SUB158 >= 3 any ring size 5 2.1468 PF00106 short chain dehydrogenase 1.9413 PF01126 Heme oxygenase 1.3436 PF00067 Cytochrome P450 0.8767 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.5782 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.4038 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.3399 PF00171 Aldehyde dehydrogenase family 0.3026 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0455 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain SUB414 S(~C)(~H) 2.1118 PF00255 Glutathione peroxidase 1.0339 PF01124 MAPEG family 0.5858 PF00656 Caspase domain SUB686 O=C-C-C-C-N 1.8035 PF01094 Receptor family ligand binding region 1.1632 PF00282 Pyridoxal-dependent decarboxylase conserved domain 1.0969 PF02798 Glutathione S-transferase, N-terminal domain 0.9849 PF00068 Phospholipase A2 0.9029 PF00464 Serine hydroxymethyltransferase 0.6007 PF00060 Ligand-gated ion channel 0.5820 PF00043 Glutathione S-transferase, C-terminal domain 0.5323 PF00155 Aminotransferase class I and II 0.4265 PF00413 Matrixin 0.4243 PF04961 Formiminotransferase-cyclodeaminase 0.4021 PF00755 Choline/Carnitine o-acyltransferase 0.3762 PF00153 Mitochondrial carrier protein 0.3520 PF00023 Ankyrin repeat 0.3090 PF00375 Sodium:dicarboxylate symporter family 0.1979 PF08763 Voltage gated calcium channel IQ domain 0.0583 PF00045 Hemopexin 0.0134 PF01471 Putative peptidoglycan binding domain 0.0091 PF07837 Formiminotransferase domain, N-terminal subdomain 0.0089 PF00202 Aminotransferase class-III SUB687 O=C-C-C-C-O 1.7707 PF03171 2OG-Fe(II), oxygenase superfamily 0.9442 PF02668 Taurine catabolism dioxygenase TauD, TfdA family 0.6616 PF00939 Sodium:sulfate symporter transmembrane region 0.3114 PF01336 OB-fold nucleic acid binding domain SUB348 C(~C)(~H)(~O)(~O) 1.7514 PF03414 Glycosyltransferase family 6 0.6926 PF00143 Interferon alpha/beta domain 0.5536 PF00337 Galactoside-binding lectin 0.4713 PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain 0.3722 PF07686 Immunoglobulin V-set domain 0.3025 PF08702 Fibrinogen alpha/beta chain family 0.2778 PF00089 Trypsin 0.2257 PF07654 Immunoglobulin C1-set domain SUB387 C(:C)(:C)(:N) 1.6343 PF00042 Globin 0.2042 PF00001 7 transmembrane receptor (rhodopsin family), 0.0965 PF00005 ABC transporter SUB409 O(~H)(~S) 1.6299 PF00167 Fibroblast growth factor SUB32 >= 2 P 1.5807 PF00348 Polyprenyl synthetase 1.1295 PF01370 NAD dependent epimerase/dehydratase family 1.0699 PF00248 Aldo/keto reductase family 0.5383 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.5118 PF00153 Mitochondrial carrier protein 0.4289 PF02770 Acyl-CoA dehydrogenase, middle domain 0.4072 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.3029 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.2136 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.1119 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0707 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0185 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0008 PF00169 PH domain SUB567 O-C-C-N 1.5797 PF00464 Serine hydroxymethyltransferase 1.3830 PF00155 Aminotransferase class I and II 1.1287 PF00266 Aminotransferase class-V 1.1078 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.8594 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.8417 PF00153 Mitochondrial carrier protein 0.6181 PF00248 Aldo/keto reductase family 0.5228 PF00764 Arginosuccinate synthase 0.3751 PF03917 Eukaryotic glutathione synthase, ATP binding domain 0.3245 PF00310 Glutamine amidotransferases class-II 0.2221 PF00324 Amino acid permease 0.1235 PF00001 7 transmembrane receptor (rhodopsin family), 0.0448 PF03199 Eukaryotic glutathione synthase 0.0336 PF01063 Aminotransferase class IV 0.0197 PF02574 Homocysteine S-methyltransferase 0.0100 PF05995 Cysteine dioxygenase type I 0.0002 PF00664 ABC transporter transmembrane region SUB309 O-H 1.5105 PF00102 Protein-tyrosine phosphatase 0.6717 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.4405 PF00557 Metallopeptidase family M24 0.2681 PF00273 Serum albumin family 0.2381 PF00576 HIUase/Transthyretin family 0.2213 PF00106 short chain dehydrogenase 0.2017 PF00153 Mitochondrial carrier protein 0.1189 PF01063 Aminotransferase class IV 0.1054 PF03098 Animal haem peroxidase 0.0891 PF00303 Thymidylate synthase 0.0603 PF01180 Dihydroorotate dehydrogenase SUB433 C(-C)(-C)(=O) 1.5065 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1.4784 PF07884 Vitamin K epoxide reductase family 0.7103 PF07690 Major Facilitator Superfamily 0.3603 PF03953 Tubulin C-terminal domain 0.2465 PF02525 Flavodoxin-like fold 0.1819 PF00091 Tubulin/FtsZ family, GTPase domain 0.0845 PF00089 Trypsin 0.0018 PF00001 7 transmembrane receptor (rhodopsin family), SUB449 C(-H)(=O) 1.5033 PF00107 Zinc-binding dehydrogenase 0.0118 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB695 O=C-C-C-C-C=O 1.4956 PF00551 Formyl transferase 0.9712 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.6114 PF00023 Ankyrin repeat 0.5932 PF00255 Glutathione peroxidase 0.4090 PF04389 Peptidase family M28 0.3656 PF03951 Glutamine synthetase, beta-Grasp domain 0.3063 PF08240 Alcohol dehydrogenase GroES-like domain 0.2851 PF00120 Glutamine synthetase, catalytic domain 0.1511 PF02793 Hormone receptor domain 0.0691 PF00749 tRNA synthetases class I (E and Q), , catalytic domain SUB706 O=C-C-C-C-C(O)-C 1.4255 PF00079 Serpin (serine protease inhibitor), 0.7135 PF00229 TNF(Tumour Necrosis Factor), family 0.3970 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1661 PF00067 Cytochrome P450 SUB484 N-S-C:C 1.4095 PF00324 Amino acid permease 0.6227 PF08403 Amino acid permease N-terminal 0.2522 PF00194 Eukaryotic-type carbonic anhydrase SUB13 >= 16 C 1.4062 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.4850 PF00171 Aldehyde dehydrogenase family 0.3329 PF00001 7 transmembrane receptor (rhodopsin family), 0.2977 PF00105 Zinc finger, C4 type (two domains), 0.2747 PF00067 Cytochrome P450 0.2417 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1848 PF00106 short chain dehydrogenase SUB360 C(~C)(:N)(:N) 1.4054 PF00106 short chain dehydrogenase 1.1965 PF00017 SH2 domain 0.5760 PF00074 Pancreatic ribonuclease 0.1409 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.0003 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain SUB799 CC1CC(O)CCC1 1.3993 PF00168 C2 domain 0.7768 PF00520 Ion transport protein 0.5525 PF01735 Lysophospholipase catalytic domain SUB4 >= 32 H 1.3972 PF00625 Guanylate kinase 1.0837 PF08725 Integrin beta cytoplasmic domain 0.4917 PF00650 CRAL/TRIO domain 0.4680 PF00149 Calcineurin-like phosphoesterase 0.3541 PF08441 Integrin alpha 0.3280 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.0702 PF00520 Ion transport protein 0.0268 PF03765 CRAL/TRIO, N-terminus SUB302 N-O 1.3827 PF00850 Histone deacetylase domain SUB714 Cc1ccc(C)cc1 1.3778 PF00017 SH2 domain SUB217 >= 1 saturated or aromatic heteroatom-containing ring size 7 1.3738 PF00069 Protein kinase domain SUB38 >= 1 Cl 1.3455 PF08403 Amino acid permease N-terminal 1.0195 PF00324 Amino acid permease 0.0981 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0597 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0377 PF00689 Cation transporting ATPase, C-terminus 0.0286 PF00043 Glutathione S-transferase, C-terminal domain SUB253 >= 1 unsaturated non-aromatic carbon-only ring size 10 1.3095 PF00191 Annexin 0.7139 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.4164 PF00656 Caspase domain SUB603 O=C-C-N-C 1.2755 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 0.5320 PF00089 Trypsin 0.1270 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0663 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB498 O-C:C:N 1.2712 PF00266 Aminotransferase class-V 1.1558 PF00155 Aminotransferase class I and II 0.2661 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.2156 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain SUB694 O=C-C-C-C-C-O 1.2692 PF00074 Pancreatic ribonuclease 0.9332 PF02798 Glutathione S-transferase, N-terminal domain 0.3098 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.2956 PF00229 TNF(Tumour Necrosis Factor), family 0.2365 PF07654 Immunoglobulin C1-set domain 0.1532 PF00023 Ankyrin repeat 0.1122 PF00324 Amino acid permease SUB336 C(~C)(~C)(~C)(~H) 1.2638 PF01007 Inward rectifier potassium channel 1.1703 PF00133 tRNA synthetases class I (I, L, M and V), 0.9040 PF00005 ABC transporter 0.6921 PF00051 Kringle domain 0.2134 PF08763 Voltage gated calcium channel IQ domain 0.2129 PF00045 Hemopexin 0.1639 PF00520 Ion transport protein 0.1521 PF00089 Trypsin 0.0462 PF01471 Putative peptidoglycan binding domain SUB364 C(~F)(~F) 1.2614 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 1.2353 PF00146 NADH dehydrogenase 0.7099 PF10613 Ligated ion channel L-glutamate- and glycine-binding site SUB840 CC1CC(C)CC1 1.2513 PF00191 Annexin 0.2621 