0.2122 SUB378 C(~N)(:C)(:C) 1274 0.2122 PF00005 ABC transporter 1275 0.2119 SUB285 C-C 1275 0.2119 PF00273 Serum albumin family 1276 0.2119 SUB687 O=C-C-C-C-O 1276 0.2119 PF00274 Fructose-bisphosphate aldolase class-I 1277 0.2119 SUB694 O=C-C-C-C-C-O 1277 0.2119 PF00274 Fructose-bisphosphate aldolase class-I 1278 0.2118 SUB780 CC1CCC(N)CC1 1278 0.2118 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1279 0.2118 SUB389 C(:C)(:N)(:N) 1279 0.2118 PF00899 ThiF family 1280 0.2117 SUB216 >= 1 saturated or aromatic nitrogen-containing ring size 7 1280 0.2117 PF00149 Calcineurin-like phosphoesterase 1281 0.2115 SUB722 Oc1ccc(N)cc1 1281 0.2115 PF00656 Caspase domain 1282 0.2112 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1282 0.2112 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1283 0.2111 SUB683 O-C-C-C-C-N 1283 0.2111 PF00106 short chain dehydrogenase 1284 0.2109 SUB572 [#1]-C-O-[#1] 1284 0.2109 PF00931 NB-ARC domain 1285 0.2104 SUB116 >= 1 any ring size 3 1285 0.2104 PF01244 Membrane dipeptidase (Peptidase family M19), 1286 0.2103 SUB639 O-C-C-C-N 1286 0.2103 PF00452 Apoptosis regulator proteins, Bcl-2 family 1287 0.2100 SUB165 >= 4 any ring size 5 1287 0.2100 PF03308 ArgK protein 1288 0.2099 SUB603 O=C-C-N-C 1288 0.2099 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 1289 0.2099 SUB683 O-C-C-C-C-N 1289 0.2099 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 1290 0.2097 SUB309 O-H 1290 0.2097 PF00018 SH3 domain 1291 0.2096 SUB228 >= 1 any ring size 8 1291 0.2096 PF03098 Animal haem peroxidase 1292 0.2096 SUB398 N(~C)(:C)(:C) 1292 0.2096 PF10276 Zinc-finger domain 1293 0.2096 SUB591 C-C:C-O-[#1] 1293 0.2096 PF00069 Protein kinase domain 1294 0.2095 SUB354 C(~C)(~S) 1294 0.2095 PF00497 Bacterial extracellular solute-binding proteins, family 3 1295 0.2093 SUB783 OC1CCC(O)CC1 1295 0.2093 PF00501 AMP-binding enzyme 1296 0.2092 SUB572 [#1]-C-O-[#1] 1296 0.2092 PF01462 Leucine rich repeat N-terminal domain 1297 0.2091 SUB406 O(~C)(~C) 1297 0.2091 PF07645 Calcium-binding EGF domain 1298 0.2088 SUB334 C(~C)(~C)(~C) 1298 0.2088 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 1299 0.2088 SUB12 >= 8 C 1299 0.2088 PF00702 haloacid dehalogenase-like hydrolase 1300 0.2088 SUB348 C(~C)(~H)(~O)(~O) 1300 0.2088 PF02837 Glycosyl hydrolases family 2, sugar binding domain 1301 0.2088 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1301 0.2088 PF00146 NADH dehydrogenase 1302 0.2085 SUB602 N-C:C:C-N 1302 0.2085 PF00041 Fibronectin type III domain 1303 0.2085 SUB360 C(~C)(:N)(:N) 1303 0.2085 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 1304 0.2083 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 1304 0.2083 PF02173 pKID domain 1305 0.2083 SUB367 C(~H)(~O) 1305 0.2083 PF00059 Lectin C-type domain 1306 0.2083 SUB537 O=C-C-N 1306 0.2083 PF03034 Phosphatidyl serine synthase 1307 0.2082 SUB242 >= 1 any ring size 9 1307 0.2082 PF01590 GAF domain 1308 0.2081 SUB714 Cc1ccc(C)cc1 1308 0.2081 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 1309 0.2080 SUB337 C(~C)(~C)(~C)(~N) 1309 0.2080 PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1310 0.2078 SUB685 O=C-C-C-C-C 1310 0.2078 PF00001 7 transmembrane receptor (rhodopsin family), 1311 0.2078 SUB144 >= 1 any ring size 5 1311 0.2078 PF00067 Cytochrome P450 1312 0.2077 SUB441 C(-C)(-O)(=O) 1312 0.2077 PF02785 Biotin carboxylase C-terminal domain 1313 0.2075 SUB360 C(~C)(:N)(:N) 1313 0.2075 PF00156 Phosphoribosyl transferase domain 1314 0.2074 SUB713 C-C(C)-C(C)-C 1314 0.2074 PF00291 Pyridoxal-phosphate dependent enzyme 1315 0.2074 SUB738 Cc1cc(N)ccc1 1315 0.2074 PF00340 Interleukin-1 / 18 1316 0.2072 SUB334 C(~C)(~C)(~C) 1316 0.2072 PF01063 Aminotransferase class IV 1317 0.2069 SUB462 O-C-C=N 1317 0.2069 PF00155 Aminotransferase class I and II 1318 0.2067 SUB249 >= 1 any ring size 10 1318 0.2067 PF00521 DNA gyrase/topoisomerase IV, subunit A 1319 0.2067 SUB529 [#1]-N-C-[#1] 1319 0.2067 PF00206 Lyase 1320 0.2066 SUB360 C(~C)(:N)(:N) 1320 0.2066 PF00001 7 transmembrane receptor (rhodopsin family), 1321 0.2063 SUB201 >= 4 saturated or aromatic carbon-only ring size 6 1321 0.2063 PF00105 Zinc finger, C4 type (two domains), 1322 0.2062 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1322 0.2062 PF05347 Complex 1 protein (LYR family), 1323 0.2060 SUB407 O(~C)(~H) 1323 0.2060 PF06079 Apyrase 1324 0.2058 SUB39 >= 2 Cl 1324 0.2058 PF00702 haloacid dehalogenase-like hydrolase 1325 0.2058 SUB572 [#1]-C-O-[#1] 1325 0.2058 PF00019 Transforming growth factor beta like domain 1326 0.2057 SUB613 N-C-O-C-C 1326 0.2057 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 1327 0.2056 SUB375 C(~H)(~H)(~H) 1327 0.2056 PF00041 Fibronectin type III domain 1328 0.2054 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1328 0.2054 PF07654 Immunoglobulin C1-set domain 1329 0.2054 SUB284 C-H 1329 0.2054 PF06617 M-phase inducer phosphatase 1330 0.2052 SUB20 >= 2 O 1330 0.2052 PF00225 Kinesin motor domain 1331 0.2052 SUB660 O-C-C-N-C 1331 0.2052 PF05199 GMC oxidoreductase 1332 0.2050 SUB376 C(~N)(~N) 1332 0.2050 PF00531 Death domain 1333 0.2047 SUB339 C(~C)(~C)(~H)(~N) 1333 0.2047 PF00152 tRNA synthetases class II (D, K and N), 1334 0.2045 SUB25 >= 2 F 1334 0.2045 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 1335 0.2043 SUB616 N-C-C-O-C 1335 0.2043 PF00067 Cytochrome P450 1336 0.2043 SUB63 >= 1 Zn 1336 0.2043 PF02798 Glutathione S-transferase, N-terminal domain 1337 0.2040 SUB717 Cc1ccc(N)cc1 1337 0.2040 PF00754 F5/8 type C domain 1338 0.2038 SUB603 O=C-C-N-C 1338 0.2038 PF00102 Protein-tyrosine phosphatase 1339 0.2038 SUB345 C(~C)(~H) 1339 0.2038 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1340 0.2037 SUB651 O=C-N-C=O 1340 0.2037 PF03360 Glycosyltransferase family 43 1341 0.2035 SUB646 O=C-N-C-C 1341 0.2035 PF01477 PLAT/LH2 domain 1342 0.2034 SUB683 O-C-C-C-C-N 1342 0.2034 PF00535 Glycosyl transferase family 2 1343 0.2031 SUB840 CC1CC(C)CC1 1343 0.2031 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1344 0.2029 SUB342 C(~C)(~C)(~O) 1344 0.2029 PF03372 Endonuclease/Exonuclease/phosphatase family 1345 0.2029 SUB597 N=C-N-C-C 1345 0.2029 PF01048 Phosphorylase superfamily 1346 0.2025 SUB698 C-C-C-C-C-C(C)-C 1346 0.2025 PF00520 Ion transport protein 1347 0.2023 SUB35 >= 2 S 1347 0.2023 PF00778 DIX domain 1348 0.2022 SUB762 Oc1c(O)cccc1 1348 0.2022 PF00918 Gastrin/cholecystokinin family 1349 0.2021 SUB362 C(~Cl)(~H) 1349 0.2021 PF00418 Tau and MAP protein, tubulin-binding repeat 1350 0.2019 SUB369 C(~H)(~S) 1350 0.2019 PF00756 Putative esterase 1351 0.2019 SUB703 O-C-C-C-C-C-N-C 1351 0.2019 PF01687 Riboflavin kinase 1352 0.2018 SUB814 NC1CC(Cl)CCC1 1352 0.2018 PF02254 TrkA-N domain 1353 0.2017 SUB249 >= 1 any ring size 10 1353 0.2017 PF00067 Cytochrome P450 1354 0.2016 SUB682 O-C-C-C-C-O 1354 0.2016 PF05118 Aspartyl/Asparaginyl beta-hydroxylase 1355 0.2016 SUB676 Br-C-C-C:C 1355 0.2016 PF02201 SWIB/MDM2 domain 1356 0.2015 SUB398 N(~C)(:C)(:C) 1356 0.2015 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 1357 0.2014 SUB409 O(~H)(~S) 1357 0.2014 PF00578 AhpC/TSA family 1358 0.2013 SUB453 C(-O)(=O) 1358 0.2013 PF00060 Ligand-gated ion channel 1359 0.2012 SUB677 N#C-C-C-C 1359 0.2012 PF00001 7 transmembrane receptor (rhodopsin family), 1360 0.2012 SUB38 >= 1 Cl 1360 0.2012 PF00324 Amino acid permease 1361 0.2007 SUB4 >= 32 H 1361 0.2007 PF00026 Eukaryotic aspartyl protease 1362 0.2006 SUB621 C:C-O-C-C 1362 0.2006 PF00650 CRAL/TRIO domain 1363 0.2005 SUB621 C:C-O-C-C 1363 0.2005 PF00102 Protein-tyrosine phosphatase 1364 0.2004 SUB14 >= 32 C 1364 0.2004 PF02886 LBP / BPI / CETP family, C-terminal domain 1365 0.2003 SUB467 N#C-C=C 1365 0.2003 PF00105 Zinc finger, C4 type (two domains), 1366 0.2003 SUB484 N-S-C:C 1366 0.2003 PF00194 Eukaryotic-type carbonic anhydrase 1367 0.2003 SUB561 N-C-N-C 1367 0.2003 PF02274 Amidinotransferase 1368 0.2002 SUB288 C-F 1368 0.2002 PF00520 Ion transport protein 1369 0.2000 SUB4 >= 32 H 1369 0.2000 PF00357 Integrin alpha cytoplasmic region 1370 0.1999 SUB603 O=C-C-N-C 1370 0.1999 PF00999 Sodium/hydrogen exchanger family 1371 0.1999 SUB536 O=C-C-C 1371 0.1999 PF00071 Ras family 1372 0.1998 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 1372 0.1998 PF00106 short chain dehydrogenase 1373 0.1993 SUB518 N-N-C-N 1373 0.1993 PF00209 Sodium:neurotransmitter symporter family 1374 0.1990 SUB242 >= 1 any ring size 9 1374 0.1990 PF05649 Peptidase family M13 1375 0.1989 SUB467 N#C-C=C 1375 0.1989 PF00104 Ligand-binding domain of nuclear hormone receptor 1376 0.1986 SUB486 N:C:C:N 1376 0.1986 PF00520 Ion transport protein 1377 0.1984 SUB345 C(~C)(~H) 1377 0.1984 PF00273 Serum albumin family 1378 0.1984 SUB263 >= 4 hetero-aromatic rings 1378 0.1984 PF01208 Uroporphyrinogen decarboxylase (URO-D), 1379 0.1981 SUB441 C(-C)(-O)(=O) 1379 0.1981 PF01699 Sodium/calcium exchanger protein 1380 0.1979 SUB862 CC1C(O)CCC1 1380 0.1979 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 1381 0.1979 SUB598 O=C-C-C:C 1381 0.1979 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1382 0.1978 SUB23 >= 16 O 1382 0.1978 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 1383 0.1976 SUB691 O-C-C-C-C-C-O 1383 0.1976 PF02574 Homocysteine S-methyltransferase 1384 0.1974 SUB145 >= 1 saturated or aromatic carbon-only ring size 5 1384 0.1974 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 1385 0.1974 SUB682 O-C-C-C-C-O 1385 0.1974 PF00549 CoA-ligase 1386 0.1973 SUB337 C(~C)(~C)(~C)(~N) 1386 0.1973 PF00243 Nerve growth factor family 1387 0.1972 SUB686 O=C-C-C-C-N 1387 0.1972 PF07837 Formiminotransferase domain, N-terminal subdomain 1388 0.1971 SUB261 >= 3 hetero-aromatic rings 1388 0.1971 PF12062 heparan sulfate-N-deacetylase 1389 0.1971 SUB695 O=C-C-C-C-C=O 1389 0.1971 PF01590 GAF domain 1390 0.1967 SUB715 Cc1ccc(O)cc1 1390 0.1967 PF00018 SH3 domain 1391 0.1964 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 1391 0.1964 PF00918 Gastrin/cholecystokinin family 1392 0.1962 SUB529 [#1]-N-C-[#1] 1392 0.1962 PF00001 7 transmembrane receptor (rhodopsin family), 1393 0.1962 SUB627 C-O-C:C-C 1393 0.1962 PF00664 ABC transporter transmembrane region 1394 0.1961 SUB300 N-H 1394 0.1961 PF00520 Ion transport protein 1395 0.1960 SUB339 C(~C)(~C)(~H)(~N) 1395 0.1960 PF00375 Sodium:dicarboxylate symporter family 1396 0.1959 SUB350 C(~C)(~H)(~S) 1396 0.1959 PF03099 Biotin/lipoate A/B protein ligase family 1397 0.1959 SUB499 O-C=C-C 1397 0.1959 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1398 0.1954 SUB549 O-C-C:C 1398 0.1954 PF01477 PLAT/LH2 domain 1399 0.1953 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 1399 0.1953 PF00664 ABC transporter transmembrane region 1400 0.1953 SUB441 C(-C)(-O)(=O) 1400 0.1953 PF01151 GNS1/SUR4 family 1401 0.1952 SUB699 O-C-C-C-C-C-C-C 1401 0.1952 PF01477 PLAT/LH2 domain 1402 0.1951 SUB441 C(-C)(-O)(=O) 1402 0.1951 PF07648 Kazal-type serine protease inhibitor domain 1403 0.1950 SUB703 O-C-C-C-C-C-N-C 1403 0.1950 PF00702 haloacid dehalogenase-like hydrolase 1404 0.1950 SUB486 N:C:C:N 1404 0.1950 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 1405 0.1950 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1405 0.1950 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 1406 0.1950 SUB345 C(~C)(~H) 1406 0.1950 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1407 0.1949 SUB407 O(~C)(~H) 1407 0.1949 PF00056 lactate/malate dehydrogenase, NAD binding domain 1408 0.1948 SUB421 C=O 1408 0.1948 PF00202 Aminotransferase class-III 1409 0.1947 SUB688 O=C-C-C-C=O 1409 0.1947 PF00731 AIR carboxylase 1410 0.1947 SUB668 C=C-C-O-[#1] 1410 0.1947 PF00001 7 transmembrane receptor (rhodopsin family), 1411 0.1947 SUB651 O=C-N-C=O 1411 0.1947 PF00001 7 transmembrane receptor (rhodopsin family), 1412 0.1946 SUB214 >= 1 any ring size 7 1412 0.1946 PF00169 PH domain 1413 0.1946 SUB514 S:C:C-[#1] 1413 0.1946 PF00059 Lectin C-type domain 1414 0.1945 SUB347 C(~C)(~H)(~O) 1414 0.1945 PF00229 TNF(Tumour Necrosis Factor), family 1415 0.1943 SUB608 N-C-C-C:C 1415 0.1943 PF00018 SH3 domain 1416 0.1942 SUB361 C(~Cl)(~Cl) 1416 0.1942 PF00111 2Fe-2S iron-sulfur cluster binding domain 1417 0.1942 SUB760 Cc1c(Cl)cccc1 1417 0.1942 PF00069 Protein kinase domain 1418 0.1941 SUB21 >= 4 O 1418 0.1941 PF03949 Malic enzyme, NAD binding domain 1419 0.1940 SUB703 O-C-C-C-C-C-N-C 1419 0.1940 PF01467 Cytidylyltransferase 1420 0.1939 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 1420 0.1939 PF00170 bZIP transcription factor 1421 0.1937 SUB537 O=C-C-N 1421 0.1937 PF01841 Transglutaminase-like superfamily 1422 0.1937 SUB444 C(-C)(=O) 1422 0.1937 PF00056 lactate/malate dehydrogenase, NAD binding domain 1423 0.1936 SUB711 C-C-C(C)-C-C 1423 0.1936 PF00520 Ion transport protein 1424 0.1936 SUB339 C(~C)(~C)(~H)(~N) 1424 0.1936 PF00040 Fibronectin type II domain 1425 0.1936 SUB660 O-C-C-N-C 1425 0.1936 PF01633 Choline/ethanolamine kinase 1426 0.1936 SUB500 N-C:C:N 1426 0.1936 PF00221 Phenylalanine and histidine ammonia-lyase 1427 0.1935 SUB696 O=C-C-C-C-C-N 1427 0.1935 PF00756 Putative esterase 1428 0.1935 SUB16 >= 2 N 1428 0.1935 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1429 0.1934 SUB582 O=C-C-C-O 1429 0.1934 PF00405 Transferrin 1430 0.1929 SUB486 N:C:C:N 1430 0.1929 PF01923 Cobalamin adenosyltransferase 1431 0.1928 SUB598 O=C-C-C:C 1431 0.1928 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1432 0.1926 SUB503 N-C=C-[#1] 1432 0.1926 PF03098 Animal haem peroxidase 1433 0.1924 SUB590 C-C:C-O-C 1433 0.1924 PF00664 ABC transporter transmembrane region 1434 0.1924 SUB581 O=C-C-C-N 1434 0.1924 PF01336 OB-fold nucleic acid binding domain 1435 0.1924 SUB543 O-C:C-[#1] 1435 0.1924 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1436 0.1921 SUB440 C(-C)(-N)(=O) 1436 0.1921 PF01471 Putative peptidoglycan binding domain 1437 0.1919 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 1437 0.1919 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 1438 0.1919 SUB705 O=C-C-C-C-C-C-C 1438 0.1919 PF08127 Peptidase family C1 propeptide 1439 0.1918 SUB337 C(~C)(~C)(~C)(~N) 1439 0.1918 PF03308 ArgK protein 1440 0.1916 SUB687 O=C-C-C-C-O 1440 0.1916 PF01336 OB-fold nucleic acid binding domain 1441 0.1915 SUB407 O(~C)(~H) 1441 0.1915 PF03949 Malic enzyme, NAD binding domain 1442 0.1915 SUB309 O-H 1442 0.1915 PF00106 short chain dehydrogenase 1443 0.1913 SUB686 O=C-C-C-C-N 1443 0.1913 PF00255 Glutathione peroxidase 1444 0.1912 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1444 0.1912 PF05071 NADH ubiquinone oxidoreductase subunit NDUFA12 1445 0.1911 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1445 0.1911 PF00135 Carboxylesterase 1446 0.1909 SUB2 >= 8 H 1446 0.1909 PF00043 Glutathione S-transferase, C-terminal domain 1447 0.1908 SUB713 C-C(C)-C(C)-C 1447 0.1908 PF00489 Interleukin-6/G-CSF/MGF family 1448 0.1908 SUB529 [#1]-N-C-[#1] 1448 0.1908 PF01564 Spermine/spermidine synthase 1449 0.1904 SUB360 C(~C)(:N)(:N) 1449 0.1904 PF00170 bZIP transcription factor 1450 0.1903 SUB376 C(~N)(~N) 1450 0.1903 PF00051 Kringle domain 1451 0.1901 SUB664 O-C-C-O-[#1] 1451 0.1901 PF00180 Isocitrate/isopropylmalate dehydrogenase 1452 0.1900 SUB368 C(~H)(~O)(~O) 1452 0.1900 PF07686 Immunoglobulin V-set domain 1453 0.1899 SUB158 >= 3 any ring size 5 1453 0.1899 PF06212 GRIM-19 protein 1454 0.1899 SUB744 Oc1cc(Cl)ccc1 1454 0.1899 PF02798 Glutathione S-transferase, N-terminal domain 1455 0.1897 SUB393 N(~C)(~C)(~H) 1455 0.1897 PF00328 Histidine acid phosphatase 1456 0.1897 SUB538 O=C-C-O 1456 0.1897 PF00224 Pyruvate kinase, barrel domain 1457 0.1894 SUB632 O-C:C-O-[#1] 1457 0.1894 PF00069 Protein kinase domain 1458 0.1893 SUB792 NC1CCC(N)CC1 1458 0.1893 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 1459 0.1893 SUB556 N=C-C=C 1459 0.1893 PF00111 2Fe-2S iron-sulfur cluster binding domain 1460 0.1892 SUB743 Oc1cc(N)ccc1 1460 0.1892 PF00123 Peptide hormone 1461 0.1891 SUB36 >= 4 S 1461 0.1891 PF03662 Glycosyl hydrolase family 79, N-terminal domain 1462 0.1889 SUB217 >= 1 saturated or aromatic heteroatom-containing ring size 7 1462 0.1889 PF00169 PH domain 1463 0.1888 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1463 0.1888 PF04116 Fatty acid hydroxylase superfamily 1464 0.1888 SUB577 N=C-C:C-[#1] 1464 0.1888 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 1465 0.1885 SUB375 C(~H)(~H)(~H) 1465 0.1885 PF01477 PLAT/LH2 domain 1466 0.1883 SUB389 C(:C)(:N)(:N) 1466 0.1883 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 1467 0.1883 SUB696 O=C-C-C-C-C-N 1467 0.1883 PF00153 Mitochondrial carrier protein 1468 0.1878 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 1468 0.1878 PF04622 ERG2 and Sigma1 receptor like protein 1469 0.1875 SUB613 N-C-O-C-C 1469 0.1875 PF02267 ADP-ribosyl cyclase 1470 0.1873 SUB687 O=C-C-C-C-O 1470 0.1873 PF00675 Insulinase (Peptidase family M16), 1471 0.1873 SUB336 C(~C)(~C)(~C)(~H) 1471 0.1873 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 1472 0.1871 SUB813 NC1CC(N)CCC1 1472 0.1871 PF00005 ABC transporter 1473 0.1870 SUB426 P=O 1473 0.1870 PF00017 SH2 domain 1474 0.1870 SUB17 >= 4 N 1474 0.1870 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 1475 0.1865 SUB284 C-H 1475 0.1865 PF00194 Eukaryotic-type carbonic anhydrase 1476 0.1864 SUB228 >= 1 any ring size 8 1476 0.1864 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1477 0.1862 SUB695 O=C-C-C-C-C=O 1477 0.1862 PF00255 Glutathione peroxidase 1478 0.1860 SUB315 O-P 1478 0.1860 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 1479 0.1855 SUB3 >= 16 H 1479 0.1855 PF00017 SH2 domain 1480 0.1854 SUB13 >= 16 C 1480 0.1854 PF03765 CRAL/TRIO, N-terminus 1481 0.1852 SUB417 C=C 1481 0.1852 PF00005 ABC transporter 1482 0.1851 SUB510 Br-C:C-C 1482 0.1851 PF02205 WH2 motif 1483 0.1849 SUB293 C-P 1483 0.1849 PF00102 Protein-tyrosine phosphatase 1484 0.1848 SUB446 C(-H)(-N)(=C) 1484 0.1848 PF00105 Zinc finger, C4 type (two domains), 1485 0.1847 SUB96 >= 1 Hg 1485 0.1847 PF00337 Galactoside-binding lectin 1486 0.1839 SUB680 C-C-C-C-C-C 1486 0.1839 PF00337 Galactoside-binding lectin 1487 0.1838 SUB517 [#1]-C=C-[#1] 1487 0.1838 PF03098 Animal haem peroxidase 1488 0.1835 SUB392 N(~C)(~C)(~C) 1488 0.1835 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1489 0.1835 SUB393 N(~C)(~C)(~H) 1489 0.1835 PF00583 Acetyltransferase (GNAT), family 1490 0.1834 SUB841 CC1CC(O)CC1 1490 0.1834 PF08377 MAP2/Tau projection domain 1491 0.1829 SUB288 C-F 1491 0.1829 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1492 0.1826 SUB193 >= 3 any ring size 6 1492 0.1826 PF00001 7 transmembrane receptor (rhodopsin family), 1493 0.1825 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 1493 0.1825 PF00001 7 transmembrane receptor (rhodopsin family), 1494 0.1823 SUB736 Cc1cc(O)ccc1 1494 0.1823 PF00643 B-box zinc finger 1495 0.1823 SUB167 >= 4 saturated or aromatic nitrogen-containing ring size 5 1495 0.1823 PF01208 Uroporphyrinogen decarboxylase (URO-D), 1496 0.1821 SUB407 O(~C)(~H) 1496 0.1821 PF00202 Aminotransferase class-III 1497 0.1821 SUB695 O=C-C-C-C-C=O 1497 0.1821 PF07722 Peptidase C26 1498 0.1819 SUB606 O=C-C-O-C 1498 0.1819 PF08429 PLU-1-like protein 1499 0.1818 SUB144 >= 1 any ring size 5 1499 0.1818 PF03171 2OG-Fe(II), oxygenase superfamily 1500 0.1816 SUB381 C(~O)(~O) 1500 0.1816 PF07654 Immunoglobulin C1-set domain 1501 0.1816 SUB625 O=C-C:C-N 1501 0.1816 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 1502 0.1814 SUB697 C-C-C-C-C-C-C-C 1502 0.1814 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 1503 0.1813 SUB757 Cc1c(O)cccc1 1503 0.1813 PF00091 Tubulin/FtsZ family, GTPase domain 1504 0.1812 SUB492 C-N:C-[#1] 1504 0.1812 PF00757 Furin-like cysteine rich region 1505 0.1811 SUB537 O=C-C-N 1505 0.1811 PF03074 Glutamate-cysteine ligase 1506 0.1810 SUB4 >= 32 H 1506 0.1810 PF00650 CRAL/TRIO domain 1507 0.1809 SUB426 P=O 1507 0.1809 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 1508 0.1809 SUB567 O-C-C-N 1508 0.1809 PF05995 Cysteine dioxygenase type I 1509 0.1804 SUB567 O-C-C-N 1509 0.1804 PF01409 tRNA synthetases class II core domain (F), 1510 0.1804 SUB486 N:C:C:N 1510 0.1804 PF00821 Phosphoenolpyruvate carboxykinase 1511 0.1801 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1511 0.1801 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 1512 0.1800 SUB339 C(~C)(~C)(~H)(~N) 1512 0.1800 PF00133 tRNA synthetases class I (I, L, M and V), 1513 0.1800 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 1513 0.1800 PF03098 Animal haem peroxidase 1514 0.1797 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 1514 0.1797 PF02161 Progesterone receptor 1515 0.1795 SUB22 >= 8 O 1515 0.1795 PF00122 E1-E2 ATPase 1516 0.1795 SUB339 C(~C)(~C)(~H)(~N) 1516 0.1795 PF02574 Homocysteine S-methyltransferase 1517 0.1795 SUB200 >= 4 any ring size 6 1517 0.1795 PF02525 Flavodoxin-like fold 1518 0.1794 SUB620 O-C-C=C-C 1518 0.1794 PF00702 haloacid dehalogenase-like hydrolase 1519 0.1794 SUB594 N-C-C-C-N 1519 0.1794 PF00067 Cytochrome P450 1520 0.1794 SUB296 C-As 1520 0.1794 PF00248 Aldo/keto reductase family 1521 0.1793 SUB186 >= 2 any ring size 6 1521 0.1793 PF03098 Animal haem peroxidase 1522 0.1787 SUB394 N(~C)(~H) 1522 0.1787 PF01593 Flavin containing amine oxidoreductase 1523 0.1780 SUB566 C:C-O-C 1523 0.1780 PF00664 ABC transporter transmembrane region 1524 0.1780 SUB453 C(-O)(=O) 1524 0.1780 PF01431 Peptidase family M13 1525 0.1780 SUB368 C(~H)(~O)(~O) 1525 0.1780 PF01869 BadF/BadG/BcrA/BcrD ATPase family 1526 0.1779 SUB375 C(~H)(~H)(~H) 1526 0.1779 PF00173 Cytochrome b5-like Heme/Steroid binding domain 1527 0.1777 SUB392 N(~C)(~C)(~C) 1527 0.1777 PF00614 Phospholipase D Active site motif 1528 0.1777 SUB200 >= 4 any ring size 6 1528 0.1777 PF00689 Cation transporting ATPase, C-terminus 1529 0.1776 SUB261 >= 3 hetero-aromatic rings 1529 0.1776 PF00023 Ankyrin repeat 1530 0.1772 SUB686 O=C-C-C-C-N 1530 0.1772 PF00069 Protein kinase domain 1531 0.1771 SUB381 C(~O)(~O) 1531 0.1771 PF00051 Kringle domain 1532 0.1771 SUB618 C-C-C-O-[#1] 1532 0.1771 PF00868 Transglutaminase family 1533 0.1766 SUB565 C=C-C=C 1533 0.1766 PF00069 Protein kinase domain 1534 0.1765 SUB532 S-C:C-C 1534 0.1765 PF00102 Protein-tyrosine phosphatase 1535 0.1765 SUB293 C-P 1535 0.1765 PF00348 Polyprenyl synthetase 1536 0.1762 SUB660 O-C-C-N-C 1536 0.1762 PF00755 Choline/Carnitine o-acyltransferase 1537 0.1762 SUB566 C:C-O-C 1537 0.1762 PF01007 Inward rectifier potassium channel 1538 0.1760 SUB647 O=C-N-C-[#1] 1538 0.1760 PF00551 Formyl transferase 1539 0.1760 SUB706 O=C-C-C-C-C(O)-C 1539 0.1760 PF02898 Nitric oxide synthase, oxygenase domain 1540 0.1760 SUB179 >= 1 any ring size 6 1540 0.1760 PF00106 short chain dehydrogenase 1541 0.1757 SUB529 [#1]-N-C-[#1] 1541 0.1757 PF03372 Endonuclease/Exonuclease/phosphatase family 1542 0.1756 SUB492 C-N:C-[#1] 1542 0.1756 PF00045 Hemopexin 1543 0.1756 SUB672 O=C-C=C-C 1543 0.1756 PF00104 Ligand-binding domain of nuclear hormone receptor 1544 0.1756 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 1544 0.1756 PF06387 D1 dopamine receptor-interacting protein (calcyon), 1545 0.1755 SUB639 O-C-C-C-N 1545 0.1755 PF01055 Glycosyl hydrolases family 31 1546 0.1755 SUB499 O-C=C-C 1546 0.1755 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 1547 0.1754 SUB284 C-H 1547 0.1754 PF00107 Zinc-binding dehydrogenase 1548 0.1754 SUB613 N-C-O-C-C 1548 0.1754 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 1549 0.1754 SUB339 C(~C)(~C)(~H)(~N) 1549 0.1754 PF02798 Glutathione S-transferase, N-terminal domain 1550 0.1752 SUB554 O=C-C=C 1550 0.1752 PF02525 Flavodoxin-like fold 1551 0.1751 SUB560 O-C-N-[#1] 1551 0.1751 PF00001 7 transmembrane receptor (rhodopsin family), 1552 0.1750 SUB368 C(~H)(~O)(~O) 1552 0.1750 PF00167 Fibroblast growth factor 1553 0.1749 SUB295 C-Cl 1553 0.1749 PF03493 Calcium-activated BK potassium channel alpha subunit 1554 0.1749 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 1554 0.1749 PF00001 7 transmembrane receptor (rhodopsin family), 1555 0.1748 SUB441 C(-C)(-O)(=O) 1555 0.1748 PF01731 Arylesterase 1556 0.1747 SUB339 C(~C)(~C)(~H)(~N) 1556 0.1747 PF01039 Carboxyl transferase domain 1557 0.1746 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 1557 0.1746 PF02525 Flavodoxin-like fold 1558 0.1744 SUB201 >= 4 saturated or aromatic carbon-only ring size 6 1558 0.1744 PF01160 Vertebrate endogenous opioids neuropeptide 1559 0.1743 SUB686 O=C-C-C-C-N 1559 0.1743 PF00413 Matrixin 1560 0.1739 SUB498 O-C:C:N 1560 0.1739 PF00294 pfkB family carbohydrate kinase 1561 0.1738 SUB804 OC1CC(O)CCC1 1561 0.1738 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1562 0.1738 SUB673 O=C-C=C-[#1] 1562 0.1738 PF07884 Vitamin K epoxide reductase family 1563 0.1733 SUB582 O=C-C-C-O 1563 0.1733 PF00454 Phosphatidylinositol 3- and 4-kinase 1564 0.1729 SUB804 OC1CC(O)CCC1 1564 0.1729 PF00459 Inositol monophosphatase family 1565 0.1727 SUB348 C(~C)(~H)(~O)(~O) 1565 0.1727 PF07686 Immunoglobulin V-set domain 1566 0.1725 SUB409 O(~H)(~S) 1566 0.1725 PF03662 Glycosyl hydrolase family 79, N-terminal domain 1567 0.1725 SUB682 O-C-C-C-C-O 1567 0.1725 PF00017 SH2 domain 1568 0.1725 SUB643 O-C-C-C=O 1568 0.1725 PF00291 Pyridoxal-phosphate dependent enzyme 1569 0.1723 SUB712 C-C(C)(C)-C-C 1569 0.1723 PF08035 Opioids neuropeptide 1570 0.1722 SUB518 N-N-C-N 1570 0.1722 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 1571 0.1718 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 1571 0.1718 PF00702 haloacid dehalogenase-like hydrolase 1572 0.1716 SUB640 O-C-C-C-O 1572 0.1716 PF02055 O-Glycosyl hydrolase family 30 1573 0.1715 SUB580 O=C-C-C-C 1573 0.1715 PF03372 Endonuclease/Exonuclease/phosphatase family 1574 0.1715 SUB16 >= 2 N 1574 0.1715 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1575 0.1714 SUB366 C(~H)(~N) 1575 0.1714 PF03073 TspO/MBR family 1576 0.1714 SUB780 CC1CCC(N)CC1 1576 0.1714 PF00001 7 transmembrane receptor (rhodopsin family), 1577 0.1712 SUB315 O-P 1577 0.1712 PF03770 Inositol polyphosphate kinase 1578 0.1712 SUB25 >= 2 F 1578 0.1712 PF00520 Ion transport protein 1579 0.1710 SUB369 C(~H)(~S) 1579 0.1710 PF06617 M-phase inducer phosphatase 1580 0.1710 SUB489 N-C=N-[#1] 1580 0.1710 PF02793 Hormone receptor domain 1581 0.1710 SUB446 C(-H)(-N)(=C) 1581 0.1710 PF08240 Alcohol dehydrogenase GroES-like domain 1582 0.1709 SUB378 C(~N)(:C)(:C) 1582 0.1709 PF01404 Ephrin receptor ligand binding domain 1583 0.1708 SUB336 C(~C)(~C)(~C)(~H) 1583 0.1708 PF08763 Voltage gated calcium channel IQ domain 1584 0.1708 SUB712 C-C(C)(C)-C-C 1584 0.1708 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1585 0.1706 SUB492 C-N:C-[#1] 1585 0.1706 PF01471 Putative peptidoglycan binding domain 1586 0.1706 SUB568 O-C-C-O 1586 0.1706 PF00018 SH3 domain 1587 0.1705 SUB338 C(~C)(~C)(~C)(~O) 1587 0.1705 PF02188 GoLoco motif 1588 0.1703 SUB625 O=C-C:C-N 1588 0.1703 PF00001 7 transmembrane receptor (rhodopsin family), 1589 0.1703 SUB441 C(-C)(-O)(=O) 1589 0.1703 PF02970 Tubulin binding cofactor A 1590 0.1702 SUB672 O=C-C=C-C 1590 0.1702 PF00337 Galactoside-binding lectin 1591 0.1699 SUB375 C(~H)(~H)(~H) 1591 0.1699 PF00001 7 transmembrane receptor (rhodopsin family), 1592 0.1696 SUB360 C(~C)(:N)(:N) 1592 0.1696 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 1593 0.1694 SUB242 >= 1 any ring size 9 1593 0.1694 PF00156 Phosphoribosyl transferase domain 1594 0.1692 SUB704 O-C-C-C-C-C(N)-C 1594 0.1692 PF00084 Sushi domain (SCR repeat), 1595 0.1692 SUB801 CC1CC(N)CCC1 1595 0.1692 PF06327 Domain of Unknown Function (DUF1053), 1596 0.1691 SUB629 C-N-C-C:C 1596 0.1691 PF00104 Ligand-binding domain of nuclear hormone receptor 1597 0.1691 SUB339 C(~C)(~C)(~H)(~N) 1597 0.1691 PF00324 Amino acid permease 1598 0.1689 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 1598 0.1689 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 1599 0.1689 SUB560 O-C-N-[#1] 1599 0.1689 PF04679 ATP dependent DNA ligase C terminal region 1600 0.1688 SUB647 O=C-N-C-[#1] 1600 0.1688 PF00089 Trypsin 1601 0.1686 SUB394 N(~C)(~H) 1601 0.1686 PF00001 7 transmembrane receptor (rhodopsin family), 1602 0.1685 SUB368 C(~H)(~O)(~O) 1602 0.1685 PF00293 NUDIX domain 1603 0.1685 SUB203 >= 4 saturated or aromatic heteroatom-containing ring size 6 1603 0.1685 PF01462 Leucine rich repeat N-terminal domain 1604 0.1684 SUB840 CC1CC(C)CC1 1604 0.1684 PF02161 Progesterone receptor 1605 0.1682 SUB660 O-C-C-N-C 1605 0.1682 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1606 0.1682 SUB504 Cl-C:C-[#1] 1606 0.1682 PF00067 Cytochrome P450 1607 0.1680 SUB684 N-C-C-C-C-C 1607 0.1680 PF00017 SH2 domain 1608 0.1679 SUB617 C:C:N:N:C 1608 0.1679 PF00069 Protein kinase domain 1609 0.1678 SUB646 O=C-N-C-C 1609 0.1678 PF00343 Carbohydrate phosphorylase 1610 0.1678 SUB284 C-H 1610 0.1678 PF00248 Aldo/keto reductase family 1611 0.1675 SUB284 C-H 1611 0.1675 PF00273 Serum albumin family 1612 0.1674 SUB710 C-C(C)-C-C-C 1612 0.1674 PF01094 Receptor family ligand binding region 1613 0.1674 SUB695 O=C-C-C-C-C=O 1613 0.1674 PF00462 Glutaredoxin 1614 0.1673 SUB580 O=C-C-C-C 1614 0.1673 PF02798 Glutathione S-transferase, N-terminal domain 1615 0.1671 SUB22 >= 8 O 1615 0.1671 PF00378 Enoyl-CoA hydratase/isomerase family 1616 0.1667 SUB536 O=C-C-C 1616 0.1667 PF00202 Aminotransferase class-III 1617 0.1667 SUB407 O(~C)(~H) 1617 0.1667 PF01180 Dihydroorotate dehydrogenase 1618 0.1666 SUB582 O=C-C-C-O 1618 0.1666 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1619 0.1666 SUB284 C-H 1619 0.1666 PF08674 Acetylcholinesterase tetramerisation domain 1620 0.1662 SUB347 C(~C)(~H)(~O) 1620 0.1662 PF00343 Carbohydrate phosphorylase 1621 0.1661 SUB411 P(~C)(~C) 1621 0.1661 PF12179 I-kappa-kinase-beta NEMO binding domain 1622 0.1657 SUB484 N-S-C:C 1622 0.1657 PF08403 Amino acid permease N-terminal 1623 0.1655 SUB1 >= 4 H 1623 0.1655 PF00043 Glutathione S-transferase, C-terminal domain 1624 0.1654 SUB655 N-C-N-C-C 1624 0.1654 PF08403 Amino acid permease N-terminal 1625 0.1654 SUB704 O-C-C-C-C-C(N)-C 1625 0.1654 PF00282 Pyridoxal-dependent decarboxylase conserved domain 1626 0.1654 SUB158 >= 3 any ring size 5 1626 0.1654 PF04116 Fatty acid hydroxylase superfamily 1627 0.1653 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1627 0.1653 PF10276 Zinc-finger domain 1628 0.1651 SUB375 C(~H)(~H)(~H) 1628 0.1651 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 1629 0.1647 SUB567 O-C-C-N 1629 0.1647 PF01212 Beta-eliminating lyase 1630 0.1647 SUB24 >= 1 F 1630 0.1647 PF08996 DNA Polymerase alpha zinc finger 1631 0.1647 SUB640 O-C-C-C-O 1631 0.1647 PF01712 Deoxynucleoside kinase 1632 0.1646 SUB608 N-C-C-C:C 1632 0.1646 PF00209 Sodium:neurotransmitter symporter family 1633 0.1645 SUB144 >= 1 any ring size 5 1633 0.1645 PF02159 Oestrogen receptor 1634 0.1640 SUB492 C-N:C-[#1] 1634 0.1640 PF01030 Receptor L domain 1635 0.1639 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 1635 0.1639 PF00571 CBS domain 1636 0.1638 SUB534 S-C:C-N 1636 0.1638 PF00001 7 transmembrane receptor (rhodopsin family), 1637 0.1637 SUB688 O=C-C-C-C=O 1637 0.1637 PF00939 Sodium:sulfate symporter transmembrane region 1638 0.1636 SUB822 CC1C(N)CCCC1 1638 0.1636 PF00135 Carboxylesterase 1639 0.1636 SUB686 O=C-C-C-C-N 1639 0.1636 PF00310 Glutamine amidotransferases class-II 1640 0.1635 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 1640 0.1635 PF00005 ABC transporter 1641 0.1631 SUB368 C(~H)(~O)(~O) 1641 0.1631 PF00236 Glycoprotein hormone 1642 0.1631 SUB730 Nc1ccc(Cl)cc1 1642 0.1631 PF03073 TspO/MBR family 1643 0.1628 SUB261 >= 3 hetero-aromatic rings 1643 0.1628 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 1644 0.1627 SUB443 C(-C)(=N) 1644 0.1627 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1645 0.1627 SUB703 O-C-C-C-C-C-N-C 1645 0.1627 PF00175 Oxidoreductase NAD-binding domain 1646 0.1626 SUB594 N-C-C-C-N 1646 0.1626 PF00069 Protein kinase domain 1647 0.1626 SUB21 >= 4 O 1647 0.1626 PF01094 Receptor family ligand binding region 1648 0.1625 SUB406 O(~C)(~C) 1648 0.1625 PF00135 Carboxylesterase 1649 0.1624 SUB390 C(:N)(:N) 1649 0.1624 PF00478 IMP dehydrogenase / GMP reductase domain 1650 0.1622 SUB681 O-C-C-C-C-C 1650 0.1622 PF00060 Ligand-gated ion channel 1651 0.1622 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1651 0.1622 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1652 0.1621 SUB688 O=C-C-C-C=O 1652 0.1621 PF07687 Peptidase dimerisation domain 1653 0.1621 SUB117 >= 1 saturated or aromatic carbon-only ring size 3 1653 0.1621 PF01160 Vertebrate endogenous opioids neuropeptide 1654 0.1619 SUB709 C-C(C)-C-C 1654 0.1619 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1655 0.1618 SUB380 C(~N)(:N) 1655 0.1618 PF00069 Protein kinase domain 1656 0.1617 SUB342 C(~C)(~C)(~O) 1656 0.1617 PF02779 Transketolase, pyrimidine binding domain 1657 0.1616 SUB301 N-N 1657 0.1616 PF00079 Serpin (serine protease inhibitor), 1658 0.1614 SUB690 O-C-C-C-C-C-C 1658 0.1614 PF01094 Receptor family ligand binding region 1659 0.1614 SUB378 C(~N)(:C)(:C) 1659 0.1614 PF00067 Cytochrome P450 1660 0.1614 SUB517 [#1]-C=C-[#1] 1660 0.1614 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1661 0.1611 SUB288 C-F 1661 0.1611 PF01094 Receptor family ligand binding region 1662 0.1610 SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 1662 0.1610 PF00001 7 transmembrane receptor (rhodopsin family), 1663 0.1610 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 1663 0.1610 PF00191 Annexin 1664 0.1609 SUB674 O=C-C=C-N 1664 0.1609 PF08669 Glycine cleavage T-protein C-terminal barrel domain 1665 0.1609 SUB738 Cc1cc(N)ccc1 1665 0.1609 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1666 0.1609 SUB703 O-C-C-C-C-C-N-C 1666 0.1609 PF00079 Serpin (serine protease inhibitor), 1667 0.1604 SUB441 C(-C)(-O)(=O) 1667 0.1604 PF08725 Integrin beta cytoplasmic domain 1668 0.1603 SUB684 N-C-C-C-C-C 1668 0.1603 PF03171 2OG-Fe(II), oxygenase superfamily 1669 0.1602 SUB284 C-H 1669 0.1602 PF00576 HIUase/Transthyretin family 1670 0.1601 SUB488 N-C=N-C 1670 0.1601 PF01571 Aminomethyltransferase folate-binding domain 1671 0.1600 SUB840 CC1CC(C)CC1 1671 0.1600 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1672 