PF00105 Zinc finger, C4 type (two domains), 0.1617 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0115 PF02155 Glucocorticoid receptor SUB656 O-C-C-C:C 1.2502 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.9925 PF00576 HIUase/Transthyretin family 0.2110 PF00989 PAS fold 0.1006 PF00027 Cyclic nucleotide-binding domain 0.0474 PF00001 7 transmembrane receptor (rhodopsin family), SUB306 N-S 1.2310 PF00194 Eukaryotic-type carbonic anhydrase 0.5737 PF01007 Inward rectifier potassium channel SUB489 N-C=N-[#1] 1.2168 PF00089 Trypsin 0.5843 PF02807 ATP:guanido phosphotransferase, N-terminal domain 0.3543 PF00002 7 transmembrane receptor (Secretin family), 0.3302 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain 0.2131 PF02793 Hormone receptor domain SUB537 O=C-C-N 1.2104 PF00375 Sodium:dicarboxylate symporter family 1.0768 PF01490 Transmembrane amino acid transporter protein 1.0618 PF00587 tRNA synthetase class II core domain (G, H, P, S and T), 0.9284 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.6389 PF00579 tRNA synthetases class I (W and Y), 0.5114 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 0.4586 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.4523 PF01841 Transglutaminase-like superfamily 0.4270 PF00155 Aminotransferase class I and II 0.3910 PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 0.3807 PF00458 WHEP-TRS domain 0.3621 PF00586 AIR synthase related protein, N-terminal domain 0.3295 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3087 PF02769 AIR synthase related protein, C-terminal domain 0.2664 PF00102 Protein-tyrosine phosphatase 0.2662 PF02142 MGS-like domain 0.2280 PF00248 Aldo/keto reductase family 0.1983 PF00045 Hemopexin 0.1966 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 0.1300 PF00133 tRNA synthetases class I (I, L, M and V), 0.1117 PF00152 tRNA synthetases class II (D, K and N), 0.1099 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 0.0928 PF01471 Putative peptidoglycan binding domain 0.0539 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region SUB657 C-C-N-C-C 1.1505 PF07562 Nine Cysteines Domain of family 3 GPCR 0.1717 PF00005 ABC transporter 0.1284 PF00989 PAS fold 0.0943 PF00001 7 transmembrane receptor (rhodopsin family), SUB615 C-C-O-C-C 1.1340 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.3642 PF03137 Organic Anion Transporter Polypeptide (OATP), family 0.2873 PF00079 Serpin (serine protease inhibitor), 0.0306 PF07645 Calcium-binding EGF domain 0.0193 PF01030 Receptor L domain SUB407 O(~C)(~H) 1.1271 PF01063 Aminotransferase class IV 0.8226 PF00576 HIUase/Transthyretin family 0.6828 PF02898 Nitric oxide synthase, oxygenase domain 0.6041 PF00557 Metallopeptidase family M24 0.5891 PF01180 Dihydroorotate dehydrogenase 0.5100 PF00079 Serpin (serine protease inhibitor), 0.5098 PF00303 Thymidylate synthase 0.4109 PF00390 Malic enzyme, N-terminal domain 0.3884 PF00273 Serum albumin family 0.3738 PF00248 Aldo/keto reductase family 0.2805 PF00202 Aminotransferase class-III 0.2556 PF00106 short chain dehydrogenase 0.2286 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1097 PF03949 Malic enzyme, NAD binding domain 0.0879 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.0710 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.0614 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0568 PF00169 PH domain 0.0509 PF00105 Zinc finger, C4 type (two domains), 0.0483 PF00343 Carbohydrate phosphorylase 0.0306 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0270 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.0261 PF02806 Alpha amylase, C-terminal all-beta domain 0.0030 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0023 PF00175 Oxidoreductase NAD-binding domain SUB389 C(:C)(:N)(:N) 1.1143 PF00106 short chain dehydrogenase 0.7130 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.4456 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 0.3250 PF00441 Acyl-CoA dehydrogenase, C-terminal domain 0.2640 PF00361 NADH-Ubiquinone/plastoquinone (complex I), , various chains 0.1686 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.1568 PF00069 Protein kinase domain 0.1359 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0994 PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 0.0644 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 0.0177 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain SUB242 >= 1 any ring size 9 1.1100 PF01048 Phosphorylase superfamily 0.9287 PF00478 IMP dehydrogenase / GMP reductase domain 0.1098 PF00069 Protein kinase domain SUB172 >= 5 any ring size 5 1.1053 PF07645 Calcium-binding EGF domain 0.6131 PF01122 Eukaryotic cobalamin-binding protein SUB841 CC1CC(O)CC1 1.0949 PF00001 7 transmembrane receptor (rhodopsin family), 0.0869 PF02155 Glucocorticoid receptor SUB337 C(~C)(~C)(~C)(~N) 1.0798 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.4017 PF00060 Ligand-gated ion channel 0.1404 PF00001 7 transmembrane receptor (rhodopsin family), 0.0316 PF00431 CUB domain SUB640 O-C-C-C-O 1.0586 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.2873 PF00071 Ras family 0.2711 PF00069 Protein kinase domain 0.2246 PF00341 Platelet-derived growth factor (PDGF), 0.1563 PF00390 Malic enzyme, N-terminal domain 0.1230 PF03953 Tubulin C-terminal domain 0.1009 PF00084 Sushi domain (SCR repeat), 0.0346 PF00091 Tubulin/FtsZ family, GTPase domain 0.0096 PF03949 Malic enzyme, NAD binding domain SUB193 >= 3 any ring size 6 1.0581 PF09396 Thrombin light chain 0.4757 PF00001 7 transmembrane receptor (rhodopsin family), 0.3666 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.3142 PF00018 SH3 domain 0.1729 PF00005 ABC transporter 0.1614 PF01471 Putative peptidoglycan binding domain 0.0717 PF00017 SH2 domain SUB249 >= 1 any ring size 10 1.0516 PF03493 Calcium-activated BK potassium channel alpha subunit 0.5561 PF08070 DTHCT (NUC029), region 0.5286 PF00204 DNA gyrase B 0.4086 PF02254 TrkA-N domain 0.3632 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.2846 PF07690 Major Facilitator Superfamily 0.0578 PF00168 C2 domain SUB633 C-C-O-C:C 1.0302 PF01023 S-100/ICaBP type calcium binding domain 0.5335 PF00650 CRAL/TRIO domain 0.3087 PF00757 Furin-like cysteine rich region 0.2579 PF00105 Zinc finger, C4 type (two domains), 0.1270 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0701 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.0625 PF01030 Receptor L domain 0.0351 PF03765 CRAL/TRIO, N-terminus SUB408 O(~C)(~P) 1.0268 PF05652 Scavenger mRNA decapping enzyme (DcpS), N-terminal 0.3080 PF00169 PH domain 0.2690 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.1573 PF00069 Protein kinase domain 0.0453 PF02223 Thymidylate kinase 0.0131 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), SUB31 >= 1 P 1.0116 PF00069 Protein kinase domain 0.8678 PF03770 Inositol polyphosphate kinase 0.2309 PF02223 Thymidylate kinase 0.1021 PF00018 SH3 domain 0.0768 PF00017 SH2 domain 0.0064 PF00074 Pancreatic ribonuclease SUB346 C(~C)(~H)(~N) 1.0087 PF02159 Oestrogen receptor 0.7043 PF00209 Sodium:neurotransmitter symporter family 0.3384 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.3209 PF00001 7 transmembrane receptor (rhodopsin family), 0.3033 PF03073 TspO/MBR family 0.0664 PF00005 ABC transporter 0.0468 PF00664 ABC transporter transmembrane region SUB703 O-C-C-C-C-C-N-C 0.9883 PF01401 Angiotensin-converting enzyme 0.8242 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.6829 PF08527 Protein-arginine deiminase (PAD), middle domain 0.3022 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.2035 PF00069 Protein kinase domain 0.1734 PF03068 Protein-arginine deiminase (PAD), 0.1536 PF08526 Protein-arginine deiminase (PAD), N-terminal domain 0.1468 PF00571 CBS domain 0.1025 PF02223 Thymidylate kinase 0.0101 PF00702 haloacid dehalogenase-like hydrolase SUB503 N-C=C-[#1] 0.9721 PF00069 Protein kinase domain 0.4027 PF07885 Ion channel 0.2287 PF00067 Cytochrome P450 0.1221 PF03098 Animal haem peroxidase 0.0084 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB398 N(~C)(:C)(:C) 0.9629 PF00071 Ras family 0.8984 PF00067 Cytochrome P450 0.3748 PF02525 Flavodoxin-like fold 0.3040 PF01467 Cytidylyltransferase 0.1301 PF00069 Protein kinase domain SUB683 O-C-C-C-C-N 0.9546 PF00225 Kinesin motor domain 0.7258 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 0.2591 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 0.0786 PF00704 Glycosyl hydrolases family 18 0.0732 PF07885 Ion channel 0.0573 PF00153 Mitochondrial carrier protein 0.0522 PF00171 Aldehyde dehydrogenase family SUB598 O=C-C-C:C 0.9526 PF06512 Sodium ion transport-associated 0.2894 PF00069 Protein kinase domain 0.2129 PF07884 Vitamin K epoxide reductase family 0.1398 PF03098 Animal haem peroxidase 0.1344 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0474 PF00464 Serine hydroxymethyltransferase SUB688 O=C-C-C-C=O 0.9491 PF00549 CoA-ligase 0.1429 PF00152 tRNA synthetases class II (D, K and N), 0.1258 PF01336 OB-fold nucleic acid binding domain 0.0532 PF00005 ABC transporter SUB618 C-C-C-O-[#1] 0.9436 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.4492 PF02574 Homocysteine S-methyltransferase 0.4332 PF00310 Glutamine amidotransferases class-II 0.4017 PF00764 Arginosuccinate synthase 0.3494 PF00128 Alpha amylase, catalytic domain 0.3308 PF00927 Transglutaminase family, C-terminal ig like domain 0.2607 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.1576 PF00571 CBS domain 0.1438 PF00071 Ras family 0.1285 PF02806 Alpha amylase, C-terminal all-beta domain 0.1191 PF01841 Transglutaminase-like superfamily 0.0882 PF00868 Transglutaminase family 0.0716 PF07654 Immunoglobulin C1-set domain 0.0532 PF00079 Serpin (serine protease inhibitor), 0.0163 PF02155 Glucocorticoid receptor 0.0039 PF01063 Aminotransferase class IV SUB673 O=C-C=C-[#1] 0.9419 PF00171 Aldehyde dehydrogenase family 0.5931 PF00531 Death domain 0.2857 PF00089 Trypsin 0.0789 PF00107 Zinc-binding dehydrogenase SUB132 >= 1 saturated or aromatic nitrogen-containing ring size 4 0.9327 PF00854 POT family SUB778 CC1CCC(O)CC1 0.9219 PF12497 Estrogen receptor beta SUB757 Cc1c(O)cccc1 0.9204 PF00001 7 transmembrane receptor (rhodopsin family), 0.8003 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0596 PF00005 ABC transporter 0.0207 PF01023 S-100/ICaBP type calcium binding domain SUB140 >= 2 saturated or aromatic heteroatom-containing ring size 4 0.9160 PF00069 Protein kinase domain SUB572 [#1]-C-O-[#1] 0.9040 PF01607 Chitin binding Peritrophin-A domain 0.5482 PF00400 WD domain, G-beta repeat 0.4696 PF00041 Fibronectin type III domain 0.4548 PF00303 Thymidylate synthase 0.4100 PF04515 Plasma-membrane choline transporter 0.3958 PF00167 Fibroblast growth factor 0.3923 PF00704 Glycosyl hydrolases family 18 0.3496 PF00169 PH domain 0.3110 PF00145 C-5 cytosine-specific DNA methylase 0.2422 PF00001 7 transmembrane receptor (rhodopsin family), 0.2164 PF00069 Protein kinase domain 0.2122 PF00175 Oxidoreductase NAD-binding domain 0.2079 PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 0.1815 PF00342 Phosphoglucose isomerase 0.1184 PF02806 Alpha amylase, C-terminal all-beta domain 0.0747 PF07686 Immunoglobulin V-set domain 0.0597 PF05221 S-adenosyl-L-homocysteine hydrolase 0.0369 PF00005 ABC transporter 0.0166 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.0012 PF00931 NB-ARC domain SUB622 N-C:C:C:N 0.8955 PF08240 Alcohol dehydrogenase GroES-like domain 0.4694 PF00069 Protein kinase domain 0.4389 PF00175 Oxidoreductase NAD-binding domain 0.2713 PF00757 Furin-like cysteine rich region 0.1122 PF00107 Zinc-binding dehydrogenase 0.1099 PF00005 ABC transporter 0.0659 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 0.0395 PF00018 SH3 domain 0.0265 PF00017 SH2 domain 0.0065 PF00106 short chain dehydrogenase SUB17 >= 4 N 0.8923 PF00186 Dihydrofolate reductase 0.5812 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.5108 PF01916 Deoxyhypusine synthase 0.4015 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.2783 PF00067 Cytochrome P450 0.1979 PF00001 7 transmembrane receptor (rhodopsin family), 0.1040 PF00005 ABC transporter 0.0213 PF00069 Protein kinase domain SUB207 >= 5 any ring size 6 0.8863 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.8781 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB379 C(~N)(:C)(:N) 0.8818 PF00962 Adenosine/AMP deaminase 0.8533 PF00858 Amiloride-sensitive sodium channel 0.7047 PF00156 Phosphoribosyl transferase domain 0.5115 PF00186 Dihydrofolate reductase 0.0726 PF00069 Protein kinase domain SUB182 >= 1 saturated or aromatic heteroatom-containing ring size 6 0.8713 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.7191 PF00041 Fibronectin type III domain 0.5585 PF00069 Protein kinase domain 0.4753 PF00059 Lectin C-type domain 0.4442 PF00229 TNF(Tumour Necrosis Factor), family 0.3017 PF00248 Aldo/keto reductase family 0.2758 PF00045 Hemopexin 0.2622 PF00702 haloacid dehalogenase-like hydrolase 0.2435 PF00089 Trypsin 0.2081 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1684 PF00204 DNA gyrase B 0.1532 PF08070 DTHCT (NUC029), region 0.1529 PF06512 Sodium ion transport-associated 0.0970 PF00521 DNA gyrase/topoisomerase IV, subunit A 0.0950 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0702 PF01471 Putative peptidoglycan binding domain SUB441 C(-C)(-O)(=O) 0.8619 PF01401 Angiotensin-converting enzyme 0.7753 PF00324 Amino acid permease 0.7315 PF00354 Pentaxin family 0.4358 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.4137 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.3996 PF00092 von Willebrand factor type A domain 0.3501 PF01063 Aminotransferase class IV 0.2960 PF00105 Zinc finger, C4 type (two domains), 0.2846 PF00571 CBS domain 0.2606 PF01433 Peptidase family M1 0.2160 PF00151 Lipase 0.1841 PF02574 Homocysteine S-methyltransferase 0.1701 PF07690 Major Facilitator Superfamily 0.1266 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0849 PF00071 Ras family 0.0650 PF00153 Mitochondrial carrier protein 0.0547 PF03098 Animal haem peroxidase 0.0508 PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase 0.0156 PF00487 Fatty acid desaturase 0.0152 PF05649 Peptidase family M13 0.0140 PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region 0.0016 PF00173 Cytochrome b5-like Heme/Steroid binding domain SUB448 C(-H)(=N) 0.8589 PF02267 ADP-ribosyl cyclase SUB647 O=C-N-C-[#1] 0.8582 PF01401 Angiotensin-converting enzyme 0.5931 PF07686 Immunoglobulin V-set domain 0.5642 PF01431 Peptidase family M13 0.3768 PF00303 Thymidylate synthase 0.3383 PF05649 Peptidase family M13 0.2763 PF00005 ABC transporter 0.1570 PF01007 Inward rectifier potassium channel 0.0696 PF00551 Formyl transferase 0.0228 PF00664 ABC transporter transmembrane region 0.0003 PF00026 Eukaryotic aspartyl protease SUB588 N-C:C-O-[#1] 0.8566 PF00266 Aminotransferase class-V 0.8254 PF00155 Aminotransferase class I and II SUB410 O(:C)(:C) 0.8538 PF00001 7 transmembrane receptor (rhodopsin family), SUB447 C(-H)(=C) 0.8528 PF03098 Animal haem peroxidase 0.0401 PF00067 Cytochrome P450 0.0355 PF00001 7 transmembrane receptor (rhodopsin family), SUB625 O=C-C:C-N 0.8525 PF00071 Ras family 0.1595 PF00001 7 transmembrane receptor (rhodopsin family), 0.1339 PF01467 Cytidylyltransferase SUB579 C-C:C-C:C 0.8379 PF00209 Sodium:neurotransmitter symporter family 0.3250 PF00001 7 transmembrane receptor (rhodopsin family), SUB696 O=C-C-C-C-C-N 0.8352 PF00026 Eukaryotic aspartyl protease 0.3141 PF02100 Ornithine decarboxylase antizyme 0.1365 PF00490 Delta-aminolevulinic acid dehydratase 0.0638 PF00491 Arginase family 0.0194 PF08527 Protein-arginine deiminase (PAD), middle domain SUB228 >= 1 any ring size 8 0.8269 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1971 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB14 >= 32 C 0.8091 PF00149 Calcineurin-like phosphoesterase 0.7384 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.6219 PF00493 MCM2/3/5 family SUB18 >= 8 N 0.8086 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.2409 PF00001 7 transmembrane receptor (rhodopsin family), SUB339 C(~C)(~C)(~H)(~N) 0.8084 PF00128 Alpha amylase, catalytic domain 0.5803 PF07690 Major Facilitator Superfamily 0.3543 PF01401 Angiotensin-converting enzyme 0.3291 PF00112 Papain family cysteine protease 0.2683 PF02574 Homocysteine S-methyltransferase 0.2629 PF00155 Aminotransferase class I and II 0.2431 PF07562 Nine Cysteines Domain of family 3 GPCR 0.1874 PF00258 Flavodoxin 0.1771 PF00017 SH2 domain 0.1183 PF00018 SH3 domain 0.0974 PF02798 Glutathione S-transferase, N-terminal domain 0.0926 PF01336 OB-fold nucleic acid binding domain 0.0510 PF00579 tRNA synthetases class I (W and Y), 0.0311 PF00520 Ion transport protein 0.0296 PF00375 Sodium:dicarboxylate symporter family 0.0200 PF00667 FAD binding domain 0.0106 PF00133 tRNA synthetases class I (I, L, M and V), 0.0011 PF00152 tRNA synthetases class II (D, K and N), SUB396 N(~C)(~O) 0.8007 PF00850 Histone deacetylase domain SUB529 [#1]-N-C-[#1] 0.7997 PF00117 Glutamine amidotransferase class-I 0.7554 PF00709 Adenylosuccinate synthetase 0.5256 PF00209 Sodium:neurotransmitter symporter family 0.4607 PF00324 Amino acid permease 0.4474 PF00051 Kringle domain 0.3843 PF00310 Glutamine amidotransferases class-II 0.3633 PF00155 Aminotransferase class I and II 0.2917 PF00001 7 transmembrane receptor (rhodopsin family), 0.2835 PF00112 Papain family cysteine protease 0.1313 PF00089 Trypsin 0.1182 PF00351 Biopterin-dependent aromatic amino acid hydroxylase 0.0703 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR 0.0425 PF00069 Protein kinase domain 0.0185 PF01490 Transmembrane amino acid transporter protein SUB653 O-C:C:C-N 0.7973 PF00001 7 