0.1599 SUB537 O=C-C-N 1672 0.1599 PF01266 FAD dependent oxidoreductase 1673 0.1597 SUB3 >= 16 H 1673 0.1597 PF00067 Cytochrome P450 1674 0.1596 SUB158 >= 3 any ring size 5 1674 0.1596 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a), 1675 0.1596 SUB759 Cc1c(N)cccc1 1675 0.1596 PF00005 ABC transporter 1676 0.1594 SUB658 C-N-C:C-C 1676 0.1594 PF00001 7 transmembrane receptor (rhodopsin family), 1677 0.1594 SUB32 >= 2 P 1677 0.1594 PF08040 MNLL subunit 1678 0.1593 SUB539 N=C-C-C 1678 0.1593 PF03073 TspO/MBR family 1679 0.1593 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 1679 0.1593 PF07690 Major Facilitator Superfamily 1680 0.1590 SUB441 C(-C)(-O)(=O) 1680 0.1590 PF01268 Formate--tetrahydrofolate ligase 1681 0.1587 SUB689 C-C-C-C-C-C-C 1681 0.1587 PF00850 Histone deacetylase domain 1682 0.1584 SUB709 C-C(C)-C-C 1682 0.1584 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1683 0.1584 SUB338 C(~C)(~C)(~C)(~O) 1683 0.1584 PF02145 Rap/ran-GAP 1684 0.1582 SUB228 >= 1 any ring size 8 1684 0.1582 PF00918 Gastrin/cholecystokinin family 1685 0.1582 SUB686 O=C-C-C-C-N 1685 0.1582 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1686 0.1581 SUB389 C(:C)(:N)(:N) 1686 0.1581 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 1687 0.1581 SUB580 O=C-C-C-C 1687 0.1581 PF00069 Protein kinase domain 1688 0.1581 SUB369 C(~H)(~S) 1688 0.1581 PF00581 Rhodanese-like domain 1689 0.1581 SUB444 C(-C)(=O) 1689 0.1581 PF00248 Aldo/keto reductase family 1690 0.1577 SUB638 O-C-C-C-C 1690 0.1577 PF00068 Phospholipase A2 1691 0.1576 SUB686 O=C-C-C-C-N 1691 0.1576 PF00153 Mitochondrial carrier protein 1692 0.1576 SUB381 C(~O)(~O) 1692 0.1576 PF00248 Aldo/keto reductase family 1693 0.1576 SUB612 N-C-C-N-C 1693 0.1576 PF00364 Biotin-requiring enzyme 1694 0.1575 SUB560 O-C-N-[#1] 1694 0.1575 PF03002 Somatostatin/Cortistatin family 1695 0.1574 SUB158 >= 3 any ring size 5 1695 0.1574 PF03404 Mo-co oxidoreductase dimerisation domain 1696 0.1569 SUB773 Nc1c(Br)cccc1 1696 0.1569 PF00001 7 transmembrane receptor (rhodopsin family), 1697 0.1568 SUB673 O=C-C=C-[#1] 1697 0.1568 PF01042 Endoribonuclease L-PSP 1698 0.1566 SUB160 >= 3 saturated or aromatic nitrogen-containing ring size 5 1698 0.1566 PF00209 Sodium:neurotransmitter symporter family 1699 0.1566 SUB572 [#1]-C-O-[#1] 1699 0.1566 PF00059 Lectin C-type domain 1700 0.1565 SUB500 N-C:C:N 1700 0.1565 PF04389 Peptidase family M28 1701 0.1562 SUB463 O-C-C=O 1701 0.1562 PF00135 Carboxylesterase 1702 0.1561 SUB439 C(-C)(-N)(=N) 1702 0.1561 PF10391 Fingers domain of DNA polymerase lambda 1703 0.1561 SUB655 N-C-N-C-C 1703 0.1561 PF10391 Fingers domain of DNA polymerase lambda 1704 0.1561 SUB613 N-C-O-C-C 1704 0.1561 PF10391 Fingers domain of DNA polymerase lambda 1705 0.1559 SUB368 C(~H)(~O)(~O) 1705 0.1559 PF00079 Serpin (serine protease inhibitor), 1706 0.1558 SUB22 >= 8 O 1706 0.1558 PF00171 Aldehyde dehydrogenase family 1707 0.1557 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 1707 0.1557 PF06512 Sodium ion transport-associated 1708 0.1556 SUB339 C(~C)(~C)(~H)(~N) 1708 0.1556 PF00258 Flavodoxin 1709 0.1555 SUB435 C(-C)(-H)(=C) 1709 0.1555 PF00001 7 transmembrane receptor (rhodopsin family), 1710 0.1555 SUB4 >= 32 H 1710 0.1555 PF07965 Integrin beta tail domain 1711 0.1553 SUB39 >= 2 Cl 1711 0.1553 PF00690 Cation transporter/ATPase, N-terminus 1712 0.1553 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 1712 0.1553 PF04622 ERG2 and Sigma1 receptor like protein 1713 0.1552 SUB780 CC1CCC(N)CC1 1713 0.1552 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1714 0.1549 SUB591 C-C:C-O-[#1] 1714 0.1549 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1715 0.1549 SUB537 O=C-C-N 1715 0.1549 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 1716 0.1548 SUB442 C(-C)(=C) 1716 0.1548 PF00005 ABC transporter 1717 0.1547 SUB200 >= 4 any ring size 6 1717 0.1547 PF00690 Cation transporter/ATPase, N-terminus 1718 0.1547 SUB624 O=C-C:C-C 1718 0.1547 PF00571 CBS domain 1719 0.1545 SUB408 O(~C)(~P) 1719 0.1545 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 1720 0.1545 SUB683 O-C-C-C-C-N 1720 0.1545 PF00153 Mitochondrial carrier protein 1721 0.1545 SUB620 O-C-C=C-C 1721 0.1545 PF00001 7 transmembrane receptor (rhodopsin family), 1722 0.1544 SUB658 C-N-C:C-C 1722 0.1544 PF06512 Sodium ion transport-associated 1723 0.1544 SUB738 Cc1cc(N)ccc1 1723 0.1544 PF01061 ABC-2 type transporter 1724 0.1544 SUB668 C=C-C-O-[#1] 1724 0.1544 PF01042 Endoribonuclease L-PSP 1725 0.1541 SUB516 N-N-C-C 1725 0.1541 PF02025 Interleukin 5 1726 0.1541 SUB688 O=C-C-C-C=O 1726 0.1541 PF00106 short chain dehydrogenase 1727 0.1541 SUB334 C(~C)(~C)(~C) 1727 0.1541 PF00689 Cation transporting ATPase, C-terminus 1728 0.1539 SUB334 C(~C)(~C)(~C) 1728 0.1539 PF00690 Cation transporter/ATPase, N-terminus 1729 0.1539 SUB691 O-C-C-C-C-C-O 1729 0.1539 PF00349 Hexokinase 1730 0.1539 SUB452 C(-N)(=O) 1730 0.1539 PF01007 Inward rectifier potassium channel 1731 0.1538 SUB759 Cc1c(N)cccc1 1731 0.1538 PF01231 Indoleamine 2,3-dioxygenase 1732 0.1537 SUB591 C-C:C-O-[#1] 1732 0.1537 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1733 0.1536 SUB341 C(~C)(~C)(~N) 1733 0.1536 PF00117 Glutamine amidotransferase class-I 1734 0.1534 SUB287 C-O 1734 0.1534 PF00194 Eukaryotic-type carbonic anhydrase 1735 0.1530 SUB158 >= 3 any ring size 5 1735 0.1530 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 1736 0.1530 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 1736 0.1530 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1737 0.1529 SUB515 O-N-C-C 1737 0.1529 PF01327 Polypeptide deformylase 1738 0.1527 SUB572 [#1]-C-O-[#1] 1738 0.1527 PF01467 Cytidylyltransferase 1739 0.1526 SUB168 >= 4 saturated or aromatic heteroatom-containing ring size 5 1739 0.1526 PF01833 IPT/TIG domain 1740 0.1526 SUB694 O=C-C-C-C-C-O 1740 0.1526 PF00255 Glutathione peroxidase 1741 0.1525 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1741 0.1525 PF00714 Interferon gamma 1742 0.1523 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 1742 0.1523 PF00343 Carbohydrate phosphorylase 1743 0.1522 SUB686 O=C-C-C-C-N 1743 0.1522 PF00493 MCM2/3/5 family 1744 0.1522 SUB717 Cc1ccc(N)cc1 1744 0.1522 PF02219 Methylenetetrahydrofolate reductase 1745 0.1521 SUB438 C(-C)(-N)(=C) 1745 0.1521 PF00194 Eukaryotic-type carbonic anhydrase 1746 0.1521 SUB664 O-C-C-O-[#1] 1746 0.1521 PF03360 Glycosyltransferase family 43 1747 0.1520 SUB780 CC1CCC(N)CC1 1747 0.1520 PF00209 Sodium:neurotransmitter symporter family 1748 0.1519 SUB1 >= 4 H 1748 0.1519 PF00248 Aldo/keto reductase family 1749 0.1518 SUB644 [#1]-C-C-N-[#1] 1749 0.1518 PF00105 Zinc finger, C4 type (two domains), 1750 0.1517 SUB550 N-C-C:C 1750 0.1517 PF00089 Trypsin 1751 0.1516 SUB698 C-C-C-C-C-C(C)-C 1751 0.1516 PF00005 ABC transporter 1752 0.1515 SUB674 O=C-C=C-N 1752 0.1515 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1753 0.1515 SUB389 C(:C)(:N)(:N) 1753 0.1515 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 1754 0.1515 SUB466 O=S-C-C 1754 0.1515 PF00664 ABC transporter transmembrane region 1755 0.1515 SUB486 N:C:C:N 1755 0.1515 PF00221 Phenylalanine and histidine ammonia-lyase 1756 0.1514 SUB691 O-C-C-C-C-C-O 1756 0.1514 PF04768 Protein of unknown function (DUF619), 1757 0.1514 SUB441 C(-C)(-O)(=O) 1757 0.1514 PF00689 Cation transporting ATPase, C-terminus 1758 0.1513 SUB33 >= 4 P 1758 0.1513 PF00069 Protein kinase domain 1759 0.1510 SUB288 C-F 1759 0.1510 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1760 0.1509 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 1760 0.1509 PF00520 Ion transport protein 1761 0.1508 SUB144 >= 1 any ring size 5 1761 0.1508 PF00689 Cation transporting ATPase, C-terminus 1762 0.1507 SUB682 O-C-C-C-C-O 1762 0.1507 PF00343 Carbohydrate phosphorylase 1763 0.1505 SUB1 >= 4 H 1763 0.1505 PF00102 Protein-tyrosine phosphatase 1764 0.1504 SUB453 C(-O)(=O) 1764 0.1504 PF07648 Kazal-type serine protease inhibitor domain 1765 0.1503 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1765 0.1503 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 1766 0.1503 SUB372 C(~H)(:C)(:C) 1766 0.1503 PF00069 Protein kinase domain 1767 0.1501 SUB334 C(~C)(~C)(~C) 1767 0.1501 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 1768 0.1501 SUB340 C(~C)(~C)(~H)(~O) 1768 0.1501 PF01462 Leucine rich repeat N-terminal domain 1769 0.1501 SUB444 C(-C)(=O) 1769 0.1501 PF01433 Peptidase family M1 1770 0.1501 SUB151 >= 2 any ring size 5 1770 0.1501 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1771 0.1500 SUB509 S=C-N-C 1771 0.1500 PF00171 Aldehyde dehydrogenase family 1772 0.1500 SUB158 >= 3 any ring size 5 1772 0.1500 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 1773 0.1499 SUB393 N(~C)(~C)(~H) 1773 0.1499 PF00069 Protein kinase domain 1774 0.1498 SUB862 CC1C(O)CCC1 1774 0.1498 PF00418 Tau and MAP protein, tubulin-binding repeat 1775 0.1498 SUB451 C(-N)(=N) 1775 0.1498 PF01048 Phosphorylase superfamily 1776 0.1498 SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 1776 0.1498 PF00474 Sodium:solute symporter family 1777 0.1496 SUB437 C(-C)(-H)(=O) 1777 0.1496 PF00282 Pyridoxal-dependent decarboxylase conserved domain 1778 0.1496 SUB350 C(~C)(~H)(~S) 1778 0.1496 PF00474 Sodium:solute symporter family 1779 0.1496 SUB20 >= 2 O 1779 0.1496 PF00574 Clp protease 1780 0.1495 SUB593 N-C-C-C-C 1780 0.1495 PF00102 Protein-tyrosine phosphatase 1781 0.1491 SUB158 >= 3 any ring size 5 1781 0.1491 PF05347 Complex 1 protein (LYR family), 1782 0.1491 SUB439 C(-C)(-N)(=N) 1782 0.1491 PF03171 2OG-Fe(II), oxygenase superfamily 1783 0.1490 SUB686 O=C-C-C-C-N 1783 0.1490 PF00155 Aminotransferase class I and II 1784 0.1489 SUB262 >= 4 aromatic rings 1784 0.1489 PF00493 MCM2/3/5 family 1785 0.1489 SUB376 C(~N)(~N) 1785 0.1489 PF00317 Ribonucleotide reductase, all-alpha domain 1786 0.1488 SUB674 O=C-C=C-N 1786 0.1488 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 1787 0.1486 SUB618 C-C-C-O-[#1] 1787 0.1486 PF00884 Sulfatase 1788 0.1486 SUB622 N-C:C:C:N 1788 0.1486 PF00023 Ankyrin repeat 1789 0.1485 SUB392 N(~C)(~C)(~C) 1789 0.1485 PF00145 C-5 cytosine-specific DNA methylase 1790 0.1485 SUB378 C(~N)(:C)(:C) 1790 0.1485 PF00536 SAM domain (Sterile alpha motif), 1791 0.1484 SUB735 Cc1cc(C)ccc1 1791 0.1484 PF00089 Trypsin 1792 0.1484 SUB572 [#1]-C-O-[#1] 1792 0.1484 PF00614 Phospholipase D Active site motif 1793 0.1483 SUB799 CC1CC(O)CCC1 1793 0.1483 PF00305 Lipoxygenase 1794 0.1482 SUB718 Cc1ccc(Cl)cc1 1794 0.1482 PF00032 Cytochrome b(C-terminal), /b6/petD 1795 0.1478 SUB369 C(~H)(~S) 1795 0.1478 PF00069 Protein kinase domain 1796 0.1477 SUB489 N-C=N-[#1] 1796 0.1477 PF01068 ATP dependent DNA ligase domain 1797 0.1476 SUB476 S-C=N-C 1797 0.1476 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1798 0.1474 SUB763 Oc1c(S)cccc1 1798 0.1474 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1799 0.1474 SUB446 C(-H)(-N)(=C) 1799 0.1474 PF03414 Glycosyltransferase family 6 1800 0.1474 SUB486 N:C:C:N 1800 0.1474 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1801 0.1472 SUB593 N-C-C-C-C 1801 0.1472 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 1802 0.1468 SUB407 O(~C)(~H) 1802 0.1468 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1803 0.1468 SUB339 C(~C)(~C)(~H)(~N) 1803 0.1468 PF01641 SelR domain 1804 0.1468 SUB537 O=C-C-N 1804 0.1468 PF02772 S-adenosylmethionine synthetase, central domain 1805 0.1467 SUB695 O=C-C-C-C-C=O 1805 0.1467 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1806 0.1467 SUB309 O-H 1806 0.1467 PF00167 Fibroblast growth factor 1807 0.1466 SUB151 >= 2 any ring size 5 1807 0.1466 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1808 0.1466 SUB691 O-C-C-C-C-C-O 1808 0.1466 PF08669 Glycine cleavage T-protein C-terminal barrel domain 1809 0.1464 SUB706 O=C-C-C-C-C(O)-C 1809 0.1464 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 1810 0.1464 SUB348 C(~C)(~H)(~O)(~O) 1810 0.1464 PF00703 domain 1811 0.1464 SUB10 >= 2 C 1811 0.1464 PF00273 Serum albumin family 1812 0.1464 SUB458 S(-C)(=O) 1812 0.1464 PF01007 Inward rectifier potassium channel 1813 0.1462 SUB653 O-C:C:C-N 1813 0.1462 PF00029 Connexin 1814 0.1462 SUB463 O-C-C=O 1814 0.1462 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 1815 0.1461 SUB337 C(~C)(~C)(~C)(~N) 1815 0.1461 PF01094 Receptor family ligand binding region 1816 0.1461 SUB683 O-C-C-C-C-N 1816 0.1461 PF02971 Formiminotransferase domain 1817 0.1461 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1817 0.1461 PF10531 SLBB domain 1818 0.1460 SUB647 O=C-N-C-[#1] 1818 0.1460 PF00303 Thymidylate synthase 1819 0.1460 SUB494 O=C-C:C 1819 0.1460 PF00001 7 transmembrane receptor (rhodopsin family), 1820 0.1459 SUB515 O-N-C-C 1820 0.1459 PF01471 Putative peptidoglycan binding domain 1821 0.1457 SUB673 O=C-C=C-[#1] 1821 0.1457 PF00111 2Fe-2S iron-sulfur cluster binding domain 1822 0.1457 SUB809 SC1CC(S)CCC1 1822 0.1457 PF02146 Sir2 family 1823 0.1457 SUB347 C(~C)(~H)(~O) 1823 0.1457 PF06512 Sodium ion transport-associated 1824 0.1456 SUB398 N(~C)(:C)(:C) 1824 0.1456 PF03308 ArgK protein 1825 0.1453 SUB608 N-C-C-C:C 1825 0.1453 PF00084 Sushi domain (SCR repeat), 1826 0.1452 SUB444 C(-C)(=O) 1826 0.1452 PF00001 7 transmembrane receptor (rhodopsin family), 1827 0.1451 SUB686 O=C-C-C-C-N 1827 0.1451 PF07690 Major Facilitator Superfamily 1828 0.1451 SUB407 O(~C)(~H) 1828 0.1451 PF00106 short chain dehydrogenase 1829 0.1450 SUB258 >= 2 aromatic rings 1829 0.1450 PF00576 HIUase/Transthyretin family 1830 0.1449 SUB572 [#1]-C-O-[#1] 1830 0.1449 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1831 0.1448 SUB592 Cl-C-C-C-C 1831 0.1448 PF03073 TspO/MBR family 1832 0.1448 SUB345 C(~C)(~H) 1832 0.1448 PF09127 Leukotriene A4 hydrolase, C-terminal 1833 0.1448 SUB200 >= 4 any ring size 6 1833 0.1448 PF01593 Flavin containing amine oxidoreductase 1834 0.1446 SUB515 O-N-C-C 1834 0.1446 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 1835 0.1446 SUB407 O(~C)(~H) 1835 0.1446 PF01063 Aminotransferase class IV 1836 0.1445 SUB335 C(~C)(~C)(~C)(~C) 1836 0.1445 PF08384 Pro-opiomelanocortin, N-terminal region 1837 0.1445 SUB777 CC1CCC(C)CC1 1837 0.1445 PF03137 Organic Anion Transporter Polypeptide (OATP), family 1838 0.1443 SUB562 Cl-C-C=O 1838 0.1443 PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain 1839 0.1443 SUB432 C(-C)(-C)(=N) 1839 0.1443 PF00343 Carbohydrate phosphorylase 1840 0.1443 SUB347 C(~C)(~H)(~O) 1840 0.1443 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1841 0.1441 SUB11 >= 4 C 1841 0.1441 PF00051 Kringle domain 1842 0.1441 SUB639 O-C-C-C-N 1842 0.1441 PF01712 Deoxynucleoside kinase 1843 0.1441 SUB664 O-C-C-O-[#1] 1843 0.1441 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 1844 0.1441 SUB260 >= 3 aromatic rings 1844 0.1441 PF01477 PLAT/LH2 domain 1845 0.1441 SUB158 >= 3 any ring size 5 1845 0.1441 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 1846 0.1440 SUB339 C(~C)(~C)(~H)(~N) 1846 0.1440 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 1847 0.1438 SUB432 C(-C)(-C)(=N) 1847 0.1438 PF00005 ABC transporter 1848 0.1437 SUB706 O=C-C-C-C-C(O)-C 1848 0.1437 PF00354 Pentaxin family 1849 0.1437 SUB441 C(-C)(-O)(=O) 1849 0.1437 PF00690 Cation transporter/ATPase, N-terminus 1850 0.1436 SUB242 >= 1 any ring size 9 1850 0.1436 PF01431 Peptidase family M13 1851 0.1436 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1851 0.1436 PF09326 Domain of unknown function (DUF1982), 1852 0.1436 SUB662 O-C-O-C-C 1852 0.1436 PF01094 Receptor family ligand binding region 1853 0.1435 SUB339 C(~C)(~C)(~H)(~N) 1853 0.1435 PF06373 Cocaine and amphetamine regulated transcript protein (CART), 1854 0.1435 SUB801 CC1CC(N)CCC1 1854 0.1435 PF00340 Interleukin-1 / 18 1855 0.1432 SUB672 O=C-C=C-C 1855 0.1432 PF00305 Lipoxygenase 1856 0.1432 SUB618 C-C-C-O-[#1] 1856 0.1432 PF00071 Ras family 1857 0.1429 SUB618 C-C-C-O-[#1] 1857 0.1429 PF01841 Transglutaminase-like superfamily 1858 0.1429 SUB529 [#1]-N-C-[#1] 1858 0.1429 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 1859 0.1429 SUB459 S(-O)(=O) 1859 0.1429 PF03098 Animal haem peroxidase 1860 0.1427 SUB538 O=C-C-O 1860 0.1427 PF00557 Metallopeptidase family M24 1861 0.1426 SUB440 C(-C)(-N)(=O) 1861 0.1426 PF00045 Hemopexin 1862 0.1425 SUB66 >= 1 As 1862 0.1425 PF01161 Phosphatidylethanolamine-binding protein 1863 0.1424 SUB407 O(~C)(~H) 1863 0.1424 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 1864 0.1422 SUB624 O=C-C:C-C 1864 0.1422 PF00354 Pentaxin family 1865 0.1422 SUB466 O=S-C-C 1865 0.1422 PF08403 Amino acid permease N-terminal 1866 0.1422 SUB294 C-S 1866 0.1422 PF00108 Thiolase, N-terminal domain 1867 0.1421 SUB354 C(~C)(~S) 1867 0.1421 PF00108 Thiolase, N-terminal domain 1868 0.1420 SUB713 C-C(C)-C(C)-C 1868 0.1420 PF00248 Aldo/keto reductase family 1869 0.1418 SUB695 O=C-C-C-C-C=O 1869 0.1418 PF00117 Glutamine amidotransferase class-I 1870 0.1417 SUB694 O=C-C-C-C-C-O 1870 0.1417 PF00171 Aldehyde dehydrogenase family 1871 0.1416 SUB537 O=C-C-N 1871 0.1416 PF00102 Protein-tyrosine phosphatase 1872 0.1414 SUB426 P=O 1872 0.1414 PF01704 UTP--glucose-1-phosphate uridylyltransferase 1873 0.1412 SUB407 O(~C)(~H) 1873 0.1412 PF02347 Glycine cleavage system P-protein 1874 0.1411 SUB353 C(~C)(~O) 1874 0.1411 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 1875 0.1410 SUB419 C=N 1875 0.1410 PF00051 Kringle domain 1876 0.1410 SUB615 C-C-O-C-C 1876 0.1410 PF06512 Sodium ion transport-associated 1877 0.1408 SUB757 Cc1c(O)cccc1 1877 0.1408 PF00643 B-box zinc finger 1878 0.1404 SUB474 S-C:N:C 1878 0.1404 PF04263 Thiamin pyrophosphokinase, catalytic domain 1879 0.1404 SUB552 Cl-C-C-O 1879 0.1404 PF00173 Cytochrome b5-like Heme/Steroid binding domain 1880 0.1401 SUB17 >= 4 N 1880 0.1401 PF00211 Adenylate and Guanylate cyclase catalytic domain 1881 0.1400 SUB692 O-C-C-C-C-C-N 1881 0.1400 PF02100 Ornithine decarboxylase antizyme 1882 0.1399 SUB12 >= 8 C 1882 0.1399 PF01477 PLAT/LH2 domain 1883 0.1398 SUB393 N(~C)(~C)(~H) 1883 0.1398 PF00229 TNF(Tumour Necrosis Factor), family 1884 0.1397 SUB681 O-C-C-C-C-C 1884 0.1397 PF00067 Cytochrome P450 1885 0.1396 SUB703 O-C-C-C-C-C-N-C 1885 0.1396 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 1886 0.1395 SUB360 C(~C)(:N)(:N) 1886 0.1395 PF00106 short chain dehydrogenase 1887 0.1394 SUB640 O-C-C-C-O 1887 0.1394 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1888 0.1393 SUB369 C(~H)(~S) 1888 0.1393 PF12497 Estrogen receptor beta 1889 0.1393 SUB453 C(-O)(=O) 1889 0.1393 PF01180 Dihydroorotate dehydrogenase 1890 0.1391 SUB32 >= 2 P 1890 0.1391 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 1891 0.1390 SUB572 [#1]-C-O-[#1] 1891 0.1390 PF00688 TGF-beta propeptide 1892 0.1388 SUB392 N(~C)(~C)(~C) 1892 0.1388 PF01633 Choline/ethanolamine kinase 1893 0.1385 SUB529 [#1]-N-C-[#1] 1893 0.1385 PF00051 Kringle domain 1894 0.1384 SUB203 >= 4 saturated or aromatic heteroatom-containing ring size 6 1894 0.1384 PF03662 Glycosyl hydrolase family 79, N-terminal domain 1895 0.1384 SUB34 >= 1 S 1895 0.1384 PF00092 von Willebrand factor type A domain 1896 0.1382 SUB439 C(-C)(-N)(=N) 1896 0.1382 PF00571 CBS domain 1897 0.1380 SUB40 >= 4 Cl 1897 0.1380 PF00111 2Fe-2S iron-sulfur cluster binding domain 1898 0.1379 SUB32 >= 2 P 1898 0.1379 PF02770 Acyl-CoA dehydrogenase, middle domain 1899 0.1378 SUB738 Cc1cc(N)ccc1 1899 0.1378 PF03002 Somatostatin/Cortistatin family 1900 0.1377 SUB738 Cc1cc(N)ccc1 1900 0.1377 PF00104 Ligand-binding domain of nuclear hormone receptor 1901 0.1374 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 1901 0.1374 PF00069 Protein kinase domain 1902 0.1373 SUB660 O-C-C-N-C 1902 0.1373 PF00702 haloacid dehalogenase-like hydrolase 1903 0.1373 SUB543 O-C:C-[#1] 1903 0.1373 PF01462 Leucine rich repeat N-terminal domain 1904 0.1370 SUB335 C(~C)(~C)(~C)(~C) 1904 0.1370 PF00976 Corticotropin ACTH domain 1905 0.1369 SUB697 C-C-C-C-C-C-C-C 1905 0.1369 PF03765 CRAL/TRIO, N-terminus 1906 0.1368 SUB646 O=C-N-C-C 1906 0.1368 PF00017 SH2 domain 1907 0.1367 SUB597 N=C-N-C-C 1907 0.1367 PF00689 Cation transporting ATPase, C-terminus 1908 0.1366 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1908 0.1366 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 1909 0.1366 SUB564 O-C-O-C 1909 0.1366 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1910 0.1366 SUB151 >= 2 any ring size 5 1910 0.1366 PF08040 MNLL subunit 1911 0.1364 SUB32 >= 2 P 1911 0.1364 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 1912 0.1362 SUB353 C(~C)(~O) 1912 0.1362 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1913 0.1361 SUB533 S-C:C-[#1] 1913 0.1361 PF08403 Amino acid permease N-terminal 1914 0.1361 SUB629 C-N-C-C:C 1914 0.1361 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 1915 0.1358 SUB537 O=C-C-N 1915 0.1358 PF01641 SelR domain 1916 0.1358 SUB369 C(~H)(~S) 1916 0.1358 PF00362 Integrin, beta chain 1917 0.1352 SUB537 O=C-C-N 1917 0.1352 PF00586 AIR synthase related protein, N-terminal domain 1918 0.1351 SUB705 O=C-C-C-C-C-C-C 1918 0.1351 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1919 0.1351 SUB726 Sc1ccc(N)cc1 1919 0.1351 PF02146 Sir2 family 1920 0.1350 SUB381 C(~O)(~O) 1920 0.1350 PF00560 Leucine Rich Repeat 1921 0.1349 SUB446 C(-H)(-N)(=C) 1921 0.1349 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 1922 0.1348 SUB407 O(~C)(~H) 1922 0.1348 PF01268 Formate--tetrahydrofolate ligase 1923 0.1347 SUB341 C(~C)(~C)(~N) 1923 0.1347 PF00310 Glutamine amidotransferases class-II 1924 0.1347 SUB18 >= 8 N 1924 0.1347 PF03308 ArgK protein 1925 0.1346 SUB60 >= 1 Co 1925 0.1346 PF01923 Cobalamin adenosyltransferase 1926 0.1345 SUB1 >= 4 H 1926 0.1345 PF00079 Serpin (serine protease inhibitor), 1927 0.1345 SUB339 C(~C)(~C)(~H)(~N) 1927 0.1345 PF01336 OB-fold nucleic acid binding domain 1928 0.1343 SUB757 Cc1c(O)cccc1 1928 0.1343 PF03953 Tubulin C-terminal domain 1929 0.1342 SUB249 >= 1 any ring size 10 1929 0.1342 PF00204 DNA gyrase B 1930 0.1340 SUB756 Cc1c(C)cccc1 1930 0.1340 PF00170 bZIP transcription factor 1931 0.1340 SUB366 C(~H)(~N) 1931 0.1340 PF00520 Ion transport protein 1932 0.1337 SUB630 S-C:C:C-N 1932 0.1337 PF00001 7 transmembrane receptor (rhodopsin family), 1933 0.1336 SUB415 S(~C)(~O) 1933 0.1336 PF00186 Dihydrofolate reductase 1934 0.1336 SUB392 N(~C)(~C)(~C) 1934 0.1336 PF00209 Sodium:neurotransmitter symporter family 1935 0.1334 SUB531 N:C-C:C 1935 0.1334 PF02803 Thiolase, C-terminal domain 1936 0.1334 SUB200 >= 4 any ring size 6 1936 0.1334 PF08384 Pro-opiomelanocortin, N-terminal region 1937 0.1334 SUB508 C-C-S-C 1937 0.1334 PF04321 RmlD substrate binding domain 1938 0.1333 SUB688 O=C-C-C-C=O 1938 0.1333 PF02910 domain 1939 0.1333 SUB703 O-C-C-C-C-C-N-C 1939 0.1333 PF03068 Protein-arginine deiminase (PAD), 1940 0.1332 SUB413 S(~C)(~C) 1940 0.1332 PF02574 Homocysteine S-methyltransferase 1941 0.1331 SUB495 O=C-C:N 1941 0.1331 PF03024 Folate receptor family 1942 0.1330 SUB515 O-N-C-C 1942 0.1330 PF00045 Hemopexin 1943 0.1330 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 1943 0.1330 PF01234 NNMT/PNMT/TEMT family 1944 0.1330 SUB660 O-C-C-N-C 1944 0.1330 PF02807 ATP:guanido phosphotransferase, N-terminal domain 1945 0.1329 SUB673 O=C-C=C-[#1] 1945 0.1329 PF01571 Aminomethyltransferase folate-binding domain 1946 0.1329 SUB433 C(-C)(-C)(=O) 1946 0.1329 PF02525 Flavodoxin-like fold 1947 0.1328 SUB633 C-C-O-C:C 1947 0.1328 PF00102 Protein-tyrosine phosphatase 1948 0.1328 SUB690 O-C-C-C-C-C-C 1948 0.1328 PF00413 Matrixin 1949 0.1323 SUB366 C(~H)(~N) 1949 0.1323 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1950 0.1323 SUB309 O-H 1950 0.1323 PF03098 Animal haem peroxidase 1951 0.1323 SUB695 O=C-C-C-C-C=O 1951 0.1323 PF00246 Zinc carboxypeptidase 1952 0.1322 SUB309 O-H 1952 0.1322 PF03917 Eukaryotic glutathione synthase, ATP binding domain 1953 0.1318 SUB362 C(~Cl)(~H) 1953 0.1318 PF00079 Serpin (serine protease inhibitor), 1954 0.1317 SUB13 >= 16 C 1954 0.1317 PF00001 7 transmembrane receptor (rhodopsin family), 1955 0.1317 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 1955 0.1317 PF00017 SH2 domain 1956 0.1314 SUB381 C(~O)(~O) 1956 0.1314 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 1957 0.1314 SUB640 O-C-C-C-O 1957 0.1314 PF00079 Serpin (serine protease inhibitor), 1958 0.1314 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 1958 0.1314 PF00001 7 transmembrane receptor (rhodopsin family), 1959 0.1311 SUB671 Br-C:C:C-C 1959 0.1311 PF02201 SWIB/MDM2 domain 1960 0.1311 SUB712 C-C(C)(C)-C-C 1960 0.1311 PF03137 Organic Anion Transporter Polypeptide (OATP), family 1961 0.1310 SUB603 O=C-C-N-C 1961 0.1310 PF01327 Polypeptide deformylase 1962 0.1310 SUB619 C:C-C-C:C 1962 0.1310 PF06512 Sodium ion transport-associated 1963 0.1310 SUB369 C(~H)(~S) 1963 0.1310 PF00245 Alkaline phosphatase 1964 0.1309 SUB657 C-C-N-C-C 1964 0.1309 PF00084 Sushi domain (SCR repeat), 1965 0.1308 SUB523 C-N-N-[#1] 1965 0.1308 PF01179 Copper amine oxidase, enzyme domain 1966 0.1306 SUB801 CC1CC(N)CCC1 1966 0.1306 PF01923 Cobalamin adenosyltransferase 1967 0.1305 SUB537 O=C-C-N 1967 0.1305 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1968 0.1305 SUB457 P(-O)(=O) 1968 0.1305 PF00146 NADH dehydrogenase 1969 0.1302 SUB20 >= 2 O 1969 0.1302 PF00043 Glutathione S-transferase, C-terminal domain 1970 0.1298 SUB342 C(~C)(~C)(~O) 1970 0.1298 PF02525 Flavodoxin-like fold 1971 0.1297 SUB703 O-C-C-C-C-C-N-C 1971 0.1297 PF00643 B-box zinc finger 1972 0.1295 SUB693 O=C-C-C-C-C-C 1972 0.1295 PF00579 tRNA synthetases class I (W and Y), 1973 0.1293 SUB337 C(~C)(~C)(~C)(~N) 1973 0.1293 PF09292 Endonuclease VIII-like 1, DNA bind 1974 0.1292 SUB366 C(~H)(~N) 1974 0.1292 PF00497 Bacterial extracellular solute-binding proteins, family 3 1975 0.1290 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 1975 0.1290 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 1976 0.1290 SUB449 C(-H)(=O) 1976 0.1290 PF00574 Clp protease 1977 0.1290 SUB578 C:C-N-C:C 1977 0.1290 PF00233 3"5"-cyclic nucleotide phosphodiesterase 1978 0.1288 SUB690 O-C-C-C-C-C-C 1978 0.1288 PF01279 Parathyroid hormone family 1979 0.1288 SUB457 P(-O)(=O) 1979 0.1288 PF02441 Flavoprotein 1980 0.1288 SUB501 C-S-C:C 1980 0.1288 PF07645 Calcium-binding EGF domain 1981 0.1287 SUB606 O=C-C-O-C 1981 0.1287 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 1982 0.1287 SUB634 N-C-C:C-C 1982 0.1287 PF02932 Neurotransmitter-gated ion-channel transmembrane region 1983 0.1286 SUB729 Nc1ccc(N)cc1 1983 0.1286 PF02166 Androgen receptor 1984 0.1286 SUB414 S(~C)(~H) 1984 0.1286 PF05649 Peptidase family M13 1985 0.1286 SUB861 CC1C(C)CCC1 1985 0.1286 PF00884 Sulfatase 1986 0.1286 SUB1 >= 4 H 1986 0.1286 PF00171 Aldehyde dehydrogenase family 1987 0.1286 SUB341 C(~C)(~C)(~N) 1987 0.1286 PF00156 Phosphoribosyl transferase domain 1988 0.1286 SUB401 N(~H)(:C)(:C) 1988 0.1286 PF00656 Caspase domain 1989 0.1284 SUB667 C=C-C-O-C 1989 0.1284 PF03953 Tubulin C-terminal domain 1990 0.1282 SUB444 C(-C)(=O) 1990 0.1282 PF06512 Sodium ion transport-associated 1991 0.1282 SUB130 >= 1 any ring size 4 1991 0.1282 PF00452 Apoptosis regulator proteins, Bcl-2 family 1992 0.1281 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 1992 0.1281 PF02872 5"-nucleotidase, C-terminal domain 1993 0.1281 SUB536 O=C-C-C 1993 0.1281 PF02780 Transketolase, C-terminal domain 1994 0.1278 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 1994 0.1278 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 1995 0.1278 SUB572 [#1]-C-O-[#1] 1995 0.1278 PF00265 Thymidine kinase 1996 0.1278 SUB664 O-C-C-O-[#1] 1996 0.1278 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 1997 0.1277 SUB756 Cc1c(C)cccc1 1997 0.1277 PF00043 Glutathione S-transferase, C-terminal domain 1998 0.1275 SUB694 O=C-C-C-C-C-O 1998 0.1275 PF04389 Peptidase family M28 1999 0.1275 SUB705 O=C-C-C-C-C-C-C 1999 0.1275 PF00579 tRNA synthetases class I (W and Y), 2000 0.1275 SUB412 P(~O)(~O) 2000 0.1275 PF02441 Flavoprotein 2001 0.1274 SUB537 O=C-C-N 2001 0.1274 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 2002 0.1272 SUB583 C-C-C-C-C 2002 0.1272 PF03171 2OG-Fe(II), oxygenase superfamily 2003 0.1270 SUB821 CC1C(S)CCCC1 2003 0.1270 PF03372 Endonuclease/Exonuclease/phosphatase family 2004 0.1270 SUB673 O=C-C=C-[#1] 2004 0.1270 PF00229 TNF(Tumour Necrosis Factor), family 2005 0.1270 SUB375 C(~H)(~H)(~H) 2005 0.1270 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 2006 0.1268 SUB529 [#1]-N-C-[#1] 2006 0.1268 PF04775 Acyl-CoA thioester hydrolase/BAAT N-terminal region 2007 0.1268 SUB537 O=C-C-N 2007 0.1268 PF04775 Acyl-CoA thioester hydrolase/BAAT N-terminal region 2008 0.1268 SUB344 C(~C)(~Cl)(~H) 2008 0.1268 PF08377 MAP2/Tau projection domain 2009 0.1268 SUB647 O=C-N-C-[#1] 2009 0.1268 PF01433 Peptidase family M1 2010 0.1267 SUB704 O-C-C-C-C-C(N)-C 2010 0.1267 PF00702 haloacid dehalogenase-like hydrolase 2011 0.1265 SUB315 O-P 2011 0.1265 PF02214 K+ channel tetramerisation domain 2012 0.1264 SUB335 C(~C)(~C)(~C)(~C) 2012 0.1264 PF00106 short chain dehydrogenase 2013 0.1264 SUB692 O-C-C-C-C-C-N 2013 0.1264 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 2014 0.1263 SUB572 [#1]-C-O-[#1] 2014 0.1263 PF01569 PAP2 superfamily 2015 0.1262 SUB572 [#1]-C-O-[#1] 2015 0.1262 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 2016 0.1261 SUB640 O-C-C-C-O 2016 0.1261 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2017 0.1261 SUB373 C(~H)(:C)(:N) 2017 0.1261 PF00107 Zinc-binding dehydrogenase 2018 0.1258 SUB667 C=C-C-O-C 2018 0.1258 PF00091 Tubulin/FtsZ family, GTPase domain 2019 0.1258 SUB353 C(~C)(~O) 2019 0.1258 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2020 0.1258 SUB577 N=C-C:C-[#1] 2020 0.1258 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2021 0.1258 SUB822 CC1C(N)CCCC1 2021 0.1258 PF02060 Slow voltage-gated potassium channel 2022 0.1257 SUB331 C(~Br)(:C) 2022 0.1257 PF02201 SWIB/MDM2 domain 2023 0.1257 SUB413 S(~C)(~C) 2023 0.1257 PF12497 Estrogen receptor beta 2024 0.1257 SUB612 N-C-C-N-C 2024 0.1257 PF07690 Major Facilitator Superfamily 2025 0.1256 SUB582 O=C-C-C-O 2025 0.1256 PF00520 Ion transport protein 2026 0.1252 SUB20 >= 2 O 2026 0.1252 PF00084 Sushi domain (SCR repeat), 2027 0.1252 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2027 0.1252 PF00175 Oxidoreductase NAD-binding domain 2028 0.1252 SUB567 O-C-C-N 2028 0.1252 PF01490 Transmembrane amino acid transporter protein 2029 0.1252 SUB692 O-C-C-C-C-C-N 2029 0.1252 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 2030 0.1251 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2030 0.1251 PF00171 Aldehyde dehydrogenase family 2031 0.1249 SUB193 >= 3 any ring size 6 2031 0.1249 PF00045 Hemopexin 2032 0.1248 SUB431 C(-C)(-C)(=C) 2032 0.1248 PF00111 2Fe-2S iron-sulfur cluster binding domain 2033 0.1247 SUB32 >= 2 P 2033 0.1247 PF01064 Activin types I and II receptor domain 2034 0.1246 SUB702 O-C-C-C-C-C(O)-C 2034 0.1246 PF00090 Thrombospondin type 1 domain 2035 0.1245 SUB536 O=C-C-C 2035 0.1245 PF00282 Pyridoxal-dependent decarboxylase conserved domain 2036 0.1244 SUB704 O-C-C-C-C-C(N)-C 2036 0.1244 PF00273 Serum albumin family 2037 0.1243 SUB580 O=C-C-C-C 2037 0.1243 PF01023 S-100/ICaBP type calcium binding domain 2038 0.1242 SUB340 C(~C)(~C)(~H)(~O) 2038 0.1242 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 2039 0.1242 SUB20 >= 2 O 2039 0.1242 PF00194 Eukaryotic-type carbonic anhydrase 2040 0.1242 SUB743 Oc1cc(N)ccc1 2040 0.1242 PF05790 Immunoglobulin C2-set domain 2041 0.1241 SUB821 CC1C(S)CCCC1 2041 0.1241 PF00001 7 transmembrane receptor (rhodopsin family), 2042 0.1241 SUB694 O=C-C-C-C-C-O 2042 0.1241 PF05193 Peptidase M16 inactive domain 2043 0.1240 SUB441 C(-C)(-O)(=O) 2043 0.1240 PF03074 Glutamate-cysteine ligase 2044 0.1240 SUB25 >= 2 F 2044 0.1240 PF00001 7 transmembrane receptor (rhodopsin family), 2045 0.1239 SUB500 N-C:C:N 2045 0.1239 PF05995 Cysteine dioxygenase type I 2046 0.1238 SUB453 C(-O)(=O) 2046 0.1238 PF01699 Sodium/calcium exchanger protein 2047 0.1237 SUB738 Cc1cc(N)ccc1 2047 0.1237 PF00454 Phosphatidylinositol 3- and 4-kinase 2048 0.1236 SUB700 O-C-C-C-C-C(C)-C 2048 0.1236 PF01842 ACT domain 2049 0.1234 SUB186 >= 2 any ring size 6 2049 0.1234 PF00204 DNA gyrase B 2050 0.1234 SUB346 C(~C)(~H)(~N) 2050 0.1234 PF00001 7 transmembrane receptor (rhodopsin family), 2051 0.1233 SUB570 N-C-C-N 2051 0.1233 PF00520 Ion transport protein 2052 0.1232 SUB200 >= 4 any ring size 6 2052 0.1232 PF00122 E1-E2 ATPase 2053 0.1232 SUB517 [#1]-C=C-[#1] 2053 0.1232 PF03949 Malic enzyme, NAD binding domain 2054 0.1231 SUB22 >= 8 O 2054 0.1231 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 2055 0.1230 SUB567 O-C-C-N 2055 0.1230 PF00005 ABC transporter 2056 0.1229 SUB353 C(~C)(~O) 2056 0.1229 PF00067 Cytochrome P450 2057 0.1228 SUB756 Cc1c(C)cccc1 2057 0.1228 PF00643 B-box zinc finger 2058 0.1228 SUB340 C(~C)(~C)(~H)(~O) 2058 0.1228 PF00084 Sushi domain (SCR repeat), 2059 0.1227 SUB639 O-C-C-C-N 2059 0.1227 PF00989 PAS fold 2060 0.1227 SUB450 C(-N)(=C) 2060 0.1227 PF03098 Animal haem peroxidase 2061 0.1223 SUB567 O-C-C-N 2061 0.1223 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 2062 0.1222 SUB691 O-C-C-C-C-C-O 2062 0.1222 PF02525 Flavodoxin-like fold 2063 0.1218 SUB44 >= 1 Br 2063 0.1218 PF02201 SWIB/MDM2 domain 2064 0.1217 SUB567 O-C-C-N 2064 0.1217 PF03199 Eukaryotic glutathione synthase 2065 0.1217 SUB686 O=C-C-C-C-N 2065 0.1217 PF02934 GatB/GatE catalytic domain 2066 0.1217 SUB389 C(:C)(:N)(:N) 2066 0.1217 PF00378 Enoyl-CoA hydratase/isomerase family 2067 0.1211 SUB700 O-C-C-C-C-C(C)-C 2067 0.1211 PF07965 Integrin beta tail domain 2068 0.1209 SUB537 O=C-C-N 2068 0.1209 PF02769 AIR synthase related protein, C-terminal domain 2069 0.1209 SUB300 N-H 2069 0.1209 PF00069 Protein kinase domain 2070 0.1207 SUB346 C(~C)(~H)(~N) 2070 0.1207 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2071 0.1207 SUB339 C(~C)(~C)(~H)(~N) 2071 0.1207 PF00764 Arginosuccinate synthase 2072 0.1207 SUB375 C(~H)(~H)(~H) 2072 0.1207 PF01180 Dihydroorotate dehydrogenase 2073 0.1207 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 2073 0.1207 PF03727 Hexokinase 2074 0.1206 SUB451 