transmembrane receptor (rhodopsin family), SUB682 O-C-C-C-C-O 0.7953 PF01532 Glycosyl hydrolase family 47 0.5755 PF00501 AMP-binding enzyme 0.5618 PF00349 Hexokinase 0.4884 PF03360 Glycosyltransferase family 43 0.4050 PF01230 HIT domain 0.3353 PF00169 PH domain 0.3031 PF00079 Serpin (serine protease inhibitor), 0.2031 PF03414 Glycosyltransferase family 6 0.1712 PF00017 SH2 domain 0.1399 PF00478 IMP dehydrogenase / GMP reductase domain 0.0942 PF00069 Protein kinase domain 0.0932 PF00343 Carbohydrate phosphorylase 0.0380 PF00171 Aldehyde dehydrogenase family SUB424 N=O 0.7924 PF00211 Adenylate and Guanylate cyclase catalytic domain SUB375 C(~H)(~H)(~H) 0.7822 PF00305 Lipoxygenase 0.7628 PF00135 Carboxylesterase 0.1949 PF00001 7 transmembrane receptor (rhodopsin family), 0.1941 PF06512 Sodium ion transport-associated 0.1853 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1781 PF01471 Putative peptidoglycan binding domain 0.1720 PF00258 Flavodoxin 0.1516 PF01477 PLAT/LH2 domain 0.1439 PF00557 Metallopeptidase family M24 0.1247 PF00667 FAD binding domain 0.1072 PF00045 Hemopexin 0.1065 PF08674 Acetylcholinesterase tetramerisation domain 0.1016 PF00173 Cytochrome b5-like Heme/Steroid binding domain 0.0965 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0636 PF03098 Animal haem peroxidase 0.0626 PF01180 Dihydroorotate dehydrogenase 0.0343 PF00702 haloacid dehalogenase-like hydrolase SUB715 Cc1ccc(O)cc1 0.7714 PF00105 Zinc finger, C4 type (two domains), 0.7430 PF00104 Ligand-binding domain of nuclear hormone receptor 0.5587 PF00017 SH2 domain 0.2774 PF00018 SH3 domain 0.0384 PF00001 7 transmembrane receptor (rhodopsin family), SUB365 C(~F)(:C) 0.7710 PF00069 Protein kinase domain 0.1001 PF00493 MCM2/3/5 family SUB643 O-C-C-C=O 0.7702 PF00291 Pyridoxal-phosphate dependent enzyme 0.2783 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.2501 PF01023 S-100/ICaBP type calcium binding domain 0.1358 PF00271 Helicase conserved C-terminal domain 0.0932 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0717 PF00005 ABC transporter 0.0572 PF00091 Tubulin/FtsZ family, GTPase domain 0.0491 PF03953 Tubulin C-terminal domain 0.0155 PF00168 C2 domain SUB602 N-C:C:C-N 0.7689 PF00069 Protein kinase domain 0.7257 PF08240 Alcohol dehydrogenase GroES-like domain 0.5771 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.3573 PF00017 SH2 domain 0.1715 PF00106 short chain dehydrogenase 0.1049 PF00175 Oxidoreductase NAD-binding domain 0.0826 PF00005 ABC transporter 0.0454 PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain SUB712 C-C(C)(C)-C-C 0.7664 PF00106 short chain dehydrogenase 0.7464 PF03953 Tubulin C-terminal domain 0.7249 PF00104 Ligand-binding domain of nuclear hormone receptor 0.5010 PF00091 Tubulin/FtsZ family, GTPase domain 0.4277 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.3456 PF00976 Corticotropin ACTH domain 0.2830 PF08384 Pro-opiomelanocortin, N-terminal region 0.1514 PF08763 Voltage gated calcium channel IQ domain 0.1277 PF00067 Cytochrome P450 0.1145 PF00520 Ion transport protein 0.0808 PF08035 Opioids neuropeptide 0.0427 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB674 O=C-C=C-N 0.7659 PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 0.7402 PF00303 Thymidylate synthase 0.7223 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P), -binding domain 0.3401 PF02219 Methylenetetrahydrofolate reductase 0.2607 PF01808 AICARFT/IMPCHase bienzyme 0.1005 PF08669 Glycine cleavage T-protein C-terminal barrel domain 0.0861 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0803 PF02142 MGS-like domain SUB825 OC1C(O)CCCC1 0.7655 PF00091 Tubulin/FtsZ family, GTPase domain 0.2864 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.2528 PF03953 Tubulin C-terminal domain 0.2317 PF01596 O-methyltransferase SUB536 O=C-C-C 0.7641 PF07690 Major Facilitator Superfamily 0.5811 PF00202 Aminotransferase class-III 0.4625 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3923 PF02166 Androgen receptor 0.3410 PF00001 7 transmembrane receptor (rhodopsin family), 0.3073 PF00071 Ras family 0.0424 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB214 >= 1 any ring size 7 0.7637 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.3817 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0614 PF00209 Sodium:neurotransmitter symporter family SUB606 O=C-C-O-C 0.7580 PF00001 7 transmembrane receptor (rhodopsin family), 0.3401 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 0.0068 PF00520 Ion transport protein SUB252 >= 1 saturated or aromatic heteroatom-containing ring size 10 0.7557 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.7510 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3297 PF01582 TIR domain 0.0113 PF00001 7 transmembrane receptor (rhodopsin family), SUB494 O=C-C:C 0.7535 PF00017 SH2 domain 0.1616 PF00071 Ras family 0.1260 PF00018 SH3 domain 0.0183 PF00001 7 transmembrane receptor (rhodopsin family), 0.0031 PF00464 Serine hydroxymethyltransferase SUB486 N:C:C:N 0.7496 PF00858 Amiloride-sensitive sodium channel 0.4877 PF00962 Adenosine/AMP deaminase 0.3394 PF00520 Ion transport protein 0.1851 PF00156 Phosphoribosyl transferase domain SUB208 >= 5 saturated or aromatic carbon-only ring size 6 0.7478 PF00089 Trypsin SUB716 Cc1ccc(S)cc1 0.7455 PF00005 ABC transporter SUB718 Cc1ccc(Cl)cc1 0.7340 PF01094 Receptor family ligand binding region SUB146 >= 1 saturated or aromatic nitrogen-containing ring size 5 0.7291 PF00501 AMP-binding enzyme 0.6334 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.4222 PF00069 Protein kinase domain 0.1913 PF00520 Ion transport protein 0.0951 PF00001 7 transmembrane receptor (rhodopsin family), SUB288 C-F 0.7234 PF00520 Ion transport protein 0.4899 PF03477 ATP cone domain 0.4269 PF01094 Receptor family ligand binding region 0.1608 PF01180 Dihydroorotate dehydrogenase 0.0875 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0732 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0609 PF00248 Aldo/keto reductase family 0.0537 PF07686 Immunoglobulin V-set domain SUB259 >= 2 hetero-aromatic rings 0.7146 PF00017 SH2 domain 0.4427 PF00005 ABC transporter 0.2773 PF00042 Globin 0.2576 PF00018 SH3 domain 0.0770 PF00001 7 transmembrane receptor (rhodopsin family), SUB708 O=C-C-C-C-C(N)-C 0.7124 PF02310 B12 binding domain 0.4547 PF07690 Major Facilitator Superfamily 0.3441 PF02219 Methylenetetrahydrofolate reductase 0.2322 PF01571 Aminomethyltransferase folate-binding domain 0.1934 PF00092 von Willebrand factor type A domain 0.1085 PF08669 Glycine cleavage T-protein C-terminal barrel domain SUB187 >= 2 saturated or aromatic carbon-only ring size 6 0.7121 PF02159 Oestrogen receptor 0.2564 PF00079 Serpin (serine protease inhibitor), 0.1814 PF00664 ABC transporter transmembrane region 0.1446 PF00001 7 transmembrane receptor (rhodopsin family), 0.0463 PF00005 ABC transporter SUB381 C(~O)(~O) 0.7108 PF00405 Transferrin 0.6231 PF00058 Low-density lipoprotein receptor repeat class B 0.5840 PF07654 Immunoglobulin C1-set domain 0.3948 PF07686 Immunoglobulin V-set domain 0.2969 PF00224 Pyruvate kinase, barrel domain 0.2518 PF01401 Angiotensin-converting enzyme 0.2160 PF00059 Lectin C-type domain 0.1473 PF03171 2OG-Fe(II), oxygenase superfamily 0.1132 PF00273 Serum albumin family 0.0993 PF00128 Alpha amylase, catalytic domain 0.0966 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0834 PF00084 Sushi domain (SCR repeat), 0.0755 PF00105 Zinc finger, C4 type (two domains), 0.0410 PF00067 Cytochrome P450 0.0398 PF02887 Pyruvate kinase, alpha/beta domain SUB693 O=C-C-C-C-C-C 0.7040 PF00089 Trypsin 0.0064 PF00069 Protein kinase domain 0.0025 PF00079 Serpin (serine protease inhibitor), SUB262 >= 4 aromatic rings 0.6969 PF00089 Trypsin SUB613 N-C-O-C-C 0.6960 PF02223 Thymidylate kinase 0.2397 PF02267 ADP-ribosyl cyclase 0.1843 PF01712 Deoxynucleoside kinase 0.0907 PF00001 7 transmembrane receptor (rhodopsin family), SUB720 Oc1ccc(O)cc1 0.6959 PF00105 Zinc finger, C4 type (two domains), 0.0652 PF00104 Ligand-binding domain of nuclear hormone receptor SUB5 >= 1 Li 0.6931 PF00459 Inositol monophosphatase family SUB760 Cc1c(Cl)cccc1 0.6915 PF00069 Protein kinase domain 0.1725 PF00520 Ion transport protein SUB459 S(-O)(=O) 0.6914 PF00194 Eukaryotic-type carbonic anhydrase 0.5404 PF00089 Trypsin 0.2341 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.1293 PF00520 Ion transport protein SUB392 N(~C)(~C)(~C) 0.6907 PF08674 Acetylcholinesterase tetramerisation domain 0.5778 PF00001 7 transmembrane receptor (rhodopsin family), 0.3302 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.3289 PF01467 Cytidylyltransferase 0.3065 PF00520 Ion transport protein 0.2168 PF00209 Sodium:neurotransmitter symporter family 0.2014 PF03073 TspO/MBR family 0.1908 PF00135 Carboxylesterase 0.1611 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB821 CC1C(S)CCCC1 0.6866 PF00001 7 transmembrane receptor (rhodopsin family), SUB25 >= 2 F 0.6859 PF00690 Cation transporter/ATPase, N-terminus 0.6310 PF00689 Cation transporting ATPase, C-terminus 0.3480 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 0.2876 PF00146 NADH dehydrogenase 0.0885 PF00520 Ion transport protein 0.0568 PF00702 haloacid dehalogenase-like hydrolase SUB345 C(~C)(~H) 0.6854 PF00273 Serum albumin family 0.1750 PF00060 Ligand-gated ion channel 0.1280 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1137 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0889 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.0102 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SUB646 O=C-N-C-C 0.6828 PF02166 Androgen receptor 0.1365 PF00005 ABC transporter 0.1185 PF07686 Immunoglobulin V-set domain 0.1071 PF00079 Serpin (serine protease inhibitor), 0.0668 PF01477 PLAT/LH2 domain 0.0425 PF00664 ABC transporter transmembrane region 0.0166 PF00026 Eukaryotic aspartyl protease 0.0124 PF00074 Pancreatic ribonuclease 0.0038 PF00105 Zinc finger, C4 type (two domains), SUB554 O=C-C=C 0.6826 PF00464 Serine hydroxymethyltransferase 0.3362 PF02525 Flavodoxin-like fold 0.0239 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB369 C(~H)(~S) 0.6777 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.5466 PF01770 Reduced folate carrier 0.4252 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.2864 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.2673 PF00043 Glutathione S-transferase, C-terminal domain 0.1571 PF08725 Integrin beta cytoplasmic domain 0.1148 PF02798 Glutathione S-transferase, N-terminal domain 0.0002 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain SUB200 >= 4 any ring size 6 0.6712 PF00089 Trypsin 0.4080 PF00069 Protein kinase domain 0.3549 PF00520 Ion transport protein 0.1067 PF00357 Integrin alpha cytoplasmic region 0.0829 PF00170 bZIP transcription factor 0.0697 PF00043 Glutathione S-transferase, C-terminal domain 0.0659 PF00001 7 transmembrane receptor (rhodopsin family), SUB691 O-C-C-C-C-C-O 0.6673 PF02806 Alpha amylase, C-terminal all-beta domain 0.6657 PF01094 Receptor family ligand binding region 0.4864 PF00005 ABC transporter 0.3954 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.3363 PF00551 Formyl transferase 0.3198 PF07654 Immunoglobulin C1-set domain 0.2273 PF01230 HIT domain 0.2251 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.2137 PF00349 Hexokinase 0.2025 PF01571 Aminomethyltransferase folate-binding domain 0.2024 PF03727 Hexokinase 0.1172 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.1053 PF02525 Flavodoxin-like fold 0.0627 PF01712 Deoxynucleoside kinase 0.0597 PF05222 Alanine dehydrogenase/PNT, N-terminal domain SUB421 C=O 0.6653 PF00107 Zinc-binding dehydrogenase 0.4256 PF00202 Aminotransferase class-III 0.3573 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.1157 PF00248 Aldo/keto reductase family 0.1033 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0943 PF00266 Aminotransferase class-V 0.0943 PF00001 7 transmembrane receptor (rhodopsin family), 0.0920 PF00051 Kringle domain SUB347 C(~C)(~H)(~O) 0.6645 PF00343 Carbohydrate phosphorylase 0.3616 PF00089 Trypsin 0.1812 PF00171 Aldehyde dehydrogenase family 0.0046 PF06512 Sodium ion transport-associated SUB541 C-N-C-[#1] 0.6639 PF00755 Choline/Carnitine o-acyltransferase 0.0619 PF00005 ABC transporter SUB440 C(-C)(-N)(=O) 0.6587 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 0.2973 PF00868 Transglutaminase family 0.2234 PF00927 Transglutaminase family, C-terminal ig like domain 0.2177 PF00079 Serpin (serine protease inhibitor), 0.1799 PF01471 Putative peptidoglycan binding domain 0.1416 PF00056 lactate/malate dehydrogenase, NAD binding domain 0.1009 PF01841 Transglutaminase-like superfamily 0.0443 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0076 PF00045 Hemopexin SUB577 N=C-C:C-[#1] 0.6544 PF03073 TspO/MBR family 0.6022 PF00089 Trypsin 0.1925 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0527 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB568 O-C-C-O 0.6464 PF00017 SH2 domain 0.1481 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.1286 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase SUB664 O-C-C-O-[#1] 0.6448 PF00728 Glycosyl hydrolase family 20, catalytic domain 0.6392 PF01370 NAD dependent epimerase/dehydratase family 0.5398 PF02065 Melibiase 0.3409 PF01842 ACT domain 0.2455 PF00180 Isocitrate/isopropylmalate dehydrogenase 0.2422 PF03414 Glycosyltransferase family 6 0.2260 PF00328 Histidine acid phosphatase 0.1768 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.1545 PF03949 Malic enzyme, NAD binding domain 0.1481 PF03360 Glycosyltransferase family 43 0.1419 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain 0.1080 PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 0.0760 PF01712 Deoxynucleoside kinase 0.0567 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0129 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0041 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 0.0001 PF00441 Acyl-CoA dehydrogenase, C-terminal domain SUB631 O-C:C-O-C 0.6438 PF07690 Major Facilitator Superfamily 0.6360 PF00643 B-box zinc finger 0.5436 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB3 >= 16 H 0.6426 PF00001 7 transmembrane receptor (rhodopsin family), 0.6004 PF03491 Serotonin (5-HT), neurotransmitter transporter, N-terminus 0.5719 PF00005 ABC transporter 0.3446 PF00664 ABC transporter transmembrane region 0.2084 PF00106 short chain dehydrogenase 0.0294 PF00520 Ion transport protein SUB422 C=S 0.6408 PF07645 Calcium-binding EGF domain SUB547 N-C:C-[#1] 0.6388 PF07885 Ion channel SUB23 >= 16 O 0.6365 PF02793 Hormone receptor domain 0.5652 PF00002 7 transmembrane receptor (Secretin family), SUB419 C=N 0.6350 PF00051 Kringle domain 0.4186 PF00175 Oxidoreductase NAD-binding domain 0.2151 PF02898 Nitric oxide synthase, oxygenase domain 0.1514 PF00001 7 transmembrane receptor (rhodopsin family), 0.1404 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB277 B-O 0.6318 PF00227 Proteasome subunit SUB406 O(~C)(~C) 0.6306 PF00059 Lectin C-type domain 0.5583 PF07645 Calcium-binding EGF domain 0.3684 PF00122 E1-E2 ATPase 0.2423 PF00001 7 transmembrane receptor (rhodopsin family), 0.2373 PF00690 Cation transporter/ATPase, N-terminus 0.2366 PF00135 Carboxylesterase 0.0756 PF00337 Galactoside-binding lectin 0.0155 PF00689 Cation transporting ATPase, C-terminus 0.0010 PF00168 C2 domain SUB594 N-C-C-C-N 0.6299 PF00583 Acetyltransferase (GNAT), family 0.2588 PF00089 Trypsin 0.2164 PF00149 Calcineurin-like phosphoesterase 0.1468 PF01564 Spermine/spermidine synthase 0.0591 PF00067 Cytochrome P450 0.0590 PF00026 Eukaryotic aspartyl protease 0.0536 PF01048 Phosphorylase superfamily 0.0277 PF00005 ABC transporter 0.0029 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SUB545 O-C:C-O 0.6285 PF00001 7 transmembrane receptor (rhodopsin family), 0.4085 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0289 PF07690 Major Facilitator Superfamily 0.0084 PF00643 B-box zinc finger SUB862 CC1C(O)CCC1 0.6267 PF00001 7 transmembrane receptor (rhodopsin family), 0.0796 PF02155 Glucocorticoid receptor SUB284 C-H 0.6256 PF00194 Eukaryotic-type carbonic anhydrase 0.2666 PF00273 Serum albumin family 0.2649 PF08674 Acetylcholinesterase tetramerisation domain 0.2100 PF00060 Ligand-gated ion channel 0.2043 PF00248 Aldo/keto reductase family 0.1226 PF00107 Zinc-binding dehydrogenase 0.0866 PF00497 Bacterial extracellular solute-binding proteins, family 3 SUB458 S(-C)(=O) 0.6191 PF01007 Inward rectifier potassium channel SUB230 >= 1 saturated or aromatic nitrogen-containing ring size 8 0.6153 PF01039 Carboxyl transferase domain 0.1854 PF00364 Biotin-requiring enzyme 0.1676 PF02785 Biotin carboxylase C-terminal domain 0.0401 PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 0.0212 PF00289 Carbamoyl-phosphate synthase L chain, N-terminal domain SUB16 >= 2 N 0.6131 PF00194 Eukaryotic-type carbonic anhydrase 0.5173 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.4037 PF02898 Nitric oxide synthase, oxygenase domain 0.3026 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0785 PF00324 Amino acid permease SUB186 >= 2 any ring size 6 0.6112 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.4661 PF00067 Cytochrome P450 0.0276 PF00204 DNA gyrase B SUB335 C(~C)(~C)(~C)(~C) 0.6095 PF00106 short chain dehydrogenase 0.3330 PF00091 Tubulin/FtsZ family, GTPase domain 0.3002 PF08384 Pro-opiomelanocortin, N-terminal region 0.2266 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1148 PF03953 Tubulin C-terminal domain 0.0731 PF08035 Opioids neuropeptide 0.0455 PF00067 Cytochrome P450 0.0205 PF00976 Corticotropin ACTH domain SUB432 C(-C)(-C)(=N) 0.6075 PF00343 Carbohydrate phosphorylase 0.0979 PF00069 Protein kinase domain 0.0574 