C(-N)(=N) 2074 0.1206 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 2075 0.1205 SUB117 >= 1 saturated or aromatic carbon-only ring size 3 2075 0.1205 PF00069 Protein kinase domain 2076 0.1205 SUB339 C(~C)(~C)(~H)(~N) 2076 0.1205 PF00520 Ion transport protein 2077 0.1202 SUB22 >= 8 O 2077 0.1202 PF07992 Pyridine nucleotide-disulphide oxidoreductase 2078 0.1202 SUB714 Cc1ccc(C)cc1 2078 0.1202 PF00104 Ligand-binding domain of nuclear hormone receptor 2079 0.1202 SUB444 C(-C)(=O) 2079 0.1202 PF00521 DNA gyrase/topoisomerase IV, subunit A 2080 0.1199 SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 2080 0.1199 PF00001 7 transmembrane receptor (rhodopsin family), 2081 0.1199 SUB364 C(~F)(~F) 2081 0.1199 PF00173 Cytochrome b5-like Heme/Steroid binding domain 2082 0.1199 SUB256 >= 1 aromatic ring 2082 0.1199 PF00478 IMP dehydrogenase / GMP reductase domain 2083 0.1198 SUB750 Nc1cc(N)ccc1 2083 0.1198 PF00754 F5/8 type C domain 2084 0.1198 SUB587 C-S-C-C-C 2084 0.1198 PF02574 Homocysteine S-methyltransferase 2085 0.1197 SUB353 C(~C)(~O) 2085 0.1197 PF00209 Sodium:neurotransmitter symporter family 2086 0.1197 SUB861 CC1C(C)CCC1 2086 0.1197 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 2087 0.1196 SUB662 O-C-O-C-C 2087 0.1196 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 2088 0.1195 SUB709 C-C(C)-C-C 2088 0.1195 PF00413 Matrixin 2089 0.1195 SUB151 >= 2 any ring size 5 2089 0.1195 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2090 0.1194 SUB21 >= 4 O 2090 0.1194 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 2091 0.1194 SUB439 C(-C)(-N)(=N) 2091 0.1194 PF01687 Riboflavin kinase 2092 0.1194 SUB407 O(~C)(~H) 2092 0.1194 PF00343 Carbohydrate phosphorylase 2093 0.1194 SUB441 C(-C)(-O)(=O) 2093 0.1194 PF00266 Aminotransferase class-V 2094 0.1192 SUB697 C-C-C-C-C-C-C-C 2094 0.1192 PF00023 Ankyrin repeat 2095 0.1192 SUB32 >= 2 P 2095 0.1192 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 2096 0.1191 SUB621 C:C-O-C-C 2096 0.1191 PF00079 Serpin (serine protease inhibitor), 2097 0.1190 SUB716 Cc1ccc(S)cc1 2097 0.1190 PF00194 Eukaryotic-type carbonic anhydrase 2098 0.1190 SUB439 C(-C)(-N)(=N) 2098 0.1190 PF00089 Trypsin 2099 0.1188 SUB13 >= 16 C 2099 0.1188 PF00173 Cytochrome b5-like Heme/Steroid binding domain 2100 0.1188 SUB683 O-C-C-C-C-N 2100 0.1188 PF04961 Formiminotransferase-cyclodeaminase 2101 0.1187 SUB717 Cc1ccc(N)cc1 2101 0.1187 PF00105 Zinc finger, C4 type (two domains), 2102 0.1186 SUB375 C(~H)(~H)(~H) 2102 0.1186 PF00104 Ligand-binding domain of nuclear hormone receptor 2103 0.1185 SUB536 O=C-C-C 2103 0.1185 PF00364 Biotin-requiring enzyme 2104 0.1184 SUB820 CC1C(O)CCCC1 2104 0.1184 PF00001 7 transmembrane receptor (rhodopsin family), 2105 0.1184 SUB548 N-C:C-N 2105 0.1184 PF01590 GAF domain 2106 0.1183 SUB582 O=C-C-C-O 2106 0.1183 PF00342 Phosphoglucose isomerase 2107 0.1182 SUB702 O-C-C-C-C-C(O)-C 2107 0.1182 PF00354 Pentaxin family 2108 0.1181 SUB673 O=C-C=C-[#1] 2108 0.1181 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 2109 0.1181 SUB537 O=C-C-N 2109 0.1181 PF00155 Aminotransferase class I and II 2110 0.1178 SUB18 >= 8 N 2110 0.1178 PF02793 Hormone receptor domain 2111 0.1177 SUB819 CC1C(C)CCCC1 2111 0.1177 PF00433 Protein kinase C terminal domain 2112 0.1174 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 2112 0.1174 PF00045 Hemopexin 2113 0.1173 SUB682 O-C-C-C-C-O 2113 0.1173 PF01144 Coenzyme A transferase 2114 0.1171 SUB336 C(~C)(~C)(~C)(~H) 2114 0.1171 PF00045 Hemopexin 2115 0.1168 SUB242 >= 1 any ring size 9 2115 0.1168 PF00069 Protein kinase domain 2116 0.1168 SUB23 >= 16 O 2116 0.1168 PF08702 Fibrinogen alpha/beta chain family 2117 0.1166 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 2117 0.1166 PF08035 Opioids neuropeptide 2118 0.1164 SUB685 O=C-C-C-C-C 2118 0.1164 PF00155 Aminotransferase class I and II 2119 0.1161 SUB398 N(~C)(:C)(:C) 2119 0.1161 PF00856 SET domain 2120 0.1160 SUB534 S-C:C-N 2120 0.1160 PF00520 Ion transport protein 2121 0.1160 SUB657 C-C-N-C-C 2121 0.1160 PF00209 Sodium:neurotransmitter symporter family 2122 0.1160 SUB284 C-H 2122 0.1160 PF09127 Leukotriene A4 hydrolase, C-terminal 2123 0.1159 SUB33 >= 4 P 2123 0.1159 PF00169 PH domain 2124 0.1159 SUB578 C:C-N-C:C 2124 0.1159 PF00291 Pyridoxal-phosphate dependent enzyme 2125 0.1159 SUB643 O-C-C-C=O 2125 0.1159 PF00273 Serum albumin family 2126 0.1159 SUB712 C-C(C)(C)-C-C 2126 0.1159 PF00520 Ion transport protein 2127 0.1158 SUB488 N-C=N-C 2127 0.1158 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 2128 0.1156 SUB453 C(-O)(=O) 2128 0.1156 PF00497 Bacterial extracellular solute-binding proteins, family 3 2129 0.1156 SUB644 [#1]-C-C-N-[#1] 2129 0.1156 PF00209 Sodium:neurotransmitter symporter family 2130 0.1156 SUB712 C-C(C)(C)-C-C 2130 0.1156 PF08384 Pro-opiomelanocortin, N-terminal region 2131 0.1155 SUB648 O=C-N-C-N 2131 0.1155 PF00001 7 transmembrane receptor (rhodopsin family), 2132 0.1155 SUB393 N(~C)(~C)(~H) 2132 0.1155 PF00059 Lectin C-type domain 2133 0.1154 SUB694 O=C-C-C-C-C-O 2133 0.1154 PF00324 Amino acid permease 2134 0.1154 SUB391 N(~C)(~C) 2134 0.1154 PF08674 Acetylcholinesterase tetramerisation domain 2135 0.1154 SUB441 C(-C)(-O)(=O) 2135 0.1154 PF00571 CBS domain 2136 0.1152 SUB653 O-C:C:C-N 2136 0.1152 PF08742 C8 domain 2137 0.1151 SUB657 C-C-N-C-C 2137 0.1151 PF01007 Inward rectifier potassium channel 2138 0.1151 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 2138 0.1151 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 2139 0.1150 SUB258 >= 2 aromatic rings 2139 0.1150 PF03623 Focal adhesion targeting region 2140 0.1150 SUB193 >= 3 any ring size 6 2140 0.1150 PF01471 Putative peptidoglycan binding domain 2141 0.1149 SUB396 N(~C)(~O) 2141 0.1149 PF02867 Ribonucleotide reductase, barrel domain 2142 0.1148 SUB713 C-C(C)-C(C)-C 2142 0.1148 PF00282 Pyridoxal-dependent decarboxylase conserved domain 2143 0.1147 SUB466 O=S-C-C 2143 0.1147 PF08246 Cathepsin propeptide inhibitor domain (I29), 2144 0.1146 SUB354 C(~C)(~S) 2144 0.1146 PF02803 Thiolase, C-terminal domain 2145 0.1145 SUB531 N:C-C:C 2145 0.1145 PF00108 Thiolase, N-terminal domain 2146 0.1145 SUB431 C(-C)(-C)(=C) 2146 0.1145 PF00069 Protein kinase domain 2147 0.1144 SUB441 C(-C)(-O)(=O) 2147 0.1144 PF09127 Leukotriene A4 hydrolase, C-terminal 2148 0.1144 SUB695 O=C-C-C-C-C=O 2148 0.1144 PF00266 Aminotransferase class-V 2149 0.1142 SUB441 C(-C)(-O)(=O) 2149 0.1142 PF02100 Ornithine decarboxylase antizyme 2150 0.1142 SUB538 O=C-C-O 2150 0.1142 PF00135 Carboxylesterase 2151 0.1142 SUB709 C-C(C)-C-C 2151 0.1142 PF00664 ABC transporter transmembrane region 2152 0.1142 SUB288 C-F 2152 0.1142 PF00248 Aldo/keto reductase family 2153 0.1140 SUB482 O-S-C:C 2153 0.1140 PF00104 Ligand-binding domain of nuclear hormone receptor 2154 0.1140 SUB613 N-C-O-C-C 2154 0.1140 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 2155 0.1137 SUB13 >= 16 C 2155 0.1137 PF00489 Interleukin-6/G-CSF/MGF family 2156 0.1136 SUB675 N-C-N-C:C 2156 0.1136 PF02196 Raf-like Ras-binding domain 2157 0.1134 SUB683 O-C-C-C-C-N 2157 0.1134 PF07654 Immunoglobulin C1-set domain 2158 0.1133 SUB700 O-C-C-C-C-C(C)-C 2158 0.1133 PF01023 S-100/ICaBP type calcium binding domain 2159 0.1133 SUB625 O=C-C:C-N 2159 0.1133 PF00028 Cadherin domain 2160 0.1133 SUB529 [#1]-N-C-[#1] 2160 0.1133 PF00324 Amino acid permease 2161 0.1131 SUB572 [#1]-C-O-[#1] 2161 0.1131 PF00001 7 transmembrane receptor (rhodopsin family), 2162 0.1130 SUB389 C(:C)(:N)(:N) 2162 0.1130 PF12062 heparan sulfate-N-deacetylase 2163 0.1130 SUB335 C(~C)(~C)(~C)(~C) 2163 0.1130 PF00067 Cytochrome P450 2164 0.1129 SUB680 C-C-C-C-C-C 2164 0.1129 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2165 0.1128 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 2165 0.1128 PF00349 Hexokinase 2166 0.1128 SUB580 O=C-C-C-C 2166 0.1128 PF00067 Cytochrome P450 2167 0.1127 SUB691 O-C-C-C-C-C-O 2167 0.1127 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 2168 0.1124 SUB537 O=C-C-N 2168 0.1124 PF01471 Putative peptidoglycan binding domain 2169 0.1124 SUB612 N-C-C-N-C 2169 0.1124 PF07686 Immunoglobulin V-set domain 2170 0.1122 SUB500 N-C:C:N 2170 0.1122 PF01590 GAF domain 2171 0.1122 SUB31 >= 1 P 2171 0.1122 PF01704 UTP--glucose-1-phosphate uridylyltransferase 2172 0.1120 SUB616 N-C-C-O-C 2172 0.1120 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2173 0.1120 SUB756 Cc1c(C)cccc1 2173 0.1120 PF02798 Glutathione S-transferase, N-terminal domain 2174 0.1120 SUB620 O-C-C=C-C 2174 0.1120 PF00822 PMP-22/EMP/MP20/Claudin family 2175 0.1119 SUB603 O=C-C-N-C 2175 0.1119 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 2176 0.1118 SUB261 >= 3 hetero-aromatic rings 2176 0.1118 PF00212 Atrial natriuretic peptide 2177 0.1118 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 2177 0.1118 PF00001 7 transmembrane receptor (rhodopsin family), 2178 0.1118 SUB261 >= 3 hetero-aromatic rings 2178 0.1118 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 2179 0.1118 SUB646 O=C-N-C-C 2179 0.1118 PF00026 Eukaryotic aspartyl protease 2180 0.1116 SUB706 O=C-C-C-C-C(O)-C 2180 0.1116 PF00341 Platelet-derived growth factor (PDGF), 2181 0.1115 SUB624 O=C-C:C-C 2181 0.1115 PF00464 Serine hydroxymethyltransferase 2182 0.1115 SUB20 >= 2 O 2182 0.1115 PF00489 Interleukin-6/G-CSF/MGF family 2183 0.1114 SUB342 C(~C)(~C)(~O) 2183 0.1114 PF02780 Transketolase, C-terminal domain 2184 0.1113 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 2184 0.1113 PF00341 Platelet-derived growth factor (PDGF), 2185 0.1113 SUB414 S(~C)(~H) 2185 0.1113 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 2186 0.1113 SUB529 [#1]-N-C-[#1] 2186 0.1113 PF01409 tRNA synthetases class II core domain (F), 2187 0.1112 SUB14 >= 32 C 2187 0.1112 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2188 0.1112 SUB385 C(:C)(:C) 2188 0.1112 PF00005 ABC transporter 2189 0.1111 SUB616 N-C-C-O-C 2189 0.1111 PF00059 Lectin C-type domain 2190 0.1110 SUB655 N-C-N-C-C 2190 0.1110 PF08527 Protein-arginine deiminase (PAD), middle domain 2191 0.1109 SUB17 >= 4 N 2191 0.1109 PF00005 ABC transporter 2192 0.1108 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 2192 0.1108 PF00106 short chain dehydrogenase 2193 0.1108 SUB249 >= 1 any ring size 10 2193 0.1108 PF08070 DTHCT (NUC029), region 2194 0.1108 SUB186 >= 2 any ring size 6 2194 0.1108 PF00521 DNA gyrase/topoisomerase IV, subunit A 2195 0.1107 SUB486 N:C:C:N 2195 0.1107 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2196 0.1107 SUB613 N-C-O-C-C 2196 0.1107 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2197 0.1106 SUB692 O-C-C-C-C-C-N 2197 0.1106 PF00927 Transglutaminase family, C-terminal ig like domain 2198 0.1106 SUB606 O=C-C-O-C 2198 0.1106 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 2199 0.1105 SUB340 C(~C)(~C)(~H)(~O) 2199 0.1105 PF00175 Oxidoreductase NAD-binding domain 2200 0.1105 SUB630 S-C:C:C-N 2200 0.1105 PF03372 Endonuclease/Exonuclease/phosphatase family 2201 0.1104 SUB555 Br-C-C-C 2201 0.1104 PF00641 Zn-finger in Ran binding protein and others 2202 0.1103 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 2202 0.1103 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 2203 0.1102 SUB32 >= 2 P 2203 0.1102 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 2204 0.1101 SUB703 O-C-C-C-C-C-N-C 2204 0.1101 PF00406 Adenylate kinase 2205 0.1100 SUB21 >= 4 O 2205 0.1100 PF00153 Mitochondrial carrier protein 2206 0.1099 SUB486 N:C:C:N 2206 0.1099 PF00153 Mitochondrial carrier protein 2207 0.1098 SUB369 C(~H)(~S) 2207 0.1098 PF01471 Putative peptidoglycan binding domain 2208 0.1096 SUB19 >= 1 O 2208 0.1096 PF00576 HIUase/Transthyretin family 2209 0.1095 SUB564 O-C-O-C 2209 0.1095 PF00059 Lectin C-type domain 2210 0.1093 SUB685 O=C-C-C-C-C 2210 0.1093 PF00850 Histone deacetylase domain 2211 0.1093 SUB537 O=C-C-N 2211 0.1093 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 2212 0.1093 SUB486 N:C:C:N 2212 0.1093 PF05995 Cysteine dioxygenase type I 2213 0.1092 SUB17 >= 4 N 2213 0.1092 PF00175 Oxidoreductase NAD-binding domain 2214 0.1092 SUB12 >= 8 C 2214 0.1092 PF00001 7 transmembrane receptor (rhodopsin family), 2215 0.1092 SUB433 C(-C)(-C)(=O) 2215 0.1092 PF00091 Tubulin/FtsZ family, GTPase domain 2216 0.1092 SUB249 >= 1 any ring size 10 2216 0.1092 PF02219 Methylenetetrahydrofolate reductase 2217 0.1091 SUB654 O-C:C:C-O 2217 0.1091 PF00478 IMP dehydrogenase / GMP reductase domain 2218 0.1091 SUB2 >= 8 H 2218 0.1091 PF00089 Trypsin 2219 0.1091 SUB688 O=C-C-C-C=O 2219 0.1091 PF04756 OST3 / OST6 family 2220 0.1090 SUB629 C-N-C-C:C 2220 0.1090 PF00702 haloacid dehalogenase-like hydrolase 2221 0.1090 SUB336 C(~C)(~C)(~C)(~H) 2221 0.1090 PF02166 Androgen receptor 2222 0.1090 SUB682 O-C-C-C-C-O 2222 0.1090 PF00501 AMP-binding enzyme 2223 0.1088 SUB567 O-C-C-N 2223 0.1088 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 2224 0.1087 SUB625 O=C-C:C-N 2224 0.1087 PF00493 MCM2/3/5 family 2225 0.1087 SUB582 O=C-C-C-O 2225 0.1087 PF00001 7 transmembrane receptor (rhodopsin family), 2226 0.1086 SUB294 C-S 2226 0.1086 PF00248 Aldo/keto reductase family 2227 0.1086 SUB429 C(#C)(-H) 2227 0.1086 PF00194 Eukaryotic-type carbonic anhydrase 2228 0.1085 SUB647 O=C-N-C-[#1] 2228 0.1085 PF00026 Eukaryotic aspartyl protease 2229 0.1083 SUB591 C-C:C-O-[#1] 2229 0.1083 PF00105 Zinc finger, C4 type (two domains), 2230 0.1083 SUB454 N(-C)(=C) 2230 0.1083 PF00051 Kringle domain 2231 0.1083 SUB444 C(-C)(=O) 2231 0.1083 PF08070 DTHCT (NUC029), region 2232 0.1082 SUB344 C(~C)(~Cl)(~H) 2232 0.1082 PF00418 Tau and MAP protein, tubulin-binding repeat 2233 0.1080 SUB366 C(~H)(~N) 2233 0.1080 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2234 0.1079 SUB603 O=C-C-N-C 2234 0.1079 PF00149 Calcineurin-like phosphoesterase 2235 0.1079 SUB656 O-C-C-C:C 2235 0.1079 PF00027 Cyclic nucleotide-binding domain 2236 0.1079 SUB441 C(-C)(-O)(=O) 2236 0.1079 PF00071 Ras family 2237 0.1077 SUB413 S(~C)(~C) 2237 0.1077 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 2238 0.1077 SUB346 C(~C)(~H)(~N) 2238 0.1077 PF00664 ABC transporter transmembrane region 2239 0.1077 SUB258 >= 2 aromatic rings 2239 0.1077 PF03520 KCNQ voltage-gated potassium channel 2240 0.1077 SUB685 O=C-C-C-C-C 2240 0.1077 PF07645 Calcium-binding EGF domain 2241 0.1075 SUB538 O=C-C-O 2241 0.1075 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 2242 0.1075 SUB432 C(-C)(-C)(=N) 2242 0.1075 PF01842 ACT domain 2243 0.1075 SUB793 NC1CCC(Cl)CC1 2243 0.1075 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2244 0.1074 SUB664 O-C-C-O-[#1] 2244 0.1074 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2245 0.1070 SUB529 [#1]-N-C-[#1] 2245 0.1070 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 2246 0.1070 SUB691 O-C-C-C-C-C-O 2246 0.1070 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 2247 0.1069 SUB709 C-C(C)-C-C 2247 0.1069 PF01063 Aminotransferase class IV 2248 0.1068 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 2248 0.1068 PF00520 Ion transport protein 2249 0.1068 SUB261 >= 3 hetero-aromatic rings 2249 0.1068 PF02770 Acyl-CoA dehydrogenase, middle domain 2250 0.1068 SUB36 >= 4 S 2250 0.1068 PF03073 TspO/MBR family 2251 0.1066 SUB38 >= 1 Cl 2251 0.1066 PF03530 Calcium-activated SK potassium channel 2252 0.1064 SUB400 N(~H)(:C) 2252 0.1064 PF01208 Uroporphyrinogen decarboxylase (URO-D), 2253 0.1063 SUB24 >= 1 F 2253 0.1063 PF02867 Ribonucleotide reductase, barrel domain 2254 0.1063 SUB597 N=C-N-C-C 2254 0.1063 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 2255 0.1062 SUB485 N-C:N:C 2255 0.1062 PF00108 Thiolase, N-terminal domain 2256 0.1062 SUB505 N:C:N-C 2256 0.1062 PF00899 ThiF family 2257 0.1062 SUB346 C(~C)(~H)(~N) 2257 0.1062 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2258 0.1060 SUB457 P(-O)(=O) 2258 0.1060 PF01704 UTP--glucose-1-phosphate uridylyltransferase 2259 0.1060 SUB643 O-C-C-C=O 2259 0.1060 PF01023 S-100/ICaBP type calcium binding domain 2260 0.1060 SUB548 N-C:C-N 2260 0.1060 PF04389 Peptidase family M28 2261 0.1059 SUB654 O-C:C:C-O 2261 0.1059 PF03623 Focal adhesion targeting region 2262 0.1058 SUB715 Cc1ccc(O)cc1 2262 0.1058 PF08441 Integrin alpha 2263 0.1057 SUB638 O-C-C-C-C 2263 0.1057 PF00175 Oxidoreductase NAD-binding domain 2264 0.1057 SUB144 >= 1 any ring size 5 2264 0.1057 PF00690 Cation transporter/ATPase, N-terminus 2265 0.1057 SUB34 >= 1 S 2265 0.1057 PF00822 PMP-22/EMP/MP20/Claudin family 2266 0.1056 SUB17 >= 4 N 2266 0.1056 PF01564 Spermine/spermidine synthase 2267 0.1056 SUB452 C(-N)(=O) 2267 0.1056 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2268 0.1054 SUB486 N:C:C:N 2268 0.1054 PF04800 ETC complex I subunit conserved region 2269 0.1054 SUB702 O-C-C-C-C-C(O)-C 2269 0.1054 PF03953 Tubulin C-terminal domain 2270 0.1054 SUB709 C-C(C)-C-C 2270 0.1054 PF00043 Glutathione S-transferase, C-terminal domain 2271 0.1053 SUB691 O-C-C-C-C-C-O 2271 0.1053 PF01347 Lipoprotein amino terminal region 2272 0.1053 SUB704 O-C-C-C-C-C(N)-C 2272 0.1053 PF00291 Pyridoxal-phosphate dependent enzyme 2273 0.1051 SUB789 SC1CCC(N)CC1 2273 0.1051 PF00069 Protein kinase domain 2274 0.1051 SUB695 O=C-C-C-C-C=O 2274 0.1051 PF07654 Immunoglobulin C1-set domain 2275 0.1050 SUB703 O-C-C-C-C-C-N-C 2275 0.1050 PF00255 Glutathione peroxidase 2276 0.1050 SUB703 O-C-C-C-C-C-N-C 2276 0.1050 PF00105 Zinc finger, C4 type (two domains), 2277 0.1050 SUB602 N-C:C:C-N 2277 0.1050 PF00023 Ankyrin repeat 2278 0.1049 SUB572 [#1]-C-O-[#1] 2278 0.1049 PF01370 NAD dependent epimerase/dehydratase family 2279 0.1049 SUB522 C:N-C-[#1] 2279 0.1049 PF00067 Cytochrome P450 2280 0.1047 SUB562 Cl-C-C=O 2280 0.1047 PF02885 Glycosyl transferase family, helical bundle domain 2281 0.1047 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 2281 0.1047 PF01030 Receptor L domain 2282 0.1047 SUB231 >= 1 saturated or aromatic heteroatom-containing ring size 8 2282 0.1047 PF00341 Platelet-derived growth factor (PDGF), 2283 0.1046 SUB412 P(~O)(~O) 2283 0.1046 PF00248 Aldo/keto reductase family 2284 0.1046 SUB401 N(~H)(:C)(:C) 2284 0.1046 PF01387 Synuclein 2285 0.1045 SUB295 C-Cl 2285 0.1045 PF00043 Glutathione S-transferase, C-terminal domain 2286 0.1044 SUB674 O=C-C=C-N 2286 0.1044 PF00822 PMP-22/EMP/MP20/Claudin family 2287 0.1043 SUB674 O=C-C=C-N 2287 0.1043 PF00069 Protein kinase domain 2288 0.1043 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 2288 0.1043 PF00989 PAS fold 2289 0.1043 SUB32 >= 2 P 2289 0.1043 PF10509 Galactokinase galactose-binding signature 2290 0.1043 SUB339 C(~C)(~C)(~H)(~N) 2290 0.1043 PF00168 C2 domain 2291 0.1041 SUB561 N-C-N-C 2291 0.1041 PF08403 Amino acid permease N-terminal 2292 0.1041 SUB677 N#C-C-C-C 2292 0.1041 PF00105 Zinc finger, C4 type (two domains), 2293 0.1039 SUB700 O-C-C-C-C-C(C)-C 2293 0.1039 PF01231 Indoleamine 2,3-dioxygenase 2294 0.1038 SUB664 O-C-C-O-[#1] 2294 0.1038 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 2295 0.1036 SUB529 [#1]-N-C-[#1] 2295 0.1036 PF00168 C2 domain 2296 0.1035 SUB537 O=C-C-N 2296 0.1035 PF01597 Glycine cleavage H-protein 2297 0.1035 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 2297 0.1035 PF00454 Phosphatidylinositol 3- and 4-kinase 2298 0.1035 SUB646 O=C-N-C-C 2298 0.1035 PF03068 Protein-arginine deiminase (PAD), 2299 0.1032 SUB426 P=O 2299 0.1032 PF02441 Flavoprotein 2300 0.1032 SUB341 C(~C)(~C)(~N) 2300 0.1032 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2301 0.1030 SUB457 P(-O)(=O) 2301 0.1030 PF00316 Fructose-1-6-bisphosphatase 2302 0.1030 SUB582 O=C-C-C-O 2302 0.1030 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 2303 0.1029 SUB193 >= 3 any ring size 6 2303 0.1029 PF00005 ABC transporter 2304 0.1028 SUB700 O-C-C-C-C-C(C)-C 2304 0.1028 PF00042 Globin 2305 0.1028 SUB408 O(~C)(~P) 2305 0.1028 PF01852 START domain 2306 0.1027 SUB603 O=C-C-N-C 2306 0.1027 PF00653 Inhibitor of Apoptosis domain 2307 0.1027 SUB743 Oc1cc(N)ccc1 2307 0.1027 PF03508 Gap junction alpha-1 protein (Cx43), 2308 0.1026 SUB664 O-C-C-O-[#1] 2308 0.1026 PF02770 Acyl-CoA dehydrogenase, middle domain 2309 0.1026 SUB426 P=O 2309 0.1026 PF00074 Pancreatic ribonuclease 2310 0.1026 SUB375 C(~H)(~H)(~H) 2310 0.1026 PF00122 E1-E2 ATPase 2311 0.1026 SUB457 P(-O)(=O) 2311 0.1026 PF02666 Phosphatidylserine decarboxylase 2312 0.1025 SUB771 Nc1c(N)cccc1 2312 0.1025 PF01437 Plexin repeat 2313 0.1024 SUB21 >= 4 O 2313 0.1024 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 2314 0.1024 SUB152 >= 2 saturated or aromatic carbon-only ring size 5 2314 0.1024 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2315 0.1023 SUB339 C(~C)(~C)(~H)(~N) 2315 0.1023 PF00557 Metallopeptidase family M24 2316 0.1021 SUB622 N-C:C:C:N 2316 0.1021 PF00005 ABC transporter 2317 0.1021 SUB778 CC1CCC(O)CC1 2317 0.1021 PF00079 Serpin (serine protease inhibitor), 2318 0.1021 SUB697 C-C-C-C-C-C-C-C 2318 0.1021 PF01593 Flavin containing amine oxidoreductase 2319 0.1021 SUB336 C(~C)(~C)(~C)(~H) 2319 0.1021 PF00341 Platelet-derived growth factor (PDGF), 2320 0.1020 SUB602 N-C:C:C-N 2320 0.1020 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 2321 0.1020 SUB341 C(~C)(~C)(~N) 2321 0.1020 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2322 0.1019 SUB572 [#1]-C-O-[#1] 2322 0.1019 PF08240 Alcohol dehydrogenase GroES-like domain 2323 0.1019 SUB392 N(~C)(~C)(~C) 2323 0.1019 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2324 0.1016 SUB554 O=C-C=C 2324 0.1016 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2325 0.1016 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2325 0.1016 PF02779 Transketolase, pyrimidine binding domain 2326 0.1015 SUB568 O-C-C-O 2326 0.1015 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 2327 0.1014 SUB607 O-C:C-C-C 2327 0.1014 PF00702 haloacid dehalogenase-like hydrolase 2328 0.1014 SUB341 C(~C)(~C)(~N) 2328 0.1014 PF00155 Aminotransferase class I and II 2329 0.1014 SUB718 Cc1ccc(Cl)cc1 2329 0.1014 PF00001 7 transmembrane receptor (rhodopsin family), 2330 0.1014 SUB392 N(~C)(~C)(~C) 2330 0.1014 PF00520 Ion transport protein 2331 0.1013 SUB688 O=C-C-C-C=O 2331 0.1013 PF00001 7 transmembrane receptor (rhodopsin family), 2332 0.1012 SUB656 O-C-C-C:C 2332 0.1012 PF00625 Guanylate kinase 2333 0.1012 SUB695 O=C-C-C-C-C=O 2333 0.1012 PF00682 HMGL-like 2334 0.1012 SUB657 C-C-N-C-C 2334 0.1012 PF01234 NNMT/PNMT/TEMT family 2335 0.1009 SUB453 C(-O)(=O) 2335 0.1009 PF01266 FAD dependent oxidoreductase 2336 0.1008 SUB353 C(~C)(~O) 2336 0.1008 PF00060 Ligand-gated ion channel 2337 0.1007 SUB360 C(~C)(:N)(:N) 2337 0.1007 PF08240 Alcohol dehydrogenase GroES-like domain 2338 0.1006 SUB412 P(~O)(~O) 2338 0.1006 PF03770 Inositol polyphosphate kinase 2339 0.1005 SUB374 C(~H)(:N) 2339 0.1005 PF00757 Furin-like cysteine rich region 2340 0.1005 SUB369 C(~H)(~S) 2340 0.1005 PF00209 Sodium:neurotransmitter symporter family 2341 0.1004 SUB515 O-N-C-C 2341 0.1004 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 2342 0.1003 SUB801 CC1CC(N)CCC1 2342 0.1003 PF02310 B12 binding domain 2343 0.1003 SUB699 O-C-C-C-C-C-C-C 2343 0.1003 PF00105 Zinc finger, C4 type (two domains), 2344 0.1002 SUB612 N-C-C-N-C 2344 0.1002 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2345 0.1002 SUB509 S=C-N-C 2345 0.1002 PF04679 ATP dependent DNA ligase C terminal region 2346 0.1001 SUB573 N:C:N:C 2346 0.1001 PF00478 IMP dehydrogenase / GMP reductase domain 2347 0.1000 SUB381 C(~O)(~O) 2347 0.1000 PF00128 Alpha amylase, catalytic domain 2348 0.1000 SUB674 O=C-C=C-N 2348 0.1000 PF00105 Zinc finger, C4 type (two domains), 2349 0.0999 SUB804 OC1CC(O)CCC1 2349 0.0999 PF00001 7 transmembrane receptor (rhodopsin family), 2350 0.0999 SUB692 O-C-C-C-C-C-N 2350 0.0999 PF00001 7 transmembrane receptor (rhodopsin family), 2351 0.0998 SUB595 C-O-C-C=C 2351 0.0998 PF00091 Tubulin/FtsZ family, GTPase domain 2352 0.0998 SUB691 O-C-C-C-C-C-O 2352 0.0998 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 2353 0.0998 SUB668 C=C-C-O-[#1] 2353 0.0998 PF00106 short chain dehydrogenase 2354 0.0997 SUB696 O=C-C-C-C-C-N 2354 0.0997 PF08527 Protein-arginine deiminase (PAD), middle domain 2355 0.0997 SUB4 >= 32 H 2355 0.0997 PF00520 Ion transport protein 2356 0.0995 SUB451 C(-N)(=N) 2356 0.0995 PF00089 Trypsin 2357 0.0994 SUB500 N-C:C:N 2357 0.0994 PF00156 Phosphoribosyl transferase domain 2358 0.0992 SUB374 C(~H)(:N) 2358 0.0992 PF01030 Receptor L domain 2359 0.0991 SUB694 O=C-C-C-C-C-O 2359 0.0991 PF01477 PLAT/LH2 domain 2360 0.0991 SUB602 N-C:C:C-N 2360 0.0991 PF12062 heparan sulfate-N-deacetylase 2361 0.0990 SUB739 Cc1cc(Cl)ccc1 2361 0.0990 PF00027 Cyclic nucleotide-binding domain 2362 0.0989 SUB261 >= 3 hetero-aromatic rings 2362 0.0989 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 2363 0.0989 SUB821 CC1C(S)CCCC1 2363 0.0989 PF02146 Sir2 family 2364 0.0988 SUB575 O-C-C:C-C 2364 0.0988 PF00001 7 transmembrane receptor (rhodopsin family), 2365 0.0987 SUB697 C-C-C-C-C-C-C-C 2365 0.0987 PF00001 7 transmembrane receptor (rhodopsin family), 2366 0.0985 SUB347 C(~C)(~H)(~O) 2366 0.0985 PF01023 S-100/ICaBP type calcium binding domain 2367 0.0985 SUB441 C(-C)(-O)(=O) 2367 0.0985 PF00122 E1-E2 ATPase 2368 0.0985 SUB508 C-C-S-C 2368 0.0985 PF12497 Estrogen receptor beta 2369 0.0984 SUB130 >= 1 any ring size 4 2369 0.0984 PF02460 Patched family 2370 0.0984 SUB806 OC1CC(N)CCC1 2370 0.0984 PF05790 Immunoglobulin C2-set domain 2371 0.0983 SUB567 O-C-C-N 2371 0.0983 PF02347 Glycine cleavage system P-protein 2372 0.0982 SUB686 O=C-C-C-C-N 2372 0.0982 PF00375 Sodium:dicarboxylate symporter family 2373 0.0981 SUB622 N-C:C:C:N 2373 0.0981 PF00106 short chain dehydrogenase 2374 0.0981 SUB608 N-C-C-C:C 2374 0.0981 PF00155 Aminotransferase class I and II 2375 0.0980 SUB640 O-C-C-C-O 2375 0.0980 PF07654 Immunoglobulin C1-set domain 2376 0.0980 SUB179 >= 1 any ring size 6 2376 0.0980 PF08534 Redoxin 2377 0.0979 SUB261 >= 3 hetero-aromatic rings 2377 0.0979 PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 2378 0.0977 SUB713 C-C(C)-C(C)-C 2378 0.0977 PF00067 Cytochrome P450 2379 0.0976 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 2379 0.0976 PF00571 CBS domain 2380 0.0976 SUB497 N:N-C-[#1] 2380 0.0976 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 2381 0.0976 SUB574 O-C-C=C 2381 0.0976 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2382 0.0975 SUB697 C-C-C-C-C-C-C-C 2382 0.0975 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 2383 0.0975 SUB663 O-C-C-O-C 2383 0.0975 PF03727 Hexokinase 2384 0.0974 SUB284 C-H 2384 0.0974 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 2385 0.0973 SUB567 O-C-C-N 2385 0.0973 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 2386 0.0973 SUB840 CC1CC(C)CC1 2386 0.0973 PF00001 7 transmembrane receptor (rhodopsin family), 2387 0.0973 SUB466 O=S-C-C 2387 0.0973 PF00045 Hemopexin 2388 0.0972 SUB777 CC1CCC(C)CC1 2388 0.0972 PF00664 ABC transporter transmembrane region 2389 0.0971 SUB263 >= 4 hetero-aromatic rings 2389 0.0971 PF01833 IPT/TIG domain 2390 0.0969 SUB346 C(~C)(~H)(~N) 2390 0.0969 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 2391 0.0969 SUB793 NC1CCC(Cl)CC1 2391 0.0969 PF07686 Immunoglobulin V-set domain 2392 0.0968 SUB375 C(~H)(~H)(~H) 2392 0.0968 PF00557 Metallopeptidase family M24 2393 0.0968 SUB342 C(~C)(~C)(~O) 2393 0.0968 PF00151 Lipase 2394 0.0967 SUB862 CC1C(O)CCC1 2394 0.0967 PF08377 MAP2/Tau projection domain 2395 0.0965 SUB193 >= 3 any ring size 6 2395 0.0965 PF00018 SH3 domain 2396 0.0964 SUB806 OC1CC(N)CCC1 2396 0.0964 PF00123 Peptide hormone 2397 0.0964 SUB398 N(~C)(:C)(:C) 2397 0.0964 PF02493 MORN repeat 2398 0.0963 SUB759 Cc1c(N)cccc1 2398 0.0963 PF00001 7 transmembrane receptor (rhodopsin family), 2399 0.0963 SUB670 Cl-C:C-C=O 2399 0.0963 PF00043 Glutathione S-transferase, C-terminal domain 2400 0.0962 SUB541 C-N-C-[#1] 2400 0.0962 PF00005 ABC transporter 2401 0.0962 SUB389 C(:C)(:N)(:N) 2401 0.0962 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 2402 0.0962 SUB426 P=O 2402 0.0962 PF03770 Inositol polyphosphate kinase 2403 0.0962 SUB517 [#1]-C=C-[#1] 2403 0.0962 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 2404 0.0961 SUB570 N-C-C-N 2404 0.0961 PF07690 Major Facilitator Superfamily 2405 0.0961 SUB361 C(~Cl)(~Cl) 2405 0.0961 PF00079 Serpin (serine protease inhibitor), 2406 0.0961 SUB692 O-C-C-C-C-C-N 2406 0.0961 PF01842 ACT domain 2407 0.0960 SUB375 C(~H)(~H)(~H) 2407 0.0960 PF00489 Interleukin-6/G-CSF/MGF family 2408 0.0960 SUB595 C-O-C-C=C 2408 0.0960 PF03953 Tubulin C-terminal domain 2409 0.0960 SUB262 >= 4 aromatic rings 2409 0.0960 PF00018 SH3 domain 2410 0.0959 SUB720 Oc1ccc(O)cc1 2410 0.0959 PF00501 AMP-binding enzyme 2411 0.0959 SUB337 C(~C)(~C)(~C)(~N) 2411 0.0959 PF00229 TNF(Tumour Necrosis Factor), family 2412 0.0959 SUB567 O-C-C-N 2412 0.0959 PF00176 SNF2 family N-terminal domain 2413 0.0955 SUB376 C(~N)(~N) 2413 0.0955 PF03477 ATP cone domain 2414 0.0955 SUB616 N-C-C-O-C 2414 0.0955 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2415 0.0954 SUB586 C-C:C-N-C 2415 0.0954 PF00001 7 transmembrane receptor (rhodopsin family), 2416 0.0953 SUB398 N(~C)(:C)(:C) 2416 0.0953 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family 2417 0.0951 SUB691 O-C-C-C-C-C-O 2417 0.0951 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 2418 0.0951 SUB258 >= 2 aromatic rings 2418 0.0951 PF00079 Serpin (serine protease inhibitor), 2419 0.0950 SUB605 C-O-C-C:C 2419 0.0950 PF06512 Sodium ion transport-associated 2420 0.0950 SUB573 N:C:N:C 2420 0.0950 PF00899 ThiF family 2421 0.0949 SUB743 Oc1cc(N)ccc1 2421 0.0949 PF00029 Connexin 2422 0.0948 SUB294 C-S 2422 0.0948 PF02803 Thiolase, C-terminal domain 2423 0.0946 SUB675 N-C-N-C:C 2423 0.0946 PF00108 Thiolase, N-terminal domain 2424 0.0946 SUB640 O-C-C-C-O 2424 0.0946 PF00390 Malic enzyme, N-terminal domain 2425 0.0946 SUB582 O=C-C-C-O 2425 0.0946 PF03034 Phosphatidyl serine synthase 2426 0.0945 SUB13 >= 16 C 2426 0.0945 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2427 0.0944 SUB644 [#1]-C-C-N-[#1] 2427 0.0944 PF00521 DNA gyrase/topoisomerase IV, subunit A 2428 0.0943 SUB633 C-C-O-C:C 2428 0.0943 PF00650 CRAL/TRIO domain 2429 0.0942 SUB531 N:C-C:C 2429 0.0942 PF09027 GTPase binding 2430 0.0942 SUB14 >= 32 C 2430 0.0942 PF01273 LBP / BPI / CETP family, N-terminal domain 2431 0.0940 SUB702 O-C-C-C-C-C(O)-C 2431 0.0940 PF07645 Calcium-binding EGF domain 2432 0.0939 SUB704 O-C-C-C-C-C(N)-C 2432 0.0939 PF00092 von Willebrand factor type A domain 2433 0.0939 SUB396 N(~C)(~O) 2433 0.0939 PF01327 Polypeptide deformylase 2434 0.0938 SUB502 Cl-C:C-C 2434 0.0938 PF00229 TNF(Tumour Necrosis Factor), family 2435 0.0937 SUB389 C(:C)(:N)(:N) 2435 0.0937 PF04116 Fatty acid hydroxylase superfamily 2436 0.0937 SUB736 Cc1cc(O)ccc1 2436 0.0937 PF00209 Sodium:neurotransmitter symporter family 2437 0.0936 SUB261 >= 3 hetero-aromatic rings 2437 0.0936 PF08996 DNA Polymerase alpha zinc finger 2438 0.0935 SUB186 >= 2 any ring size 6 2438 0.0935 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 2439 0.0935 SUB360 C(~C)(:N)(:N) 2439 0.0935 PF00070 Pyridine nucleotide-disulphide oxidoreductase 2440 0.0935 SUB336 C(~C)(~C)(~C)(~H) 2440 0.0935 PF08441 Integrin alpha 2441 0.0934 SUB374 C(~H)(:N) 2441 0.0934 PF00478 IMP dehydrogenase / GMP reductase domain 2442 0.0934 SUB643 O-C-C-C=O 2442 0.0934 PF02666 Phosphatidylserine decarboxylase 2443 0.0933 SUB581 O=C-C-C-N 2443 0.0933 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2444 0.0931 SUB660 O-C-C-N-C 2444 0.0931 PF00001 7 transmembrane receptor (rhodopsin family), 2445 0.0931 SUB687 O=C-C-C-C-O 2445 0.0931 PF00104 Ligand-binding domain of nuclear hormone receptor 2446 0.0930 SUB454 N(-C)(=C) 2446 0.0930 PF03073 TspO/MBR family 2447 0.0928 SUB695 O=C-C-C-C-C=O 2447 0.0928 PF00756 Putative esterase 2448 0.0928 SUB462 O-C-C=N 2448 0.0928 PF01063 Aminotransferase class IV 2449 0.0927 SUB756 Cc1c(C)cccc1 2449 0.0927 PF00209 Sodium:neurotransmitter symporter family 2450 0.0927 SUB667 C=C-C-O-C 2450 0.0927 PF00702 haloacid dehalogenase-like hydrolase 2451 0.0927 SUB574 O-C-C=C 2451 0.0927 PF03098 Animal haem peroxidase 2452 0.0926 SUB431 C(-C)(-C)(=C) 2452 0.0926 PF00175 Oxidoreductase NAD-binding domain 2453 0.0923 SUB572 [#1]-C-O-[#1] 2453 0.0923 PF00520 Ion transport protein 2454 0.0923 SUB13 >= 16 C 2454 0.0923 PF00070 Pyridine nucleotide-disulphide oxidoreductase 2455 0.0923 SUB309 O-H 2455 0.0923 PF03199 Eukaryotic glutathione synthase 2456 0.0922 SUB637 C-N-C-N-C 2456 0.0922 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2457 0.0922 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 2457 0.0922 PF00521 DNA gyrase/topoisomerase IV, subunit A 2458 0.0922 SUB375 C(~H)(~H)(~H) 2458 0.0922 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 2459 0.0921 SUB633 C-C-O-C:C 2459 0.0921 PF00149 Calcineurin-like phosphoesterase 2460 0.0921 SUB567 O-C-C-N 2460 0.0921 PF00060 Ligand-gated ion channel 2461 0.0920 SUB22 >= 8 O 2461 0.0920 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 2462 0.0919 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2462 0.0919 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 2463 0.0917 SUB260 >= 3 aromatic rings 2463 0.0917 PF00520 Ion transport protein 2464 0.0917 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 2464 0.0917 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 2465 0.0916 SUB509 S=C-N-C 2465 0.0916 PF01404 Ephrin receptor ligand binding domain 2466 0.0916 SUB441 C(-C)(-O)(=O) 2466 0.0916 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 2467 0.0915 SUB23 >= 16 O 2467 0.0915 PF00378 Enoyl-CoA hydratase/isomerase family 2468 0.0914 SUB517 [#1]-C=C-[#1] 2468 0.0914 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2469 0.0913 SUB602 N-C:C:C-N 2469 0.0913 PF02817 e3 binding domain 2470 0.0913 SUB4 >= 32 H 2470 0.0913 PF00362 Integrin, beta chain 2471 0.0912 SUB243 >= 1 saturated or aromatic carbon-only ring size 9 2471 0.0912 PF00884 Sulfatase 2472 0.0911 SUB622 N-C:C:C:N 2472 0.0911 PF00107 Zinc-binding dehydrogenase 2473 0.0910 SUB614 C-N-C-C-C 2473 0.0910 PF00135 Carboxylesterase 2474 0.0908 SUB295 C-Cl 2474 0.0908 PF02254 TrkA-N domain 2475 0.0908 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2475 