PF03073 TspO/MBR family 0.0229 PF00225 Kinesin motor domain SUB183 >= 1 unsaturated non-aromatic carbon-only ring size 6 0.6051 PF00106 short chain dehydrogenase 0.2923 PF00104 Ligand-binding domain of nuclear hormone receptor 0.2444 PF02525 Flavodoxin-like fold SUB250 >= 1 saturated or aromatic carbon-only ring size 10 0.5981 PF08491 Squalene epoxidase SUB161 >= 3 saturated or aromatic heteroatom-containing ring size 5 0.5976 PF00676 Dehydrogenase E1 component 0.5597 PF00171 Aldehyde dehydrogenase family 0.0296 PF00180 Isocitrate/isopropylmalate dehydrogenase SUB717 Cc1ccc(N)cc1 0.5946 PF02310 B12 binding domain SUB595 C-O-C-C=C 0.5940 PF00091 Tubulin/FtsZ family, GTPase domain 0.3319 PF03953 Tubulin C-terminal domain 0.1249 PF00689 Cation transporting ATPase, C-terminus 0.0929 PF00690 Cation transporter/ATPase, N-terminus 0.0276 PF00105 Zinc finger, C4 type (two domains), SUB668 C=C-C-O-[#1] 0.5926 PF00171 Aldehyde dehydrogenase family 0.5749 PF00102 Protein-tyrosine phosphatase 0.3094 PF00001 7 transmembrane receptor (rhodopsin family), 0.1574 PF00576 HIUase/Transthyretin family 0.1490 PF00106 short chain dehydrogenase 0.0389 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SUB286 C-N 0.5921 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.1473 PF00001 7 transmembrane receptor (rhodopsin family), 0.1123 PF00209 Sodium:neurotransmitter symporter family SUB147 >= 1 saturated or aromatic heteroatom-containing ring size 5 0.5914 PF00478 IMP dehydrogenase / GMP reductase domain 0.0928 PF00001 7 transmembrane receptor (rhodopsin family), SUB660 O-C-C-N-C 0.5895 PF01467 Cytidylyltransferase 0.2843 PF04515 Plasma-membrane choline transporter 0.2393 PF00005 ABC transporter 0.1869 PF00614 Phospholipase D Active site motif 0.1510 PF00664 ABC transporter transmembrane region 0.1025 PF00755 Choline/Carnitine o-acyltransferase 0.0943 PF00067 Cytochrome P450 SUB700 O-C-C-C-C-C(C)-C 0.5807 PF01401 Angiotensin-converting enzyme 0.2697 PF00042 Globin 0.1820 PF00520 Ion transport protein 0.1232 PF00069 Protein kinase domain SUB367 C(~H)(~O) 0.5740 PF02214 K+ channel tetramerisation domain 0.4697 PF00084 Sushi domain (SCR repeat), 0.4686 PF00069 Protein kinase domain 0.0534 PF00520 Ion transport protein 0.0045 PF00343 Carbohydrate phosphorylase 0.0029 PF00059 Lectin C-type domain SUB591 C-C:C-O-[#1] 0.5710 PF00069 Protein kinase domain 0.5371 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB260 >= 3 aromatic rings 0.5694 PF00989 PAS fold SUB522 C:N-C-[#1] 0.5658 PF00105 Zinc finger, C4 type (two domains), 0.0902 PF00104 Ligand-binding domain of nuclear hormone receptor 0.0159 PF00017 SH2 domain SUB417 C=C 0.5621 PF03098 Animal haem peroxidase 0.1319 PF00001 7 transmembrane receptor (rhodopsin family), SUB549 O-C-C:C 0.5604 PF00989 PAS fold 0.1996 PF00027 Cyclic nucleotide-binding domain 0.0120 PF00001 7 transmembrane receptor (rhodopsin family), SUB216 >= 1 saturated or aromatic nitrogen-containing ring size 7 0.5598 PF00069 Protein kinase domain SUB624 O=C-C:C-C 0.5593 PF00343 Carbohydrate phosphorylase 0.3359 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.1220 PF00464 Serine hydroxymethyltransferase 0.0848 PF00571 CBS domain 0.0034 PF07884 Vitamin K epoxide reductase family SUB343 C(~C)(~Cl) 0.5580 PF02254 TrkA-N domain 0.3807 PF03493 Calcium-activated BK potassium channel alpha subunit 0.2421 PF00084 Sushi domain (SCR repeat), 0.0093 PF03073 TspO/MBR family 0.0089 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0071 PF00520 Ion transport protein 0.0054 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB672 O=C-C=C-C 0.5534 PF00069 Protein kinase domain 0.3058 PF00005 ABC transporter 0.2831 PF00104 Ligand-binding domain of nuclear hormone receptor 0.2142 PF00229 TNF(Tumour Necrosis Factor), family 0.1401 PF03098 Animal haem peroxidase 0.0295 PF00105 Zinc finger, C4 type (two domains), SUB415 S(~C)(~O) 0.5476 PF01007 Inward rectifier potassium channel 0.2367 PF08403 Amino acid permease N-terminal SUB629 C-N-C-C:C 0.5470 PF02180 Bcl-2 homology region 4 0.4784 PF00248 Aldo/keto reductase family 0.3287 PF01234 NNMT/PNMT/TEMT family 0.1462 PF00452 Apoptosis regulator proteins, Bcl-2 family 0.1292 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1155 PF00225 Kinesin motor domain 0.0405 PF00001 7 transmembrane receptor (rhodopsin family), 0.0400 PF00105 Zinc finger, C4 type (two domains), 0.0378 PF00702 haloacid dehalogenase-like hydrolase SUB756 Cc1c(C)cccc1 0.5446 PF07645 Calcium-binding EGF domain 0.3198 PF00069 Protein kinase domain 0.2033 PF00643 B-box zinc finger SUB24 >= 1 F 0.5428 PF07686 Immunoglobulin V-set domain 0.5191 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0518 PF01094 Receptor family ligand binding region 0.0014 PF01180 Dihydroorotate dehydrogenase SUB20 >= 2 O 0.5416 PF03098 Animal haem peroxidase 0.5005 PF00821 Phosphoenolpyruvate carboxykinase 0.4154 PF00273 Serum albumin family 0.2651 PF00194 Eukaryotic-type carbonic anhydrase 0.2067 PF00074 Pancreatic ribonuclease 0.1322 PF00625 Guanylate kinase 0.0084 PF00084 Sushi domain (SCR repeat), SUB180 >= 1 saturated or aromatic carbon-only ring size 6 0.5376 PF02159 Oestrogen receptor 0.2061 PF00001 7 transmembrane receptor (rhodopsin family), 0.1184 PF00520 Ion transport protein SUB151 >= 2 any ring size 5 0.5362 PF00170 bZIP transcription factor 0.5161 PF00069 Protein kinase domain 0.3647 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.3265 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1923 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1013 PF00364 Biotin-requiring enzyme SUB15 >= 1 N 0.5256 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.2866 PF01094 Receptor family ligand binding region 0.0863 PF00001 7 transmembrane receptor (rhodopsin family), 0.0633 PF00209 Sodium:neurotransmitter symporter family SUB444 C(-C)(=O) 0.5209 PF00202 Aminotransferase class-III 0.3948 PF00413 Matrixin 0.3674 PF00248 Aldo/keto reductase family 0.3515 PF00266 Aminotransferase class-V 0.1777 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1429 PF00045 Hemopexin 0.0946 PF01471 Putative peptidoglycan binding domain 0.0378 PF00001 7 transmembrane receptor (rhodopsin family), 0.0347 PF00105 Zinc finger, C4 type (two domains), SUB751 Nc1cc(Cl)ccc1 0.5187 PF00043 Glutathione S-transferase, C-terminal domain SUB762 Oc1c(O)cccc1 0.5185 PF00001 7 transmembrane receptor (rhodopsin family), 0.3531 PF01596 O-methyltransferase 0.1904 PF00643 B-box zinc finger 0.1062 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB154 >= 2 saturated or aromatic heteroatom-containing ring size 5 0.5154 PF00364 Biotin-requiring enzyme 0.2258 PF00067 Cytochrome P450 0.1353 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.0660 PF00001 7 transmembrane receptor (rhodopsin family), SUB738 Cc1cc(N)ccc1 0.5139 PF00105 Zinc finger, C4 type (two domains), 0.3766 PF01122 Eukaryotic cobalamin-binding protein 0.2986 PF00104 Ligand-binding domain of nuclear hormone receptor 0.2513 PF00175 Oxidoreductase NAD-binding domain 0.0565 PF00324 Amino acid permease 0.0491 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), SUB516 N-N-C-C 0.5076 PF00664 ABC transporter transmembrane region SUB342 C(~C)(~C)(~O) 0.5060 PF02525 Flavodoxin-like fold 0.0260 PF02159 Oestrogen receptor 0.0242 PF00069 Protein kinase domain SUB675 N-C-N-C:C 0.5032 PF00001 7 transmembrane receptor (rhodopsin family), 0.2104 PF00186 Dihydrofolate reductase 0.1581 PF00520 Ion transport protein 0.1187 PF02196 Raf-like Ras-binding domain SUB390 C(:N)(:N) 0.4999 PF00478 IMP dehydrogenase / GMP reductase domain 0.0619 PF00757 Furin-like cysteine rich region 0.0502 PF01030 Receptor L domain SUB801 CC1CC(N)CCC1 0.4983 PF00001 7 transmembrane receptor (rhodopsin family), 0.2939 PF02166 Androgen receptor 0.2352 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase SUB261 >= 3 hetero-aromatic rings 0.4931 PF00017 SH2 domain 0.2514 PF00106 short chain dehydrogenase 0.1406 PF02771 Acyl-CoA dehydrogenase, N-terminal domain 0.0785 PF02770 Acyl-CoA dehydrogenase, middle domain 0.0658 PF00005 ABC transporter 0.0435 PF00018 SH3 domain SUB574 O-C-C=C 0.4909 PF00822 PMP-22/EMP/MP20/Claudin family 0.2290 PF00702 haloacid dehalogenase-like hydrolase SUB7 >= 1 B 0.4903 PF00227 Proteasome subunit SUB759 Cc1c(N)cccc1 0.4897 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.3020 PF00017 SH2 domain 0.1615 PF00001 7 transmembrane receptor (rhodopsin family), SUB520 N=C-N-C 0.4896 PF04739 5"-AMP-activated protein kinase beta subunit, interation domain 0.2385 PF01048 Phosphorylase superfamily SUB21 >= 4 O 0.4896 PF00822 PMP-22/EMP/MP20/Claudin family 0.4042 PF01094 Receptor family ligand binding region 0.3416 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.3025 PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 0.2668 PF00413 Matrixin 0.2044 PF03949 Malic enzyme, NAD binding