0.0908 PF01208 Uroporphyrinogen decarboxylase (URO-D), 2476 0.0907 SUB348 C(~C)(~H)(~O)(~O) 2476 0.0907 PF00041 Fibronectin type III domain 2477 0.0907 SUB622 N-C:C:C:N 2477 0.0907 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 2478 0.0905 SUB348 C(~C)(~H)(~O)(~O) 2478 0.0905 PF00089 Trypsin 2479 0.0905 SUB369 C(~H)(~S) 2479 0.0905 PF00045 Hemopexin 2480 0.0905 SUB561 N-C-N-C 2480 0.0905 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 2481 0.0904 SUB615 C-C-O-C-C 2481 0.0904 PF07654 Immunoglobulin C1-set domain 2482 0.0904 SUB576 O-C-C:C-O 2482 0.0904 PF00656 Caspase domain 2483 0.0904 SUB344 C(~C)(~Cl)(~H) 2483 0.0904 PF00079 Serpin (serine protease inhibitor), 2484 0.0902 SUB446 C(-H)(-N)(=C) 2484 0.0902 PF00282 Pyridoxal-dependent decarboxylase conserved domain 2485 0.0902 SUB681 O-C-C-C-C-C 2485 0.0902 PF02770 Acyl-CoA dehydrogenase, middle domain 2486 0.0901 SUB648 O=C-N-C-N 2486 0.0901 PF03185 Calcium-activated potassium channel, beta subunit 2487 0.0900 SUB441 C(-C)(-O)(=O) 2487 0.0900 PF03098 Animal haem peroxidase 2488 0.0900 SUB490 N-C-S-C 2488 0.0900 PF04679 ATP dependent DNA ligase C terminal region 2489 0.0899 SUB442 C(-C)(=C) 2489 0.0899 PF00664 ABC transporter transmembrane region 2490 0.0899 SUB603 O=C-C-N-C 2490 0.0899 PF00045 Hemopexin 2491 0.0899 SUB618 C-C-C-O-[#1] 2491 0.0899 PF01532 Glycosyl hydrolase family 47 2492 0.0899 SUB638 O-C-C-C-C 2492 0.0899 PF02574 Homocysteine S-methyltransferase 2493 0.0899 SUB702 O-C-C-C-C-C(O)-C 2493 0.0899 PF00105 Zinc finger, C4 type (two domains), 2494 0.0898 SUB615 C-C-O-C-C 2494 0.0898 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2495 0.0897 SUB687 O=C-C-C-C-O 2495 0.0897 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 2496 0.0897 SUB683 O-C-C-C-C-N 2496 0.0897 PF00619 Caspase recruitment domain 2497 0.0897 SUB762 Oc1c(O)cccc1 2497 0.0897 PF00001 7 transmembrane receptor (rhodopsin family), 2498 0.0897 SUB674 O=C-C=C-N 2498 0.0897 PF00056 lactate/malate dehydrogenase, NAD binding domain 2499 0.0896 SUB339 C(~C)(~C)(~H)(~N) 2499 0.0896 PF00579 tRNA synthetases class I (W and Y), 2500 0.0895 SUB825 OC1C(O)CCCC1 2500 0.0895 PF00001 7 transmembrane receptor (rhodopsin family), 2501 0.0894 SUB618 C-C-C-O-[#1] 2501 0.0894 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 2502 0.0893 SUB580 O=C-C-C-C 2502 0.0893 PF03171 2OG-Fe(II), oxygenase superfamily 2503 0.0893 SUB444 C(-C)(=O) 2503 0.0893 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2504 0.0892 SUB378 C(~N)(:C)(:C) 2504 0.0892 PF00171 Aldehyde dehydrogenase family 2505 0.0892 SUB622 N-C:C:C:N 2505 0.0892 PF00017 SH2 domain 2506 0.0891 SUB572 [#1]-C-O-[#1] 2506 0.0891 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 2507 0.0891 SUB554 O=C-C=C 2507 0.0891 PF00821 Phosphoenolpyruvate carboxykinase 2508 0.0891 SUB389 C(:C)(:N)(:N) 2508 0.0891 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 2509 0.0890 SUB531 N:C-C:C 2509 0.0890 PF00291 Pyridoxal-phosphate dependent enzyme 2510 0.0889 SUB31 >= 1 P 2510 0.0889 PF00074 Pancreatic ribonuclease 2511 0.0888 SUB780 CC1CCC(N)CC1 2511 0.0888 PF01571 Aminomethyltransferase folate-binding domain 2512 0.0888 SUB261 >= 3 hetero-aromatic rings 2512 0.0888 PF04716 ETC complex I subunit conserved region 2513 0.0886 SUB517 [#1]-C=C-[#1] 2513 0.0886 PF00023 Ankyrin repeat 2514 0.0885 SUB573 N:C:N:C 2514 0.0885 PF01591 6-phosphofructo-2-kinase 2515 0.0883 SUB494 O=C-C:C 2515 0.0883 PF00102 Protein-tyrosine phosphatase 2516 0.0883 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 2516 0.0883 PF00362 Integrin, beta chain 2517 0.0882 SUB433 C(-C)(-C)(=O) 2517 0.0882 PF03953 Tubulin C-terminal domain 2518 0.0881 SUB709 C-C(C)-C-C 2518 0.0881 PF01471 Putative peptidoglycan binding domain 2519 0.0881 SUB249 >= 1 any ring size 10 2519 0.0881 PF00229 TNF(Tumour Necrosis Factor), family 2520 0.0877 SUB360 C(~C)(:N)(:N) 2520 0.0877 PF01747 ATP-sulfurylase 2521 0.0876 SUB739 Cc1cc(Cl)ccc1 2521 0.0876 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2522 0.0875 SUB672 O=C-C=C-C 2522 0.0875 PF00005 ABC transporter 2523 0.0875 SUB586 C-C:C-N-C 2523 0.0875 PF02254 TrkA-N domain 2524 0.0874 SUB717 Cc1ccc(N)cc1 2524 0.0874 PF08669 Glycine cleavage T-protein C-terminal barrel domain 2525 0.0872 SUB644 [#1]-C-C-N-[#1] 2525 0.0872 PF00051 Kringle domain 2526 0.0871 SUB510 Br-C:C-C 2526 0.0871 PF00641 Zn-finger in Ran binding protein and others 2527 0.0871 SUB440 C(-C)(-N)(=O) 2527 0.0871 PF00105 Zinc finger, C4 type (two domains), 2528 0.0870 SUB375 C(~H)(~H)(~H) 2528 0.0870 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 2529 0.0870 SUB756 Cc1c(C)cccc1 2529 0.0870 PF03098 Animal haem peroxidase 2530 0.0870 SUB531 N:C-C:C 2530 0.0870 PF11555 EGFR receptor inhibitor Mig-6 2531 0.0869 SUB345 C(~C)(~H) 2531 0.0869 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 2532 0.0869 SUB309 O-H 2532 0.0869 PF00474 Sodium:solute symporter family 2533 0.0868 SUB338 C(~C)(~C)(~C)(~O) 2533 0.0868 PF02898 Nitric oxide synthase, oxygenase domain 2534 0.0868 SUB259 >= 2 hetero-aromatic rings 2534 0.0868 PF00069 Protein kinase domain 2535 0.0868 SUB681 O-C-C-C-C-C 2535 0.0868 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 2536 0.0867 SUB333 C(~C)(~C) 2536 0.0867 PF00958 GMP synthase C terminal domain 2537 0.0866 SUB582 O=C-C-C-O 2537 0.0866 PF01202 Shikimate kinase 2538 0.0866 SUB660 O-C-C-N-C 2538 0.0866 PF01619 Proline dehydrogenase 2539 0.0866 SUB16 >= 2 N 2539 0.0866 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 2540 0.0865 SUB529 [#1]-N-C-[#1] 2540 0.0865 PF01593 Flavin containing amine oxidoreductase 2541 0.0865 SUB412 P(~O)(~O) 2541 0.0865 PF00017 SH2 domain 2542 0.0865 SUB735 Cc1cc(C)ccc1 2542 0.0865 PF03098 Animal haem peroxidase 2543 0.0864 SUB31 >= 1 P 2543 0.0864 PF00017 SH2 domain 2544 0.0864 SUB703 O-C-C-C-C-C-N-C 2544 0.0864 PF00017 SH2 domain 2545 0.0864 SUB398 N(~C)(:C)(:C) 2545 0.0864 PF10509 Galactokinase galactose-binding signature 2546 0.0864 SUB713 C-C(C)-C(C)-C 2546 0.0864 PF00452 Apoptosis regulator proteins, Bcl-2 family 2547 0.0864 SUB568 O-C-C-O 2547 0.0864 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 2548 0.0863 SUB673 O=C-C=C-[#1] 2548 0.0863 PF00001 7 transmembrane receptor (rhodopsin family), 2549 0.0863 SUB489 N-C=N-[#1] 2549 0.0863 PF00221 Phenylalanine and histidine ammonia-lyase 2550 0.0861 SUB612 N-C-C-N-C 2550 0.0861 PF09027 GTPase binding 2551 0.0861 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 2551 0.0861 PF01471 Putative peptidoglycan binding domain 2552 0.0861 SUB823 CC1C(Cl)CCCC1 2552 0.0861 PF00079 Serpin (serine protease inhibitor), 2553 0.0859 SUB548 N-C:C-N 2553 0.0859 PF05995 Cysteine dioxygenase type I 2554 0.0857 SUB261 >= 3 hetero-aromatic rings 2554 0.0857 PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2555 0.0856 SUB673 O=C-C=C-[#1] 2555 0.0856 PF08669 Glycine cleavage T-protein C-terminal barrel domain 2556 0.0856 SUB309 O-H 2556 0.0856 PF00850 Histone deacetylase domain 2557 0.0856 SUB438 C(-C)(-N)(=C) 2557 0.0856 PF00051 Kringle domain 2558 0.0854 SUB340 C(~C)(~C)(~H)(~O) 2558 0.0854 PF00520 Ion transport protein 2559 0.0853 SUB697 C-C-C-C-C-C-C-C 2559 0.0853 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2560 0.0853 SUB591 C-C:C-O-[#1] 2560 0.0853 PF00225 Kinesin motor domain 2561 0.0853 SUB309 O-H 2561 0.0853 PF00328 Histidine acid phosphatase 2562 0.0852 SUB378 C(~N)(:C)(:C) 2562 0.0852 PF08669 Glycine cleavage T-protein C-terminal barrel domain 2563 0.0852 SUB16 >= 2 N 2563 0.0852 PF01033 Somatomedin B domain 2564 0.0852 SUB561 N-C-N-C 2564 0.0852 PF00175 Oxidoreductase NAD-binding domain 2565 0.0851 SUB667 C=C-C-O-C 2565 0.0851 PF00102 Protein-tyrosine phosphatase 2566 0.0851 SUB350 C(~C)(~H)(~S) 2566 0.0851 PF06617 M-phase inducer phosphatase 2567 0.0851 SUB315 O-P 2567 0.0851 PF00316 Fructose-1-6-bisphosphatase 2568 0.0850 SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 2568 0.0850 PF00664 ABC transporter transmembrane region 2569 0.0850 SUB633 C-C-O-C:C 2569 0.0850 PF02885 Glycosyl transferase family, helical bundle domain 2570 0.0850 SUB500 N-C:C:N 2570 0.0850 PF01923 Cobalamin adenosyltransferase 2571 0.0850 SUB392 N(~C)(~C)(~C) 2571 0.0850 PF00149 Calcineurin-like phosphoesterase 2572 0.0849 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2572 0.0849 PF04800 ETC complex I subunit conserved region 2573 0.0848 SUB412 P(~O)(~O) 2573 0.0848 PF00316 Fructose-1-6-bisphosphatase 2574 0.0847 SUB336 C(~C)(~C)(~C)(~H) 2574 0.0847 PF01471 Putative peptidoglycan binding domain 2575 0.0846 SUB634 N-C-C:C-C 2575 0.0846 PF00702 haloacid dehalogenase-like hydrolase 2576 0.0846 SUB633 C-C-O-C:C 2576 0.0846 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 2577 0.0846 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 2577 0.0846 PF08040 MNLL subunit 2578 0.0846 SUB735 Cc1cc(C)ccc1 2578 0.0846 PF00104 Ligand-binding domain of nuclear hormone receptor 2579 0.0845 SUB398 N(~C)(:C)(:C) 2579 0.0845 PF00501 AMP-binding enzyme 2580 0.0845 SUB399 N(~H)(~N) 2580 0.0845 PF02025 Interleukin 5 2581 0.0845 SUB13 >= 16 C 2581 0.0845 PF00106 short chain dehydrogenase 2582 0.0844 SUB436 C(-C)(-H)(=N) 2582 0.0844 PF08127 Peptidase family C1 propeptide 2583 0.0843 SUB463 O-C-C=O 2583 0.0843 PF00224 Pyruvate kinase, barrel domain 2584 0.0843 SUB23 >= 16 O 2584 0.0843 PF00675 Insulinase (Peptidase family M16), 2585 0.0843 SUB751 Nc1cc(Cl)ccc1 2585 0.0843 PF00209 Sodium:neurotransmitter symporter family 2586 0.0841 SUB529 [#1]-N-C-[#1] 2586 0.0841 PF00069 Protein kinase domain 2587 0.0841 SUB657 C-C-N-C-C 2587 0.0841 PF00689 Cation transporting ATPase, C-terminus 2588 0.0840 SUB350 C(~C)(~H)(~S) 2588 0.0840 PF00557 Metallopeptidase family M24 2589 0.0839 SUB681 O-C-C-C-C-C 2589 0.0839 PF00324 Amino acid permease 2590 0.0839 SUB572 [#1]-C-O-[#1] 2590 0.0839 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2591 0.0839 SUB810 SC1CC(N)CCC1 2591 0.0839 PF03372 Endonuclease/Exonuclease/phosphatase family 2592 0.0839 SUB489 N-C=N-[#1] 2592 0.0839 PF04679 ATP dependent DNA ligase C terminal region 2593 0.0838 SUB572 [#1]-C-O-[#1] 2593 0.0838 PF01369 Sec7 domain 2594 0.0838 SUB702 O-C-C-C-C-C(O)-C 2594 0.0838 PF01055 Glycosyl hydrolases family 31 2595 0.0837 SUB681 O-C-C-C-C-C 2595 0.0837 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 2596 0.0836 SUB675 N-C-N-C:C 2596 0.0836 PF00069 Protein kinase domain 2597 0.0836 SUB407 O(~C)(~H) 2597 0.0836 PF00474 Sodium:solute symporter family 2598 0.0833 SUB683 O-C-C-C-C-N 2598 0.0833 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 2599 0.0832 SUB567 O-C-C-N 2599 0.0832 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 2600 0.0831 SUB4 >= 32 H 2600 0.0831 PF01118 Semialdehyde dehydrogenase, NAD binding domain 2601 0.0829 SUB683 O-C-C-C-C-N 2601 0.0829 PF02310 B12 binding domain 2602 0.0826 SUB411 P(~C)(~C) 2602 0.0826 PF00069 Protein kinase domain 2603 0.0826 SUB644 [#1]-C-C-N-[#1] 2603 0.0826 PF00204 DNA gyrase B 2604 0.0826 SUB683 O-C-C-C-C-N 2604 0.0826 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 2605 0.0825 SUB302 N-O 2605 0.0825 PF01327 Polypeptide deformylase 2606 0.0825 SUB3 >= 16 H 2606 0.0825 PF00106 short chain dehydrogenase 2607 0.0825 SUB408 O(~C)(~P) 2607 0.0825 PF01704 UTP--glucose-1-phosphate uridylyltransferase 2608 0.0823 SUB820 CC1C(O)CCCC1 2608 0.0823 PF00554 Rel homology domain (RHD), 2609 0.0822 SUB714 Cc1ccc(C)cc1 2609 0.0822 PF00754 F5/8 type C domain 2610 0.0820 SUB603 O=C-C-N-C 2610 0.0820 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 2611 0.0816 SUB615 C-C-O-C-C 2611 0.0816 PF00714 Interferon gamma 2612 0.0816 SUB695 O=C-C-C-C-C=O 2612 0.0816 PF00023 Ankyrin repeat 2613 0.0813 SUB376 C(~N)(~N) 2613 0.0813 PF02867 Ribonucleotide reductase, barrel domain 2614 0.0813 SUB336 C(~C)(~C)(~C)(~H) 2614 0.0813 PF01039 Carboxyl transferase domain 2615 0.0812 SUB556 N=C-C=C 2615 0.0812 PF00001 7 transmembrane receptor (rhodopsin family), 2616 0.0812 SUB367 C(~H)(~O) 2616 0.0812 PF00043 Glutathione S-transferase, C-terminal domain 2617 0.0811 SUB655 N-C-N-C-C 2617 0.0811 PF06512 Sodium ion transport-associated 2618 0.0810 SUB698 C-C-C-C-C-C(C)-C 2618 0.0810 PF00092 von Willebrand factor type A domain 2619 0.0810 SUB712 C-C(C)(C)-C-C 2619 0.0810 PF00653 Inhibitor of Apoptosis domain 2620 0.0809 SUB705 O=C-C-C-C-C-C-C 2620 0.0809 PF03099 Biotin/lipoate A/B protein ligase family 2621 0.0809 SUB362 C(~Cl)(~H) 2621 0.0809 PF08377 MAP2/Tau projection domain 2622 0.0806 SUB14 >= 32 C 2622 0.0806 PF00104 Ligand-binding domain of nuclear hormone receptor 2623 0.0805 SUB426 P=O 2623 0.0805 PF00018 SH3 domain 2624 0.0804 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 2624 0.0804 PF00341 Platelet-derived growth factor (PDGF), 2625 0.0804 SUB452 C(-N)(=O) 2625 0.0804 PF02008 CXXC zinc finger domain 2626 0.0802 SUB16 >= 2 N 2626 0.0802 PF01223 DNA/RNA non-specific endonuclease 2627 0.0801 SUB335 C(~C)(~C)(~C)(~C) 2627 0.0801 PF00439 Bromodomain 2628 0.0800 SUB407 O(~C)(~H) 2628 0.0800 PF02770 Acyl-CoA dehydrogenase, middle domain 2629 0.0800 SUB466 O=S-C-C 2629 0.0800 PF00690 Cation transporter/ATPase, N-terminus 2630 0.0800 SUB165 >= 4 any ring size 5 2630 0.0800 PF01437 Plexin repeat 2631 0.0798 SUB683 O-C-C-C-C-N 2631 0.0798 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 2632 0.0798 SUB564 O-C-O-C 2632 0.0798 PF07654 Immunoglobulin C1-set domain 2633 0.0798 SUB622 N-C:C:C:N 2633 0.0798 PF01017 STAT protein, all-alpha domain 2634 0.0797 SUB574 O-C-C=C 2634 0.0797 PF00822 PMP-22/EMP/MP20/Claudin family 2635 0.0796 SUB681 O-C-C-C-C-C 2635 0.0796 PF01094 Receptor family ligand binding region 2636 0.0796 SUB339 C(~C)(~C)(~H)(~N) 2636 0.0796 PF05649 Peptidase family M13 2637 0.0796 SUB375 C(~H)(~H)(~H) 2637 0.0796 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2638 0.0795 SUB431 C(-C)(-C)(=C) 2638 0.0795 PF00667 FAD binding domain 2639 0.0795 SUB158 >= 3 any ring size 5 2639 0.0795 PF01257 Respiratory-chain NADH dehydrogenase 24 Kd subunit 2640 0.0794 SUB402 N(~O)(~O) 2640 0.0794 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 2641 0.0792 SUB462 O-C-C=N 2641 0.0792 PF01212 Beta-eliminating lyase 2642 0.0791 SUB462 O-C-C=N 2642 0.0791 PF08742 C8 domain 2643 0.0790 SUB677 N#C-C-C-C 2643 0.0790 PF00104 Ligand-binding domain of nuclear hormone receptor 2644 0.0790 SUB704 O-C-C-C-C-C(N)-C 2644 0.0790 PF08742 C8 domain 2645 0.0789 SUB522 C:N-C-[#1] 2645 0.0789 PF00069 Protein kinase domain 2646 0.0788 SUB529 [#1]-N-C-[#1] 2646 0.0788 PF01597 Glycine cleavage H-protein 2647 0.0787 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 2647 0.0787 PF00341 Platelet-derived growth factor (PDGF), 2648 0.0787 SUB407 O(~C)(~H) 2648 0.0787 PF00175 Oxidoreductase NAD-binding domain 2649 0.0784 SUB702 O-C-C-C-C-C(O)-C 2649 0.0784 PF00088 Trefoil (P-type), domain 2650 0.0784 SUB717 Cc1ccc(N)cc1 2650 0.0784 PF00089 Trypsin 2651 0.0784 SUB389 C(:C)(:N)(:N) 2651 0.0784 PF00300 Phosphoglycerate mutase family 2652 0.0784 SUB151 >= 2 any ring size 5 2652 0.0784 PF09027 GTPase binding 2653 0.0783 SUB294 C-S 2653 0.0783 PF00433 Protein kinase C terminal domain 2654 0.0783 SUB602 N-C:C:C-N 2654 0.0783 PF00017 SH2 domain 2655 0.0782 SUB522 C:N-C-[#1] 2655 0.0782 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 2656 0.0782 SUB460 S(=O)(=O) 2656 0.0782 PF03098 Animal haem peroxidase 2657 0.0781 SUB151 >= 2 any ring size 5 2657 0.0781 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2658 0.0780 SUB738 Cc1cc(N)ccc1 2658 0.0780 PF01403 Sema domain 2659 0.0780 SUB375 C(~H)(~H)(~H) 2659 0.0780 PF00149 Calcineurin-like phosphoesterase 2660 0.0779 SUB554 O=C-C=C 2660 0.0779 PF00171 Aldehyde dehydrogenase family 2661 0.0778 SUB686 O=C-C-C-C-N 2661 0.0778 PF02637 GatB domain 2662 0.0778 SUB408 O(~C)(~P) 2662 0.0778 PF02441 Flavoprotein 2663 0.0778 SUB1 >= 4 H 2663 0.0778 PF00560 Leucine Rich Repeat 2664 0.0776 SUB354 C(~C)(~S) 2664 0.0776 PF00689 Cation transporting ATPase, C-terminus 2665 0.0775 SUB555 Br-C-C-C 2665 0.0775 PF02201 SWIB/MDM2 domain 2666 0.0774 SUB743 Oc1cc(N)ccc1 2666 0.0774 PF10582 Gap junction channel protein cysteine-rich domain 2667 0.0774 SUB657 C-C-N-C-C 2667 0.0774 PF00194 Eukaryotic-type carbonic anhydrase 2668 0.0773 SUB693 O=C-C-C-C-C-C 2668 0.0773 PF08127 Peptidase family C1 propeptide 2669 0.0773 SUB759 Cc1c(N)cccc1 2669 0.0773 PF01401 Angiotensin-converting enzyme 2670 0.0772 SUB700 O-C-C-C-C-C(C)-C 2670 0.0772 PF00520 Ion transport protein 2671 0.0771 SUB705 O=C-C-C-C-C-C-C 2671 0.0771 PF00474 Sodium:solute symporter family 2672 0.0771 SUB662 O-C-O-C-C 2672 0.0771 PF00041 Fibronectin type III domain 2673 0.0770 SUB642 O-C-C-C=C 2673 0.0770 PF03098 Animal haem peroxidase 2674 0.0770 SUB168 >= 4 saturated or aromatic heteroatom-containing ring size 5 2674 0.0770 PF01403 Sema domain 2675 0.0769 SUB341 C(~C)(~C)(~N) 2675 0.0769 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2676 0.0769 SUB195 >= 3 saturated or aromatic nitrogen-containing ring size 6 2676 0.0769 PF01462 Leucine rich repeat N-terminal domain 2677 0.0769 SUB379 C(~N)(:C)(:N) 2677 0.0769 PF02803 Thiolase, C-terminal domain 2678 0.0767 SUB695 O=C-C-C-C-C=O 2678 0.0767 PF02637 GatB domain 2679 0.0766 SUB801 CC1CC(N)CCC1 2679 0.0766 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2680 0.0764 SUB35 >= 2 S 2680 0.0764 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2681 0.0762 SUB14 >= 32 C 2681 0.0762 PF06448 Domain of Unknown Function (DUF1081), 2682 0.0761 SUB615 C-C-O-C-C 2682 0.0761 PF00079 Serpin (serine protease inhibitor), 2683 0.0760 SUB32 >= 2 P 2683 0.0760 PF00074 Pancreatic ribonuclease 2684 0.0760 SUB618 C-C-C-O-[#1] 2684 0.0760 PF00079 Serpin (serine protease inhibitor), 2685 0.0760 SUB457 P(-O)(=O) 2685 0.0760 PF02886 LBP / BPI / CETP family, C-terminal domain 2686 0.0760 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 2686 0.0760 PF01731 Arylesterase 2687 0.0759 SUB13 >= 16 C 2687 0.0759 PF00650 CRAL/TRIO domain 2688 0.0759 SUB706 O=C-C-C-C-C(O)-C 2688 0.0759 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 2689 0.0758 SUB695 O=C-C-C-C-C=O 2689 0.0758 PF03024 Folate receptor family 2690 0.0757 SUB606 O=C-C-O-C 2690 0.0757 PF01388 ARID/BRIGHT DNA binding domain 2691 0.0757 SUB639 O-C-C-C-N 2691 0.0757 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 2692 0.0756 SUB722 Oc1ccc(N)cc1 2692 0.0756 PF06512 Sodium ion transport-associated 2693 0.0756 SUB431 C(-C)(-C)(=C) 2693 0.0756 PF00067 Cytochrome P450 2694 0.0755 SUB717 Cc1ccc(N)cc1 2694 0.0755 PF00258 Flavodoxin 2695 0.0754 SUB503 N-C=C-[#1] 2695 0.0754 PF03949 Malic enzyme, NAD binding domain 2696 0.0754 SUB372 C(~H)(:C)(:C) 2696 0.0754 PF00001 7 transmembrane receptor (rhodopsin family), 2697 0.0754 SUB700 O-C-C-C-C-C(C)-C 2697 0.0754 PF02159 Oestrogen receptor 2698 0.0753 SUB735 Cc1cc(C)ccc1 2698 0.0753 PF08491 Squalene epoxidase 2699 0.0752 SUB439 C(-C)(-N)(=N) 2699 0.0752 PF01747 ATP-sulfurylase 2700 0.0751 SUB674 O=C-C=C-N 2700 0.0751 PF10526 NADH-ubiquinone reductase complex 1 MLRQ subunit 2701 0.0750 SUB735 Cc1cc(C)ccc1 2701 0.0750 PF00069 Protein kinase domain 2702 0.0750 SUB600 [#1]-C-C=C-[#1] 2702 0.0750 PF00104 Ligand-binding domain of nuclear hormone receptor 2703 0.0749 SUB32 >= 2 P 2703 0.0749 PF00619 Caspase recruitment domain 2704 0.0749 SUB315 O-P 2704 0.0749 PF02441 Flavoprotein 2705 0.0748 SUB572 [#1]-C-O-[#1] 2705 0.0748 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 2706 0.0748 SUB511 [#1]-N-N-[#1] 2706 0.0748 PF01179 Copper amine oxidase, enzyme domain 2707 0.0748 SUB710 C-C(C)-C-C-C 2707 0.0748 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2708 0.0747 SUB339 C(~C)(~C)(~H)(~N) 2708 0.0747 PF04072 Leucine carboxyl methyltransferase 2709 0.0746 SUB682 O-C-C-C-C-O 2709 0.0746 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 2710 0.0746 SUB771 Nc1c(N)cccc1 2710 0.0746 PF01923 Cobalamin adenosyltransferase 2711 0.0745 SUB2 >= 8 H 2711 0.0745 PF00474 Sodium:solute symporter family 2712 0.0743 SUB288 C-F 2712 0.0743 PF08996 DNA Polymerase alpha zinc finger 2713 0.0743 SUB537 O=C-C-N 2713 0.0743 PF00045 Hemopexin 2714 0.0741 SUB703 O-C-C-C-C-C-N-C 2714 0.0741 PF02274 Amidinotransferase 2715 0.0740 SUB535 S-C:C-O 2715 0.0740 PF00001 7 transmembrane receptor (rhodopsin family), 2716 0.0740 SUB717 Cc1ccc(N)cc1 2716 0.0740 PF00175 Oxidoreductase NAD-binding domain 2717 0.0739 SUB763 Oc1c(S)cccc1 2717 0.0739 PF00001 7 transmembrane receptor (rhodopsin family), 2718 0.0739 SUB449 C(-H)(=O) 2718 0.0739 PF00112 Papain family cysteine protease 2719 0.0738 SUB576 O-C-C:C-O 2719 0.0738 PF00571 CBS domain 2720 0.0738 SUB408 O(~C)(~P) 2720 0.0738 PF00316 Fructose-1-6-bisphosphatase 2721 0.0736 SUB398 N(~C)(:C)(:C) 2721 0.0736 PF08544 GHMP kinases C terminal 2722 0.0736 SUB697 C-C-C-C-C-C-C-C 2722 0.0736 PF08399 VWA N-terminal 2723 0.0734 SUB446 C(-H)(-N)(=C) 2723 0.0734 PF00357 Integrin alpha cytoplasmic region 2724 0.0733 SUB684 N-C-C-C-C-C 2724 0.0733 PF02159 Oestrogen receptor 2725 0.0733 SUB548 N-C:C-N 2725 0.0733 PF01923 Cobalamin adenosyltransferase 2726 0.0732 SUB834 NC1C(N)CCCC1 2726 0.0732 PF00001 7 transmembrane receptor (rhodopsin family), 2727 0.0731 SUB618 C-C-C-O-[#1] 2727 0.0731 PF00128 Alpha amylase, catalytic domain 2728 0.0731 SUB259 >= 2 hetero-aromatic rings 2728 0.0731 PF00067 Cytochrome P450 2729 0.0730 SUB481 C:S:C-C 2729 0.0730 PF00001 7 transmembrane receptor (rhodopsin family), 2730 0.0730 SUB686 O=C-C-C-C-N 2730 0.0730 PF00202 Aminotransferase class-III 2731 0.0729 SUB263 >= 4 hetero-aromatic rings 2731 0.0729 PF01437 Plexin repeat 2732 0.0729 SUB417 C=C 2732 0.0729 PF00001 7 transmembrane receptor (rhodopsin family), 2733 0.0728 SUB640 O-C-C-C-O 2733 0.0728 PF00714 Interferon gamma 2734 0.0727 SUB664 O-C-C-O-[#1] 2734 0.0727 PF01712 Deoxynucleoside kinase 2735 0.0725 SUB664 O-C-C-O-[#1] 2735 0.0725 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 2736 0.0725 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 2736 0.0725 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 2737 0.0725 SUB417 C=C 2737 0.0725 PF00664 ABC transporter transmembrane region 2738 0.0725 SUB444 C(-C)(=O) 2738 0.0725 PF00557 Metallopeptidase family M24 2739 0.0724 SUB834 NC1C(N)CCCC1 2739 0.0724 PF00454 Phosphatidylinositol 3- and 4-kinase 2740 0.0724 SUB696 O=C-C-C-C-C-N 2740 0.0724 PF03068 Protein-arginine deiminase (PAD), 2741 0.0723 SUB466 O=S-C-C 2741 0.0723 PF00689 Cation transporting ATPase, C-terminus 2742 0.0723 SUB34 >= 1 S 2742 0.0723 PF00060 Ligand-gated ion channel 2743 0.0721 SUB801 CC1CC(N)CCC1 2743 0.0721 PF01833 IPT/TIG domain 2744 0.0721 SUB771 Nc1c(N)cccc1 2744 0.0721 PF01833 IPT/TIG domain 2745 0.0721 SUB577 N=C-C:C-[#1] 2745 0.0721 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 2746 0.0719 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2746 0.0719 PF00248 Aldo/keto reductase family 2747 0.0719 SUB633 C-C-O-C:C 2747 0.0719 PF00233 3"5"-cyclic nucleotide phosphodiesterase 2748 0.0719 SUB793 NC1CCC(Cl)CC1 2748 0.0719 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2749 0.0718 SUB660 O-C-C-N-C 2749 0.0718 PF01569 PAP2 superfamily 2750 0.0717 SUB613 N-C-O-C-C 2750 0.0717 PF00211 Adenylate and Guanylate cyclase catalytic domain 2751 0.0716 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 2751 0.0716 PF00001 7 transmembrane receptor (rhodopsin family), 2752 0.0716 SUB396 N(~C)(~O) 2752 0.0716 PF01180 Dihydroorotate dehydrogenase 2753 0.0716 SUB615 C-C-O-C-C 2753 0.0716 PF00571 CBS domain 2754 0.0716 SUB743 Oc1cc(N)ccc1 2754 0.0716 PF00094 von Willebrand factor type D domain 2755 0.0715 SUB261 >= 3 hetero-aromatic rings 2755 0.0715 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 2756 0.0715 SUB540 N=C-C-[#1] 2756 0.0715 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 2757 0.0713 SUB610 Cl-C-C-N-C 2757 0.0713 PF08377 MAP2/Tau projection domain 2758 0.0713 SUB765 Oc1c(Cl)cccc1 2758 0.0713 PF00001 7 transmembrane receptor (rhodopsin family), 2759 0.0710 SUB544 O-C:C-N 2759 0.0710 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 2760 0.0710 SUB389 C(:C)(:N)(:N) 2760 0.0710 PF00248 Aldo/keto reductase family 2761 0.0709 SUB51 >= 1 Mg 2761 0.0709 PF08763 Voltage gated calcium channel IQ domain 2762 0.0709 SUB685 O=C-C-C-C-C 2762 0.0709 PF00248 Aldo/keto reductase family 2763 0.0708 SUB350 C(~C)(~H)(~S) 2763 0.0708 PF08441 Integrin alpha 2764 0.0707 SUB538 O=C-C-O 2764 0.0707 PF02887 Pyruvate kinase, alpha/beta domain 2765 0.0707 SUB441 C(-C)(-O)(=O) 2765 0.0707 PF00105 Zinc finger, C4 type (two domains), 2766 0.0706 SUB673 O=C-C=C-[#1] 2766 0.0706 PF00089 Trypsin 2767 0.0706 SUB200 >= 4 any ring size 6 2767 0.0706 PF03137 Organic Anion Transporter Polypeptide (OATP), family 2768 0.0704 SUB738 Cc1cc(N)ccc1 2768 0.0704 PF00792 Phosphoinositide 3-kinase C2 2769 0.0704 SUB446 C(-H)(-N)(=C) 2769 0.0704 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 2770 0.0704 SUB603 O=C-C-N-C 2770 0.0704 PF00413 Matrixin 2771 0.0703 SUB381 C(~O)(~O) 2771 0.0703 PF00209 Sodium:neurotransmitter symporter family 2772 0.0702 SUB582 O=C-C-C-O 2772 0.0702 PF00271 Helicase conserved C-terminal domain 2773 0.0702 SUB586 C-C:C-N-C 2773 0.0702 PF00550 Phosphopantetheine attachment site 2774 0.0700 SUB398 N(~C)(:C)(:C) 2774 0.0700 PF00354 Pentaxin family 2775 0.0699 SUB637 C-N-C-N-C 2775 0.0699 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2776 0.0699 SUB350 C(~C)(~H)(~S) 2776 0.0699 PF00581 Rhodanese-like domain 2777 0.0698 SUB1 >= 4 H 2777 0.0698 PF00107 Zinc-binding dehydrogenase 2778 0.0698 SUB655 N-C-N-C-C 2778 0.0698 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 2779 0.0697 SUB348 C(~C)(~H)(~O)(~O) 2779 0.0697 PF00236 Glycoprotein hormone 2780 0.0697 SUB440 C(-C)(-N)(=O) 2780 0.0697 PF00622 SPRY domain 2781 0.0696 SUB639 O-C-C-C-N 2781 0.0696 PF02180 Bcl-2 homology region 4 2782 0.0695 SUB528 C:C:N-[#1] 2782 0.0695 PF00001 7 transmembrane receptor (rhodopsin family), 2783 0.0695 SUB613 N-C-O-C-C 2783 0.0695 PF00001 7 transmembrane receptor (rhodopsin family), 2784 0.0695 SUB625 O=C-C:C-N 2784 0.0695 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 2785 0.0695 SUB691 O-C-C-C-C-C-O 2785 0.0695 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2786 0.0694 SUB548 N-C:C-N 2786 0.0694 PF00156 Phosphoribosyl transferase domain 2787 0.0694 SUB315 O-P 2787 0.0694 PF00018 SH3 domain 2788 0.0694 SUB696 O=C-C-C-C-C-N 2788 0.0694 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 2789 0.0693 SUB158 >= 3 any ring size 5 2789 0.0693 PF04716 ETC complex I subunit conserved region 2790 0.0692 SUB643 O-C-C-C=O 2790 0.0692 PF03034 Phosphatidyl serine synthase 2791 0.0692 SUB704 O-C-C-C-C-C(N)-C 2791 0.0692 PF00094 von Willebrand factor type D domain 2792 0.0691 SUB412 P(~O)(~O) 2792 0.0691 PF00018 SH3 domain 2793 0.0690 SUB646 O=C-N-C-C 2793 0.0690 PF00079 Serpin (serine protease inhibitor), 2794 0.0690 SUB640 O-C-C-C-O 2794 0.0690 PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 2795 0.0689 SUB739 Cc1cc(Cl)ccc1 2795 0.0689 PF00989 PAS fold 2796 0.0688 SUB603 O=C-C-N-C 2796 0.0688 PF02798 Glutathione S-transferase, N-terminal domain 2797 0.0688 SUB594 N-C-C-C-N 2797 0.0688 PF00057 Low-density lipoprotein receptor domain class A 2798 0.0688 SUB696 O=C-C-C-C-C-N 2798 0.0688 PF01467 Cytidylyltransferase 2799 0.0688 SUB459 S(-O)(=O) 2799 0.0688 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 2800 0.0688 SUB757 Cc1c(O)cccc1 2800 0.0688 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2801 0.0687 SUB22 >= 8 O 2801 0.0687 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2802 0.0687 SUB218 >= 1 unsaturated non-aromatic carbon-only ring size 7 2802 0.0687 PF03953 Tubulin C-terminal domain 2803 0.0687 SUB548 N-C:C-N 2803 0.0687 PF00221 Phenylalanine and histidine ammonia-lyase 2804 0.0685 SUB629 C-N-C-C:C 2804 0.0685 PF00069 Protein kinase domain 2805 0.0684 SUB374 C(~H)(:N) 2805 0.0684 PF02196 Raf-like Ras-binding domain 2806 0.0683 SUB620 O-C-C=C-C 2806 0.0683 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2807 0.0683 SUB365 C(~F)(:C) 2807 0.0683 PF00071 Ras family 2808 0.0683 SUB622 N-C:C:C:N 2808 0.0683 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2809 0.0682 SUB476 S-C=N-C 2809 0.0682 PF05193 Peptidase M16 inactive domain 2810 0.0681 SUB653 O-C:C:C-N 2810 0.0681 PF05790 Immunoglobulin C2-set domain 2811 0.0681 SUB703 O-C-C-C-C-C-N-C 2811 0.0681 PF00214 Calcitonin / CGRP / IAPP family 2812 0.0680 SUB22 >= 8 O 2812 0.0680 PF02666 Phosphatidylserine decarboxylase 2813 0.0680 SUB606 O=C-C-O-C 2813 0.0680 PF03171 2OG-Fe(II), oxygenase superfamily 2814 0.0680 SUB38 >= 1 Cl 2814 0.0680 PF00689 Cation transporting ATPase, C-terminus 2815 0.0679 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 2815 0.0679 PF00211 Adenylate and Guanylate cyclase catalytic domain 2816 0.0678 SUB643 O-C-C-C=O 2816 0.0678 PF01187 Macrophage migration inhibitory factor (MIF), 2817 0.0677 SUB406 O(~C)(~C) 2817 0.0677 PF00057 Low-density lipoprotein receptor domain class A 2818 0.0675 SUB702 O-C-C-C-C-C(O)-C 2818 0.0675 PF00236 Glycoprotein hormone 2819 0.0675 SUB375 C(~H)(~H)(~H) 2819 0.0675 PF00105 Zinc finger, C4 type (two domains), 2820 0.0674 SUB708 O=C-C-C-C-C(N)-C 2820 0.0674 PF08669 Glycine cleavage T-protein C-terminal barrel domain 2821 0.0673 SUB32 >= 2 P 2821 0.0673 PF00288 GHMP kinases N terminal domain 2822 0.0673 SUB486 N:C:C:N 2822 0.0673 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 2823 0.0671 SUB336 C(~C)(~C)(~C)(~H) 2823 0.0671 PF04704 Zfx / Zfy transcription activation region 2824 0.0670 SUB577 N=C-C:C-[#1] 2824 0.0670 PF03073 TspO/MBR family 2825 0.0670 SUB340 C(~C)(~C)(~H)(~O) 2825 0.0670 PF00248 Aldo/keto reductase family 2826 0.0668 SUB612 N-C-C-N-C 2826 0.0668 PF00689 Cation transporting ATPase, C-terminus 2827 0.0666 SUB476 S-C=N-C 2827 0.0666 PF04679 ATP dependent DNA ligase C terminal region 2828 0.0666 SUB543 O-C:C-[#1] 2828 0.0666 PF00001 7 transmembrane receptor (rhodopsin family), 2829 0.0664 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 2829 0.0664 PF00204 DNA gyrase B 2830 0.0661 SUB444 C(-C)(=O) 2830 0.0661 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2831 0.0660 SUB31 >= 1 P 2831 0.0660 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 2832 0.0660 SUB771 Nc1c(N)cccc1 2832 0.0660 PF00175 Oxidoreductase NAD-binding domain 2833 0.0659 SUB694 O=C-C-C-C-C-O 2833 0.0659 PF00023 Ankyrin repeat 2834 0.0658 SUB541 C-N-C-[#1] 2834 0.0658 PF00209 Sodium:neurotransmitter symporter family 2835 0.0658 SUB378 C(~N)(:C)(:C) 2835 0.0658 PF00092 von Willebrand factor type A domain 2836 0.0657 SUB258 >= 2 aromatic rings 2836 0.0657 PF00675 Insulinase (Peptidase family M16), 2837 0.0656 SUB572 [#1]-C-O-[#1] 2837 0.0656 PF05221 S-adenosyl-L-homocysteine hydrolase 2838 0.0655 SUB406 O(~C)(~C) 2838 0.0655 PF00168 C2 domain 2839 0.0655 SUB683 O-C-C-C-C-N 2839 0.0655 PF01571 Aminomethyltransferase folate-binding domain 2840 0.0654 SUB589 O=C-C-C=O 2840 0.0654 PF00405 Transferrin 2841 0.0654 SUB454 N(-C)(=C) 2841 0.0654 PF00464 Serine hydroxymethyltransferase 2842 0.0654 SUB618 C-C-C-O-[#1] 2842 0.0654 PF00224 Pyruvate kinase, barrel domain 2843 0.0654 SUB441 C(-C)(-O)(=O) 2843 0.0654 PF00074 Pancreatic ribonuclease 2844 0.0653 SUB614 C-N-C-C-C 2844 0.0653 PF00520 Ion transport protein 2845 0.0653 SUB200 >= 4 any ring size 6 2845 0.0653 PF08763 Voltage gated calcium channel IQ domain 2846 0.0652 SUB708 O=C-C-C-C-C(N)-C 2846 0.0652 PF01403 Sema domain 2847 0.0651 SUB11 >= 4 C 2847 0.0651 PF00337 Galactoside-binding lectin 2848 0.0649 SUB696 O=C-C-C-C-C-N 2848 0.0649 PF00058 Low-density lipoprotein receptor repeat class B 2849 0.0649 SUB242 >= 1 any ring size 9 2849 0.0649 PF00067 Cytochrome P450 2850 0.0648 SUB738 Cc1cc(N)ccc1 2850 0.0648 PF00017 SH2 domain 2851 0.0648 SUB379 C(~N)(:C)(:N) 2851 0.0648 PF00069 Protein kinase domain 2852 0.0648 SUB690 O-C-C-C-C-C-C 2852 0.0648 PF07706 Aminotransferase ubiquitination site 2853 0.0647 SUB683 O-C-C-C-C-N 2853 0.0647 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2854 0.0647 SUB4 >= 32 H 2854 0.0647 PF00273 Serum albumin family 2855 0.0647 SUB496 C-N-C:C 2855 0.0647 PF00702 haloacid dehalogenase-like hydrolase 2856 0.0647 SUB687 O=C-C-C-C-O 2856 0.0647 PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term 2857 0.0646 SUB10 >= 2 C 2857 0.0646 PF03160 Calx-beta domain 2858 0.0646 SUB360 C(~C)(:N)(:N) 2858 0.0646 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 2859 0.0645 SUB511 [#1]-N-N-[#1] 2859 0.0645 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 2860 0.0645 SUB452 C(-N)(=O) 2860 0.0645 PF00045 Hemopexin 2861 0.0645 SUB258 >= 2 aromatic rings 2861 0.0645 PF00069 Protein kinase domain 2862 0.0645 SUB538 O=C-C-O 2862 0.0645 PF00091 Tubulin/FtsZ family, GTPase domain 2863 0.0644 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 2863 0.0644 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 2864 0.0642 SUB360 C(~C)(:N)(:N) 2864 0.0642 PF00300 Phosphoglycerate mutase family 2865 0.0642 SUB567 O-C-C-N 2865 0.0642 PF01597 Glycine cleavage H-protein 2866 0.0642 SUB515 O-N-C-C 2866 0.0642 PF01180 Dihydroorotate dehydrogenase 2867 0.0640 SUB618 C-C-C-O-[#1] 2867 0.0640 PF02574 Homocysteine S-methyltransferase 2868 0.0640 SUB664 O-C-C-O-[#1] 2868 0.0640 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 2869 0.0639 SUB664 O-C-C-O-[#1] 2869 0.0639 PF00535 Glycosyl transferase family 2 2870 0.0638 SUB646 O=C-N-C-C 2870 0.0638 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 2871 0.0638 SUB537 O=C-C-N 2871 0.0638 PF00291 Pyridoxal-phosphate dependent enzyme 2872 0.0638 SUB597 N=C-N-C-C 2872 0.0638 PF02807 ATP:guanido phosphotransferase, N-terminal domain 2873 0.0637 SUB160 >= 3 saturated or aromatic nitrogen-containing ring size 5 2873 0.0637 PF04679 ATP dependent DNA ligase C terminal region 2874 0.0637 SUB802 CC1CC(Cl)CCC1 2874 0.0637 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2875 0.0636 SUB215 >= 1 saturated or aromatic carbon-only ring size 7 2875 0.0636 PF00520 Ion transport protein 2876 0.0635 SUB548 N-C:C-N 2876 0.0635 PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit 2877 0.0634 SUB711 C-C-C(C)-C-C 