domain 0.1290 PF00390 Malic enzyme, N-terminal domain 0.0884 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.0665 PF00005 ABC transporter 0.0506 PF00153 Mitochondrial carrier protein 0.0121 PF00070 Pyridine nucleotide-disulphide oxidoreductase 0.0089 PF00102 Protein-tyrosine phosphatase SUB517 [#1]-C=C-[#1] 0.4850 PF03098 Animal haem peroxidase 0.1182 PF00069 Protein kinase domain 0.0756 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.0463 PF06512 Sodium ion transport-associated 0.0381 PF00105 Zinc finger, C4 type (two domains), SUB689 C-C-C-C-C-C-C 0.4803 PF01593 Flavin containing amine oxidoreductase SUB245 >= 1 saturated or aromatic heteroatom-containing ring size 9 0.4771 PF00211 Adenylate and Guanylate cyclase catalytic domain 0.4087 PF00571 CBS domain 0.2617 PF01262 Alanine dehydrogenase/PNT, C-terminal domain 0.2061 PF05222 Alanine dehydrogenase/PNT, N-terminal domain 0.1734 PF00170 bZIP transcription factor 0.0508 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.0092 PF00069 Protein kinase domain SUB460 S(=O)(=O) 0.4720 PF00194 Eukaryotic-type carbonic anhydrase 0.4601 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.4045 PF00520 Ion transport protein SUB533 S-C:C-[#1] 0.4717 PF00045 Hemopexin 0.1514 PF01471 Putative peptidoglycan binding domain 0.1468 PF08403 Amino acid permease N-terminal SUB452 C(-N)(=O) 0.4701 PF01007 Inward rectifier potassium channel 0.1822 PF01180 Dihydroorotate dehydrogenase 0.0178 PF00107 Zinc-binding dehydrogenase 0.0087 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0066 PF07992 Pyridine nucleotide-disulphide oxidoreductase SUB12 >= 8 C 0.4665 PF01593 Flavin containing amine oxidoreductase 0.0545 PF06512 Sodium ion transport-associated SUB580 O=C-C-C-C 0.4657 PF03171 2OG-Fe(II), oxygenase superfamily 0.4350 PF00153 Mitochondrial carrier protein 0.2467 PF00248 Aldo/keto reductase family 0.0953 PF00106 short chain dehydrogenase 0.0655 PF00067 Cytochrome P450 SUB48 >= 2 I 0.4655 PF00105 Zinc finger, C4 type (two domains), SUB666 N-C:C-C-C 0.4623 PF00520 Ion transport protein 0.2427 PF06512 Sodium ion transport-associated SUB651 O=C-N-C=O 0.4612 PF00520 Ion transport protein 0.0682 PF00001 7 transmembrane receptor (rhodopsin family), SUB357 C(~C)(:C)(:C) 0.4551 PF01593 Flavin containing amine oxidoreductase 0.1411 PF02159 Oestrogen receptor 0.0639 PF00209 Sodium:neurotransmitter symporter family SUB426 P=O 0.4539 PF00017 SH2 domain 0.2087 PF02223 Thymidylate kinase 0.1313 PF00018 SH3 domain 0.0664 PF00074 Pancreatic ribonuclease SUB488 N-C=N-C 0.4491 PF01048 Phosphorylase superfamily 0.2619 PF00206 Lyase 0.1181 PF00069 Protein kinase domain 0.0812 PF00186 Dihydrofolate reductase SUB690 O-C-C-C-C-C-C 0.4483 PF08763 Voltage gated calcium channel IQ domain 0.0646 PF00105 Zinc finger, C4 type (two domains), 0.0441 PF00413 Matrixin SUB453 C(-O)(=O) 0.4477 PF00324 Amino acid permease 0.3884 PF03098 Animal haem peroxidase 0.2033 PF00571 CBS domain 0.1055 PF01063 Aminotransferase class IV 0.0671 PF00092 von Willebrand factor type A domain 0.0667 PF01433 Peptidase family M1 0.0592 PF01401 Angiotensin-converting enzyme 0.0395 PF01180 Dihydroorotate dehydrogenase SUB451 C(-N)(=N) 0.4470 PF00186 Dihydrofolate reductase 0.2514 PF00089 Trypsin 0.2219 PF00001 7 transmembrane receptor (rhodopsin family), 0.0958 PF00069 Protein kinase domain 0.0133 PF01048 Phosphorylase superfamily SUB341 C(~C)(~C)(~N) 0.4465 PF06512 Sodium ion transport-associated 0.3000 PF00291 Pyridoxal-phosphate dependent enzyme 0.2944 PF00155 Aminotransferase class I and II 0.2052 PF00310 Glutamine amidotransferases class-II SUB667 C=C-C-O-C 0.4435 PF00091 Tubulin/FtsZ family, GTPase domain 0.3983 PF03953 Tubulin C-terminal domain 0.1531 PF00689 Cation transporting ATPase, C-terminus 0.0230 PF00105 Zinc finger, C4 type (two domains), 0.0157 PF00690 Cation transporter/ATPase, N-terminus SUB680 C-C-C-C-C-C 0.4416 PF08718 Glycolipid transfer protein (GLTP), 0.3766 PF00089 Trypsin 0.3743 PF00105 Zinc finger, C4 type (two domains), 0.0924 PF00273 Serum albumin family SUB492 C-N:C-[#1] 0.4397 PF00571 CBS domain 0.2570 PF01471 Putative peptidoglycan binding domain 0.0899 PF00045 Hemopexin 0.0247 PF02196 Raf-like Ras-binding domain SUB578 C:C-N-C:C 0.4369 PF00858 Amiloride-sensitive sodium channel 0.4107 PF00343 Carbohydrate phosphorylase 0.3281 PF00291 Pyridoxal-phosphate dependent enzyme 0.1429 PF00042 Globin 0.1274 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB340 C(~C)(~C)(~H)(~O) 0.4364 PF00001 7 transmembrane receptor (rhodopsin family), 0.2145 PF00027 Cyclic nucleotide-binding domain 0.1861 PF00368 Hydroxymethylglutaryl-coenzyme A reductase 0.0707 PF00229 TNF(Tumour Necrosis Factor), family 0.0101 PF00175 Oxidoreductase NAD-binding domain SUB681 O-C-C-C-C-C 0.4360 PF00023 Ankyrin repeat 0.2355 PF00067 Cytochrome P450 0.2083 PF00501 AMP-binding enzyme 0.1271 PF08763 Voltage gated calcium channel IQ domain SUB500 N-C:C:N 0.4358 PF00156 Phosphoribosyl transferase domain 0.4119 PF00962 Adenosine/AMP deaminase 0.3053 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.2280 PF00069 Protein kinase domain 0.0276 PF01048 Phosphorylase superfamily SUB663 O-C-C-O-C 0.4292 PF00454 Phosphatidylinositol 3- and 4-kinase 0.1520 PF00501 AMP-binding enzyme SUB515 O-N-C-C 0.4287 PF01471 Putative peptidoglycan binding domain 0.2647 PF00045 Hemopexin 0.0487 PF00413 Matrixin SUB519 O=C-N-N 0.4263 PF00664 ABC transporter transmembrane region SUB258 >= 2 aromatic rings 0.4248 PF00520 Ion transport protein 0.3257 PF00005 ABC transporter 0.0510 PF00069 Protein kinase domain 0.0214 PF00067 Cytochrome P450 SUB575 O-C-C:C-C 0.4219 PF00989 PAS fold 0.1543 PF00027 Cyclic nucleotide-binding domain 0.0456 PF00001 7 transmembrane receptor (rhodopsin family), SUB499 O-C=C-C 0.4132 PF00069 Protein kinase domain 0.3791 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.2169 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1916 PF01477 PLAT/LH2 domain 0.0760 PF00001 7 transmembrane receptor (rhodopsin family), SUB582 O=C-C-C-O 0.4129 PF00005 ABC transporter 0.3301 PF00091 Tubulin/FtsZ family, GTPase domain 0.2917 PF00271 Helicase conserved C-terminal domain 0.1912 PF00069 Protein kinase domain 0.1481 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1391 PF00454 Phosphatidylinositol 3- and 4-kinase 0.0934 PF00168 C2 domain 0.0796 PF00001 7 transmembrane receptor (rhodopsin family), 0.0610 PF00291 Pyridoxal-phosphate dependent enzyme 0.0437 PF03953 Tubulin C-terminal domain SUB22 >= 8 O 0.4105 PF07992 Pyridine nucleotide-disulphide oxidoreductase 0.3055 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 0.2624 PF00171 Aldehyde dehydrogenase family SUB505 N:C:N-C 0.4091 PF00005 ABC transporter 0.1126 PF00478 IMP dehydrogenase / GMP reductase domain 0.0282 PF01030 Receptor L domain 0.0253 PF00821 Phosphoenolpyruvate carboxykinase SUB366 C(~H)(~N) 0.4086 PF00209 Sodium:neurotransmitter symporter family 0.2412 PF00001 7 transmembrane receptor (rhodopsin family), 0.2403 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region 0.0834 PF02159 Oestrogen receptor 0.0489 PF00497 Bacterial extracellular solute-binding proteins, family 3 0.0189 PF03073 TspO/MBR family 0.0032 PF00005 ABC transporter SUB534 S-C:C-N 0.4061 PF00001 7 transmembrane receptor (rhodopsin family), SUB350 C(~C)(~H)(~S) 0.4060 PF02798 Glutathione S-transferase, N-terminal domain 0.2609 PF08725 Integrin beta cytoplasmic domain 0.1564 PF00043 Glutathione S-transferase, C-terminal domain 0.1159 PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 0.0148 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 0.0093 PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain SUB295 C-Cl 0.4034 PF00043 Glutathione S-transferase, C-terminal domain 0.2271 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1659 PF00690 Cation transporter/ATPase, N-terminus 0.1313 PF00689 Cation transporting ATPase, C-terminus 0.1022 PF02254 TrkA-N domain 0.0845 PF03493 Calcium-activated BK potassium channel alpha subunit 0.0739 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0492 PF00520 Ion transport protein 0.0242 PF00084 Sushi domain (SCR repeat), SUB430 C(#N)(-C) 0.3997 PF00625 Guanylate kinase SUB19 >= 1 O 0.3992 PF00194 Eukaryotic-type carbonic anhydrase 0.1224 PF01180 Dihydroorotate dehydrogenase 0.0945 PF00520 Ion transport protein 0.0632 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0242 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0092 PF03098 Animal haem peroxidase SUB704 O-C-C-C-C-C(N)-C 0.3974 PF00282 Pyridoxal-dependent decarboxylase conserved domain 0.0985 PF00291 Pyridoxal-phosphate dependent enzyme 0.0193 PF00214 Calcitonin / CGRP / IAPP family SUB699 O-C-C-C-C-C-C-C 0.3950 PF08473 Neuronal voltage-dependent calcium channel alpha 2acd 0.3376 PF01477 PLAT/LH2 domain 0.1645 PF02743 Cache domain 0.1563 PF00664 ABC