2877 0.0634 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2878 0.0632 SUB550 N-C-C:C 2878 0.0632 PF01234 NNMT/PNMT/TEMT family 2879 0.0632 SUB595 C-O-C-C=C 2879 0.0632 PF00102 Protein-tyrosine phosphatase 2880 0.0631 SUB441 C(-C)(-O)(=O) 2880 0.0631 PF02807 ATP:guanido phosphotransferase, N-terminal domain 2881 0.0630 SUB16 >= 2 N 2881 0.0630 PF00822 PMP-22/EMP/MP20/Claudin family 2882 0.0630 SUB644 [#1]-C-C-N-[#1] 2882 0.0630 PF03002 Somatostatin/Cortistatin family 2883 0.0628 SUB703 O-C-C-C-C-C-N-C 2883 0.0628 PF00571 CBS domain 2884 0.0628 SUB435 C(-C)(-H)(=C) 2884 0.0628 PF00067 Cytochrome P450 2885 0.0627 SUB613 N-C-O-C-C 2885 0.0627 PF00316 Fructose-1-6-bisphosphatase 2886 0.0625 SUB616 N-C-C-O-C 2886 0.0625 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 2887 0.0625 SUB461 C-C-C#C 2887 0.0625 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 2888 0.0624 SUB759 Cc1c(N)cccc1 2888 0.0624 PF00579 tRNA synthetases class I (W and Y), 2889 0.0623 SUB343 C(~C)(~Cl) 2889 0.0623 PF03530 Calcium-activated SK potassium channel 2890 0.0622 SUB231 >= 1 saturated or aromatic heteroatom-containing ring size 8 2890 0.0622 PF00001 7 transmembrane receptor (rhodopsin family), 2891 0.0622 SUB201 >= 4 saturated or aromatic carbon-only ring size 6 2891 0.0622 PF00104 Ligand-binding domain of nuclear hormone receptor 2892 0.0622 SUB698 C-C-C-C-C-C(C)-C 2892 0.0622 PF00026 Eukaryotic aspartyl protease 2893 0.0621 SUB637 C-N-C-N-C 2893 0.0621 PF00757 Furin-like cysteine rich region 2894 0.0618 SUB696 O=C-C-C-C-C-N 2894 0.0618 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 2895 0.0618 SUB643 O-C-C-C=O 2895 0.0618 PF00005 ABC transporter 2896 0.0617 SUB711 C-C-C(C)-C-C 2896 0.0617 PF00229 TNF(Tumour Necrosis Factor), family 2897 0.0617 SUB494 O=C-C:C 2897 0.0617 PF00105 Zinc finger, C4 type (two domains), 2898 0.0617 SUB339 C(~C)(~C)(~H)(~N) 2898 0.0617 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 2899 0.0617 SUB618 C-C-C-O-[#1] 2899 0.0617 PF01279 Parathyroid hormone family 2900 0.0617 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 2900 0.0617 PF08070 DTHCT (NUC029), region 2901 0.0617 SUB338 C(~C)(~C)(~C)(~O) 2901 0.0617 PF00068 Phospholipase A2 2902 0.0616 SUB665 C-C=C-C=C 2902 0.0616 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 2903 0.0616 SUB760 Cc1c(Cl)cccc1 2903 0.0616 PF07686 Immunoglobulin V-set domain 2904 0.0616 SUB145 >= 1 saturated or aromatic carbon-only ring size 5 2904 0.0616 PF00884 Sulfatase 2905 0.0614 SUB45 >= 2 Br 2905 0.0614 PF02201 SWIB/MDM2 domain 2906 0.0614 SUB717 Cc1ccc(N)cc1 2906 0.0614 PF03372 Endonuclease/Exonuclease/phosphatase family 2907 0.0614 SUB616 N-C-C-O-C 2907 0.0614 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2908 0.0614 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 2908 0.0614 PF03807 NADP oxidoreductase coenzyme F420-dependent 2909 0.0612 SUB567 O-C-C-N 2909 0.0612 PF00458 WHEP-TRS domain 2910 0.0612 SUB32 >= 2 P 2910 0.0612 PF00071 Ras family 2911 0.0612 SUB703 O-C-C-C-C-C-N-C 2911 0.0612 PF01323 DSBA-like thioredoxin domain 2912 0.0611 SUB529 [#1]-N-C-[#1] 2912 0.0611 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 2913 0.0610 SUB644 [#1]-C-C-N-[#1] 2913 0.0610 PF00089 Trypsin 2914 0.0610 SUB495 O=C-C:N 2914 0.0610 PF07690 Major Facilitator Superfamily 2915 0.0610 SUB375 C(~H)(~H)(~H) 2915 0.0610 PF02770 Acyl-CoA dehydrogenase, middle domain 2916 0.0609 SUB657 C-C-N-C-C 2916 0.0609 PF00690 Cation transporter/ATPase, N-terminus 2917 0.0609 SUB20 >= 2 O 2917 0.0609 PF00092 von Willebrand factor type A domain 2918 0.0608 SUB632 O-C:C-O-[#1] 2918 0.0608 PF00918 Gastrin/cholecystokinin family 2919 0.0605 SUB580 O=C-C-C-C 2919 0.0605 PF00202 Aminotransferase class-III 2920 0.0603 SUB548 N-C:C-N 2920 0.0603 PF00501 AMP-binding enzyme 2921 0.0603 SUB32 >= 2 P 2921 0.0603 PF08544 GHMP kinases C terminal 2922 0.0602 SUB638 O-C-C-C-C 2922 0.0602 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2923 0.0600 SUB705 O=C-C-C-C-C-C-C 2923 0.0600 PF00026 Eukaryotic aspartyl protease 2924 0.0600 SUB32 >= 2 P 2924 0.0600 PF01467 Cytidylyltransferase 2925 0.0599 SUB664 O-C-C-O-[#1] 2925 0.0599 PF03351 DOMON domain 2926 0.0599 SUB823 CC1C(Cl)CCCC1 2926 0.0599 PF07686 Immunoglobulin V-set domain 2927 0.0599 SUB517 [#1]-C=C-[#1] 2927 0.0599 PF00104 Ligand-binding domain of nuclear hormone receptor 2928 0.0598 SUB407 O(~C)(~H) 2928 0.0598 PF00821 Phosphoenolpyruvate carboxykinase 2929 0.0598 SUB606 O=C-C-O-C 2929 0.0598 PF02928 C5HC2 zinc finger 2930 0.0597 SUB503 N-C=C-[#1] 2930 0.0597 PF00264 Common central domain of tyrosinase 2931 0.0597 SUB158 >= 3 any ring size 5 2931 0.0597 PF00171 Aldehyde dehydrogenase family 2932 0.0597 SUB756 Cc1c(C)cccc1 2932 0.0597 PF00040 Fibronectin type II domain 2933 0.0597 SUB537 O=C-C-N 2933 0.0597 PF03483 B3/4 domain 2934 0.0597 SUB258 >= 2 aromatic rings 2934 0.0597 PF12497 Estrogen receptor beta 2935 0.0597 SUB730 Nc1ccc(Cl)cc1 2935 0.0597 PF07686 Immunoglobulin V-set domain 2936 0.0594 SUB714 Cc1ccc(C)cc1 2936 0.0594 PF00018 SH3 domain 2937 0.0594 SUB426 P=O 2937 0.0594 PF00146 NADH dehydrogenase 2938 0.0594 SUB408 O(~C)(~P) 2938 0.0594 PF00169 PH domain 2939 0.0594 SUB673 O=C-C=C-[#1] 2939 0.0594 PF01467 Cytidylyltransferase 2940 0.0592 SUB529 [#1]-N-C-[#1] 2940 0.0592 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 2941 0.0590 SUB404 N(:C)(:C) 2941 0.0590 PF00067 Cytochrome P450 2942 0.0590 SUB453 C(-O)(=O) 2942 0.0590 PF02970 Tubulin binding cofactor A 2943 0.0590 SUB622 N-C:C:C:N 2943 0.0590 PF12062 heparan sulfate-N-deacetylase 2944 0.0589 SUB386 C(:C)(:C)(:C) 2944 0.0589 PF00305 Lipoxygenase 2945 0.0589 SUB537 O=C-C-N 2945 0.0589 PF00458 WHEP-TRS domain 2946 0.0588 SUB415 S(~C)(~O) 2946 0.0588 PF01007 Inward rectifier potassium channel 2947 0.0588 SUB457 P(-O)(=O) 2947 0.0588 PF00018 SH3 domain 2948 0.0587 SUB640 O-C-C-C-O 2948 0.0587 PF01536 Adenosylmethionine decarboxylase 2949 0.0586 SUB697 C-C-C-C-C-C-C-C 2949 0.0586 PF00650 CRAL/TRIO domain 2950 0.0585 SUB646 O=C-N-C-C 2950 0.0585 PF07992 Pyridine nucleotide-disulphide oxidoreductase 2951 0.0585 SUB574 O-C-C=C 2951 0.0585 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2952 0.0584 SUB421 C=O 2952 0.0584 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2953 0.0584 SUB360 C(~C)(:N)(:N) 2953 0.0584 PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2954 0.0583 SUB663 O-C-C-O-C 2954 0.0583 PF00041 Fibronectin type III domain 2955 0.0583 SUB186 >= 2 any ring size 6 2955 0.0583 PF00069 Protein kinase domain 2956 0.0583 SUB22 >= 8 O 2956 0.0583 PF01467 Cytidylyltransferase 2957 0.0582 SUB618 C-C-C-O-[#1] 2957 0.0582 PF00571 CBS domain 2958 0.0582 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 2958 0.0582 PF00576 HIUase/Transthyretin family 2959 0.0580 SUB572 [#1]-C-O-[#1] 2959 0.0580 PF03781 Formylglycine-generating sulfatase enzyme 2960 0.0579 SUB497 N:N-C-[#1] 2960 0.0579 PF01033 Somatomedin B domain 2961 0.0578 SUB444 C(-C)(=O) 2961 0.0578 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 2962 0.0577 SUB354 C(~C)(~S) 2962 0.0577 PF00690 Cation transporter/ATPase, N-terminus 2963 0.0577 SUB618 C-C-C-O-[#1] 2963 0.0577 PF00764 Arginosuccinate synthase 2964 0.0577 SUB537 O=C-C-N 2964 0.0577 PF00491 Arginase family 2965 0.0576 SUB612 N-C-C-N-C 2965 0.0576 PF11555 EGFR receptor inhibitor Mig-6 2966 0.0575 SUB606 O=C-C-O-C 2966 0.0575 PF00628 PHD-finger 2967 0.0574 SUB414 S(~C)(~H) 2967 0.0574 PF00070 Pyridine nucleotide-disulphide oxidoreductase 2968 0.0574 SUB548 N-C:C-N 2968 0.0574 PF00001 7 transmembrane receptor (rhodopsin family), 2969 0.0573 SUB621 C:C-O-C-C 2969 0.0573 PF00001 7 transmembrane receptor (rhodopsin family), 2970 0.0572 SUB554 O=C-C=C 2970 0.0572 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 2971 0.0571 SUB674 O=C-C=C-N 2971 0.0571 PF00464 Serine hydroxymethyltransferase 2972 0.0570 SUB801 CC1CC(N)CCC1 2972 0.0570 PF00001 7 transmembrane receptor (rhodopsin family), 2973 0.0570 SUB708 O=C-C-C-C-C(N)-C 2973 0.0570 PF00017 SH2 domain 2974 0.0569 SUB4 >= 32 H 2974 0.0569 PF00102 Protein-tyrosine phosphatase 2975 0.0569 SUB341 C(~C)(~C)(~N) 2975 0.0569 PF07686 Immunoglobulin V-set domain 2976 0.0567 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 2976 0.0567 PF00069 Protein kinase domain 2977 0.0567 SUB288 C-F 2977 0.0567 PF01180 Dihydroorotate dehydrogenase 2978 0.0566 SUB350 C(~C)(~H)(~S) 2978 0.0566 PF05995 Cysteine dioxygenase type I 2979 0.0566 SUB448 C(-H)(=N) 2979 0.0566 PF00105 Zinc finger, C4 type (two domains), 2980 0.0566 SUB572 [#1]-C-O-[#1] 2980 0.0566 PF00079 Serpin (serine protease inhibitor), 2981 0.0563 SUB813 NC1CC(N)CCC1 2981 0.0563 PF00091 Tubulin/FtsZ family, GTPase domain 2982 0.0562 SUB643 O-C-C-C=O 2982 0.0562 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 2983 0.0562 SUB717 Cc1ccc(N)cc1 2983 0.0562 PF03024 Folate receptor family 2984 0.0562 SUB696 O=C-C-C-C-C-N 2984 0.0562 PF02932 Neurotransmitter-gated ion-channel transmembrane region 2985 0.0561 SUB32 >= 2 P 2985 0.0561 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 2986 0.0561 SUB393 N(~C)(~C)(~H) 2986 0.0561 PF00214 Calcitonin / CGRP / IAPP family 2987 0.0560 SUB459 S(-O)(=O) 2987 0.0560 PF07885 Ion channel 2988 0.0560 SUB490 N-C-S-C 2988 0.0560 PF01068 ATP dependent DNA ligase domain 2989 0.0559 SUB389 C(:C)(:N)(:N) 2989 0.0559 PF00056 lactate/malate dehydrogenase, NAD binding domain 2990 0.0558 SUB673 O=C-C=C-[#1] 2990 0.0558 PF07686 Immunoglobulin V-set domain 2991 0.0556 SUB717 Cc1ccc(N)cc1 2991 0.0556 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 2992 0.0555 SUB446 C(-H)(-N)(=C) 2992 0.0555 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 2993 0.0555 SUB342 C(~C)(~C)(~O) 2993 0.0555 PF07686 Immunoglobulin V-set domain 2994 0.0553 SUB700 O-C-C-C-C-C(C)-C 2994 0.0553 PF00045 Hemopexin 2995 0.0553 SUB691 O-C-C-C-C-C-O 2995 0.0553 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2996 0.0553 SUB652 O-C:C:C-C 2996 0.0553 PF00702 haloacid dehalogenase-like hydrolase 2997 0.0553 SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 2997 0.0553 PF00689 Cation transporting ATPase, C-terminus 2998 0.0552 SUB13 >= 16 C 2998 0.0552 PF00487 Fatty acid desaturase 2999 0.0552 SUB741 Oc1cc(O)ccc1 2999 0.0552 PF00478 IMP dehydrogenase / GMP reductase domain 3000 0.0551 SUB21 >= 4 O 3000 0.0551 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 3001 0.0551 SUB715 Cc1ccc(O)cc1 3001 0.0551 PF00001 7 transmembrane receptor (rhodopsin family), 3002 0.0549 SUB664 O-C-C-O-[#1] 3002 0.0549 PF03949 Malic enzyme, NAD binding domain 3003 0.0549 SUB537 O=C-C-N 3003 0.0549 PF00096 Zinc finger, C2H2 type 3004 0.0548 SUB522 C:N-C-[#1] 3004 0.0548 PF00104 Ligand-binding domain of nuclear hormone receptor 3005 0.0548 SUB489 N-C=N-[#1] 3005 0.0548 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 3006 0.0546 SUB342 C(~C)(~C)(~O) 3006 0.0546 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3007 0.0545 SUB25 >= 2 F 3007 0.0545 PF02166 Androgen receptor 3008 0.0545 SUB497 N:N-C-[#1] 3008 0.0545 PF01223 DNA/RNA non-specific endonuclease 3009 0.0544 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 3009 0.0544 PF04716 ETC complex I subunit conserved region 3010 0.0544 SUB663 O-C-C-O-C 3010 0.0544 PF00349 Hexokinase 3011 0.0543 SUB509 S=C-N-C 3011 0.0543 PF04263 Thiamin pyrophosphokinase, catalytic domain 3012 0.0543 SUB4 >= 32 H 3012 0.0543 PF00017 SH2 domain 3013 0.0543 SUB288 C-F 3013 0.0543 PF00989 PAS fold 3014 0.0542 SUB168 >= 4 saturated or aromatic heteroatom-containing ring size 5 3014 0.0542 PF01437 Plexin repeat 3015 0.0542 SUB344 C(~C)(~Cl)(~H) 3015 0.0542 PF00173 Cytochrome b5-like Heme/Steroid binding domain 3016 0.0542 SUB228 >= 1 any ring size 8 3016 0.0542 PF00341 Platelet-derived growth factor (PDGF), 3017 0.0541 SUB602 N-C:C:C-N 3017 0.0541 PF05221 S-adenosyl-L-homocysteine hydrolase 3018 0.0541 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 3018 0.0541 PF03171 2OG-Fe(II), oxygenase superfamily 3019 0.0541 SUB4 >= 32 H 3019 0.0541 PF00653 Inhibitor of Apoptosis domain 3020 0.0541 SUB529 [#1]-N-C-[#1] 3020 0.0541 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 3021 0.0541 SUB689 C-C-C-C-C-C-C 3021 0.0541 PF00001 7 transmembrane receptor (rhodopsin family), 3022 0.0541 SUB606 O=C-C-O-C 3022 0.0541 PF02375 jmjN domain 3023 0.0538 SUB444 C(-C)(=O) 3023 0.0538 PF00571 CBS domain 3024 0.0538 SUB444 C(-C)(=O) 3024 0.0538 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 3025 0.0538 SUB363 C(~Cl)(:C) 3025 0.0538 PF00229 TNF(Tumour Necrosis Factor), family 3026 0.0538 SUB288 C-F 3026 0.0538 PF02867 Ribonucleotide reductase, barrel domain 3027 0.0538 SUB806 OC1CC(N)CCC1 3027 0.0538 PF00069 Protein kinase domain 3028 0.0537 SUB643 O-C-C-C=O 3028 0.0537 PF00271 Helicase conserved C-terminal domain 3029 0.0537 SUB441 C(-C)(-O)(=O) 3029 0.0537 PF08763 Voltage gated calcium channel IQ domain 3030 0.0537 SUB644 [#1]-C-C-N-[#1] 3030 0.0537 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 3031 0.0534 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 3031 0.0534 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 3032 0.0534 SUB435 C(-C)(-H)(=C) 3032 0.0534 PF00273 Serum albumin family 3033 0.0532 SUB813 NC1CC(N)CCC1 3033 0.0532 PF03953 Tubulin C-terminal domain 3034 0.0531 SUB144 >= 1 any ring size 5 3034 0.0531 PF00001 7 transmembrane receptor (rhodopsin family), 3035 0.0530 SUB389 C(:C)(:N)(:N) 3035 0.0530 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3036 0.0530 SUB347 C(~C)(~H)(~O) 3036 0.0530 PF00084 Sushi domain (SCR repeat), 3037 0.0529 SUB536 O=C-C-C 3037 0.0529 PF02779 Transketolase, pyrimidine binding domain 3038 0.0529 SUB346 C(~C)(~H)(~N) 3038 0.0529 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3039 0.0528 SUB13 >= 16 C 3039 0.0528 PF00043 Glutathione S-transferase, C-terminal domain 3040 0.0528 SUB717 Cc1ccc(N)cc1 3040 0.0528 PF01437 Plexin repeat 3041 0.0528 SUB704 O-C-C-C-C-C(N)-C 3041 0.0528 PF00622 SPRY domain 3042 0.0528 SUB132 >= 1 saturated or aromatic nitrogen-containing ring size 4 3042 0.0528 PF01433 Peptidase family M1 3043 0.0527 SUB614 C-N-C-C-C 3043 0.0527 PF00755 Choline/Carnitine o-acyltransferase 3044 0.0527 SUB789 SC1CCC(N)CC1 3044 0.0527 PF02146 Sir2 family 3045 0.0526 SUB463 O-C-C=O 3045 0.0526 PF02887 Pyruvate kinase, alpha/beta domain 3046 0.0526 SUB14 >= 32 C 3046 0.0526 PF00026 Eukaryotic aspartyl protease 3047 0.0524 SUB664 O-C-C-O-[#1] 3047 0.0524 PF05790 Immunoglobulin C2-set domain 3048 0.0524 SUB338 C(~C)(~C)(~C)(~O) 3048 0.0524 PF01477 PLAT/LH2 domain 3049 0.0522 SUB339 C(~C)(~C)(~H)(~N) 3049 0.0522 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 3050 0.0522 SUB371 C(~H)(:C) 3050 0.0522 PF00001 7 transmembrane receptor (rhodopsin family), 3051 0.0521 SUB668 C=C-C-O-[#1] 3051 0.0521 PF07885 Ion channel 3052 0.0520 SUB195 >= 3 saturated or aromatic nitrogen-containing ring size 6 3052 0.0520 PF00754 F5/8 type C domain 3053 0.0520 SUB389 C(:C)(:N)(:N) 3053 0.0520 PF08544 GHMP kinases C terminal 3054 0.0519 SUB533 S-C:C-[#1] 3054 0.0519 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3055 0.0518 SUB632 O-C:C-O-[#1] 3055 0.0518 PF00001 7 transmembrane receptor (rhodopsin family), 3056 0.0518 SUB598 O=C-C-C:C 3056 0.0518 PF07884 Vitamin K epoxide reductase family 3057 0.0517 SUB691 O-C-C-C-C-C-O 3057 0.0517 PF00478 IMP dehydrogenase / GMP reductase domain 3058 0.0517 SUB629 C-N-C-C:C 3058 0.0517 PF00005 ABC transporter 3059 0.0517 SUB258 >= 2 aromatic rings 3059 0.0517 PF05193 Peptidase M16 inactive domain 3060 0.0517 SUB392 N(~C)(~C)(~C) 3060 0.0517 PF06512 Sodium ion transport-associated 3061 0.0516 SUB462 O-C-C=N 3061 0.0516 PF01068 ATP dependent DNA ligase domain 3062 0.0514 SUB336 C(~C)(~C)(~C)(~H) 3062 0.0514 PF05193 Peptidase M16 inactive domain 3063 0.0514 SUB627 C-O-C:C-C 3063 0.0514 PF08441 Integrin alpha 3064 0.0514 SUB522 C:N-C-[#1] 3064 0.0514 PF00794 PI3-kinase family, ras-binding domain 3065 0.0514 SUB646 O=C-N-C-C 3065 0.0514 PF00454 Phosphatidylinositol 3- and 4-kinase 3066 0.0513 SUB567 O-C-C-N 3066 0.0513 PF00324 Amino acid permease 3067 0.0513 SUB486 N:C:C:N 3067 0.0513 PF00962 Adenosine/AMP deaminase 3068 0.0512 SUB697 C-C-C-C-C-C-C-C 3068 0.0512 PF00079 Serpin (serine protease inhibitor), 3069 0.0511 SUB700 O-C-C-C-C-C(C)-C 3069 0.0511 PF01471 Putative peptidoglycan binding domain 3070 0.0510 SUB494 O=C-C:C 3070 0.0510 PF00478 IMP dehydrogenase / GMP reductase domain 3071 0.0509 SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 3071 0.0509 PF00122 E1-E2 ATPase 3072 0.0509 SUB564 O-C-O-C 3072 0.0509 PF00209 Sodium:neurotransmitter symporter family 3073 0.0508 SUB261 >= 3 hetero-aromatic rings 3073 0.0508 PF00017 SH2 domain 3074 0.0508 SUB22 >= 8 O 3074 0.0508 PF00176 SNF2 family N-terminal domain 3075 0.0507 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 3075 0.0507 PF00112 Papain family cysteine protease 3076 0.0507 SUB529 [#1]-N-C-[#1] 3076 0.0507 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 3077 0.0506 SUB602 N-C:C:C-N 3077 0.0506 PF00106 short chain dehydrogenase 3078 0.0505 SUB337 C(~C)(~C)(~C)(~N) 3078 0.0505 PF00273 Serum albumin family 3079 0.0504 SUB698 C-C-C-C-C-C(C)-C 3079 0.0504 PF03765 CRAL/TRIO, N-terminus 3080 0.0504 SUB186 >= 2 any ring size 6 3080 0.0504 PF00106 short chain dehydrogenase 3081 0.0502 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 3081 0.0502 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 3082 0.0501 SUB781 CC1CCC(Cl)CC1 3082 0.0501 PF00032 Cytochrome b(C-terminal), /b6/petD 3083 0.0501 SUB804 OC1CC(O)CCC1 3083 0.0501 PF03623 Focal adhesion targeting region 3084 0.0501 SUB360 C(~C)(:N)(:N) 3084 0.0501 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 3085 0.0501 SUB831 SC1C(N)CCCC1 3085 0.0501 PF00520 Ion transport protein 3086 0.0501 SUB683 O-C-C-C-C-N 3086 0.0501 PF00171 Aldehyde dehydrogenase family 3087 0.0500 SUB214 >= 1 any ring size 7 3087 0.0500 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 3088 0.0500 SUB685 O=C-C-C-C-C 3088 0.0500 PF00202 Aminotransferase class-III 3089 0.0499 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 3089 0.0499 PF00976 Corticotropin ACTH domain 3090 0.0499 SUB640 O-C-C-C-O 3090 0.0499 PF00068 Phospholipase A2 3091 0.0497 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 3091 0.0497 PF00001 7 transmembrane receptor (rhodopsin family), 3092 0.0497 SUB459 S(-O)(=O) 3092 0.0497 PF00230 Major intrinsic protein 3093 0.0496 SUB572 [#1]-C-O-[#1] 3093 0.0496 PF07686 Immunoglobulin V-set domain 3094 0.0496 SUB615 C-C-O-C-C 3094 0.0496 PF00106 short chain dehydrogenase 3095 0.0495 SUB660 O-C-C-N-C 3095 0.0495 PF00664 ABC transporter transmembrane region 3096 0.0495 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 3096 0.0495 PF05544 Proline racemase 3097 0.0495 SUB705 O=C-C-C-C-C-C-C 3097 0.0495 PF04704 Zfx / Zfy transcription activation region 3098 0.0493 SUB686 O=C-C-C-C-N 3098 0.0493 PF01124 MAPEG family 3099 0.0492 SUB440 C(-C)(-N)(=O) 3099 0.0492 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 3100 0.0492 SUB633 C-C-O-C:C 3100 0.0492 PF00001 7 transmembrane receptor (rhodopsin family), 3101 0.0490 SUB717 Cc1ccc(N)cc1 3101 0.0490 PF01403 Sema domain 3102 0.0489 SUB537 O=C-C-N 3102 0.0489 PF02100 Ornithine decarboxylase antizyme 3103 0.0488 SUB806 OC1CC(N)CCC1 3103 0.0488 PF03508 Gap junction alpha-1 protein (Cx43), 3104 0.0487 SUB444 C(-C)(=O) 3104 0.0487 PF03949 Malic enzyme, NAD binding domain 3105 0.0487 SUB633 C-C-O-C:C 3105 0.0487 PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain 3106 0.0486 SUB687 O=C-C-C-C-O 3106 0.0486 PF00571 CBS domain 3107 0.0486 SUB407 O(~C)(~H) 3107 0.0486 PF00248 Aldo/keto reductase family 3108 0.0485 SUB387 C(:C)(:C)(:N) 3108 0.0485 PF00005 ABC transporter 3109 0.0484 SUB390 C(:N)(:N) 3109 0.0484 PF00689 Cation transporting ATPase, C-terminus 3110 0.0483 SUB636 N-N-C-N-[#1] 3110 0.0483 PF00520 Ion transport protein 3111 0.0483 SUB454 N(-C)(=C) 3111 0.0483 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3112 0.0483 SUB696 O=C-C-C-C-C-N 3112 0.0483 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3113 0.0482 SUB567 O-C-C-N 3113 0.0482 PF03484 tRNA synthetase B5 domain 3114 0.0481 SUB443 C(-C)(=N) 3114 0.0481 PF08127 Peptidase family C1 propeptide 3115 0.0480 SUB687 O=C-C-C-C-O 3115 0.0480 PF00105 Zinc finger, C4 type (two domains), 3116 0.0479 SUB335 C(~C)(~C)(~C)(~C) 3116 0.0479 PF00040 Fibronectin type II domain 3117 0.0479 SUB492 C-N:C-[#1] 3117 0.0479 PF02196 Raf-like Ras-binding domain 3118 0.0479 SUB820 CC1C(O)CCCC1 3118 0.0479 PF00023 Ankyrin repeat 3119 0.0479 SUB24 >= 1 F 3119 0.0479 PF03477 ATP cone domain 3120 0.0479 SUB690 O-C-C-C-C-C-C 3120 0.0479 PF00520 Ion transport protein 3121 0.0478 SUB686 O=C-C-C-C-N 3121 0.0478 PF02310 B12 binding domain 3122 0.0478 SUB556 N=C-C=C 3122 0.0478 PF03171 2OG-Fe(II), oxygenase superfamily 3123 0.0478 SUB381 C(~O)(~O) 3123 0.0478 PF00005 ABC transporter 3124 0.0477 SUB20 >= 2 O 3124 0.0477 PF00337 Galactoside-binding lectin 3125 0.0477 SUB492 C-N:C-[#1] 3125 0.0477 PF00571 CBS domain 3126 0.0476 SUB517 [#1]-C=C-[#1] 3126 0.0476 PF00390 Malic enzyme, N-terminal domain 3127 0.0476 SUB16 >= 2 N 3127 0.0476 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 3128 0.0476 SUB448 C(-H)(=N) 3128 0.0476 PF08418 DNA polymerase alpha subunit B N-terminal 3129 0.0475 SUB441 C(-C)(-O)(=O) 3129 0.0475 PF00084 Sushi domain (SCR repeat), 3130 0.0474 SUB453 C(-O)(=O) 3130 0.0474 PF00169 PH domain 3131 0.0474 SUB376 C(~N)(~N) 3131 0.0474 PF00303 Thymidylate synthase 3132 0.0473 SUB720 Oc1ccc(O)cc1 3132 0.0473 PF01733 Nucleoside transporter 3133 0.0473 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 3133 0.0473 PF00122 E1-E2 ATPase 3134 0.0473 SUB615 C-C-O-C-C 3134 0.0473 PF01401 Angiotensin-converting enzyme 3135 0.0472 SUB709 C-C(C)-C-C 3135 0.0472 PF00045 Hemopexin 3136 0.0472 SUB673 O=C-C=C-[#1] 3136 0.0472 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 3137 0.0472 SUB426 P=O 3137 0.0472 PF00929 Exonuclease 3138 0.0472 SUB387 C(:C)(:C)(:N) 3138 0.0472 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 3139 0.0471 SUB433 C(-C)(-C)(=O) 3139 0.0471 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3140 0.0470 SUB339 C(~C)(~C)(~H)(~N) 3140 0.0470 PF01431 Peptidase family M13 3141 0.0470 SUB398 N(~C)(:C)(:C) 3141 0.0470 PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 3142 0.0468 SUB348 C(~C)(~H)(~O)(~O) 3142 0.0468 PF00079 Serpin (serine protease inhibitor), 3143 0.0468 SUB622 N-C:C:C:N 3143 0.0468 PF02817 e3 binding domain 3144 0.0468 SUB389 C(:C)(:N)(:N) 3144 0.0468 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 3145 0.0468 SUB452 C(-N)(=O) 3145 0.0468 PF00107 Zinc-binding dehydrogenase 3146 0.0467 SUB461 C-C-C#C 3146 0.0467 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3147 0.0467 SUB643 O-C-C-C=O 3147 0.0467 PF01202 Shikimate kinase 3148 0.0465 SUB612 N-C-C-N-C 3148 0.0465 PF01061 ABC-2 type transporter 3149 0.0464 SUB368 C(~H)(~O)(~O) 3149 0.0464 PF05089 Alpha-N-acetylglucosaminidase (NAGLU), 3150 0.0464 SUB441 C(-C)(-O)(=O) 3150 0.0464 PF11825 Protein of unknown function (DUF3345), 3151 0.0464 SUB717 Cc1ccc(N)cc1 3151 0.0464 PF01571 Aminomethyltransferase folate-binding domain 3152 0.0463 SUB642 O-C-C-C=C 3152 0.0463 PF00027 Cyclic nucleotide-binding domain 3153 0.0463 SUB698 C-C-C-C-C-C(C)-C 3153 0.0463 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 3154 0.0462 SUB536 O=C-C-C 3154 0.0462 PF00175 Oxidoreductase NAD-binding domain 3155 0.0462 SUB475 S:C:C:N 3155 0.0462 PF01770 Reduced folate carrier 3156 0.0462 SUB658 C-N-C:C-C 3156 0.0462 PF00550 Phosphopantetheine attachment site 3157 0.0462 SUB261 >= 3 hetero-aromatic rings 3157 0.0462 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 3158 0.0462 SUB705 O=C-C-C-C-C-C-C 3158 0.0462 PF00362 Integrin, beta chain 3159 0.0462 SUB639 O-C-C-C-N 3159 0.0462 PF00709 Adenylosuccinate synthetase 3160 0.0461 SUB453 C(-O)(=O) 3160 0.0461 PF02785 Biotin carboxylase C-terminal domain 3161 0.0461 SUB682 O-C-C-C-C-O 3161 0.0461 PF03414 Glycosyltransferase family 6 3162 0.0460 SUB537 O=C-C-N 3162 0.0460 PF00454 Phosphatidylinositol 3- and 4-kinase 3163 0.0460 SUB536 O=C-C-C 3163 0.0460 PF00291 Pyridoxal-phosphate dependent enzyme 3164 0.0460 SUB16 >= 2 N 3164 0.0460 PF00152 tRNA synthetases class II (D, K and N), 3165 0.0460 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 3165 0.0460 PF00005 ABC transporter 3166 0.0460 SUB683 O-C-C-C-C-N 3166 0.0460 PF07837 Formiminotransferase domain, N-terminal subdomain 3167 0.0460 SUB462 O-C-C=N 3167 0.0460 PF00149 Calcineurin-like phosphoesterase 3168 0.0459 SUB694 O=C-C-C-C-C-O 3168 0.0459 PF00462 Glutaredoxin 3169 0.0458 SUB413 S(~C)(~C) 3169 0.0458 PF01641 SelR domain 3170 0.0458 SUB401 N(~H)(:C)(:C) 3170 0.0458 PF00001 7 transmembrane receptor (rhodopsin family), 3171 0.0454 SUB392 N(~C)(~C)(~C) 3171 0.0454 PF01007 Inward rectifier potassium channel 3172 0.0454 SUB554 O=C-C=C 3172 0.0454 PF00104 Ligand-binding domain of nuclear hormone receptor 3173 0.0453 SUB511 [#1]-N-N-[#1] 3173 0.0453 PF02727 Copper amine oxidase, N2 domain 3174 0.0450 SUB260 >= 3 aromatic rings 3174 0.0450 PF02159 Oestrogen receptor 3175 0.0450 SUB446 C(-H)(-N)(=C) 3175 0.0450 PF00107 Zinc-binding dehydrogenase 3176 0.0449 SUB639 O-C-C-C-N 3176 0.0449 PF00202 Aminotransferase class-III 3177 0.0449 SUB681 O-C-C-C-C-C 3177 0.0449 PF00487 Fatty acid desaturase 3178 0.0448 SUB249 >= 1 any ring size 10 3178 0.0448 PF00069 Protein kinase domain 3179 0.0448 SUB639 O-C-C-C-N 3179 0.0448 PF00535 Glycosyl transferase family 2 3180 0.0448 SUB616 N-C-C-O-C 3180 0.0448 PF00023 Ankyrin repeat 3181 0.0448 SUB525 C-C=C-C 3181 0.0448 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 3182 0.0448 SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 3182 0.0448 PF00690 Cation transporter/ATPase, N-terminus 3183 0.0448 SUB407 O(~C)(~H) 3183 0.0448 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 3184 0.0448 SUB389 C(:C)(:N)(:N) 3184 0.0448 PF04716 ETC complex I subunit conserved region 3185 0.0447 SUB375 C(~H)(~H)(~H) 3185 0.0447 PF00702 haloacid dehalogenase-like hydrolase 3186 0.0447 SUB643 O-C-C-C=O 3186 0.0447 PF01130 CD36 family 3187 0.0447 SUB462 O-C-C=N 3187 0.0447 PF00294 pfkB family carbohydrate kinase 3188 0.0446 SUB359 C(~C)(:N) 3188 0.0446 PF00531 Death domain 3189 0.0446 SUB346 C(~C)(~H)(~N) 3189 0.0446 PF00194 Eukaryotic-type carbonic anhydrase 3190 0.0445 SUB537 O=C-C-N 3190 0.0445 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3191 0.0443 SUB567 O-C-C-N 3191 0.0443 PF00787 PX domain 3192 0.0443 SUB709 C-C(C)-C-C 3192 0.0443 PF02798 Glutathione S-transferase, N-terminal domain 3193 0.0442 SUB637 C-N-C-N-C 3193 0.0442 PF01030 Receptor L domain 3194 0.0442 SUB144 >= 1 any ring size 5 3194 0.0442 PF00069 Protein kinase domain 3195 0.0441 SUB386 C(:C)(:C)(:C) 3195 0.0441 PF00051 Kringle domain 3196 0.0441 SUB457 P(-O)(=O) 3196 0.0441 PF01467 Cytidylyltransferase 3197 0.0441 SUB389 C(:C)(:N)(:N) 3197 0.0441 PF00316 Fructose-1-6-bisphosphatase 3198 0.0441 SUB741 Oc1cc(O)ccc1 3198 0.0441 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 3199 0.0441 SUB644 [#1]-C-C-N-[#1] 3199 0.0441 PF00112 Papain family cysteine protease 3200 0.0440 SUB567 O-C-C-N 3200 0.0440 PF00079 Serpin (serine protease inhibitor), 3201 0.0440 SUB540 N=C-C-[#1] 3201 0.0440 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 3202 0.0440 SUB375 C(~H)(~H)(~H) 3202 0.0440 PF00690 Cation transporter/ATPase, N-terminus 3203 0.0440 SUB541 C-N-C-[#1] 3203 0.0440 PF00474 Sodium:solute symporter family 3204 0.0439 SUB705 O=C-C-C-C-C-C-C 3204 0.0439 PF08725 Integrin beta cytoplasmic domain 3205 0.0439 SUB401 N(~H)(:C)(:C) 3205 0.0439 PF01231 Indoleamine 2,3-dioxygenase 3206 0.0438 SUB664 O-C-C-O-[#1] 3206 0.0438 PF00390 Malic enzyme, N-terminal domain 3207 0.0438 SUB392 N(~C)(~C)(~C) 3207 0.0438 PF01569 PAP2 superfamily 3208 0.0438 SUB389 C(:C)(:N)(:N) 3208 0.0438 PF00070 Pyridine nucleotide-disulphide oxidoreductase 3209 0.0437 SUB343 C(~C)(~Cl) 3209 0.0437 PF02254 TrkA-N domain 3210 0.0437 SUB353 C(~C)(~O) 3210 0.0437 PF00520 Ion transport protein 3211 0.0436 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 3211 0.0436 PF00067 Cytochrome P450 3212 0.0436 SUB32 >= 2 P 3212 0.0436 PF00069 Protein kinase domain 3213 0.0435 SUB463 O-C-C=O 3213 0.0435 PF00091 Tubulin/FtsZ family, GTPase domain 3214 0.0434 SUB660 O-C-C-N-C 3214 0.0434 PF06888 Putative Phosphatase 3215 0.0434 SUB453 C(-O)(=O) 3215 0.0434 PF07706 Aminotransferase ubiquitination site 3216 0.0434 SUB685 O=C-C-C-C-C 3216 0.0434 PF00487 Fatty acid desaturase 3217 0.0434 SUB517 [#1]-C=C-[#1] 3217 0.0434 PF00413 Matrixin 3218 0.0433 SUB500 N-C:C:N 3218 0.0433 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3219 0.0430 SUB759 Cc1c(N)cccc1 3219 0.0430 PF01030 Receptor L domain 3220 0.0430 SUB340 C(~C)(~C)(~H)(~O) 3220 0.0430 PF00135 Carboxylesterase 3221 0.0430 SUB344 C(~C)(~Cl)(~H) 3221 0.0430 PF00111 2Fe-2S iron-sulfur cluster binding domain 3222 0.0430 SUB441 C(-C)(-O)(=O) 3222 0.0430 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 3223 0.0430 SUB505 N:C:N-C 3223 0.0430 PF00478 IMP dehydrogenase / GMP reductase domain 3224 0.0429 SUB654 O-C:C:C-O 3224 0.0429 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 3225 0.0429 SUB704 O-C-C-C-C-C(N)-C 3225 0.0429 PF01869 BadF/BadG/BcrA/BcrD ATPase family 3226 0.0427 SUB431 C(-C)(-C)(=C) 3226 0.0427 PF00079 Serpin (serine protease inhibitor), 3227 0.0427 SUB543 O-C:C-[#1] 3227 0.0427 PF00005 ABC transporter 3228 0.0427 SUB12 >= 8 C 3228 0.0427 PF00067 Cytochrome P450 3229 0.0424 SUB520 N=C-N-C 3229 0.0424 PF00209 Sodium:neurotransmitter symporter family 3230 0.0424 SUB538 O=C-C-O 3230 0.0424 PF00274 Fructose-bisphosphate aldolase class-I 3231 0.0423 SUB17 >= 4 N 3231 0.0423 PF00206 Lyase 3232 0.0423 SUB644 [#1]-C-C-N-[#1] 3232 0.0423 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 3233 0.0423 SUB229 >= 1 saturated or aromatic carbon-only ring size 8 3233 0.0423 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3234 0.0423 SUB38 >= 1 Cl 3234 0.0423 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3235 0.0422 SUB387 C(:C)(:C)(:N) 3235 0.0422 PF00962 Adenosine/AMP deaminase 3236 0.0422 SUB407 O(~C)(~H) 3236 0.0422 PF00560 Leucine Rich Repeat 3237 0.0421 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 3237 0.0421 PF00042 Globin 3238 0.0421 SUB693 O=C-C-C-C-C-C 3238 0.0421 PF04704 Zfx / Zfy transcription activation region 3239 0.0420 SUB399 N(~H)(~N) 3239 0.0420 PF00001 7 transmembrane receptor (rhodopsin family), 3240 0.0420 SUB710 C-C(C)-C-C-C 3240 0.0420 PF00248 Aldo/keto reductase family 3241 0.0420 SUB602 N-C:C:C-N 3241 0.0420 PF02865 STAT protein, protein interaction domain 3242 0.0420 SUB683 O-C-C-C-C-N 3242 0.0420 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 3243 0.0420 SUB441 C(-C)(-O)(=O) 3243 0.0420 PF01023 S-100/ICaBP type calcium binding domain 3244 0.0418 SUB682 O-C-C-C-C-O 3244 0.0418 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 3245 0.0418 SUB495 O=C-C:N 3245 0.0418 PF00927 Transglutaminase family, C-terminal ig like domain 3246 0.0417 SUB350 C(~C)(~H)(~S) 3246 0.0417 PF00043 Glutathione S-transferase, C-terminal domain 3247 0.0417 SUB700 O-C-C-C-C-C(C)-C 3247 0.0417 PF00571 CBS domain 3248 0.0416 SUB158 >= 3 any ring size 5 3248 0.0416 PF00175 Oxidoreductase NAD-binding domain 3249 0.0416 SUB694 O=C-C-C-C-C-O 3249 0.0416 PF00060 Ligand-gated ion channel 3250 0.0416 SUB401 N(~H)(:C)(:C) 3250 0.0416 PF00458 WHEP-TRS domain 3251 0.0415 SUB250 >= 1 saturated or aromatic carbon-only ring size 10 3251 0.0415 PF00092 von Willebrand factor type A domain 3252 0.0414 SUB566 C:C-O-C 3252 0.0414 PF08441 Integrin alpha 3253 0.0414 SUB702 O-C-C-C-C-C(O)-C 3253 0.0414 PF00093 von Willebrand factor type C domain 3254 0.0414 SUB703 O-C-C-C-C-C-N-C 3254 0.0414 PF00104 Ligand-binding domain of nuclear hormone receptor 3255 0.0413 SUB596 C:C-C-C-C 3255 0.0413 PF00001 7 transmembrane receptor (rhodopsin family), 3256 0.0413 SUB653 O-C:C:C-N 3256 0.0413 PF10582 Gap junction channel protein cysteine-rich domain 3257 0.0412 SUB24 >= 1 F 3257 0.0412 PF00317 Ribonucleotide reductase, all-alpha domain 3258 0.0412 SUB757 Cc1c(O)cccc1 3258 0.0412 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3259 0.0411 SUB407 O(~C)(~H) 3259 0.0411 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 3260 0.0411 SUB625 O=C-C:C-N 3260 0.0411 PF02877 Poly(ADP-ribose), polymerase, regulatory domain 3261 0.0410 SUB338 C(~C)(~C)(~C)(~O) 3261 0.0410 PF08035 Opioids neuropeptide 3262 0.0410 SUB743 Oc1cc(N)ccc1 3262 0.0410 PF00214 Calcitonin / CGRP / IAPP family 3263 0.0410 SUB682 O-C-C-C-C-O 3263 0.0410 PF00104 Ligand-binding domain of nuclear hormone receptor 3264 0.0409 SUB569 N#C-C-C 3264 0.0409 PF01007 Inward rectifier potassium channel 3265 0.0409 SUB821 CC1C(S)CCCC1 3265 0.0409 PF00104 Ligand-binding domain of nuclear hormone receptor 3266 0.0409 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 3266 0.0409 PF01231 Indoleamine 2,3-dioxygenase 3267 0.0408 SUB3 >= 16 H 3267 0.0408 PF00664 ABC transporter transmembrane region 3268 0.0408 SUB339 C(~C)(~C)(~H)(~N) 3268 0.0408 PF02310 B12 binding domain 3269 0.0407 SUB496 C-N-C:C 3269 0.0407 PF03493 Calcium-activated BK potassium channel alpha subunit 3270 0.0407 SUB444 C(-C)(=O) 3270 0.0407 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 3271 0.0406 SUB522 C:N-C-[#1] 3271 0.0406 PF00792 Phosphoinositide 3-kinase C2 3272 0.0406 SUB666 N-C:C-C-C 3272 0.0406 PF00273 Serum albumin family 3273 0.0405 SUB517 [#1]-C=C-[#1] 3273 0.0405 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3274 0.0404 SUB814 NC1CC(Cl)CCC1 3274 0.0404 PF00209 Sodium:neurotransmitter symporter family 3275 0.0404 SUB647 O=C-N-C-[#1] 3275 0.0404 PF01007 Inward rectifier potassium channel 3276 0.0404 SUB406 O(~C)(~C) 3276 0.0404 PF00146 NADH dehydrogenase 3277 0.0403 SUB620 O-C-C=C-C 3277 0.0403 PF08035 Opioids neuropeptide 3278 0.0403 SUB570 N-C-C-N 3278 0.0403 PF07686 Immunoglobulin V-set domain 3279 0.0402 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 3279 0.0402 PF00089 Trypsin 3280 0.0401 SUB360 C(~C)(:N)(:N) 3280 0.0401 PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit 3281 0.0401 SUB442 C(-C)(=C) 3281 0.0401 PF00501 AMP-binding enzyme 3282 0.0401 SUB14 >= 32 C 3282 0.0401 PF00067 Cytochrome P450 3283 0.0400 SUB35 >= 2 S 3283 0.0400 PF08833 Axin beta-catenin binding domain 3284 0.0399 SUB612 N-C-C-N-C 3284 0.0399 PF02798 Glutathione S-transferase, N-terminal domain 3285 0.0399 SUB31 >= 1 P 3285 0.0399 PF01130 CD36 family 3286 0.0399 SUB360 C(~C)(:N)(:N) 3286 0.0399 PF00041 Fibronectin type III domain 3287 0.0398 SUB758 Cc1c(S)cccc1 3287 0.0398 PF03372 Endonuclease/Exonuclease/phosphatase family 3288 0.0398 SUB295 C-Cl 3288 0.0398 PF03073 TspO/MBR family 3289 0.0397 SUB630 S-C:C:C-N 3289 0.0397 PF02146 Sir2 family 3290 0.0397 SUB419 C=N 3290 0.0397 PF00001 7 transmembrane receptor (rhodopsin family), 3291 0.0396 SUB375 C(~H)(~H)(~H) 3291 0.0396 PF00045 Hemopexin 3292 0.0396 SUB260 >= 3 aromatic rings 3292 0.0396 PF00068 Phospholipase A2 3293 0.0394 SUB779 CC1CCC(S)CC1 3293 0.0394 PF00104 Ligand-binding domain of nuclear hormone receptor 3294 0.0394 SUB735 Cc1cc(C)ccc1 3294 0.0394 PF00664 ABC transporter transmembrane region 3295 0.0394 SUB537 O=C-C-N 3295 0.0394 PF03484 tRNA synthetase B5 domain 3296 0.0393 SUB414 S(~C)(~H) 3296 0.0393 PF10590 Pyridoxine 5"-phosphate oxidase C-terminal dimerisation region 3297 0.0393 SUB756 Cc1c(C)cccc1 3297 0.0393 PF00105 Zinc finger, C4 type (two domains), 3298 0.0392 SUB697 C-C-C-C-C-C-C-C 3298 0.0392 PF00092 von Willebrand factor type A domain 3299 0.0391 SUB342 C(~C)(~C)(~O) 3299 0.0391 PF00069 Protein kinase domain 3300 0.0391 SUB486 N:C:C:N 3300 0.0391 PF00067 Cytochrome P450 3301 0.0390 SUB655 N-C-N-C-C 3301 0.0390 PF02274 Amidinotransferase 3302 0.0389 SUB446 C(-H)(-N)(=C) 3302 0.0389 PF00001 7 transmembrane receptor (rhodopsin family), 3303 0.0388 SUB648 O=C-N-C-N 3303 0.0388 PF00343 Carbohydrate phosphorylase 3304 0.0387 SUB658 C-N-C:C-C 3304 0.0387 PF00005 ABC transporter 3305 0.0386 SUB408 O(~C)(~P) 3305 0.0386 PF01467 Cytidylyltransferase 3306 0.0386 SUB624 O=C-C:C-C 3306 0.0386 PF02971 Formiminotransferase domain 3307 0.0386 SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 3307 0.0386 PF00664 ABC transporter transmembrane region 3308 0.0386 SUB617 C:C:N:N:C 3308 0.0386 PF00106 short chain dehydrogenase 3309 0.0386 SUB367 C(~H)(~O) 3309 0.0386 PF06512 Sodium ion transport-associated 3310 0.0385 SUB572 [#1]-C-O-[#1] 3310 0.0385 PF00041 Fibronectin type III domain 3311 0.0385 SUB681 O-C-C-C-C-C 3311 0.0385 PF00105 Zinc finger, C4 type (two domains), 3312 0.0384 SUB572 [#1]-C-O-[#1] 3312 0.0384 PF00236 Glycoprotein hormone 3313 0.0383 SUB301 N-N 3313 0.0383 PF04042 DNA polymerase alpha/epsilon subunit B 3314 0.0382 SUB340 C(~C)(~C)(~H)(~O) 3314 0.0382 PF03062 MBOAT family 3315 0.0381 SUB589 O=C-C-C=O 3315 0.0381 PF03098 Animal haem peroxidase 3316 0.0381 SUB694 O=C-C-C-C-C-O 3316 0.0381 PF00005 ABC transporter 3317 0.0380 SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 3317 0.0380 PF00001 7 transmembrane receptor (rhodopsin family), 3318 0.0380 SUB674 O=C-C=C-N 3318 0.0380 PF08063 PADR1 (NUC008), domain 3319 0.0380 SUB592 Cl-C-C-C-C 3319 0.0380 PF00229 TNF(Tumour Necrosis Factor), family 3320 0.0379 SUB540 N=C-C-[#1] 3320 0.0379 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 3321 0.0379 SUB685 O=C-C-C-C-C 3321 0.0379 PF00501 AMP-binding enzyme 3322 0.0379 SUB389 C(:C)(:N)(:N) 3322 0.0379 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3323 0.0379 SUB622 N-C:C:C:N 3323 0.0379 PF05221 S-adenosyl-L-homocysteine hydrolase 3324 0.0378 SUB613 N-C-O-C-C 3324 0.0378 PF02770 Acyl-CoA dehydrogenase, middle domain 3325 0.0377 SUB738 Cc1cc(N)ccc1 3325 0.0377 PF01437 Plexin repeat 3326 0.0377 SUB460 S(=O)(=O) 3326 0.0377 PF00092 von Willebrand factor type A domain 3327 0.0376 SUB500 N-C:C:N 3327 0.0376 PF00153 Mitochondrial carrier protein 3328 0.0375 SUB746 Sc1cc(S)ccc1 3328 0.0375 PF00194 Eukaryotic-type carbonic anhydrase 3329 0.0375 SUB235 >= 2 any ring size 8 3329 0.0375 PF02180 Bcl-2 homology region 4 3330 0.0372 SUB408 O(~C)(~P) 3330 0.0372 PF01023 S-100/ICaBP type calcium binding domain 3331 0.0369 SUB336 C(~C)(~C)(~C)(~H) 3331 0.0369 PF00149 Calcineurin-like phosphoesterase 3332 0.0369 SUB688 O=C-C-C-C=O 3332 0.0369 PF01259 SAICAR synthetase 3333 0.0368 SUB556 N=C-C=C 3333 0.0368 PF03098 Animal haem peroxidase 3334 0.0367 SUB717 Cc1ccc(N)cc1 3334 0.0367 PF00084 Sushi domain (SCR repeat), 3335 0.0367 SUB801 CC1CC(N)CCC1 3335 0.0367 PF00324 Amino acid permease 3336 0.0366 SUB417 C=C 3336 0.0366 PF00501 AMP-binding enzyme 3337 0.0364 SUB387 C(:C)(:C)(:N) 3337 0.0364 PF05347 Complex 1 protein (LYR family), 3338 0.0364 SUB683 O-C-C-C-C-N 3338 0.0364 PF00068 Phospholipase A2 3339 0.0363 SUB249 >= 1 any ring size 10 3339 0.0363 PF00051 Kringle domain 3340 0.0363 SUB659 C-C-S-C-C 3340 0.0363 PF01564 Spermine/spermidine synthase 3341 0.0363 SUB463 O-C-C=O 3341 0.0363 PF03953 Tubulin C-terminal domain 3342 0.0363 SUB567 O-C-C-N 3342 0.0363 PF01336 OB-fold nucleic acid binding domain 3343 0.0361 SUB660 O-C-C-N-C 3343 0.0361 PF00005 ABC transporter 3344 0.0361 SUB441 C(-C)(-O)(=O) 3344 0.0361 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 3345 0.0360 SUB662 O-C-O-C-C 3345 0.0360 PF07654 Immunoglobulin C1-set domain 3346 0.0360 SUB648 O=C-N-C-N 3346 0.0360 PF03360 Glycosyltransferase family 43 3347 0.0360 SUB381 C(~O)(~O) 3347 0.0360 PF07686 Immunoglobulin V-set domain 3348 0.0360 SUB392 N(~C)(~C)(~C) 3348 0.0360 PF00497 Bacterial extracellular solute-binding proteins, family 3 3349 0.0359 SUB664 O-C-C-O-[#1] 3349 0.0359 PF01118 Semialdehyde dehydrogenase, NAD binding domain 3350 0.0358 SUB381 C(~O)(~O) 3350 0.0358 PF00001 7 transmembrane receptor (rhodopsin family), 3351 0.0358 SUB461 C-C-C#C 3351 0.0358 PF00194 Eukaryotic-type carbonic anhydrase 3352 0.0358 SUB452 C(-N)(=O) 3352 0.0358 PF01471 Putative peptidoglycan binding domain 3353 0.0358 SUB463 O-C-C=O 3353 0.0358 PF03949 Malic enzyme, NAD binding domain 3354 0.0358 SUB622 N-C:C:C:N 3354 0.0358 PF00300 Phosphoglycerate mutase family 3355 0.0357 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 3355 0.0357 PF08040 MNLL subunit 3356 0.0356 SUB387 C(:C)(:C)(:N) 3356 0.0356 PF00501 AMP-binding enzyme 3357 0.0356 SUB613 N-C-O-C-C 3357 0.0356 PF00400 WD domain, G-beta repeat 3358 0.0355 SUB315 O-P 3358 0.0355 PF08674 Acetylcholinesterase tetramerisation domain 3359 0.0355 SUB158 >= 3 any ring size 5 3359 0.0355 PF00384 Molybdopterin oxidoreductase 3360 0.0355 SUB567 O-C-C-N 3360 0.0355 PF01641 SelR domain 3361 0.0354 SUB640 O-C-C-C-O 3361 0.0354 PF03623 Focal adhesion targeting region 3362 0.0353 SUB363 C(~Cl)(:C) 3362 0.0353 PF03630 Fumble 3363 0.0353 SUB701 O-C-C-C-C-C-O-C 3363 0.0353 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3364 0.0351 SUB340 C(~C)(~C)(~H)(~O) 3364 0.0351 PF00019 Transforming growth factor beta like domain 3365 0.0350 SUB324 P-H 3365 0.0350 PF00069 Protein kinase domain 3366 0.0350 SUB477 C-O-C=C 3366 0.0350 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 3367 0.0349 SUB375 C(~H)(~H)(~H) 3367 0.0349 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3368 0.0349 SUB528 C:C:N-[#1] 3368 0.0349 PF00458 WHEP-TRS domain 3369 0.0349 SUB713 C-C(C)-C(C)-C 3369 0.0349 PF00571 CBS domain 3370 0.0348 SUB699 O-C-C-C-C-C-C-C 3370 0.0348 PF07706 Aminotransferase ubiquitination site 3371 0.0347 SUB337 C(~C)(~C)(~C)(~N) 3371 0.0347 PF00001 7 transmembrane receptor (rhodopsin family), 3372 0.0347 SUB713 C-C(C)-C(C)-C 3372 0.0347 PF04622 ERG2 and Sigma1 receptor like protein 3373 0.0346 SUB655 N-C-N-C-C 3373 0.0346 PF01180 Dihydroorotate dehydrogenase 3374 0.0346 SUB392 N(~C)(~C)(~C) 3374 0.0346 PF06888 Putative Phosphatase 3375 0.0346 SUB708 O=C-C-C-C-C(N)-C 3375 0.0346 PF00084 Sushi domain (SCR repeat), 3376 0.0345 SUB556 N=C-C=C 3376 0.0345 PF01712 Deoxynucleoside kinase 3377 0.0344 SUB620 O-C-C=C-C 3377 0.0344 PF03098 Animal haem peroxidase 3378 0.0343 SUB647 O=C-N-C-[#1] 3378 0.0343 PF00115 Cytochrome C and Quinol oxidase polypeptide I 3379 0.0343 SUB646 O=C-N-C-C 3379 0.0343 PF00115 Cytochrome C and Quinol oxidase polypeptide I 3380 0.0343 SUB367 C(~H)(~O) 3380 0.0343 PF08246 Cathepsin propeptide inhibitor domain (I29), 3381 0.0343 SUB250 >= 1 saturated or aromatic carbon-only ring size 10 3381 0.0343 PF00248 Aldo/keto reductase family 3382 0.0342 SUB186 >= 2 any ring size 6 3382 0.0342 PF08070 DTHCT (NUC029), region 3383 0.0342 SUB687 O=C-C-C-C-O 3383 0.0342 PF00549 CoA-ligase 3384 0.0341 SUB531 N:C-C:C 3384 0.0341 PF01467 Cytidylyltransferase 3385 0.0341 SUB567 O-C-C-N 3385 0.0341 PF00375 Sodium:dicarboxylate symporter family 3386 0.0341 SUB683 O-C-C-C-C-N 3386 0.0341 PF00069 Protein kinase domain 3387 0.0341 SUB684 N-C-C-C-C-C 3387 0.0341 PF00057 Low-density lipoprotein receptor domain class A 3388 0.0340 SUB375 C(~H)(~H)(~H) 3388 0.0340 PF01411 tRNA synthetases class II (A), 3389 0.0339 SUB31 >= 1 P 3389 0.0339 PF00316 Fructose-1-6-bisphosphatase 3390 0.0339 SUB564 O-C-O-C 3390 0.0339 PF03171 2OG-Fe(II), oxygenase superfamily 3391 0.0339 SUB613 N-C-O-C-C 3391 0.0339 PF01467 Cytidylyltransferase 3392 0.0339 SUB597 N=C-N-C-C 3392 0.0339 PF00690 Cation transporter/ATPase, N-terminus 3393 0.0337 SUB342 C(~C)(~C)(~O) 3393 0.0337 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3394 0.0336 SUB506 Cl-C:C-O 3394 0.0336 PF00001 7 transmembrane receptor (rhodopsin family), 3395 0.0336 SUB31 >= 1 P 3395 0.0336 PF00929 Exonuclease 3396 0.0335 SUB646 O=C-N-C-C 3396 0.0335 PF00105 Zinc finger, C4 type (two domains), 3397 0.0334 SUB346 C(~C)(~H)(~N) 3397 0.0334 PF00005 ABC transporter 3398 0.0334 SUB655 N-C-N-C-C 3398 0.0334 PF07992 Pyridine nucleotide-disulphide oxidoreductase 3399 0.0333 SUB620 O-C-C=C-C 3399 0.0333 PF07648 Kazal-type serine protease inhibitor domain 3400 0.0330 SUB336 C(~C)(~C)(~C)(~H) 3400 0.0330 PF00755 Choline/Carnitine o-acyltransferase 3401 0.0330 SUB822 CC1C(N)CCCC1 3401 0.0330 PF01582 TIR domain 3402 0.0329 SUB640 O-C-C-C-O 3402 0.0329 PF06079 Apyrase 3403 0.0328 SUB172 >= 5 any ring size 5 3403 0.0328 PF01923 Cobalamin adenosyltransferase 3404 0.0327 SUB35 >= 2 S 3404 0.0327 PF00324 Amino acid permease 3405 0.0327 SUB158 >= 3 any ring size 5 3405 0.0327 PF02466 Tim17/Tim22/Tim23 family 3406 0.0327 SUB31 >= 1 P 3406 0.0327 PF02666 Phosphatidylserine decarboxylase 3407 0.0326 SUB438 C(-C)(-N)(=C) 3407 0.0326 PF03098 Animal haem peroxidase 3408 0.0326 SUB684 N-C-C-C-C-C 3408 0.0326 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 3409 0.0325 SUB602 N-C:C:C-N 3409 0.0325 PF00300 Phosphoglycerate mutase family 3410 0.0325 SUB642 O-C-C-C=C 3410 0.0325 PF00362 Integrin, beta chain 3411 0.0324 SUB17 >= 4 N 3411 0.0324 PF00001 7 transmembrane receptor (rhodopsin family), 3412 0.0322 SUB688 O=C-C-C-C=O 3412 0.0322 PF00023 Ankyrin repeat 3413 0.0322 SUB438 C(-C)(-N)(=C) 3413 0.0322 PF00092 von Willebrand factor type A domain 3414 0.0321 SUB462 O-C-C=N 3414 0.0321 PF01826 Trypsin Inhibitor like cysteine rich domain 3415 0.0321 SUB441 C(-C)(-O)(=O) 3415 0.0321 PF00104 Ligand-binding domain of nuclear hormone receptor 3416 0.0320 SUB713 C-C(C)-C(C)-C 3416 0.0320 PF02180 Bcl-2 homology region 4 3417 0.0320 SUB466 O=S-C-C 3417 0.0320 PF01471 Putative peptidoglycan binding domain 3418 0.0320 SUB286 C-N 3418 0.0320 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 3419 0.0319 SUB700 O-C-C-C-C-C(C)-C 3419 0.0319 PF00282 Pyridoxal-dependent decarboxylase conserved domain 3420 0.0318 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 3420 0.0318 PF00069 Protein kinase domain 3421 0.0318 SUB582 O=C-C-C-O 3421 0.0318 PF00091 Tubulin/FtsZ family, GTPase domain 3422 0.0318 SUB398 N(~C)(:C)(:C) 3422 0.0318 PF01923 Cobalamin adenosyltransferase 3423 0.0318 SUB315 O-P 3423 0.0318 PF00146 NADH dehydrogenase 3424 0.0318 SUB360 C(~C)(:N)(:N) 3424 0.0318 PF12062 heparan sulfate-N-deacetylase 3425 0.0318 SUB346 C(~C)(~H)(~N) 3425 0.0318 PF04389 Peptidase family M28 3426 0.0316 SUB340 C(~C)(~C)(~H)(~O) 3426 0.0316 PF00027 Cyclic nucleotide-binding domain 3427 0.0315 SUB335 C(~C)(~C)(~C)(~C) 3427 0.0315 PF00890 FAD binding domain 3428 0.0313 SUB633 C-C-O-C:C 3428 0.0313 PF00591 Glycosyl transferase family, a/b domain 3429 0.0313 SUB421 C=O 3429 0.0313 PF00248 Aldo/keto reductase family 3430 0.0312 SUB582 O=C-C-C-O 3430 0.0312 PF03372 Endonuclease/Exonuclease/phosphatase family 3431 0.0312 SUB151 >= 2 any ring size 5 3431 0.0312 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 3432 0.0312 SUB354 C(~C)(~S) 3432 0.0312 PF00958 GMP synthase C terminal domain 3433 0.0311 SUB602 N-C:C:C-N 3433 0.0311 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3434 0.0311 SUB780 CC1CCC(N)CC1 3434 0.0311 PF00067 Cytochrome P450 3435 0.0309 SUB336 C(~C)(~C)(~C)(~H) 3435 0.0309 PF00096 Zinc finger, C2H2 type 3436 0.0309 SUB259 >= 2 hetero-aromatic rings 3436 0.0309 PF00005 ABC transporter 3437 0.0308 SUB598 O=C-C-C:C 3437 0.0308 PF03098 Animal haem peroxidase 3438 0.0308 SUB476 S-C=N-C 3438 0.0308 PF01068 ATP dependent DNA ligase domain 3439 0.0308 SUB336 C(~C)(~C)(~C)(~H) 3439 0.0308 PF08264 Anticodon-binding domain 3440 0.0307 SUB363 C(~Cl)(:C) 3440 0.0307 PF00194 Eukaryotic-type carbonic anhydrase 3441 0.0306 SUB335 C(~C)(~C)(~C)(~C) 3441 0.0306 PF03137 Organic Anion Transporter Polypeptide (OATP), family 3442 0.0304 SUB13 >= 16 C 3442 0.0304 PF00248 Aldo/keto reductase family 3443 0.0304 SUB683 O-C-C-C-C-N 3443 0.0304 PF00375 Sodium:dicarboxylate symporter family 3444 0.0303 SUB10 >= 2 C 3444 0.0303 PF01370 NAD dependent epimerase/dehydratase family 3445 0.0302 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 3445 0.0302 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3446 0.0302 SUB496 C-N-C:C 3446 0.0302 PF00550 Phosphopantetheine attachment site 3447 0.0302 SUB20 >= 2 O 3447 0.0302 PF00520 Ion transport protein 3448 0.0302 SUB653 O-C:C:C-N 3448 0.0302 PF01826 Trypsin Inhibitor like cysteine rich domain 3449 0.0301 SUB567 O-C-C-N 3449 0.0301 PF03483 B3/4 domain 3450 0.0300 SUB529 [#1]-N-C-[#1] 3450 0.0300 PF00005 ABC transporter 3451 0.0300 SUB375 C(~H)(~H)(~H) 3451 0.0300 PF01471 Putative peptidoglycan binding domain 3452 0.0297 SUB663 O-C-C-O-C 3452 0.0297 PF00001 7 transmembrane receptor (rhodopsin family), 3453 0.0297 SUB708 O=C-C-C-C-C(N)-C 3453 0.0297 PF01571 Aminomethyltransferase folate-binding domain 3454 0.0297 SUB421 C=O 3454 0.0297 PF08240 Alcohol dehydrogenase GroES-like domain 3455 0.0295 SUB633 C-C-O-C:C 3455 0.0295 PF00079 Serpin (serine protease inhibitor), 3456 0.0295 SUB340 C(~C)(~C)(~H)(~O) 3456 0.0295 PF00688 TGF-beta propeptide 3457 0.0294 SUB256 >= 1 aromatic ring 3457 0.0294 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3458 0.0293 SUB509 S=C-N-C 3458 0.0293 PF01068 ATP dependent DNA ligase domain 3459 0.0293 SUB624 O=C-C:C-C 3459 0.0293 PF00343 Carbohydrate phosphorylase 3460 0.0292 SUB599 Cl-C:C:C-C 3460 0.0292 PF00229 TNF(Tumour Necrosis Factor), family 3461 0.0292 SUB654 O-C:C:C-O 3461 0.0292 PF00069 Protein kinase domain 3462 0.0291 SUB580 O=C-C-C-C 3462 0.0291 PF00413 Matrixin 3463 0.0291 SUB412 P(~O)(~O) 3463 0.0291 PF00146 NADH dehydrogenase 3464 0.0290 SUB500 N-C:C:N 3464 0.0290 PF00501 AMP-binding enzyme 3465 0.0290 SUB346 C(~C)(~H)(~N) 3465 0.0290 PF00464 Serine hydroxymethyltransferase 3466 0.0290 SUB601 N-C:C:C-C 3466 0.0290 PF00273 Serum albumin family 3467 0.0290 SUB444 C(-C)(=O) 3467 0.0290 PF00089 Trypsin 3468 0.0288 SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 3468 0.0288 PF02460 Patched family 3469 0.0287 SUB426 P=O 3469 0.0287 PF02886 LBP / BPI / CETP family, C-terminal domain 3470 0.0287 SUB433 C(-C)(-C)(=O) 3470 0.0287 PF03098 Animal haem peroxidase 3471 0.0287 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 3471 0.0287 PF00689 Cation transporting ATPase, C-terminus 3472 0.0287 SUB14 >= 32 C 3472 0.0287 PF00001 7 transmembrane receptor (rhodopsin family), 3473 0.0285 SUB389 C(:C)(:N)(:N) 3473 0.0285 PF10509 Galactokinase galactose-binding signature 3474 0.0284 SUB587 C-S-C-C-C 3474 0.0284 PF12497 Estrogen receptor beta 3475 0.0284 SUB663 O-C-C-O-C 3475 0.0284 PF00625 Guanylate kinase 3476 0.0284 SUB529 [#1]-N-C-[#1] 3476 0.0284 PF00156 Phosphoribosyl transferase domain 3477 0.0283 SUB461 C-C-C#C 3477 0.0283 PF00104 Ligand-binding domain of nuclear hormone receptor 3478 0.0282 SUB572 [#1]-C-O-[#1] 3478 0.0282 PF01048 Phosphorylase superfamily 3479 0.0281 SUB536 O=C-C-C 3479 0.0281 PF00001 7 transmembrane receptor (rhodopsin family), 3480 0.0280 SUB696 O=C-C-C-C-C-N 3480 0.0280 PF07645 Calcium-binding EGF domain 3481 0.0278 SUB710 C-C(C)-C-C-C 3481 0.0278 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3482 0.0278 SUB453 C(-O)(=O) 3482 0.0278 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 3483 0.0278 SUB577 N=C-C:C-[#1] 3483 0.0278 PF08240 Alcohol dehydrogenase GroES-like domain 3484 0.0278 SUB357 C(~C)(:C)(:C) 3484 0.0278 PF01431 Peptidase family M13 3485 0.0277 SUB458 S(-C)(=O) 3485 0.0277 PF00186 Dihydrofolate reductase 3486 0.0277 SUB389 C(:C)(:N)(:N) 3486 0.0277 PF00288 GHMP kinases N terminal domain 3487 0.0277 SUB336 C(~C)(~C)(~C)(~H) 3487 0.0277 PF00675 Insulinase (Peptidase family M16), 3488 0.0276 SUB345 C(~C)(~H) 3488 0.0276 PF00102 Protein-tyrosine phosphatase 3489 0.0276 SUB415 S(~C)(~O) 3489 0.0276 PF08403 Amino acid permease N-terminal 3490 0.0276 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 3490 0.0276 PF00005 ABC transporter 3491 0.0274 SUB581 O=C-C-C-N 3491 0.0274 PF00153 Mitochondrial carrier protein 3492 0.0274 SUB214 >= 1 any ring size 7 3492 0.0274 PF00209 Sodium:neurotransmitter symporter family 3493 0.0274 SUB536 O=C-C-C 3493 0.0274 PF01590 GAF domain 3494 0.0274 SUB642 O-C-C-C=C 3494 0.0274 PF08725 Integrin beta cytoplasmic domain 3495 0.0272 SUB700 O-C-C-C-C-C(C)-C 3495 0.0272 PF08725 Integrin beta cytoplasmic domain 3496 0.0272 SUB453 C(-O)(=O) 3496 0.0272 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3497 0.0272 SUB660 O-C-C-N-C 3497 0.0272 PF00255 Glutathione peroxidase 3498 0.0272 SUB717 Cc1ccc(N)cc1 3498 0.0272 PF01833 IPT/TIG domain 3499 0.0272 SUB799 CC1CC(O)CCC1 3499 0.0272 PF00225 Kinesin motor domain 3500 0.0271 SUB409 O(~H)(~S) 3500 0.0271 PF07562 Nine Cysteines Domain of family 3 GPCR 3501 0.0270 SUB426 P=O 3501 0.0270 PF01273 LBP / BPI / CETP family, N-terminal domain 3502 0.0270 SUB428 C(#C)(-C) 3502 0.0270 PF00194 Eukaryotic-type carbonic anhydrase 3503 0.0269 SUB381 C(~O)(~O) 3503 0.0269 PF00067 Cytochrome P450 3504 0.0268 SUB746 Sc1cc(S)ccc1 3504 0.0268 PF02146 Sir2 family 3505 0.0268 SUB412 P(~O)(~O) 3505 0.0268 PF01704 UTP--glucose-1-phosphate uridylyltransferase 3506 0.0267 SUB599 Cl-C:C:C-C 3506 0.0267 PF01477 PLAT/LH2 domain 3507 0.0266 SUB647 O=C-N-C-[#1] 3507 0.0266 PF00653 Inhibitor of Apoptosis domain 3508 0.0266 SUB439 C(-C)(-N)(=N) 3508 0.0266 PF04042 DNA polymerase alpha/epsilon subunit B 3509 0.0266 SUB426 P=O 3509 0.0266 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 3510 0.0266 SUB2 >= 8 H 3510 0.0266 PF00069 Protein kinase domain 3511 0.0266 SUB392 N(~C)(~C)(~C) 3511 0.0266 PF04515 Plasma-membrane choline transporter 3512 0.0265 SUB350 C(~C)(~H)(~S) 3512 0.0265 PF00084 Sushi domain (SCR repeat), 3513 0.0265 SUB341 C(~C)(~C)(~N) 3513 0.0265 PF00709 Adenylosuccinate synthetase 3514 0.0265 SUB373 C(~H)(:C)(:N) 3514 0.0265 PF00702 haloacid dehalogenase-like hydrolase 3515 0.0263 SUB446 C(-H)(-N)(=C) 3515 0.0263 PF00676 Dehydrogenase E1 component 3516 0.0263 SUB517 [#1]-C=C-[#1] 3516 0.0263 PF00018 SH3 domain 3517 0.0263 SUB444 C(-C)(=O) 3517 0.0263 PF00929 Exonuclease 3518 0.0262 SUB567 O-C-C-N 3518 0.0262 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 3519 0.0261 SUB616 N-C-C-O-C 3519 0.0261 PF00209 Sodium:neurotransmitter symporter family 3520 0.0261 SUB637 C-N-C-N-C 3520 0.0261 PF00067 Cytochrome P450 3521 0.0260 SUB440 C(-C)(-N)(=O) 3521 0.0260 PF00056 lactate/malate dehydrogenase, NAD binding domain 3522 0.0259 SUB682 O-C-C-C-C-O 3522 0.0259 PF02910 domain 3523 0.0259 SUB809 SC1CC(S)CCC1 3523 0.0259 PF00194 Eukaryotic-type carbonic anhydrase 3524 0.0258 SUB409 O(~H)(~S) 3524 0.0258 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 3525 0.0258 SUB347 C(~C)(~H)(~O) 3525 0.0258 PF02155 Glucocorticoid receptor 3526 0.0257 SUB433 C(-C)(-C)(=O) 3526 0.0257 PF08771 Rapamycin binding domain 3527 0.0256 SUB580 O=C-C-C-C 3527 0.0256 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 3528 0.0256 SUB517 [#1]-C=C-[#1] 3528 0.0256 PF00107 Zinc-binding dehydrogenase 3529 0.0255 SUB799 CC1CC(O)CCC1 3529 0.0255 PF01735 Lysophospholipase catalytic domain 3530 0.0255 SUB342 C(~C)(~C)(~O) 3530 0.0255 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3531 0.0255 SUB389 C(:C)(:N)(:N) 3531 0.0255 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 3532 0.0254 SUB339 C(~C)(~C)(~H)(~N) 3532 0.0254 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 3533 0.0253 SUB680 C-C-C-C-C-C 3533 0.0253 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 3534 0.0253 SUB474 S-C:N:C 3534 0.0253 PF04679 ATP dependent DNA ligase C terminal region 3535 0.0253 SUB780 CC1CCC(N)CC1 3535 0.0253 PF08669 Glycine cleavage T-protein C-terminal barrel domain 3536 0.0252 SUB683 O-C-C-C-C-N 3536 0.0252 PF01030 Receptor L domain 3537 0.0252 SUB582 O=C-C-C-O 3537 0.0252 PF02666 Phosphatidylserine decarboxylase 3538 0.0252 SUB488 N-C=N-C 3538 0.0252 PF01048 Phosphorylase superfamily 3539 0.0252 SUB703 O-C-C-C-C-C-N-C 3539 0.0252 PF00619 Caspase recruitment domain 3540 0.0250 SUB412 P(~O)(~O) 3540 0.0250 PF02214 K+ channel tetramerisation domain 3541 0.0250 SUB412 P(~O)(~O) 3541 0.0250 PF02666 Phosphatidylserine decarboxylase 3542 0.0250 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 3542 0.0250 PF00111 2Fe-2S iron-sulfur cluster binding domain 3543 0.0249 SUB657 C-C-N-C-C 3543 0.0249 PF00999 Sodium/hydrogen exchanger family 3544 0.0249 SUB697 C-C-C-C-C-C-C-C 3544 0.0249 PF00102 Protein-tyrosine phosphatase 3545 0.0249 SUB696 O=C-C-C-C-C-N 3545 0.0249 PF00079 Serpin (serine protease inhibitor), 3546 0.0247 SUB705 O=C-C-C-C-C-C-C 3546 0.0247 PF00173 Cytochrome b5-like Heme/Steroid binding domain 3547 0.0246 SUB705 O=C-C-C-C-C-C-C 3547 0.0246 PF00096 Zinc finger, C2H2 type 3548 0.0245 SUB372 C(~H)(:C)(:C) 3548 0.0245 PF00413 Matrixin 3549 0.0245 SUB642 O-C-C-C=C 3549 0.0245 PF00413 Matrixin 3550 0.0245 SUB502 Cl-C:C-C 3550 0.0245 PF00194 Eukaryotic-type carbonic anhydrase 3551 0.0245 SUB4 >= 32 H 3551 0.0245 PF01007 Inward rectifier potassium channel 3552 0.0244 SUB381 C(~O)(~O) 3552 0.0244 PF01590 GAF domain 3553 0.0244 SUB315 O-P 3553 0.0244 PF01704 UTP--glucose-1-phosphate uridylyltransferase 3554 0.0244 SUB446 C(-H)(-N)(=C) 3554 0.0244 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 3555 0.0242 SUB529 [#1]-N-C-[#1] 3555 0.0242 PF00145 C-5 cytosine-specific DNA methylase 3556 0.0242 SUB610 Cl-C-C-N-C 3556 0.0242 PF00418 Tau and MAP protein, tubulin-binding repeat 3557 0.0241 SUB66 >= 1 As 3557 0.0241 PF00690 Cation transporter/ATPase, N-terminus 3558 0.0240 SUB578 C:C-N-C:C 3558 0.0240 PF07690 Major Facilitator Superfamily 3559 0.0240 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 3559 0.0240 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3560 0.0239 SUB694 O=C-C-C-C-C-O 3560 0.0239 PF02538 Hydantoinase B/oxoprolinase 3561 0.0239 SUB453 C(-O)(=O) 3561 0.0239 PF03098 Animal haem peroxidase 3562 0.0239 SUB820 CC1C(O)CCCC1 3562 0.0239 PF00976 Corticotropin ACTH domain 3563 0.0238 SUB422 C=S 3563 0.0238 PF00001 7 transmembrane receptor (rhodopsin family), 3564 0.0238 SUB10 >= 2 C 3564 0.0238 PF00576 HIUase/Transthyretin family 3565 0.0237 SUB719 Cc1ccc(Br)cc1 3565 0.0237 PF00641 Zn-finger in Ran binding protein and others 3566 0.0237 SUB620 O-C-C=C-C 3566 0.0237 PF00976 Corticotropin ACTH domain 3567 0.0235 SUB315 O-P 3567 0.0235 PF02666 Phosphatidylserine decarboxylase 3568 0.0235 SUB777 CC1CCC(C)CC1 3568 0.0235 PF00105 Zinc finger, C4 type (two domains), 3569 0.0234 SUB587 C-S-C-C-C 3569 0.0234 PF00043 Glutathione S-transferase, C-terminal domain 3570 0.0234 SUB309 O-H 3570 0.0234 PF01223 DNA/RNA non-specific endonuclease 3571 0.0234 SUB646 O=C-N-C-C 3571 0.0234 PF08527 Protein-arginine deiminase (PAD), middle domain 3572 0.0234 SUB658 C-N-C:C-C 3572 0.0234 PF02254 TrkA-N domain 3573 0.0233 SUB315 O-P 3573 0.0233 PF01033 Somatomedin B domain 3574 0.0233 SUB695 O=C-C-C-C-C=O 3574 0.0233 PF00180 Isocitrate/isopropylmalate dehydrogenase 3575 0.0233 SUB379 C(~N)(:C)(:N) 3575 0.0233 PF02817 e3 binding domain 3576 0.0233 SUB570 N-C-C-N 3576 0.0233 PF00001 7 transmembrane receptor (rhodopsin family), 3577 0.0232 SUB288 C-F 3577 0.0232 PF03104 DNA polymerase family B, exonuclease domain 3578 0.0232 SUB503 N-C=C-[#1] 3578 0.0232 PF00390 Malic enzyme, N-terminal domain 3579 0.0231 SUB541 C-N-C-[#1] 3579 0.0231 PF00194 Eukaryotic-type carbonic anhydrase 3580 0.0230 SUB629 C-N-C-C:C 3580 0.0230 PF08674 Acetylcholinesterase tetramerisation domain 3581 0.0230 SUB779 CC1CCC(S)CC1 3581 0.0230 PF00105 Zinc finger, C4 type (two domains), 3582 0.0229 SUB433 C(-C)(-C)(=O) 3582 0.0229 PF02259 FAT domain 3583 0.0228 SUB537 O=C-C-N 3583 0.0228 PF03917 Eukaryotic glutathione synthase, ATP binding domain 3584 0.0228 SUB573 N:C:N:C 3584 0.0228 PF00690 Cation transporter/ATPase, N-terminus 3585 0.0228 SUB639 O-C-C-C-N 3585 0.0228 PF00001 7 transmembrane receptor (rhodopsin family), 3586 0.0228 SUB537 O=C-C-N 3586 0.0228 PF00868 Transglutaminase family 3587 0.0226 SUB646 O=C-N-C-C 3587 0.0226 PF00001 7 transmembrane receptor (rhodopsin family), 3588 0.0225 SUB504 Cl-C:C-[#1] 3588 0.0225 PF03073 TspO/MBR family 3589 0.0225 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 3589 0.0225 PF00135 Carboxylesterase 3590 0.0224 SUB180 >= 1 saturated or aromatic carbon-only ring size 6 3590 0.0224 PF00690 Cation transporter/ATPase, N-terminus 3591 0.0223 SUB621 C:C-O-C-C 3591 0.0223 PF00149 Calcineurin-like phosphoesterase 3592 0.0223 SUB457 P(-O)(=O) 3592 0.0223 PF00074 Pancreatic ribonuclease 3593 0.0222 SUB137 >= 2 any ring size 4 3593 0.0222 PF00689 Cation transporting ATPase, C-terminus 3594 0.0222 SUB500 N-C:C:N 3594 0.0222 PF01591 6-phosphofructo-2-kinase 3595 0.0222 SUB695 O=C-C-C-C-C=O 3595 0.0222 PF01124 MAPEG family 3596 0.0221 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 3596 0.0221 PF08725 Integrin beta cytoplasmic domain 3597 0.0220 SUB674 O=C-C=C-N 3597 0.0220 PF00104 Ligand-binding domain of nuclear hormone receptor 3598 0.0220 SUB708 O=C-C-C-C-C(N)-C 3598 0.0220 PF01437 Plexin repeat 3599 0.0219 SUB462 O-C-C=N 3599 0.0219 PF00001 7 transmembrane receptor (rhodopsin family), 3600 0.0219 SUB662 O-C-O-C-C 3600 0.0219 PF03171 2OG-Fe(II), oxygenase superfamily 3601 0.0218 SUB621 C:C-O-C-C 3601 0.0218 PF08441 Integrin alpha 3602 0.0218 SUB708 O=C-C-C-C-C(N)-C 3602 0.0218 PF00092 von Willebrand factor type A domain 3603 0.0217 SUB624 O=C-C:C-C 3603 0.0217 PF00520 Ion transport protein 3604 0.0217 SUB180 >= 1 saturated or aromatic carbon-only ring size 6 3604 0.0217 PF00689 Cation transporting ATPase, C-terminus 3605 0.0217 SUB66 >= 1 As 3605 0.0217 PF00122 E1-E2 ATPase 3606 0.0217 SUB31 >= 1 P 3606 0.0217 PF00692 dUTPase 3607 0.0216 SUB756 Cc1c(C)cccc1 3607 0.0216 PF01593 Flavin containing amine oxidoreductase 3608 0.0216 SUB339 C(~C)(~C)(~H)(~N) 3608 0.0216 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 3609 0.0215 SUB712 C-C(C)(C)-C-C 3609 0.0215 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3610 0.0214 SUB688 O=C-C-C-C=O 3610 0.0214 PF00709 Adenylosuccinate synthetase 3611 0.0213 SUB31 >= 1 P 3611 0.0213 PF01033 Somatomedin B domain 3612 0.0213 SUB692 O-C-C-C-C-C-N 3612 0.0213 PF00764 Arginosuccinate synthase 3613 0.0211 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 3613 0.0211 PF00204 DNA gyrase B 3614 0.0210 SUB439 C(-C)(-N)(=N) 3614 0.0210 PF08418 DNA polymerase alpha subunit B N-terminal 3615 0.0210 SUB399 N(~H)(~N) 3615 0.0210 PF08418 DNA polymerase alpha subunit B N-terminal 3616 0.0209 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 3616 0.0209 PF08384 Pro-opiomelanocortin, N-terminal region 3617 0.0209 SUB333 C(~C)(~C) 3617 0.0209 PF00337 Galactoside-binding lectin 3618 0.0209 SUB574 O-C-C=C 3618 0.0209 PF08035 Opioids neuropeptide 3619 0.0209 SUB690 O-C-C-C-C-C-C 3619 0.0209 PF10420 Cytokine interleukin-12p40 C-terminus 3620 0.0208 SUB668 C=C-C-O-[#1] 3620 0.0208 PF00650 CRAL/TRIO domain 3621 0.0207 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 3621 0.0207 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 3622 0.0207 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 3622 0.0207 PF00664 ABC transporter transmembrane region 3623 0.0205 SUB375 C(~H)(~H)(~H) 3623 0.0205 PF00689 Cation transporting ATPase, C-terminus 3624 0.0205 SUB606 O=C-C-O-C 3624 0.0205 PF02260 FATC domain 3625 0.0204 SUB348 C(~C)(~H)(~O)(~O) 3625 0.0204 PF07645 Calcium-binding EGF domain 3626 0.0204 SUB287 C-O 3626 0.0204 PF00520 Ion transport protein 3627 0.0203 SUB380 C(~N)(:N) 3627 0.0203 PF01591 6-phosphofructo-2-kinase 3628 0.0203 SUB647 O=C-N-C-[#1] 3628 0.0203 PF00005 ABC transporter 3629 0.0202 SUB441 C(-C)(-O)(=O) 3629 0.0202 PF02772 S-adenosylmethionine synthetase, central domain 3630 0.0202 SUB536 O=C-C-C 3630 0.0202 PF00520 Ion transport protein 3631 0.0202 SUB690 O-C-C-C-C-C-C 3631 0.0202 PF00089 Trypsin 3632 0.0202 SUB547 N-C:C-[#1] 3632 0.0202 PF00091 Tubulin/FtsZ family, GTPase domain 3633 0.0201 SUB368 C(~H)(~O)(~O) 3633 0.0201 PF07645 Calcium-binding EGF domain 3634 0.0201 SUB200 >= 4 any ring size 6 3634 0.0201 PF00976 Corticotropin ACTH domain 3635 0.0201 SUB537 O=C-C-N 3635 0.0201 PF00343 Carbohydrate phosphorylase 3636 0.0201 SUB529 [#1]-N-C-[#1] 3636 0.0201 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 3637 0.0201 SUB694 O=C-C-C-C-C-O 3637 0.0201 PF02637 GatB domain 3638 0.0201 SUB295 C-Cl 3638 0.0201 PF00690 Cation transporter/ATPase, N-terminus 3639 0.0201 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 3639 0.0201 PF03404 Mo-co oxidoreductase dimerisation domain 3640 0.0200 SUB486 N:C:C:N 3640 0.0200 PF00156 Phosphoribosyl transferase domain 3641 0.0200 SUB250 >= 1 saturated or aromatic carbon-only ring size 10 3641 0.0200 PF00067 Cytochrome P450 3642 0.0199 SUB644 [#1]-C-C-N-[#1] 3642 0.0199 PF00069 Protein kinase domain 3643 0.0199 SUB657 C-C-N-C-C 3643 0.0199 PF00001 7 transmembrane receptor (rhodopsin family), 3644 0.0198 SUB390 C(:N)(:N) 3644 0.0198 PF00300 Phosphoglycerate mutase family 3645 0.0198 SUB488 N-C=N-C 3645 0.0198 PF00069 Protein kinase domain 3646 0.0198 SUB581 O=C-C-C-N 3646 0.0198 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 3647 0.0197 SUB692 O-C-C-C-C-C-N 3647 0.0197 PF03950 tRNA synthetases class I (E and Q), , anti-codon binding domain 3648 0.0197 SUB820 CC1C(O)CCCC1 3648 0.0197 PF08384 Pro-opiomelanocortin, N-terminal region 3649 0.0197 SUB2 >= 8 H 3649 0.0197 PF08674 Acetylcholinesterase tetramerisation domain 3650 0.0197 SUB694 O=C-C-C-C-C-O 3650 0.0197 PF02934 GatB/GatE catalytic domain 3651 0.0196 SUB262 >= 4 aromatic rings 3651 0.0196 PF00989 PAS fold 3652 0.0196 SUB460 S(=O)(=O) 3652 0.0196 PF00625 Guanylate kinase 3653 0.0196 SUB215 >= 1 saturated or aromatic carbon-only ring size 7 3653 0.0196 PF00001 7 transmembrane receptor (rhodopsin family), 3654 0.0194 SUB444 C(-C)(=O) 3654 0.0194 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 3655 0.0193 SUB447 C(-H)(=C) 3655 0.0193 PF00067 Cytochrome P450 3656 0.0192 SUB682 O-C-C-C-C-O 3656 0.0192 PF00001 7 transmembrane receptor (rhodopsin family), 3657 0.0192 SUB409 O(~H)(~S) 3657 0.0192 PF09193 Cholecystokinin A receptor, N-terminal 3658 0.0192 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 3658 0.0192 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3659 0.0191 SUB594 N-C-C-C-N 3659 0.0191 PF08669 Glycine cleavage T-protein C-terminal barrel domain 3660 0.0191 SUB446 C(-H)(-N)(=C) 3660 0.0191 PF03949 Malic enzyme, NAD binding domain 3661 0.0191 SUB587 C-S-C-C-C 3661 0.0191 PF00856 SET domain 3662 0.0191 SUB537 O=C-C-N 3662 0.0191 PF00856 SET domain 3663 0.0191 SUB644 [#1]-C-C-N-[#1] 3663 0.0191 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 3664 0.0190 SUB439 C(-C)(-N)(=N) 3664 0.0190 PF01591 6-phosphofructo-2-kinase 3665 0.0190 SUB453 C(-O)(=O) 3665 0.0190 PF02773 S-adenosylmethionine synthetase, C-terminal domain 3666 0.0190 SUB477 C-O-C=C 3666 0.0190 PF08441 Integrin alpha 3667 0.0189 SUB799 CC1CC(O)CCC1 3667 0.0189 PF00452 Apoptosis regulator proteins, Bcl-2 family 3668 0.0189 SUB148 >= 1 unsaturated non-aromatic carbon-only ring size 5 3668 0.0189 PF00071 Ras family 3669 0.0188 SUB611 C-O-C-O-C 3669 0.0188 PF00001 7 transmembrane receptor (rhodopsin family), 3670 0.0188 SUB448 C(-H)(=N) 3670 0.0188 PF00104 Ligand-binding domain of nuclear hormone receptor 3671 0.0187 SUB369 C(~H)(~S) 3671 0.0187 PF07965 Integrin beta tail domain 3672 0.0186 SUB35 >= 2 S 3672 0.0186 PF08499 3"5"-cyclic nucleotide phosphodiesterase N-terminal 3673 0.0186 SUB485 N-C:N:C 3673 0.0186 PF01591 6-phosphofructo-2-kinase 3674 0.0186 SUB697 C-C-C-C-C-C-C-C 3674 0.0186 PF00579 tRNA synthetases class I (W and Y), 3675 0.0185 SUB622 N-C:C:C:N 3675 0.0185 PF01582 TIR domain 3676 0.0185 SUB412 P(~O)(~O) 3676 0.0185 PF00692 dUTPase 3677 0.0184 SUB32 >= 2 P 3677 0.0184 PF00004 ATPase family associated with various cellular activities (AAA), 3678 0.0183 SUB560 O-C-N-[#1] 3678 0.0183 PF01068 ATP dependent DNA ligase domain 3679 0.0183 SUB567 O-C-C-N 3679 0.0183 PF00152 tRNA synthetases class II (D, K and N), 3680 0.0183 SUB537 O=C-C-N 3680 0.0183 PF01279 Parathyroid hormone family 3681 0.0182 SUB582 O=C-C-C-O 3681 0.0182 PF01130 CD36 family 3682 0.0182 SUB433 C(-C)(-C)(=O) 3682 0.0182 PF02260 FATC domain 3683 0.0182 SUB567 O-C-C-N 3683 0.0182 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 3684 0.0182 SUB547 N-C:C-[#1] 3684 0.0182 PF03953 Tubulin C-terminal domain 3685 0.0182 SUB647 O=C-N-C-[#1] 3685 0.0182 PF01477 PLAT/LH2 domain 3686 0.0181 SUB25 >= 2 F 3686 0.0181 PF10613 Ligated ion channel L-glutamate- and glycine-binding site 3687 0.0180 SUB620 O-C-C=C-C 3687 0.0180 PF08384 Pro-opiomelanocortin, N-terminal region 3688 0.0180 SUB144 >= 1 any ring size 5 3688 0.0180 PF00209 Sodium:neurotransmitter symporter family 3689 0.0179 SUB501 C-S-C:C 3689 0.0179 PF03098 Animal haem peroxidase 3690 0.0178 SUB444 C(-C)(=O) 3690 0.0178 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3691 0.0177 SUB398 N(~C)(:C)(:C) 3691 0.0177 PF01770 Reduced folate carrier 3692 0.0177 SUB375 C(~H)(~H)(~H) 3692 0.0177 PF00168 C2 domain 3693 0.0177 SUB200 >= 4 any ring size 6 3693 0.0177 PF00001 7 transmembrane receptor (rhodopsin family), 3694 0.0176 SUB594 N-C-C-C-N 3694 0.0176 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 3695 0.0176 SUB375 C(~H)(~H)(~H) 3695 0.0176 PF00787 PX domain 3696 0.0175 SUB684 N-C-C-C-C-C 3696 0.0175 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 3697 0.0174 SUB261 >= 3 hetero-aromatic rings 3697 0.0174 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 3698 0.0174 SUB398 N(~C)(:C)(:C) 3698 0.0174 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3699 0.0173 SUB137 >= 2 any ring size 4 3699 0.0173 PF00702 haloacid dehalogenase-like hydrolase 3700 0.0173 SUB785 OC1CCC(N)CC1 3700 0.0173 PF06512 Sodium ion transport-associated 3701 0.0171 SUB459 S(-O)(=O) 3701 0.0171 PF00520 Ion transport protein 3702 0.0171 SUB730 Nc1ccc(Cl)cc1 3702 0.0171 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3703 0.0171 SUB736 Cc1cc(O)ccc1 3703 0.0171 PF00884 Sulfatase 3704 0.0171 SUB389 C(:C)(:N)(:N) 3704 0.0171 PF00501 AMP-binding enzyme 3705 0.0171 SUB668 C=C-C-O-[#1] 3705 0.0171 PF03765 CRAL/TRIO, N-terminus 3706 0.0170 SUB505 N:C:N-C 3706 0.0170 PF00067 Cytochrome P450 3707 0.0170 SUB165 >= 4 any ring size 5 3707 0.0170 PF01403 Sema domain 3708 0.0169 SUB672 O=C-C=C-C 3708 0.0169 PF00273 Serum albumin family 3709 0.0169 SUB580 O=C-C-C-C 3709 0.0169 PF01061 ABC-2 type transporter 3710 0.0169 SUB612 N-C-C-N-C 3710 0.0169 PF00214 Calcitonin / CGRP / IAPP family 3711 0.0168 SUB644 [#1]-C-C-N-[#1] 3711 0.0168 PF08070 DTHCT (NUC029), region 3712 0.0166 SUB594 N-C-C-C-N 3712 0.0166 PF01571 Aminomethyltransferase folate-binding domain 3713 0.0164 SUB735 Cc1cc(C)ccc1 3713 0.0164 PF00501 AMP-binding enzyme 3714 0.0163 SUB706 O=C-C-C-C-C(O)-C 3714 0.0163 PF00005 ABC transporter 3715 0.0163 SUB454 N(-C)(=C) 3715 0.0163 PF00089 Trypsin 3716 0.0163 SUB31 >= 1 P 3716 0.0163 PF11404 Potassium voltage-gated channel 3717 0.0162 SUB751 Nc1cc(Cl)ccc1 3717 0.0162 PF03493 Calcium-activated BK potassium channel alpha subunit 3718 0.0161 SUB657 C-C-N-C-C 3718 0.0161 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3719 0.0160 SUB706 O=C-C-C-C-C(O)-C 3719 0.0160 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 3720 0.0159 SUB683 O-C-C-C-C-N 3720 0.0159 PF00023 Ankyrin repeat 3721 0.0159 SUB523 C-N-N-[#1] 3721 0.0159 PF08418 DNA polymerase alpha subunit B N-terminal 3722 0.0159 SUB374 C(~H)(:N) 3722 0.0159 PF00069 Protein kinase domain 3723 0.0159 SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 3723 0.0159 PF00170 bZIP transcription factor 3724 0.0157 SUB618 C-C-C-O-[#1] 3724 0.0157 PF00282 Pyridoxal-dependent decarboxylase conserved domain 3725 0.0157 SUB799 CC1CC(O)CCC1 3725 0.0157 PF02180 Bcl-2 homology region 4 3726 0.0156 SUB567 O-C-C-N 3726 0.0156 PF00614 Phospholipase D Active site motif 3727 0.0156 SUB16 >= 2 N 3727 0.0156 PF00023 Ankyrin repeat 3728 0.0156 SUB643 O-C-C-C=O 3728 0.0156 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 3729 0.0155 SUB644 [#1]-C-C-N-[#1] 3729 0.0155 PF01593 Flavin containing amine oxidoreductase 3730 0.0155 SUB708 O=C-C-C-C-C(N)-C 3730 0.0155 PF00464 Serine hydroxymethyltransferase 3731 0.0155 SUB612 N-C-C-N-C 3731 0.0155 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 3732 0.0155 SUB346 C(~C)(~H)(~N) 3732 0.0155 PF00024 PAN domain 3733 0.0154 SUB611 C-O-C-O-C 3733 0.0154 PF04711 Apolipoprotein A-II (ApoA-II), 3734 0.0154 SUB693 O=C-C-C-C-C-C 3734 0.0154 PF03099 Biotin/lipoate A/B protein ligase family 3735 0.0154 SUB597 N=C-N-C-C 3735 0.0154 PF00043 Glutathione S-transferase, C-terminal domain 3736 0.0153 SUB572 [#1]-C-O-[#1] 3736 0.0153 PF00732 GMC oxidoreductase 3737 0.0153 SUB380 C(~N)(:N) 3737 0.0153 PF00300 Phosphoglycerate mutase family 3738 0.0153 SUB580 O=C-C-C-C 3738 0.0153 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 3739 0.0153 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 3739 0.0153 PF00128 Alpha amylase, catalytic domain 3740 0.0152 SUB368 C(~H)(~O)(~O) 3740 0.0152 PF00089 Trypsin 3741 0.0152 SUB375 C(~H)(~H)(~H) 3741 0.0152 PF00354 Pentaxin family 3742 0.0152 SUB339 C(~C)(~C)(~H)(~N) 3742 0.0152 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 3743 0.0152 SUB24 >= 1 F 3743 0.0152 PF00136 DNA polymerase family B 3744 0.0151 SUB683 O-C-C-C-C-N 3744 0.0151 PF08669 Glycine cleavage T-protein C-terminal barrel domain 3745 0.0151 SUB778 CC1CCC(O)CC1 3745 0.0151 PF00702 haloacid dehalogenase-like hydrolase 3746 0.0150 SUB420 C#N 3746 0.0150 PF01007 Inward rectifier potassium channel 3747 0.0150 SUB202 >= 4 saturated or aromatic nitrogen-containing ring size 6 3747 0.0150 PF00520 Ion transport protein 3748 0.0149 SUB759 Cc1c(N)cccc1 3748 0.0149 PF01387 Synuclein 3749 0.0147 SUB179 >= 1 any ring size 6 3749 0.0147 PF00343 Carbohydrate phosphorylase 3750 0.0146 SUB710 C-C(C)-C-C-C 3750 0.0146 PF00069 Protein kinase domain 3751 0.0146 SUB574 O-C-C=C 3751 0.0146 PF00976 Corticotropin ACTH domain 3752 0.0145 SUB603 O=C-C-N-C 3752 0.0145 PF06512 Sodium ion transport-associated 3753 0.0145 SUB572 [#1]-C-O-[#1] 3753 0.0145 PF00303 Thymidylate synthase 3754 0.0144 SUB537 O=C-C-N 3754 0.0144 PF01135 Protein-L-isoaspartate(D-aspartate), O-methyltransferase (PCMT), 3755 0.0144 SUB441 C(-C)(-O)(=O) 3755 0.0144 PF01042 Endoribonuclease L-PSP 3756 0.0143 SUB644 [#1]-C-C-N-[#1] 3756 0.0143 PF00152 tRNA synthetases class II (D, K and N), 3757 0.0143 SUB408 O(~C)(~P) 3757 0.0143 PF00074 Pancreatic ribonuclease 3758 0.0143 SUB31 >= 1 P 3758 0.0143 PF02214 K+ channel tetramerisation domain 3759 0.0143 SUB438 C(-C)(-N)(=C) 3759 0.0143 PF00822 PMP-22/EMP/MP20/Claudin family 3760 0.0141 SUB801 CC1CC(N)CCC1 3760 0.0141 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3761 0.0141 SUB34 >= 1 S 3761 0.0141 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 3762 0.0141 SUB608 N-C-C-C:C 3762 0.0141 PF02159 Oestrogen receptor 3763 0.0139 SUB700 O-C-C-C-C-C(C)-C 3763 0.0139 PF00452 Apoptosis regulator proteins, Bcl-2 family 3764 0.0139 SUB574 O-C-C=C 3764 0.0139 PF08384 Pro-opiomelanocortin, N-terminal region 3765 0.0139 SUB359 C(~C)(:N) 3765 0.0139 PF00229 TNF(Tumour Necrosis Factor), family 3766 0.0139 SUB537 O=C-C-N 3766 0.0139 PF03199 Eukaryotic glutathione synthase 3767 0.0138 SUB573 N:C:N:C 3767 0.0138 PF00067 Cytochrome P450 3768 0.0138 SUB414 S(~C)(~H) 3768 0.0138 PF01431 Peptidase family M13 3769 0.0138 SUB491 C-C-C=C 3769 0.0138 PF00273 Serum albumin family 3770 0.0137 SUB439 C(-C)(-N)(=N) 3770 0.0137 PF00931 NB-ARC domain 3771 0.0137 SUB696 O=C-C-C-C-C-N 3771 0.0137 PF01124 MAPEG family 3772 0.0136 SUB3 >= 16 H 3772 0.0136 PF00168 C2 domain 3773 0.0135 SUB609 C-C-C-C:C 3773 0.0135 PF00001 7 transmembrane receptor (rhodopsin family), 3774 0.0135 SUB551 Cl-C-C-C 3774 0.0135 PF00069 Protein kinase domain 3775 0.0135 SUB407 O(~C)(~H) 3775 0.0135 PF01212 Beta-eliminating lyase 3776 0.0134 SUB777 CC1CCC(C)CC1 3776 0.0134 PF00005 ABC transporter 3777 0.0133 SUB433 C(-C)(-C)(=O) 3777 0.0133 PF00273 Serum albumin family 3778 0.0133 SUB578 C:C-N-C:C 3778 0.0133 PF00282 Pyridoxal-dependent decarboxylase conserved domain 3779 0.0133 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 3779 0.0133 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 3780 0.0132 SUB599 Cl-C:C:C-C 3780 0.0132 PF00194 Eukaryotic-type carbonic anhydrase 3781 0.0132 SUB540 N=C-C-[#1] 3781 0.0132 PF00042 Globin 3782 0.0132 SUB572 [#1]-C-O-[#1] 3782 0.0132 PF05199 GMC oxidoreductase 3783 0.0131 SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 3783 0.0131 PF02806 Alpha amylase, C-terminal all-beta domain 3784 0.0131 SUB393 N(~C)(~C)(~H) 3784 0.0131 PF09127 Leukotriene A4 hydrolase, C-terminal 3785 0.0131 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 3785 0.0131 PF02770 Acyl-CoA dehydrogenase, middle domain 3786 0.0130 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 3786 0.0130 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 3787 0.0129 SUB408 O(~C)(~P) 3787 0.0129 PF03372 Endonuclease/Exonuclease/phosphatase family 3788 0.0129 SUB137 >= 2 any ring size 4 3788 0.0129 PF00122 E1-E2 ATPase 3789 0.0129 SUB12 >= 8 C 3789 0.0129 PF00501 AMP-binding enzyme 3790 0.0128 SUB35 >= 2 S 3790 0.0128 PF00079 Serpin (serine protease inhibitor), 3791 0.0128 SUB394 N(~C)(~H) 3791 0.0128 PF00092 von Willebrand factor type A domain 3792 0.0127 SUB461 C-C-C#C 3792 0.0127 PF00105 Zinc finger, C4 type (two domains), 3793 0.0126 SUB743 Oc1cc(N)ccc1 3793 0.0126 PF08742 C8 domain 3794 0.0126 SUB339 C(~C)(~C)(~H)(~N) 3794 0.0126 PF00749 tRNA synthetases class I (E and Q), , catalytic domain 3795 0.0125 SUB597 N=C-N-C-C 3795 0.0125 PF00001 7 transmembrane receptor (rhodopsin family), 3796 0.0125 SUB785 OC1CCC(N)CC1 3796 0.0125 PF00656 Caspase domain 3797 0.0125 SUB426 P=O 3797 0.0125 PF00316 Fructose-1-6-bisphosphatase 3798 0.0125 SUB861 CC1C(C)CCC1 3798 0.0125 PF00273 Serum albumin family 3799 0.0125 SUB242 >= 1 any ring size 9 3799 0.0125 PF00071 Ras family 3800 0.0125 SUB751 Nc1cc(Cl)ccc1 3800 0.0125 PF02254 TrkA-N domain 3801 0.0125 SUB262 >= 4 aromatic rings 3801 0.0125 PF07992 Pyridine nucleotide-disulphide oxidoreductase 3802 0.0124 SUB260 >= 3 aromatic rings 3802 0.0124 PF02180 Bcl-2 homology region 4 3803 0.0124 SUB300 N-H 3803 0.0124 PF00092 von Willebrand factor type A domain 3804 0.0123 SUB66 >= 1 As 3804 0.0123 PF00702 haloacid dehalogenase-like hydrolase 3805 0.0122 SUB567 O-C-C-N 3805 0.0122 PF02574 Homocysteine S-methyltransferase 3806 0.0122 SUB336 C(~C)(~C)(~C)(~H) 3806 0.0122 PF00194 Eukaryotic-type carbonic anhydrase 3807 0.0122 SUB179 >= 1 any ring size 6 3807 0.0122 PF00105 Zinc finger, C4 type (two domains), 3808 0.0120 SUB463 O-C-C=O 3808 0.0120 PF00102 Protein-tyrosine phosphatase 3809 0.0120 SUB504 Cl-C:C-[#1] 3809 0.0120 PF00229 TNF(Tumour Necrosis Factor), family 3810 0.0119 SUB336 C(~C)(~C)(~C)(~H) 3810 0.0119 PF01431 Peptidase family M13 3811 0.0119 SUB438 C(-C)(-N)(=C) 3811 0.0119 PF00089 Trypsin 3812 0.0119 SUB458 S(-C)(=O) 3812 0.0119 PF03098 Animal haem peroxidase 3813 0.0119 SUB621 C:C-O-C-C 3813 0.0119 PF00561 alpha/beta hydrolase fold 3814 0.0118 SUB644 [#1]-C-C-N-[#1] 3814 0.0118 PF01336 OB-fold nucleic acid binding domain 3815 0.0118 SUB306 N-S 3815 0.0118 PF07885 Ion channel 3816 0.0118 SUB350 C(~C)(~H)(~S) 3816 0.0118 PF00756 Putative esterase 3817 0.0117 SUB158 >= 3 any ring size 5 3817 0.0117 PF10531 SLBB domain 3818 0.0116 SUB561 N-C-N-C 3818 0.0116 PF06512 Sodium ion transport-associated 3819 0.0115 SUB529 [#1]-N-C-[#1] 3819 0.0115 PF01842 ACT domain 3820 0.0115 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 3820 0.0115 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 3821 0.0114 SUB261 >= 3 hetero-aromatic rings 3821 0.0114 PF00378 Enoyl-CoA hydratase/isomerase family 3822 0.0114 SUB665 C-C=C-C=C 3822 0.0114 PF00105 Zinc finger, C4 type (two domains), 3823 0.0114 SUB594 N-C-C-C-N 3823 0.0114 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3824 0.0113 SUB620 O-C-C=C-C 3824 0.0113 PF06907 Latexin 3825 0.0113 SUB440 C(-C)(-N)(=O) 3825 0.0113 PF00533 BRCA1 C Terminus (BRCT), domain 3826 0.0113 SUB665 C-C=C-C=C 3826 0.0113 PF02159 Oestrogen receptor 3827 0.0112 SUB633 C-C-O-C:C 3827 0.0112 PF00248 Aldo/keto reductase family 3828 0.0112 SUB396 N(~C)(~O) 3828 0.0112 PF03098 Animal haem peroxidase 3829 0.0111 SUB708 O=C-C-C-C-C(N)-C 3829 0.0111 PF01826 Trypsin Inhibitor like cysteine rich domain 3830 0.0111 SUB32 >= 2 P 3830 0.0111 PF00692 dUTPase 3831 0.0111 SUB331 C(~Br)(:C) 3831 0.0111 PF00641 Zn-finger in Ran binding protein and others 3832 0.0110 SUB296 C-As 3832 0.0110 PF00041 Fibronectin type III domain 3833 0.0110 SUB694 O=C-C-C-C-C-O 3833 0.0110 PF00155 Aminotransferase class I and II 3834 0.0105 SUB309 O-H 3834 0.0105 PF01033 Somatomedin B domain 3835 0.0104 SUB799 CC1CC(O)CCC1 3835 0.0104 PF00209 Sodium:neurotransmitter symporter family 3836 0.0104 SUB655 N-C-N-C-C 3836 0.0104 PF00001 7 transmembrane receptor (rhodopsin family), 3837 0.0104 SUB700 O-C-C-C-C-C(C)-C 3837 0.0104 PF02180 Bcl-2 homology region 4 3838 0.0103 SUB375 C(~H)(~H)(~H) 3838 0.0103 PF07645 Calcium-binding EGF domain 3839 0.0103 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 3839 0.0103 PF00248 Aldo/keto reductase family 3840 0.0103 SUB452 C(-N)(=O) 3840 0.0103 PF01426 BAH domain 3841 0.0103 SUB11 >= 4 C 3841 0.0103 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 3842 0.0103 SUB499 O-C=C-C 3842 0.0103 PF01477 PLAT/LH2 domain 3843 0.0102 SUB598 O=C-C-C:C 3843 0.0102 PF08403 Amino acid permease N-terminal 3844 0.0101 SUB407 O(~C)(~H) 3844 0.0101 PF00557 Metallopeptidase family M24 3845 0.0101 SUB509 S=C-N-C 3845 0.0101 PF00041 Fibronectin type III domain 3846 0.0101 SUB679 C-C-C=C-C 3846 0.0101 PF00104 Ligand-binding domain of nuclear hormone receptor 3847 0.0101 SUB664 O-C-C-O-[#1] 3847 0.0101 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 3848 0.0101 SUB393 N(~C)(~C)(~H) 3848 0.0101 PF00521 DNA gyrase/topoisomerase IV, subunit A 3849 0.0101 SUB380 C(~N)(:N) 3849 0.0101 PF01030 Receptor L domain 3850 0.0100 SUB572 [#1]-C-O-[#1] 3850 0.0100 PF01433 Peptidase family M1 3851 0.0100 SUB694 O=C-C-C-C-C-O 3851 0.0100 PF02219 Methylenetetrahydrofolate reductase 3852 0.0099 SUB577 N=C-C:C-[#1] 3852 0.0099 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 3853 0.0099 SUB752 Nc1cc(Br)ccc1 3853 0.0099 PF00001 7 transmembrane receptor (rhodopsin family), 3854 0.0098 SUB392 N(~C)(~C)(~C) 3854 0.0098 PF00105 Zinc finger, C4 type (two domains), 3855 0.0098 SUB341 C(~C)(~C)(~N) 3855 0.0098 PF00324 Amino acid permease 3856 0.0098 SUB258 >= 2 aromatic rings 3856 0.0098 PF00667 FAD binding domain 3857 0.0097 SUB640 O-C-C-C-O 3857 0.0097 PF02180 Bcl-2 homology region 4 3858 0.0097 SUB610 Cl-C-C-N-C 3858 0.0097 PF03098 Animal haem peroxidase 3859 0.0097 SUB582 O=C-C-C-O 3859 0.0097 PF02928 C5HC2 zinc finger 3860 0.0097 SUB690 O-C-C-C-C-C-C 3860 0.0097 PF01151 GNS1/SUR4 family 3861 0.0097 SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 3861 0.0097 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 3862 0.0096 SUB495 O=C-C:N 3862 0.0096 PF00071 Ras family 3863 0.0096 SUB426 P=O 3863 0.0096 PF11404 Potassium voltage-gated channel 3864 0.0095 SUB696 O=C-C-C-C-C-N 3864 0.0095 PF00149 Calcineurin-like phosphoesterase 3865 0.0094 SUB681 O-C-C-C-C-C 3865 0.0094 PF00413 Matrixin 3866 0.0093 SUB389 C(:C)(:N)(:N) 3866 0.0093 PF05221 S-adenosyl-L-homocysteine hydrolase 3867 0.0093 SUB492 C-N:C-[#1] 3867 0.0093 PF00478 IMP dehydrogenase / GMP reductase domain 3868 0.0093 SUB336 C(~C)(~C)(~C)(~H) 3868 0.0093 PF00520 Ion transport protein 3869 0.0092 SUB582 O=C-C-C-O 3869 0.0092 PF00656 Caspase domain 3870 0.0092 SUB713 C-C(C)-C(C)-C 3870 0.0092 PF00497 Bacterial extracellular solute-binding proteins, family 3 3871 0.0091 SUB698 C-C-C-C-C-C(C)-C 3871 0.0091 PF00209 Sodium:neurotransmitter symporter family 3872 0.0091 SUB339 C(~C)(~C)(~H)(~N) 3872 0.0091 PF03483 B3/4 domain 3873 0.0090 SUB647 O=C-N-C-[#1] 3873 0.0090 PF08246 Cathepsin propeptide inhibitor domain (I29), 3874 0.0089 SUB21 >= 4 O 3874 0.0089 PF00001 7 transmembrane receptor (rhodopsin family), 3875 0.0089 SUB654 O-C:C:C-O 3875 0.0089 PF00001 7 transmembrane receptor (rhodopsin family), 3876 0.0089 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 3876 0.0089 PF00690 Cation transporter/ATPase, N-terminus 3877 0.0088 SUB537 O=C-C-N 3877 0.0088 PF05544 Proline racemase 3878 0.0088 SUB567 O-C-C-N 3878 0.0088 PF02666 Phosphatidylserine decarboxylase 3879 0.0087 SUB705 O=C-C-C-C-C-C-C 3879 0.0087 PF07965 Integrin beta tail domain 3880 0.0087 SUB582 O=C-C-C-O 3880 0.0087 PF00168 C2 domain 3881 0.0087 SUB640 O-C-C-C-O 3881 0.0087 PF00452 Apoptosis regulator proteins, Bcl-2 family 3882 0.0087 SUB360 C(~C)(:N)(:N) 3882 0.0087 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 3883 0.0086 SUB366 C(~H)(~N) 3883 0.0086 PF00024 PAN domain 3884 0.0085 SUB390 C(:N)(:N) 3884 0.0085 PF01591 6-phosphofructo-2-kinase 3885 0.0085 SUB615 C-C-O-C-C 3885 0.0085 PF01841 Transglutaminase-like superfamily 3886 0.0085 SUB390 C(:N)(:N) 3886 0.0085 PF00757 Furin-like cysteine rich region 3887 0.0083 SUB570 N-C-C-N 3887 0.0083 PF02798 Glutathione S-transferase, N-terminal domain 3888 0.0083 SUB601 N-C:C:C-C 3888 0.0083 PF00001 7 transmembrane receptor (rhodopsin family), 3889 0.0083 SUB338 C(~C)(~C)(~C)(~O) 3889 0.0083 PF00091 Tubulin/FtsZ family, GTPase domain 3890 0.0083 SUB708 O=C-C-C-C-C(N)-C 3890 0.0083 PF01833 IPT/TIG domain 3891 0.0081 SUB694 O=C-C-C-C-C-O 3891 0.0081 PF00104 Ligand-binding domain of nuclear hormone receptor 3892 0.0081 SUB638 O-C-C-C-C 3892 0.0081 PF07706 Aminotransferase ubiquitination site 3893 0.0081 SUB605 C-O-C-C:C 3893 0.0081 PF00102 Protein-tyrosine phosphatase 3894 0.0081 SUB703 O-C-C-C-C-C-N-C 3894 0.0081 PF00071 Ras family 3895 0.0081 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 3895 0.0081 PF00521 DNA gyrase/topoisomerase IV, subunit A 3896 0.0080 SUB201 >= 4 saturated or aromatic carbon-only ring size 6 3896 0.0080 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3897 0.0080 SUB554 O=C-C=C 3897 0.0080 PF08403 Amino acid permease N-terminal 3898 0.0079 SUB441 C(-C)(-O)(=O) 3898 0.0079 PF01234 NNMT/PNMT/TEMT family 3899 0.0079 SUB540 N=C-C-[#1] 3899 0.0079 PF03953 Tubulin C-terminal domain 3900 0.0078 SUB505 N:C:N-C 3900 0.0078 PF00690 Cation transporter/ATPase, N-terminus 3901 0.0078 SUB582 O=C-C-C-O 3901 0.0078 PF00273 Serum albumin family 3902 0.0077 SUB633 C-C-O-C:C 3902 0.0077 PF03765 CRAL/TRIO, N-terminus 3903 0.0077 SUB362 C(~Cl)(~H) 3903 0.0077 PF00173 Cytochrome b5-like Heme/Steroid binding domain 3904 0.0077 SUB633 C-C-O-C:C 3904 0.0077 PF00561 alpha/beta hydrolase fold 3905 0.0076 SUB378 C(~N)(:C)(:C) 3905 0.0076 PF00305 Lipoxygenase 3906 0.0076 SUB452 C(-N)(=O) 3906 0.0076 PF00533 BRCA1 C Terminus (BRCT), domain 3907 0.0076 SUB32 >= 2 P 3907 0.0076 PF01571 Aminomethyltransferase folate-binding domain 3908 0.0075 SUB602 N-C:C:C-N 3908 0.0075 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 3909 0.0075 SUB258 >= 2 aromatic rings 3909 0.0075 PF00258 Flavodoxin 3910 0.0074 SUB439 C(-C)(-N)(=N) 3910 0.0074 PF00300 Phosphoglycerate mutase family 3911 0.0074 SUB336 C(~C)(~C)(~C)(~H) 3911 0.0074 PF05649 Peptidase family M13 3912 0.0073 SUB420 C#N 3912 0.0073 PF00194 Eukaryotic-type carbonic anhydrase 3913 0.0072 SUB567 O-C-C-N 3913 0.0072 PF00017 SH2 domain 3914 0.0072 SUB662 O-C-O-C-C 3914 0.0072 PF00067 Cytochrome P450 3915 0.0072 SUB261 >= 3 hetero-aromatic rings 3915 0.0072 PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 3916 0.0071 SUB301 N-N 3916 0.0071 PF08418 DNA polymerase alpha subunit B N-terminal 3917 0.0071 SUB565 C=C-C=C 3917 0.0071 PF02159 Oestrogen receptor 3918 0.0070 SUB1 >= 4 H 3918 0.0070 PF00497 Bacterial extracellular solute-binding proteins, family 3 3919 0.0070 SUB339 C(~C)(~C)(~H)(~N) 3919 0.0070 PF00186 Dihydrofolate reductase 3920 0.0070 SUB187 >= 2 saturated or aromatic carbon-only ring size 6 3920 0.0070 PF00757 Furin-like cysteine rich region 3921 0.0070 SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 3921 0.0070 PF02872 5"-nucleotidase, C-terminal domain 3922 0.0069 SUB503 N-C=C-[#1] 3922 0.0069 PF01007 Inward rectifier potassium channel 3923 0.0069 SUB624 O=C-C:C-C 3923 0.0069 PF00273 Serum albumin family 3924 0.0068 SUB358 C(~C)(:C)(:N) 3924 0.0068 PF09027 GTPase binding 3925 0.0068 SUB336 C(~C)(~C)(~C)(~H) 3925 0.0068 PF02770 Acyl-CoA dehydrogenase, middle domain 3926 0.0067 SUB331 C(~Br)(:C) 3926 0.0067 PF00568 WH1 domain 3927 0.0067 SUB564 O-C-O-C 3927 0.0067 PF04711 Apolipoprotein A-II (ApoA-II), 3928 0.0066 SUB564 O-C-O-C 3928 0.0066 PF01094 Receptor family ligand binding region 3929 0.0066 SUB541 C-N-C-[#1] 3929 0.0066 PF00102 Protein-tyrosine phosphatase 3930 0.0066 SUB505 N:C:N-C 3930 0.0066 PF00300 Phosphoglycerate mutase family 3931 0.0065 SUB336 C(~C)(~C)(~C)(~H) 3931 0.0065 PF01433 Peptidase family M1 3932 0.0064 SUB664 O-C-C-O-[#1] 3932 0.0064 PF02806 Alpha amylase, C-terminal all-beta domain 3933 0.0064 SUB618 C-C-C-O-[#1] 3933 0.0064 PF00487 Fatty acid desaturase 3934 0.0064 SUB621 C:C-O-C-C 3934 0.0064 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3935 0.0064 SUB19 >= 1 O 3935 0.0064 PF00194 Eukaryotic-type carbonic anhydrase 3936 0.0063 SUB51 >= 1 Mg 3936 0.0063 PF00702 haloacid dehalogenase-like hydrolase 3937 0.0063 SUB602 N-C:C:C-N 3937 0.0063 PF01591 6-phosphofructo-2-kinase 3938 0.0063 SUB435 C(-C)(-H)(=C) 3938 0.0063 PF01007 Inward rectifier potassium channel 3939 0.0063 SUB391 N(~C)(~C) 3939 0.0063 PF00755 Choline/Carnitine o-acyltransferase 3940 0.0063 SUB16 >= 2 N 3940 0.0063 PF01336 OB-fold nucleic acid binding domain 3941 0.0062 SUB673 O=C-C=C-[#1] 3941 0.0062 PF00622 SPRY domain 3942 0.0062 SUB679 C-C-C=C-C 3942 0.0062 PF00273 Serum albumin family 3943 0.0061 SUB448 C(-H)(=N) 3943 0.0061 PF08127 Peptidase family C1 propeptide 3944 0.0061 SUB548 N-C:C-N 3944 0.0061 PF00153 Mitochondrial carrier protein 3945 0.0061 SUB18 >= 8 N 3945 0.0061 PF00001 7 transmembrane receptor (rhodopsin family), 3946 0.0061 SUB306 N-S 3946 0.0061 PF00520 Ion transport protein 3947 0.0060 SUB486 N:C:C:N 3947 0.0060 PF00233 3"5"-cyclic nucleotide phosphodiesterase 3948 0.0060 SUB561 N-C-N-C 3948 0.0060 PF07992 Pyridine nucleotide-disulphide oxidoreductase 3949 0.0060 SUB391 N(~C)(~C) 3949 0.0060 PF00001 7 transmembrane receptor (rhodopsin family), 3950 0.0060 SUB702 O-C-C-C-C-C(O)-C 3950 0.0060 PF00560 Leucine Rich Repeat 3951 0.0059 SUB660 O-C-C-N-C 3951 0.0059 PF00209 Sodium:neurotransmitter symporter family 3952 0.0059 SUB504 Cl-C:C-[#1] 3952 0.0059 PF01477 PLAT/LH2 domain 3953 0.0059 SUB66 >= 1 As 3953 0.0059 PF00107 Zinc-binding dehydrogenase 3954 0.0058 SUB642 O-C-C-C=C 3954 0.0058 PF00071 Ras family 3955 0.0058 SUB369 C(~H)(~S) 3955 0.0058 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 3956 0.0058 SUB315 O-P 3956 0.0058 PF00692 dUTPase 3957 0.0058 SUB400 N(~H)(:C) 3957 0.0058 PF01048 Phosphorylase superfamily 3958 0.0057 SUB435 C(-C)(-H)(=C) 3958 0.0057 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 3959 0.0057 SUB452 C(-N)(=O) 3959 0.0057 PF06464 DMAP1-binding Domain 3960 0.0057 SUB710 C-C(C)-C-C-C 3960 0.0057 PF10565 N-methyl D-aspartate receptor 2B3 C-terminus 3961 0.0057 SUB621 C:C-O-C-C 3961 0.0057 PF00757 Furin-like cysteine rich region 3962 0.0057 SUB31 >= 1 P 3962 0.0057 PF01852 START domain 3963 0.0056 SUB661 C-C=C-C-C 3963 0.0056 PF00273 Serum albumin family 3964 0.0056 SUB339 C(~C)(~C)(~H)(~N) 3964 0.0056 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3965 0.0056 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 3965 0.0056 PF05790 Immunoglobulin C2-set domain 3966 0.0056 SUB594 N-C-C-C-N 3966 0.0056 PF07966 A1 Propeptide 3967 0.0056 SUB739 Cc1cc(Cl)ccc1 3967 0.0056 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 3968 0.0056 SUB408 O(~C)(~P) 3968 0.0056 PF00155 Aminotransferase class I and II 3969 0.0055 SUB23 >= 16 O 3969 0.0055 PF00088 Trefoil (P-type), domain 3970 0.0054 SUB446 C(-H)(-N)(=C) 3970 0.0054 PF01408 Oxidoreductase family, NAD-binding Rossmann fold 3971 0.0053 SUB437 C(-C)(-H)(=O) 3971 0.0053 PF00291 Pyridoxal-phosphate dependent enzyme 3972 0.0052 SUB339 C(~C)(~C)(~H)(~N) 3972 0.0052 PF02932 Neurotransmitter-gated ion-channel transmembrane region 3973 0.0052 SUB23 >= 16 O 3973 0.0052 PF01704 UTP--glucose-1-phosphate uridylyltransferase 3974 0.0052 SUB540 N=C-C-[#1] 3974 0.0052 PF00001 7 transmembrane receptor (rhodopsin family), 3975 0.0052 SUB315 O-P 3975 0.0052 PF11404 Potassium voltage-gated channel 3976 0.0050 SUB158 >= 3 any ring size 5 3976 0.0050 PF00111 2Fe-2S iron-sulfur cluster binding domain 3977 0.0050 SUB369 C(~H)(~S) 3977 0.0050 PF00070 Pyridine nucleotide-disulphide oxidoreductase 3978 0.0050 SUB834 NC1C(N)CCCC1 3978 0.0050 PF01403 Sema domain 3979 0.0050 SUB804 OC1CC(O)CCC1 3979 0.0050 PF00373 FERM central domain 3980 0.0049 SUB621 C:C-O-C-C 3980 0.0049 PF00248 Aldo/keto reductase family 3981 0.0049 SUB683 O-C-C-C-C-N 3981 0.0049 PF00088 Trefoil (P-type), domain 3982 0.0049 SUB658 C-N-C:C-C 3982 0.0049 PF00850 Histone deacetylase domain 3983 0.0048 SUB610 Cl-C-C-N-C 3983 0.0048 PF00001 7 transmembrane receptor (rhodopsin family), 3984 0.0048 SUB38 >= 1 Cl 3984 0.0048 PF00690 Cation transporter/ATPase, N-terminus 3985 0.0047 SUB389 C(:C)(:N)(:N) 3985 0.0047 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7), 3986 0.0047 SUB712 C-C(C)(C)-C-C 3986 0.0047 PF00497 Bacterial extracellular solute-binding proteins, family 3 3987 0.0046 SUB408 O(~C)(~P) 3987 0.0046 PF02214 K+ channel tetramerisation domain 3988 0.0046 SUB618 C-C-C-O-[#1] 3988 0.0046 PF00343 Carbohydrate phosphorylase 3989 0.0045 SUB662 O-C-O-C-C 3989 0.0045 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 3990 0.0045 SUB564 O-C-O-C 3990 0.0045 PF00067 Cytochrome P450 3991 0.0044 SUB567 O-C-C-N 3991 0.0044 PF00795 Carbon-nitrogen hydrolase 3992 0.0044 SUB3 >= 16 H 3992 0.0044 PF00023 Ankyrin repeat 3993 0.0044 SUB603 O=C-C-N-C 3993 0.0044 PF02807 ATP:guanido phosphotransferase, N-terminal domain 3994 0.0044 SUB66 >= 1 As 3994 0.0044 PF00664 ABC transporter transmembrane region 3995 0.0044 SUB575 O-C-C:C-C 3995 0.0044 PF00102 Protein-tyrosine phosphatase 3996 0.0044 SUB569 N#C-C-C 3996 0.0044 PF00625 Guanylate kinase 3997 0.0044 SUB408 O(~C)(~P) 3997 0.0044 PF00692 dUTPase 3998 0.0044 SUB540 N=C-C-[#1] 3998 0.0044 PF00091 Tubulin/FtsZ family, GTPase domain 3999 0.0044 SUB680 C-C-C-C-C-C 3999 0.0044 PF02932 Neurotransmitter-gated ion-channel transmembrane region 4000 0.0043 SUB260 >= 3 aromatic rings 4000 0.0043 PF00452 Apoptosis regulator proteins, Bcl-2 family 4001 0.0043 SUB802 CC1CC(Cl)CCC1 4001 0.0043 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4002 0.0043 SUB618 C-C-C-O-[#1] 4002 0.0043 PF07706 Aminotransferase ubiquitination site 4003 0.0043 SUB415 S(~C)(~O) 4003 0.0043 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 4004 0.0043 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 4004 0.0043 PF02173 pKID domain 4005 0.0043 SUB699 O-C-C-C-C-C-C-C 4005 0.0043 PF01151 GNS1/SUR4 family 4006 0.0042 SUB243 >= 1 saturated or aromatic carbon-only ring size 9 4006 0.0042 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 4007 0.0042 SUB573 N:C:N:C 4007 0.0042 PF01030 Receptor L domain 4008 0.0041 SUB615 C-C-O-C-C 4008 0.0041 PF00927 Transglutaminase family, C-terminal ig like domain 4009 0.0041 SUB309 O-H 4009 0.0041 PF01471 Putative peptidoglycan binding domain 4010 0.0041 SUB309 O-H 4010 0.0041 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 4011 0.0040 SUB421 C=O 4011 0.0040 PF02166 Androgen receptor 4012 0.0040 SUB662 O-C-O-C-C 4012 0.0040 PF04711 Apolipoprotein A-II (ApoA-II), 4013 0.0040 SUB444 C(-C)(=O) 4013 0.0040 PF00273 Serum albumin family 4014 0.0040 SUB622 N-C:C:C:N 4014 0.0040 PF01591 6-phosphofructo-2-kinase 4015 0.0040 SUB302 N-O 4015 0.0040 PF01180 Dihydroorotate dehydrogenase 4016 0.0040 SUB21 >= 4 O 4016 0.0040 PF00089 Trypsin 4017 0.0040 SUB528 C:C:N-[#1] 4017 0.0040 PF01048 Phosphorylase superfamily 4018 0.0039 SUB813 NC1CC(N)CCC1 4018 0.0039 PF00405 Transferrin 4019 0.0039 SUB686 O=C-C-C-C-N 4019 0.0039 PF00028 Cadherin domain 4020 0.0039 SUB249 >= 1 any ring size 10 4020 0.0039 PF02161 Progesterone receptor 4021 0.0039 SUB194 >= 3 saturated or aromatic carbon-only ring size 6 4021 0.0039 PF08070 DTHCT (NUC029), region 4022 0.0039 SUB457 P(-O)(=O) 4022 0.0039 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 4023 0.0039 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 4023 0.0039 PF00405 Transferrin 4024 0.0038 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 4024 0.0038 PF00209 Sodium:neurotransmitter symporter family 4025 0.0038 SUB666 N-C:C-C-C 4025 0.0038 PF06512 Sodium ion transport-associated 4026 0.0038 SUB798 CC1CC(C)CCC1 4026 0.0038 PF02161 Progesterone receptor 4027 0.0037 SUB34 >= 1 S 4027 0.0037 PF01234 NNMT/PNMT/TEMT family 4028 0.0037 SUB597 N=C-N-C-C 4028 0.0037 PF02798 Glutathione S-transferase, N-terminal domain 4029 0.0037 SUB3 >= 16 H 4029 0.0037 PF00536 SAM domain (Sterile alpha motif), 4030 0.0037 SUB581 O=C-C-C-N 4030 0.0037 PF00536 SAM domain (Sterile alpha motif), 4031 0.0036 SUB350 C(~C)(~H)(~S) 4031 0.0036 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 4032 0.0036 SUB633 C-C-O-C:C 4032 0.0036 PF01030 Receptor L domain 4033 0.0035 SUB524 N:C:C-C 4033 0.0035 PF01234 NNMT/PNMT/TEMT family 4034 0.0035 SUB51 >= 1 Mg 4034 0.0035 PF00689 Cation transporting ATPase, C-terminus 4035 0.0034 SUB3 >= 16 H 4035 0.0034 PF01404 Ephrin receptor ligand binding domain 4036 0.0034 SUB698 C-C-C-C-C-C(C)-C 4036 0.0034 PF00650 CRAL/TRIO domain 4037 0.0034 SUB572 [#1]-C-O-[#1] 4037 0.0034 PF03572 Peptidase family S41 4038 0.0034 SUB196 >= 3 saturated or aromatic heteroatom-containing ring size 6 4038 0.0034 PF01068 ATP dependent DNA ligase domain 4039 0.0034 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 4039 0.0034 PF00005 ABC transporter 4040 0.0033 SUB350 C(~C)(~H)(~S) 4040 0.0033 PF07992 Pyridine nucleotide-disulphide oxidoreductase 4041 0.0033 SUB350 C(~C)(~H)(~S) 4041 0.0033 PF00362 Integrin, beta chain 4042 0.0033 SUB565 C=C-C=C 4042 0.0033 PF00105 Zinc finger, C4 type (two domains), 4043 0.0033 SUB309 O-H 4043 0.0033 PF01063 Aminotransferase class IV 4044 0.0033 SUB701 O-C-C-C-C-C-O-C 4044 0.0033 PF04711 Apolipoprotein A-II (ApoA-II), 4045 0.0032 SUB444 C(-C)(=O) 4045 0.0032 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 4046 0.0032 SUB821 CC1C(S)CCCC1 4046 0.0032 PF00105 Zinc finger, C4 type (two domains), 4047 0.0032 SUB350 C(~C)(~H)(~S) 4047 0.0032 PF00070 Pyridine nucleotide-disulphide oxidoreductase 4048 0.0031 SUB196 >= 3 saturated or aromatic heteroatom-containing ring size 6 4048 0.0031 PF01055 Glycosyl hydrolases family 31 4049 0.0031 SUB294 C-S 4049 0.0031 PF01234 NNMT/PNMT/TEMT family 4050 0.0031 SUB529 [#1]-N-C-[#1] 4050 0.0031 PF00214 Calcitonin / CGRP / IAPP family 4051 0.0031 SUB615 C-C-O-C-C 4051 0.0031 PF00757 Furin-like cysteine rich region 4052 0.0031 SUB51 >= 1 Mg 4052 0.0031 PF00122 E1-E2 ATPase 4053 0.0030 SUB415 S(~C)(~O) 4053 0.0030 PF03098 Animal haem peroxidase 4054 0.0030 SUB718 Cc1ccc(Cl)cc1 4054 0.0030 PF00043 Glutathione S-transferase, C-terminal domain 4055 0.0030 SUB673 O=C-C=C-[#1] 4055 0.0030 PF00194 Eukaryotic-type carbonic anhydrase 4056 0.0030 SUB369 C(~H)(~S) 4056 0.0030 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 4057 0.0029 SUB35 >= 2 S 4057 0.0029 PF07992 Pyridine nucleotide-disulphide oxidoreductase 4058 0.0029 SUB151 >= 2 any ring size 5 4058 0.0029 PF01048 Phosphorylase superfamily 4059 0.0029 SUB640 O-C-C-C-O 4059 0.0029 PF00149 Calcineurin-like phosphoesterase 4060 0.0027 SUB384 C(~S)(:C) 4060 0.0027 PF00102 Protein-tyrosine phosphatase 4061 0.0026 SUB673 O=C-C=C-[#1] 4061 0.0026 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 4062 0.0025 SUB615 C-C-O-C-C 4062 0.0025 PF00868 Transglutaminase family 4063 0.0025 SUB502 Cl-C:C-C 4063 0.0025 PF01477 PLAT/LH2 domain 4064 0.0025 SUB449 C(-H)(=O) 4064 0.0025 PF08246 Cathepsin propeptide inhibitor domain (I29), 4065 0.0025 SUB1 >= 4 H 4065 0.0025 PF06079 Apyrase 4066 0.0025 SUB485 N-C:N:C 4066 0.0025 PF00757 Furin-like cysteine rich region 4067 0.0024 SUB66 >= 1 As 4067 0.0024 PF00689 Cation transporting ATPase, C-terminus 4068 0.0024 SUB389 C(:C)(:N)(:N) 4068 0.0024 PF00156 Phosphoribosyl transferase domain 4069 0.0024 SUB158 >= 3 any ring size 5 4069 0.0024 PF00209 Sodium:neurotransmitter symporter family 4070 0.0023 SUB299 C-I 4070 0.0023 PF00079 Serpin (serine protease inhibitor), 4071 0.0023 SUB460 S(=O)(=O) 4071 0.0023 PF00822 PMP-22/EMP/MP20/Claudin family 4072 0.0023 SUB500 N-C:C:N 4072 0.0023 PF00794 PI3-kinase family, ras-binding domain 4073 0.0023 SUB840 CC1CC(C)CC1 4073 0.0023 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 4074 0.0023 SUB640 O-C-C-C-O 4074 0.0023 PF09292 Endonuclease VIII-like 1, DNA bind 4075 0.0022 SUB408 O(~C)(~P) 4075 0.0022 PF11404 Potassium voltage-gated channel 4076 0.0022 SUB695 O=C-C-C-C-C=O 4076 0.0022 PF00310 Glutamine amidotransferases class-II 4077 0.0022 SUB504 Cl-C:C-[#1] 4077 0.0022 PF00194 Eukaryotic-type carbonic anhydrase 4078 0.0022 SUB19 >= 1 O 4078 0.0022 PF00105 Zinc finger, C4 type (two domains), 4079 0.0022 SUB693 O=C-C-C-C-C-C 4079 0.0022 PF01279 Parathyroid hormone family 4080 0.0021 SUB594 N-C-C-C-N 4080 0.0021 PF02932 Neurotransmitter-gated ion-channel transmembrane region 4081 0.0021 SUB23 >= 16 O 4081 0.0021 PF01055 Glycosyl hydrolases family 31 4082 0.0021 SUB421 C=O 4082 0.0021 PF00051 Kringle domain 4083 0.0020 SUB398 N(~C)(:C)(:C) 4083 0.0020 PF12605 Casein kinase 1 gamma C terminal 4084 0.0020 SUB499 O-C=C-C 4084 0.0020 PF03098 Animal haem peroxidase 4085 0.0020 SUB841 CC1CC(O)CC1 4085 0.0020 PF00418 Tau and MAP protein, tubulin-binding repeat 4086 0.0020 SUB714 Cc1ccc(C)cc1 4086 0.0020 PF00105 Zinc finger, C4 type (two domains), 4087 0.0020 SUB618 C-C-C-O-[#1] 4087 0.0020 PF10420 Cytokine interleukin-12p40 C-terminus 4088 0.0020 SUB673 O=C-C=C-[#1] 4088 0.0020 PF00056 lactate/malate dehydrogenase, NAD binding domain 4089 0.0020 SUB369 C(~H)(~S) 4089 0.0020 PF07992 Pyridine nucleotide-disulphide oxidoreductase 4090 0.0020 SUB614 C-N-C-C-C 4090 0.0020 PF00001 7 transmembrane receptor (rhodopsin family), 4091 0.0019 SUB780 CC1CCC(N)CC1 4091 0.0019 PF00754 F5/8 type C domain 4092 0.0019 SUB586 C-C:C-N-C 4092 0.0019 PF06512 Sodium ion transport-associated 4093 0.0019 SUB137 >= 2 any ring size 4 4093 0.0019 PF00005 ABC transporter 4094 0.0019 SUB602 N-C:C:C-N 4094 0.0019 PF01017 STAT protein, all-alpha domain 4095 0.0019 SUB643 O-C-C-C=O 4095 0.0019 PF03372 Endonuclease/Exonuclease/phosphatase family 4096 0.0019 SUB683 O-C-C-C-C-N 4096 0.0019 PF00704 Glycosyl hydrolases family 18 4097 0.0019 SUB24 >= 1 F 4097 0.0019 PF03104 DNA polymerase family B, exonuclease domain 4098 0.0019 SUB298 C-Br 4098 0.0019 PF00689 Cation transporting ATPase, C-terminus 4099 0.0018 SUB482 O-S-C:C 4099 0.0018 PF00105 Zinc finger, C4 type (two domains), 4100 0.0018 SUB367 C(~H)(~O) 4100 0.0018 PF00084 Sushi domain (SCR repeat), 4101 0.0018 SUB243 >= 1 saturated or aromatic carbon-only ring size 9 4101 0.0018 PF00106 short chain dehydrogenase 4102 0.0018 SUB687 O=C-C-C-C-O 4102 0.0018 PF00149 Calcineurin-like phosphoesterase 4103 0.0018 SUB802 CC1CC(Cl)CCC1 4103 0.0018 PF00989 PAS fold 4104 0.0017 SUB421 C=O 4104 0.0017 PF00233 3"5"-cyclic nucleotide phosphodiesterase 4105 0.0017 SUB243 >= 1 saturated or aromatic carbon-only ring size 9 4105 0.0017 PF00762 Ferrochelatase 4106 0.0017 SUB540 N=C-C-[#1] 4106 0.0017 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4107 0.0016 SUB444 C(-C)(=O) 4107 0.0016 PF02770 Acyl-CoA dehydrogenase, middle domain 4108 0.0016 SUB446 C(-H)(-N)(=C) 4108 0.0016 PF00104 Ligand-binding domain of nuclear hormone receptor 4109 0.0016 SUB814 NC1CC(Cl)CCC1 4109 0.0016 PF00168 C2 domain 4110 0.0015 SUB35 >= 2 S 4110 0.0015 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 4111 0.0015 SUB814 NC1CC(Cl)CCC1 4111 0.0015 PF03493 Calcium-activated BK potassium channel alpha subunit 4112 0.0015 SUB457 P(-O)(=O) 4112 0.0015 PF11404 Potassium voltage-gated channel 4113 0.0014 SUB702 O-C-C-C-C-C(O)-C 4113 0.0014 PF04711 Apolipoprotein A-II (ApoA-II), 4114 0.0014 SUB137 >= 2 any ring size 4 4114 0.0014 PF00690 Cation transporter/ATPase, N-terminus 4115 0.0014 SUB606 O=C-C-O-C 4115 0.0014 PF02373 JmjC domain 4116 0.0014 SUB408 O(~C)(~P) 4116 0.0014 PF00248 Aldo/keto reductase family 4117 0.0013 SUB582 O=C-C-C-O 4117 0.0013 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 4118 0.0013 SUB741 Oc1cc(O)ccc1 4118 0.0013 PF00373 FERM central domain 4119 0.0013 SUB32 >= 2 P 4119 0.0013 PF00056 lactate/malate dehydrogenase, NAD binding domain 4120 0.0013 SUB38 >= 1 Cl 4120 0.0013 PF03073 TspO/MBR family 4121 0.0013 SUB703 O-C-C-C-C-C-N-C 4121 0.0013 PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2), 4122 0.0013 SUB549 O-C-C:C 4122 0.0013 PF00027 Cyclic nucleotide-binding domain 4123 0.0013 SUB533 S-C:C-[#1] 4123 0.0013 PF00105 Zinc finger, C4 type (two domains), 4124 0.0012 SUB137 >= 2 any ring size 4 4124 0.0012 PF00664 ABC transporter transmembrane region 4125 0.0012 SUB337 C(~C)(~C)(~C)(~N) 4125 0.0012 PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 4126 0.0012 SUB529 [#1]-N-C-[#1] 4126 0.0012 PF08441 Integrin alpha 4127 0.0012 SUB456 N(-O)(=O) 4127 0.0012 PF02166 Androgen receptor 4128 0.0011 SUB168 >= 4 saturated or aromatic heteroatom-containing ring size 5 4128 0.0011 PF00174 Oxidoreductase molybdopterin binding domain 4129 0.0011 SUB598 O=C-C-C:C 4129 0.0011 PF00089 Trypsin 4130 0.0011 SUB547 N-C:C-[#1] 4130 0.0011 PF00001 7 transmembrane receptor (rhodopsin family), 4131 0.0011 SUB646 O=C-N-C-C 4131 0.0011 PF00104 Ligand-binding domain of nuclear hormone receptor 4132 0.0011 SUB421 C=O 4132 0.0011 PF02347 Glycine cleavage system P-protein 4133 0.0010 SUB31 >= 1 P 4133 0.0010 PF00018 SH3 domain 4134 0.0010 SUB25 >= 2 F 4134 0.0010 PF00690 Cation transporter/ATPase, N-terminus 4135 0.0010 SUB66 >= 1 As 4135 0.0010 PF00104 Ligand-binding domain of nuclear hormone receptor 4136 0.0010 SUB373 C(~H)(:C)(:N) 4136 0.0010 PF00282 Pyridoxal-dependent decarboxylase conserved domain 4137 0.0010 SUB426 P=O 4137 0.0010 PF08674 Acetylcholinesterase tetramerisation domain 4138 0.0010 SUB525 C-C=C-C 4138 0.0010 PF00104 Ligand-binding domain of nuclear hormone receptor 4139 0.0010 SUB296 C-As 4139 0.0010 PF08240 Alcohol dehydrogenase GroES-like domain 4140 0.0009 SUB2 >= 8 H 4140 0.0009 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 4141 0.0009 SUB66 >= 1 As 4141 0.0009 PF00248 Aldo/keto reductase family 4142 0.0009 SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 4142 0.0009 PF00664 ABC transporter transmembrane region 4143 0.0009 SUB342 C(~C)(~C)(~O) 4143 0.0009 PF02887 Pyruvate kinase, alpha/beta domain 4144 0.0009 SUB593 N-C-C-C-C 4144 0.0009 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 4145 0.0009 SUB436 C(-C)(-H)(=N) 4145 0.0009 PF00282 Pyridoxal-dependent decarboxylase conserved domain 4146 0.0009 SUB421 C=O 4146 0.0009 PF01212 Beta-eliminating lyase 4147 0.0009 SUB369 C(~H)(~S) 4147 0.0009 PF09334 tRNA synthetases class I (M), 4148 0.0008 SUB576 O-C-C:C-O 4148 0.0008 PF00001 7 transmembrane receptor (rhodopsin family), 4149 0.0008 SUB453 C(-O)(=O) 4149 0.0008 PF00074 Pancreatic ribonuclease 4150 0.0008 SUB409 O(~H)(~S) 4150 0.0008 PF02146 Sir2 family 4151 0.0008 SUB2 >= 8 H 4151 0.0008 PF00169 PH domain 4152 0.0008 SUB534 S-C:C-N 4152 0.0008 PF00536 SAM domain (Sterile alpha motif), 4153 0.0008 SUB538 O=C-C-O 4153 0.0008 PF00102 Protein-tyrosine phosphatase 4154 0.0008 SUB683 O-C-C-C-C-N 4154 0.0008 PF00757 Furin-like cysteine rich region 4155 0.0008 SUB444 C(-C)(=O) 4155 0.0008 PF02347 Glycine cleavage system P-protein 4156 0.0007 SUB259 >= 2 hetero-aromatic rings 4156 0.0007 PF00001 7 transmembrane receptor (rhodopsin family), 4157 0.0007 SUB342 C(~C)(~C)(~O) 4157 0.0007 PF00224 Pyruvate kinase, barrel domain 4158 0.0007 SUB661 C-C=C-C-C 4158 0.0007 PF00104 Ligand-binding domain of nuclear hormone receptor 4159 0.0007 SUB472 S:C:C:C 4159 0.0007 PF00059 Lectin C-type domain 4160 0.0007 SUB622 N-C:C:C:N 4160 0.0007 PF02865 STAT protein, protein interaction domain 4161 0.0007 SUB701 O-C-C-C-C-C-O-C 4161 0.0007 PF02932 Neurotransmitter-gated ion-channel transmembrane region 4162 0.0007 SUB487 N-C:N:N 4162 0.0007 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 4163 0.0007 SUB309 O-H 4163 0.0007 PF07706 Aminotransferase ubiquitination site 4164 0.0007 SUB540 N=C-C-[#1] 4164 0.0007 PF08127 Peptidase family C1 propeptide 4165 0.0007 SUB339 C(~C)(~C)(~H)(~N) 4165 0.0007 PF00085 Thioredoxin 4166 0.0007 SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 4166 0.0007 PF02932 Neurotransmitter-gated ion-channel transmembrane region 4167 0.0006 SUB536 O=C-C-C 4167 0.0006 PF07706 Aminotransferase ubiquitination site 4168 0.0006 SUB674 O=C-C=C-N 4168 0.0006 PF00644 Poly(ADP-ribose), polymerase catalytic domain 4169 0.0006 SUB831 SC1C(N)CCCC1 4169 0.0006 PF06512 Sodium ion transport-associated 4170 0.0006 SUB474 S-C:N:C 4170 0.0006 PF00536 SAM domain (Sterile alpha motif), 4171 0.0006 SUB613 N-C-O-C-C 4171 0.0006 PF00300 Phosphoglycerate mutase family 4172 0.0006 SUB538 O=C-C-O 4172 0.0006 PF03953 Tubulin C-terminal domain 4173 0.0006 SUB572 [#1]-C-O-[#1] 4173 0.0006 PF00005 ABC transporter 4174 0.0006 SUB835 NC1C(Cl)CCCC1 4174 0.0006 PF01404 Ephrin receptor ligand binding domain 4175 0.0006 SUB296 C-As 4175 0.0006 PF00107 Zinc-binding dehydrogenase 4176 0.0006 SUB482 O-S-C:C 4176 0.0006 PF00337 Galactoside-binding lectin 4177 0.0005 SUB302 N-O 4177 0.0005 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 4178 0.0005 SUB502 Cl-C:C-C 4178 0.0005 PF03073 TspO/MBR family 4179 0.0005 SUB379 C(~N)(:C)(:N) 4179 0.0005 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 4180 0.0005 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 4180 0.0005 PF01591 6-phosphofructo-2-kinase 4181 0.0005 SUB572 [#1]-C-O-[#1] 4181 0.0005 PF02806 Alpha amylase, C-terminal all-beta domain 4182 0.0005 SUB295 C-Cl 4182 0.0005 PF03530 Calcium-activated SK potassium channel 4183 0.0005 SUB580 O=C-C-C-C 4183 0.0005 PF07706 Aminotransferase ubiquitination site 4184 0.0004 SUB402 N(~O)(~O) 4184 0.0004 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 4185 0.0004 SUB641 C=C-C-C-C 4185 0.0004 PF00273 Serum albumin family 4186 0.0004 SUB772 Nc1c(Cl)cccc1 4186 0.0004 PF02932 Neurotransmitter-gated ion-channel transmembrane region 4187 0.0004 SUB390 C(:N)(:N) 4187 0.0004 PF01030 Receptor L domain 4188 0.0004 SUB444 C(-C)(=O) 4188 0.0004 PF01212 Beta-eliminating lyase 4189 0.0004 SUB336 C(~C)(~C)(~C)(~H) 4189 0.0004 PF00690 Cation transporter/ATPase, N-terminus 4190 0.0004 SUB354 C(~C)(~S) 4190 0.0004 PF01234 NNMT/PNMT/TEMT family 4191 0.0004 SUB453 C(-O)(=O) 4191 0.0004 PF00682 HMGL-like 4192 0.0004 SUB643 O-C-C-C=O 4192 0.0004 PF00091 Tubulin/FtsZ family, GTPase domain 4193 0.0004 SUB615 C-C-O-C-C 4193 0.0004 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4194 0.0003 SUB512 S=C-N-[#1] 4194 0.0003 PF01404 Ephrin receptor ligand binding domain 4195 0.0003 SUB564 O-C-O-C 4195 0.0003 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 4196 0.0003 SUB674 O=C-C=C-N 4196 0.0003 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 4197 0.0003 SUB534 S-C:C-N 4197 0.0003 PF06512 Sodium ion transport-associated 4198 0.0003 SUB18 >= 8 N 4198 0.0003 PF01607 Chitin binding Peritrophin-A domain 4199 0.0003 SUB583 C-C-C-C-C 4199 0.0003 PF07706 Aminotransferase ubiquitination site 4200 0.0003 SUB700 O-C-C-C-C-C(C)-C 4200 0.0003 PF07966 A1 Propeptide 4201 0.0003 SUB378 C(~N)(:C)(:C) 4201 0.0003 PF00822 PMP-22/EMP/MP20/Claudin family 4202 0.0003 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 4202 0.0003 PF02785 Biotin carboxylase C-terminal domain 4203 0.0003 SUB537 O=C-C-N 4203 0.0003 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 4204 0.0003 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 4204 0.0003 PF02196 Raf-like Ras-binding domain 4205 0.0003 SUB557 C=C-C-C 4205 0.0003 PF00273 Serum albumin family 4206 0.0003 SUB758 Cc1c(S)cccc1 4206 0.0003 PF02146 Sir2 family 4207 0.0003 SUB581 O=C-C-C-N 4207 0.0003 PF02932 Neurotransmitter-gated ion-channel transmembrane region 4208 0.0003 SUB494 O=C-C:C 4208 0.0003 PF08403 Amino acid permease N-terminal 4209 0.0003 SUB458 S(-C)(=O) 4209 0.0003 PF01590 GAF domain 4210 0.0003 SUB458 S(-C)(=O) 4210 0.0003 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 4211 0.0003 SUB604 C-C:C:C-C 4211 0.0003 PF00209 Sodium:neurotransmitter symporter family 4212 0.0003 SUB551 Cl-C-C-C 4212 0.0003 PF03073 TspO/MBR family 4213 0.0003 SUB642 O-C-C-C=C 4213 0.0003 PF07965 Integrin beta tail domain 4214 0.0003 SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 4214 0.0003 PF02260 FATC domain 4215 0.0003 SUB390 C(:N)(:N) 4215 0.0003 PF00690 Cation transporter/ATPase, N-terminus 4216 0.0002 SUB768 Sc1c(N)cccc1 4216 0.0002 PF06512 Sodium ion transport-associated 4217 0.0002 SUB647 O=C-N-C-[#1] 4217 0.0002 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 4218 0.0002 SUB825 OC1C(O)CCCC1 4218 0.0002 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4219 0.0002 SUB624 O=C-C:C-C 4219 0.0002 PF08403 Amino acid permease N-terminal 4220 0.0002 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 4220 0.0002 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain 4221 0.0002 SUB695 O=C-C-C-C-C=O 4221 0.0002 PF00586 AIR synthase related protein, N-terminal domain 4222 0.0002 SUB670 Cl-C:C-C=O 4222 0.0002 PF02798 Glutathione S-transferase, N-terminal domain 4223 0.0002 SUB18 >= 8 N 4223 0.0002 PF02310 B12 binding domain 4224 0.0002 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 4224 0.0002 PF01437 Plexin repeat 4225 0.0002 SUB572 [#1]-C-O-[#1] 4225 0.0002 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 4226 0.0002 SUB456 N(-O)(=O) 4226 0.0002 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 4227 0.0002 SUB172 >= 5 any ring size 5 4227 0.0002 PF02310 B12 binding domain 4228 0.0002 SUB697 C-C-C-C-C-C-C-C 4228 0.0002 PF02743 Cache domain 4229 0.0002 SUB295 C-Cl 4229 0.0002 PF00001 7 transmembrane receptor (rhodopsin family), 4230 0.0002 SUB158 >= 3 any ring size 5 4230 0.0002 PF02779 Transketolase, pyrimidine binding domain 4231 0.0002 SUB95 >= 1 Au 4231 0.0002 PF00069 Protein kinase domain 4232 0.0002 SUB586 C-C:C-N-C 4232 0.0002 PF00850 Histone deacetylase domain 4233 0.0002 SUB32 >= 2 P 4233 0.0002 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 4234 0.0002 SUB512 S=C-N-[#1] 4234 0.0002 PF00041 Fibronectin type III domain 4235 0.0002 SUB606 O=C-C-O-C 4235 0.0002 PF08771 Rapamycin binding domain 4236 0.0002 SUB202 >= 4 saturated or aromatic nitrogen-containing ring size 6 4236 0.0002 PF01462 Leucine rich repeat N-terminal domain 4237 0.0002 SUB625 O=C-C:C-N 4237 0.0002 PF08063 PADR1 (NUC008), domain 4238 0.0002 SUB759 Cc1c(N)cccc1 4238 0.0002 PF01404 Ephrin receptor ligand binding domain 4239 0.0002 SUB790 SC1CCC(Cl)CC1 4239 0.0002 PF00067 Cytochrome P450 4240 0.0002 SUB333 C(~C)(~C) 4240 0.0002 PF03171 2OG-Fe(II), oxygenase superfamily 4241 0.0001 SUB625 O=C-C:C-N 4241 0.0001 PF00536 SAM domain (Sterile alpha motif), 4242 0.0001 SUB351 C(~C)(~I) 4242 0.0001 PF00079 Serpin (serine protease inhibitor), 4243 0.0001 SUB381 C(~O)(~O) 4243 0.0001 PF07706 Aminotransferase ubiquitination site 4244 0.0001 SUB389 C(:C)(:N)(:N) 4244 0.0001 PF02817 e3 binding domain 4245 0.0001 SUB284 C-H 4245 0.0001 PF00581 Rhodanese-like domain 4246 0.0001 SUB826 OC1C(S)CCCC1 4246 0.0001 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 4247 0.0001 SUB350 C(~C)(~H)(~S) 4247 0.0001 PF07965 Integrin beta tail domain 4248 0.0001 SUB575 O-C-C:C-C 4248 0.0001 PF00027 Cyclic nucleotide-binding domain 4249 0.0001 SUB32 >= 2 P 4249 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 4250 0.0001 SUB373 C(~H)(:C)(:N) 4250 0.0001 PF00266 Aminotransferase class-V 4251 0.0001 SUB175 >= 5 saturated or aromatic heteroatom-containing ring size 5 4251 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), 4252 0.0001 SUB495 O=C-C:N 4252 0.0001 PF01841 Transglutaminase-like superfamily 4253 0.0001 SUB462 O-C-C=N 4253 0.0001 PF04679 ATP dependent DNA ligase C terminal region 4254 0.0001 SUB771 Nc1c(N)cccc1 4254 0.0001 PF00454 Phosphatidylinositol 3- and 4-kinase 4255 0.0001 SUB412 P(~O)(~O) 4255 0.0001 PF11404 Potassium voltage-gated channel 4256 0.0001 SUB21 >= 4 O 4256 0.0001 PF00390 Malic enzyme, N-terminal domain 4257 0.0001 SUB18 >= 8 N 4257 0.0001 PF09193 Cholecystokinin A receptor, N-terminal 4258 0.0001 SUB387 C(:C)(:C)(:N) 4258 0.0001 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 4259 0.0001 SUB14 >= 32 C 4259 0.0001 PF09193 Cholecystokinin A receptor, N-terminal 4260 0.0001 SUB655 N-C-N-C-C 4260 0.0001 PF00225 Kinesin motor domain 4261 0.0001 SUB298 C-Br 4261 0.0001 PF00122 E1-E2 ATPase 4262 0.0001 SUB373 C(~H)(:C)(:N) 4262 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), 4263 0.0001 SUB500 N-C:C:N 4263 0.0001 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 4264 0.0001 SUB18 >= 8 N 4264 0.0001 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 4265 0.0001 SUB683 O-C-C-C-C-N 4265 0.0001 PF08399 VWA N-terminal 4266 0.0001 SUB495 O=C-C:N 4266 0.0001 PF00868 Transglutaminase family 4267 0.0001 SUB622 N-C:C:C:N 4267 0.0001 PF02864 STAT protein, DNA binding domain 4268 0.0001 SUB528 C:C:N-[#1] 4268 0.0001 PF05790 Immunoglobulin C2-set domain 4269 0.0001 SUB363 C(~Cl)(:C) 4269 0.0001 PF01477 PLAT/LH2 domain 4270 0.0001 SUB643 O-C-C-C=O 4270 0.0001 PF00656 Caspase domain 4271 0.0001 SUB613 N-C-O-C-C 4271 0.0001 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 4272 0.0001 SUB343 C(~C)(~Cl) 4272 0.0001 PF00689 Cation transporting ATPase, C-terminus 4273 0.0001 SUB717 Cc1ccc(N)cc1 4273 0.0001 PF00792 Phosphoinositide 3-kinase C2 4274 0.0001 SUB658 C-N-C:C-C 4274 0.0001 PF03493 Calcium-activated BK potassium channel alpha subunit 4275 0.0001 SUB692 O-C-C-C-C-C-N 4275 0.0001 PF00619 Caspase recruitment domain 4276 0.0001 SUB369 C(~H)(~S) 4276 0.0001 PF08725 Integrin beta cytoplasmic domain 4277 0.0001 SUB582 O=C-C-C-O 4277 0.0001 PF03953 Tubulin C-terminal domain 4278 0.0001 SUB625 O=C-C:C-N 4278 0.0001 PF00644 Poly(ADP-ribose), polymerase catalytic domain 4279 0.0001 SUB793 NC1CCC(Cl)CC1 4279 0.0001 PF03073 TspO/MBR family 4280 0.0001 SUB644 [#1]-C-C-N-[#1] 4280 0.0001 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 4281 0.0001 SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 4281 0.0001 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 4282 0.0001 SUB60 >= 1 Co 4282 0.0001 PF02310 B12 binding domain 4283 0.0001 SUB262 >= 4 aromatic rings 4283 0.0001 PF00174 Oxidoreductase molybdopterin binding domain 4284 0.0001 SUB588 N-C:C-O-[#1] 4284 0.0001 PF02347 Glycine cleavage system P-protein 4285 0.0001 SUB354 C(~C)(~S) 4285 0.0001 PF00433 Protein kinase C terminal domain 4286 0.0001 SUB20 >= 2 O 4286 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), 4287 0.0001 SUB47 >= 1 I 4287 0.0001 PF12605 Casein kinase 1 gamma C terminal 4288 0.0001 SUB392 N(~C)(~C)(~C) 4288 0.0001 PF00104 Ligand-binding domain of nuclear hormone receptor 4289 0.0001 SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 4289 0.0001 PF02173 pKID domain 4290 0.0001 SUB685 O=C-C-C-C-C 4290 0.0001 PF07706 Aminotransferase ubiquitination site 4291 0.0001 SUB499 O-C=C-C 4291 0.0001 PF00001 7 transmembrane receptor (rhodopsin family), 4292 0.0001 SUB389 C(:C)(:N)(:N) 4292 0.0001 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 4293 0.0000 SUB541 C-N-C-[#1] 4293 0.0000 PF00497 Bacterial extracellular solute-binding proteins, family 3 4294 0.0000 SUB525 C-C=C-C 4294 0.0000 PF00105 Zinc finger, C4 type (two domains), 4295 0.0000 SUB691 O-C-C-C-C-C-O 4295 0.0000 PF03727 Hexokinase 4296 0.0000 SUB496 C-N-C:C 4296 0.0000 PF00850 Histone deacetylase domain 4297 0.0000 SUB380 C(~N)(:N) 4297 0.0000 PF00757 Furin-like cysteine rich region 4298 0.0000 SUB296 C-As 4298 0.0000 PF07965 Integrin beta tail domain 4299 0.0000 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 4299 0.0000 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 4300 0.0000 SUB603 O=C-C-N-C 4300 0.0000 PF01431 Peptidase family M13 4301 0.0000 SUB835 NC1C(Cl)CCCC1 4301 0.0000 PF00041 Fibronectin type III domain 4302 0.0000 SUB705 O=C-C-C-C-C-C-C 4302 0.0000 PF05649 Peptidase family M13 4303 0.0000 SUB771 Nc1c(N)cccc1 4303 0.0000 PF00001 7 transmembrane receptor (rhodopsin family), 4304 0.0000 SUB343 C(~C)(~Cl) 4304 0.0000 PF00229 TNF(Tumour Necrosis Factor), family 4305 0.0000 SUB765 Oc1c(Cl)cccc1 4305 0.0000 PF00069 Protein kinase domain 4306 0.0000 SUB686 O=C-C-C-C-N 4306 0.0000 PF00045 Hemopexin 4307 0.0000 SUB702 O-C-C-C-C-C(O)-C 4307 0.0000 PF00091 Tubulin/FtsZ family, GTPase domain 4308 0.0000 SUB693 O=C-C-C-C-C-C 4308 0.0000 PF05649 Peptidase family M13 4309 0.0000 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 4309 0.0000 PF00362 Integrin, beta chain 4310 0.0000 SUB31 >= 1 P 4310 0.0000 PF00248 Aldo/keto reductase family 4311 0.0000 SUB673 O=C-C=C-[#1] 4311 0.0000 PF08403 Amino acid permease N-terminal 4312 0.0000 SUB738 Cc1cc(N)ccc1 4312 0.0000 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4313 0.0000 SUB398 N(~C)(:C)(:C) 4313 0.0000 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4314 0.0000 SUB440 C(-C)(-N)(=O) 4314 0.0000 PF05406 WGR domain 4315 0.0000 SUB48 >= 2 I 4315 0.0000 PF00079 Serpin (serine protease inhibitor), 4316 0.0000 SUB369 C(~H)(~S) 4316 0.0000 PF00474 Sodium:solute symporter family 4317 0.0000 SUB343 C(~C)(~Cl) 4317 0.0000 PF00690 Cation transporter/ATPase, N-terminus 4318 0.0000 SUB158 >= 3 any ring size 5 4318 0.0000 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 4319 0.0000 SUB440 C(-C)(-N)(=O) 4319 0.0000 PF00104 Ligand-binding domain of nuclear hormone receptor 4320 0.0000 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 4320 0.0000 PF00478 IMP dehydrogenase / GMP reductase domain 4321 0.0000 SUB444 C(-C)(=O) 4321 0.0000 PF00204 DNA gyrase B 4322 0.0000 SUB561 N-C-N-C 4322 0.0000 PF00225 Kinesin motor domain 4323 0.0000 SUB295 C-Cl 4323 0.0000 PF00689 Cation transporting ATPase, C-terminus 4324 0.0000 SUB693 O=C-C-C-C-C-C 4324 0.0000 PF01431 Peptidase family M13 4325 0.0000 SUB674 O=C-C=C-N 4325 0.0000 PF05406 WGR domain 4326 0.0000 SUB590 C-C:C-O-C 4326 0.0000 PF08441 Integrin alpha 4327 0.0000 SUB633 C-C-O-C:C 4327 0.0000 PF00989 PAS fold 4328 0.0000 SUB284 C-H 4328 0.0000 PF06079 Apyrase 4329 0.0000 SUB581 O=C-C-C-N 4329 0.0000 PF00152 tRNA synthetases class II (D, K and N), 4330 0.0000 SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 4330 0.0000 PF01582 TIR domain 4331 0.0000 SUB835 NC1C(Cl)CCCC1 4331 0.0000 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4332 0.0000 SUB451 C(-N)(=N) 4332 0.0000 PF00206 Lyase 4333 0.0000 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 4333 0.0000 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 4334 0.0000 SUB44 >= 1 Br 4334 0.0000 PF00690 Cation transporter/ATPase, N-terminus 4335 0.0000 SUB32 >= 2 P 4335 0.0000 PF00931 NB-ARC domain 4336 0.0000 SUB677 N#C-C-C-C 4336 0.0000 PF00625 Guanylate kinase 4337 0.0000 SUB611 C-O-C-O-C 4337 0.0000 PF01068 ATP dependent DNA ligase domain 4338 0.0000 SUB459 S(-O)(=O) 4338 0.0000 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 4339 0.0000 SUB190 >= 2 unsaturated non-aromatic carbon-only ring size 6 4339 0.0000 PF08725 Integrin beta cytoplasmic domain 4340 0.0000 SUB345 C(~C)(~H) 4340 0.0000 PF06079 Apyrase 4341 0.0000 SUB365 C(~F)(:C) 4341 0.0000 PF00405 Transferrin 4342 0.0000 SUB38 >= 1 Cl 4342 0.0000 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4343 0.0000 SUB603 O=C-C-N-C 4343 0.0000 PF05649 Peptidase family M13 4344 0.0000 SUB593 N-C-C-C-C 4344 0.0000 PF07706 Aminotransferase ubiquitination site 4345 0.0000 SUB360 C(~C)(:N)(:N) 4345 0.0000 PF00619 Caspase recruitment domain 4346 0.0000 SUB741 Oc1cc(O)ccc1 4346 0.0000 PF03623 Focal adhesion targeting region 4347 0.0000 SUB453 C(-O)(=O) 4347 0.0000 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 4348 0.0000 SUB407 O(~C)(~H) 4348 0.0000 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 4349 0.0000 SUB398 N(~C)(:C)(:C) 4349 0.0000 PF00931 NB-ARC domain 4350 0.0000 SUB622 N-C:C:C:N 4350 0.0000 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain), 4351 0.0000 SUB702 O-C-C-C-C-C(O)-C 4351 0.0000 PF05735 Thrombospondin C-terminal region 4352 0.0000 SUB453 C(-O)(=O) 4352 0.0000 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 4353 0.0000 SUB315 O-P 4353 0.0000 PF00017 SH2 domain 4354 0.0000 SUB379 C(~N)(:C)(:N) 4354 0.0000 PF00619 Caspase recruitment domain 4355 0.0000 SUB389 C(:C)(:N)(:N) 4355 0.0000 PF00931 NB-ARC domain 4356 0.0000 SUB453 C(-O)(=O) 4356 0.0000 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 4357 0.0000 SUB622 N-C:C:C:N 4357 0.0000 PF00400 WD domain, G-beta repeat 4358 0.0000 SUB474 S-C:N:C 4358 0.0000 PF01404 Ephrin receptor ligand binding domain 4359 0.0000 SUB610 Cl-C-C-N-C 4359 0.0000 PF00041 Fibronectin type III domain 4360 0.0000 SUB443 C(-C)(=N) 4360 0.0000 PF03073 TspO/MBR family 4361 0.0000 SUB66 >= 1 As 4361 0.0000 PF00105 Zinc finger, C4 type (two domains), 4362 0.0000 SUB379 C(~N)(:C)(:N) 4362 0.0000 PF00931 NB-ARC domain 4363 0.0000 SUB63 >= 1 Zn 4363 0.0000 PF00043 Glutathione S-transferase, C-terminal domain 4364 0.0000 SUB453 C(-O)(=O) 4364 0.0000 PF01268 Formate--tetrahydrofolate ligase 4365 0.0000 SUB360 C(~C)(:N)(:N) 4365 0.0000 PF00931 NB-ARC domain 4366 0.0000 SUB360 C(~C)(:N)(:N) 4366 0.0000 PF00400 WD domain, G-beta repeat 4367 0.0000 SUB615 C-C-O-C-C 4367 0.0000 PF01030 Receptor L domain 4368 0.0000 SUB750 Nc1cc(N)ccc1 4368 0.0000 PF00405 Transferrin 4369 0.0000 SUB457 P(-O)(=O) 4369 0.0000 PF00017 SH2 domain 4370 0.0000 SUB611 C-O-C-O-C 4370 0.0000 PF04679 ATP dependent DNA ligase C terminal region 4371 0.0000 SUB625 O=C-C:C-N 4371 0.0000 PF00533 BRCA1 C Terminus (BRCT), domain 4372 0.0000 SUB771 Nc1c(N)cccc1 4372 0.0000 PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain), 4373 0.0000 SUB426 P=O 4373 0.0000 PF00692 dUTPase 4374 0.0000 SUB440 C(-C)(-N)(=O) 4374 0.0000 PF00644 Poly(ADP-ribose), polymerase catalytic domain 4375 0.0000 SUB366 C(~H)(~N) 4375 0.0000 PF00709 Adenylosuccinate synthetase 4376 0.0000 SUB792 NC1CCC(N)CC1 4376 0.0000 PF02166 Androgen receptor 4377 0.0000 SUB369 C(~H)(~S) 4377 0.0000 PF03099 Biotin/lipoate A/B protein ligase family 4378 0.0000 SUB341 C(~C)(~C)(~N) 4378 0.0000 PF00958 GMP synthase C terminal domain 4379 0.0000 SUB389 C(:C)(:N)(:N) 4379 0.0000 PF00400 WD domain, G-beta repeat 4380 0.0000 SUB158 >= 3 any ring size 5 4380 0.0000 PF00174 Oxidoreductase molybdopterin binding domain 4381 0.0000 SUB834 NC1C(N)CCCC1 4381 0.0000 PF01687 Riboflavin kinase 4382 0.0000 SUB759 Cc1c(N)cccc1 4382 0.0000 PF00536 SAM domain (Sterile alpha motif), 4383 0.0000 SUB460 S(=O)(=O) 4383 0.0000 PF02743 Cache domain 4384 0.0000 SUB315 O-P 4384 0.0000 PF00074 Pancreatic ribonuclease 4385 0.0000 SUB66 >= 1 As 4385 0.0000 PF03160 Calx-beta domain 4386 0.0000 SUB158 >= 3 any ring size 5 4386 0.0000 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 4387 0.0000 SUB586 C-C:C-N-C 4387 0.0000 PF03493 Calcium-activated BK potassium channel alpha subunit 4388 0.0000 SUB457 P(-O)(=O) 4388 0.0000 PF00692 dUTPase 4389 0.0000 SUB31 >= 1 P 4389 0.0000 PF08674 Acetylcholinesterase tetramerisation domain 4390 0.0000 SUB389 C(:C)(:N)(:N) 4390 0.0000 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 4391 0.0000 SUB379 C(~N)(:C)(:N) 4391 0.0000 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 4392 0.0000 SUB158 >= 3 any ring size 5 4392 0.0000 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 4393 0.0000 SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 4393 0.0000 PF07965 Integrin beta tail domain 4394 0.0000 SUB408 O(~C)(~P) 4394 0.0000 PF02666 Phosphatidylserine decarboxylase 4395 0.0000 SUB682 O-C-C-C-C-O 4395 0.0000 PF03727 Hexokinase 4396 0.0000 SUB393 N(~C)(~C)(~H) 4396 0.0000 PF00204 DNA gyrase B 4397 0.0000 SUB14 >= 32 C 4397 0.0000 PF12491 Apolipoprotein B100 C terminal 4398 0.0000 SUB360 C(~C)(:N)(:N) 4398 0.0000 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 4399 0.0000 SUB757 Cc1c(O)cccc1 4399 0.0000 PF00918 Gastrin/cholecystokinin family 4400 0.0000 SUB414 S(~C)(~H) 4400 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4401 0.0000 SUB343 C(~C)(~Cl) 4401 0.0000 PF02888 Calmodulin binding domain 4402 0.0000 SUB459 S(-O)(=O) 4402 0.0000 PF08399 VWA N-terminal 4403 0.0000 SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 4403 0.0000 PF00384 Molybdopterin oxidoreductase 4404 0.0000 SUB622 N-C:C:C:N 4404 0.0000 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 4405 0.0000 SUB488 N-C=N-C 4405 0.0000 PF08669 Glycine cleavage T-protein C-terminal barrel domain 4406 0.0000 SUB151 >= 2 any ring size 5 4406 0.0000 PF00439 Bromodomain 4407 0.0000 SUB158 >= 3 any ring size 5 4407 0.0000 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 4408 0.0000 SUB338 C(~C)(~C)(~C)(~O) 4408 0.0000 PF00976 Corticotropin ACTH domain 4409 0.0000 SUB231 >= 1 saturated or aromatic heteroatom-containing ring size 8 4409 0.0000 PF00918 Gastrin/cholecystokinin family 4410 0.0000 SUB387 C(:C)(:C)(:N) 4410 0.0000 PF00384 Molybdopterin oxidoreductase 4411 0.0000 SUB261 >= 3 hetero-aromatic rings 4411 0.0000 PF00384 Molybdopterin oxidoreductase 4412 0.0000 SUB781 CC1CCC(Cl)CC1 4412 0.0000 PF02798 Glutathione S-transferase, N-terminal domain 4413 0.0000 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 4413 0.0000 PF00439 Bromodomain 4414 0.0000 SUB622 N-C:C:C:N 4414 0.0000 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 4415 0.0000 SUB261 >= 3 hetero-aromatic rings 4415 0.0000 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 4416 0.0000 SUB602 N-C:C:C-N 4416 0.0000 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 4417 0.0000 SUB441 C(-C)(-O)(=O) 4417 0.0000 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 4418 0.0000 SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 4418 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4419 0.0000 SUB32 >= 2 P 4419 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4420 0.0000 SUB387 C(:C)(:C)(:N) 4420 0.0000 PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 4421 0.0000 SUB548 N-C:C-N 4421 0.0000 PF01591 6-phosphofructo-2-kinase 4422 0.0000 SUB389 C(:C)(:N)(:N) 4422 0.0000 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 4423 0.0000 SUB369 C(~H)(~S) 4423 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4424 0.0000 SUB23 >= 16 O 4424 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4425 0.0000 SUB335 C(~C)(~C)(~C)(~C) 4425 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4426 0.0000 SUB158 >= 3 any ring size 5 4426 0.0000 PF09326 Domain of unknown function (DUF1982), 4427 0.0000 SUB572 [#1]-C-O-[#1] 4427 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4428 0.0000 SUB369 C(~H)(~S) 4428 0.0000 PF00439 Bromodomain 4429 0.0000 SUB360 C(~C)(:N)(:N) 4429 0.0000 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 4430 0.0000 SUB520 N=C-N-C 4430 0.0000 PF02807 ATP:guanido phosphotransferase, N-terminal domain 4431 0.0000 SUB712 C-C(C)(C)-C-C 4431 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4432 0.0000 SUB640 O-C-C-C-O 4432 0.0000 PF00439 Bromodomain 4433 0.0000 SUB23 >= 16 O 4433 0.0000 PF00439 Bromodomain 4434 0.0000 SUB520 N=C-N-C 4434 0.0000 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 4435 0.0000 SUB572 [#1]-C-O-[#1] 4435 0.0000 PF00439 Bromodomain 4436 0.0000 SUB261 >= 3 hetero-aromatic rings 4436 0.0000 PF09326 Domain of unknown function (DUF1982), 4437 0.0000 SUB38 >= 1 Cl 4437 0.0000 PF02888 Calmodulin binding domain 4438 0.0000 SUB621 C:C-O-C-C 4438 0.0000 PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain 4439 0.0000 SUB712 C-C(C)(C)-C-C 4439 0.0000 PF00439 Bromodomain 4440 0.0000 SUB387 C(:C)(:C)(:N) 4440 0.0000 PF09326 Domain of unknown function (DUF1982), 4441 0.0000 SUB412 P(~O)(~O) 4441 0.0000 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 4442 0.0000 SUB594 N-C-C-C-N 4442 0.0000 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 4443 0.0000 SUB640 O-C-C-C-O 4443 0.0000 PF06466 PCAF (P300/CBP-associated factor), N-terminal domain 4444 0.0000 SUB381 C(~O)(~O) 4444 0.0000 PF02887 Pyruvate kinase, alpha/beta domain 4445 0.0000 SUB463 O-C-C=O 4445 0.0000 PF00274 Fructose-bisphosphate aldolase class-I 4446 0.0000 SUB691 O-C-C-C-C-C-O 4446 0.0000 PF00439 Bromodomain 4447 0.0000 SUB31 >= 1 P 4447 0.0000 PF01223 DNA/RNA non-specific endonuclease 4448 0.0000 SUB315 O-P 4448 0.0000 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 4449 0.0000 SUB673 O=C-C=C-[#1] 4449 0.0000 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 4450 0.0000 SUB457 P(-O)(=O) 4450 0.0000 PF01223 DNA/RNA non-specific endonuclease 4451 0.0000 SUB426 P=O 4451 0.0000 PF01223 DNA/RNA non-specific endonuclease 4452 0.0000 SUB426 P=O 4452 0.0000 PF01033 Somatomedin B domain 4453 0.0000 SUB315 O-P 4453 0.0000 PF01223 DNA/RNA non-specific endonuclease 4454 0.0000 SUB412 P(~O)(~O) 4454 0.0000 PF01033 Somatomedin B domain 4455 0.0000 SUB682 O-C-C-C-C-O 4455 0.0000 PF02055 O-Glycosyl hydrolase family 30 4456 0.0000 SUB457 P(-O)(=O) 4456 0.0000 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 4457 0.0000 SUB412 P(~O)(~O) 4457 0.0000 PF01223 DNA/RNA non-specific endonuclease 4458 0.0000 SUB350 C(~C)(~H)(~S) 4458 0.0000 PF00439 Bromodomain 4459 0.0000 SUB485 N-C:N:C 4459 0.0000 PF00300 Phosphoglycerate mutase family 4460 0.0000 SUB378 C(~N)(:C)(:C) 4460 0.0000 PF01571 Aminomethyltransferase folate-binding domain 4461 0.0000 SUB390 C(:N)(:N) 4461 0.0000 PF00821 Phosphoenolpyruvate carboxykinase 4462 0.0000 SUB621 C:C-O-C-C 4462 0.0000 PF02885 Glycosyl transferase family, helical bundle domain 4463 0.0000 SUB426 P=O 4463 0.0000 PF01130 CD36 family 4464 0.0000 SUB412 P(~O)(~O) 4464 0.0000 PF01130 CD36 family 4465 0.0000 SUB457 P(-O)(=O) 4465 0.0000 PF01033 Somatomedin B domain 4466 0.0000 SUB414 S(~C)(~H) 4466 0.0000 PF00439 Bromodomain 4467 0.0000 SUB505 N:C:N-C 4467 0.0000 PF00821 Phosphoenolpyruvate carboxykinase 4468 0.0000 SUB32 >= 2 P 4468 0.0000 PF08669 Glycine cleavage T-protein C-terminal barrel domain 4469 0.0000 SUB621 C:C-O-C-C 4469 0.0000 PF03765 CRAL/TRIO, N-terminus 4470 0.0000 SUB407 O(~C)(~H) 4470 0.0000 PF10420 Cytokine interleukin-12p40 C-terminus 4471 0.0000 SUB293 C-P 4471 0.0000 PF00328 Histidine acid phosphatase 4472 0.0000 SUB474 S-C:N:C 4472 0.0000 PF01770 Reduced folate carrier 4473 0.0000 SUB18 >= 8 N 4473 0.0000 PF00002 7 transmembrane receptor (Secretin family), 4474 0.0000 SUB520 N=C-N-C 4474 0.0000 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 4475 0.0000 SUB407 O(~C)(~H) 4475 0.0000 PF03199 Eukaryotic glutathione synthase 4476 0.0000 SUB408 O(~C)(~P) 4476 0.0000 PF00146 NADH dehydrogenase 4477 0.0000 SUB407 O(~C)(~H) 4477 0.0000 PF03917 Eukaryotic glutathione synthase, ATP binding domain 4478 0.0000 SUB31 >= 1 P 4478 0.0000 PF00146 NADH dehydrogenase 4479 0.0000 SUB806 OC1CC(N)CCC1 4479 0.0000 PF00214 Calcitonin / CGRP / IAPP family 4480 0.0000 SUB426 P=O 4480 0.0000 PF00224 Pyruvate kinase, barrel domain 4481 0.0000 SUB158 >= 3 any ring size 5 4481 0.0000 PF00146 NADH dehydrogenase 4482 0.0000 SUB426 P=O 4482 0.0000 PF02666 Phosphatidylserine decarboxylase 4483 0.0000 SUB651 O=C-N-C=O 4483 0.0000 PF00692 dUTPase 4484 0.0000 SUB309 O-H 4484 0.0000 PF00317 Ribonucleotide reductase, all-alpha domain 4485 0.0000 SUB66 >= 1 As 4485 0.0000 PF00489 Interleukin-6/G-CSF/MGF family 4486 0.0000 SUB640 O-C-C-C-O 4486 0.0000 PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 4487 0.0000 SUB449 C(-H)(=O) 4487 0.0000 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 4488 0.0000 SUB31 >= 1 P 4488 0.0000 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 4489 0.0000 SUB494 O=C-C:C 4489 0.0000 PF02971 Formiminotransferase domain 4490 0.0000 SUB437 C(-C)(-H)(=O) 4490 0.0000 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 4491 0.0000 SUB462 O-C-C=N 4491 0.0000 PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen), 4492 0.0000 SUB32 >= 2 P 4492 0.0000 PF00146 NADH dehydrogenase 4493 0.0000 SUB408 O(~C)(~P) 4493 0.0000 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 4494 0.0000 SUB412 P(~O)(~O) 4494 0.0000 PF01222 Ergosterol biosynthesis ERG4/ERG24 family 4495 0.0000 SUB494 O=C-C:C 4495 0.0000 PF04961 Formiminotransferase-cyclodeaminase