transporter transmembrane region 0.0403 PF08399 VWA N-terminal 0.0204 PF00520 Ion transport protein 0.0116 PF00579 tRNA synthetases class I (W and Y), 0.0033 PF00005 ABC transporter SUB257 >= 1 hetero-aromatic ring 0.3945 PF00067 Cytochrome P450 SUB702 O-C-C-C-C-C(O)-C 0.3939 PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 0.3798 PF00128 Alpha amylase, catalytic domain 0.3149 PF01055 Glycosyl hydrolases family 31 0.1943 PF00048 Small cytokines (intecrine/chemokine), , interleukin-8 like 0.1820 PF00088 Trefoil (P-type), domain 0.1740 PF00930 Dipeptidyl peptidase IV (DPP IV), N-terminal region 0.1677 PF02806 Alpha amylase, C-terminal all-beta domain 0.0854 PF00091 Tubulin/FtsZ family, GTPase domain 0.0523 PF03953 Tubulin C-terminal domain SUB431 C(-C)(-C)(=C) 0.3869 PF01593 Flavin containing amine oxidoreductase 0.2557 PF00171 Aldehyde dehydrogenase family 0.0703 PF00067 Cytochrome P450 0.0663 PF00305 Lipoxygenase SUB466 O=S-C-C 0.3813 PF00045 Hemopexin 0.3209 PF08403 Amino acid permease N-terminal 0.1378 PF00690 Cation transporter/ATPase, N-terminus 0.1184 PF00689 Cation transporting ATPase, C-terminus 0.0884 PF01471 Putative peptidoglycan binding domain 0.0625 PF00664 ABC transporter transmembrane region SUB454 N(-C)(=C) 0.3781 PF03073 TspO/MBR family 0.3376 PF00069 Protein kinase domain 0.0101 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB315 O-P 0.3780 PF02223 Thymidylate kinase 0.2065 PF00018 SH3 domain 0.0593 PF03770 Inositol polyphosphate kinase 0.0151 PF00017 SH2 domain SUB443 C(-C)(=N) 0.3752 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.0038 PF03073 TspO/MBR family 0.0032 PF00001 7 transmembrane receptor (rhodopsin family), SUB201 >= 4 saturated or aromatic carbon-only ring size 6 0.3743 PF00001 7 transmembrane receptor (rhodopsin family), SUB243 >= 1 saturated or aromatic carbon-only ring size 9 0.3717 PF00191 Annexin 0.0896 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0440 PF02155 Glucocorticoid receptor SUB1 >= 4 H 0.3710 PF08674 Acetylcholinesterase tetramerisation domain 0.1312 PF00248 Aldo/keto reductase family SUB713 C-C(C)-C(C)-C 0.3709 PF00341 Platelet-derived growth factor (PDGF), 0.2855 PF00079 Serpin (serine protease inhibitor), 0.1282 PF00067 Cytochrome P450 SUB692 O-C-C-C-C-C-N 0.3707 PF00491 Arginase family 0.3472 PF03807 NADP oxidoreductase coenzyme F420-dependent 0.1897 PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 0.1273 PF00927 Transglutaminase family, C-terminal ig like domain 0.1052 PF00074 Pancreatic ribonuclease 0.0514 PF00209 Sodium:neurotransmitter symporter family 0.0218 PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 0.0052 PF00868 Transglutaminase family SUB465 N-C-C=C 0.3707 PF00091 Tubulin/FtsZ family, GTPase domain 0.3463 PF00061 Lipocalin / cytosolic fatty-acid binding protein family 0.1714 PF03953 Tubulin C-terminal domain SUB539 N=C-C-C 0.3705 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.3186 PF03073 TspO/MBR family SUB531 N:C-C:C 0.3683 PF02196 Raf-like Ras-binding domain 0.0110 PF00017 SH2 domain SUB300 N-H 0.3662 PF06512 Sodium ion transport-associated 0.2014 PF00520 Ion transport protein 0.1616 PF00001 7 transmembrane receptor (rhodopsin family), 0.1582 PF06464 DMAP1-binding Domain 0.1552 PF00051 Kringle domain 0.1461 PF01426 BAH domain SUB378 C(~N)(:C)(:C) 0.3623 PF00005 ABC transporter 0.1269 PF00229 TNF(Tumour Necrosis Factor), family 0.0016 PF00001 7 transmembrane receptor (rhodopsin family), SUB285 C-C 0.3621 PF00273 Serum albumin family 0.1640 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1404 PF02898 Nitric oxide synthase, oxygenase domain SUB600 [#1]-C-C=C-[#1] 0.3621 PF00171 Aldehyde dehydrogenase family 0.1023 PF00001 7 transmembrane receptor (rhodopsin family), 0.0676 PF03098 Animal haem peroxidase SUB52 >= 1 Al 0.3580 PF01459 Eukaryotic porin SUB293 C-P 0.3562 PF00102 Protein-tyrosine phosphatase SUB467 N#C-C=C 0.3523 PF00105 Zinc finger, C4 type (two domains), SUB793 NC1CCC(Cl)CC1 0.3494 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.2562 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0007 PF00343 Carbohydrate phosphorylase SUB368 C(~H)(~O)(~O) 0.3410 PF07686 Immunoglobulin V-set domain 0.0602 PF00167 Fibroblast growth factor SUB698 C-C-C-C-C-C(C)-C 0.3398 PF00149 Calcineurin-like phosphoesterase 0.3118 PF00520 Ion transport protein 0.1516 PF00413 Matrixin 0.0620 PF00092 von Willebrand factor type A domain SUB495 O=C-C:N 0.3396 PF00227 Proteasome subunit SUB800 CC1CC(S)CCC1 0.3359 PF00001 7 transmembrane receptor (rhodopsin family), SUB543 O-C:C-[#1] 0.3352 PF00656 Caspase domain 0.1407 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB313 O-Al 0.3351 PF01459 Eukaryotic porin SUB394 N(~C)(~H) 0.3320 PF02008 CXXC zinc finger domain 0.2721 PF00051 Kringle domain 0.2578 PF01593 Flavin containing amine oxidoreductase 0.2408 PF00186 Dihydrofolate reductase 0.2332 PF01179 Copper amine oxidase, enzyme domain 0.0945 PF02728 Copper amine oxidase, N3 domain 0.0662 PF02727 Copper amine oxidase, N2 domain 0.0647 PF06464 DMAP1-binding Domain 0.0466 PF00520 Ion transport protein 0.0401 PF00001 7 transmembrane receptor (rhodopsin family), 0.0307 PF00209 Sodium:neurotransmitter symporter family 0.0189 PF01426 BAH domain SUB10 >= 2 C 0.3314 PF00273 Serum albumin family 0.1559 PF00107 Zinc-binding dehydrogenase 0.0135 PF00248 Aldo/keto reductase family SUB772 Nc1c(Cl)cccc1 0.3308 PF00001 7 transmembrane receptor (rhodopsin family), SUB781 CC1CCC(Cl)CC1 0.3298 PF01094 Receptor family ligand binding region SUB548 N-C:C-N 0.3192 PF01687 Riboflavin kinase 0.3134 PF01048 Phosphorylase superfamily 0.1697 PF00156 Phosphoribosyl transferase domain 0.1615 PF00962 Adenosine/AMP deaminase 0.0060 PF00069 Protein kinase domain SUB735 Cc1cc(C)ccc1 0.3178 PF01030 Receptor L domain 0.2454 PF00105 Zinc finger, C4 type (two domains), 0.1569 PF00757 Furin-like cysteine rich region 0.0543 PF00069 Protein kinase domain 0.0193 PF00104 Ligand-binding domain of nuclear hormone receptor SUB709 C-C(C)-C-C 0.3164 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.2761 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1005 PF00520 Ion transport protein SUB587 C-S-C-C-C 0.3141 PF02772 S-adenosylmethionine synthetase, central domain 0.1761 PF00105 Zinc finger, C4 type (two domains), 0.1599 PF02773 S-adenosylmethionine synthetase, C-terminal domain 0.0995 PF00438 S-adenosylmethionine synthetase, N-terminal domain 0.0033 PF00104 Ligand-binding domain of nuclear hormone receptor SUB780 CC1CCC(N)CC1 0.3141 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.2260 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0700 PF00001 7 transmembrane receptor (rhodopsin family), SUB593 N-C-C-C-C 0.3077 PF00102 Protein-tyrosine phosphatase 0.0607 PF01593 Flavin containing amine oxidoreductase SUB438 C(-C)(-N)(=C) 0.3046 PF00520 Ion transport protein SUB639 O-C-C-C-N 0.3029 PF00088 Trefoil (P-type), domain 0.2573 PF00001 7 transmembrane receptor (rhodopsin family), 0.0927 PF01055 Glycosyl hydrolases family 31 SUB814 NC1CC(Cl)CCC1 0.3024 PF00043 Glutathione S-transferase, C-terminal domain SUB590 C-C:C-O-C 0.3021 PF00664 ABC transporter transmembrane region 0.1813 PF08441 Integrin alpha SUB400 N(~H)(:C) 0.2997 PF00001 7 transmembrane receptor (rhodopsin family), SUB353 C(~C)(~O) 0.2971 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.2610 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0711 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB621 C:C-O-C-C 0.2968 PF00105 Zinc finger, C4 type (two domains), 0.2916 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain), 0.2192 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.2037 PF01023 S-100/ICaBP type calcium binding domain 0.1386 PF01030 Receptor L domain 0.0814 PF00757 Furin-like cysteine rich region 0.0047 PF03765 CRAL/TRIO, N-terminus 0.0029 PF00650 CRAL/TRIO domain SUB130 >= 1 any ring size 4 0.2926 PF00854 POT family SUB144 >= 1 any ring size 5 0.2874 PF00067 Cytochrome P450 0.1741 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1733 PF00689 Cation transporting ATPase, C-terminus 0.1268 PF00001 7 transmembrane receptor (rhodopsin family), 0.1244 PF00690 Cation transporter/ATPase, N-terminus SUB39 >= 2 Cl 0.2835 PF00689 Cation transporting ATPase, C-terminus 0.1392 PF00067 Cytochrome P450 SUB457 P(-O)(=O) 0.2824 PF00017 SH2 domain 0.1963 PF02223 Thymidylate kinase 0.1661 PF00074 Pancreatic ribonuclease 0.1349 PF00018 SH3 domain 0.0635 PF01467 Cytidylyltransferase 0.0006 PF03770 Inositol polyphosphate kinase SUB792 NC1CCC(N)CC1 0.2812 PF00001 7 transmembrane receptor (rhodopsin family), SUB779 CC1CCC(S)CC1 0.2790 PF00005 ABC transporter SUB356 C(~C)(:C) 0.2789 PF00001 7 transmembrane receptor (rhodopsin family), 0.2519 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB540 N=C-C-[#1] 0.2774 PF00645 Poly(ADP-ribose), polymerase and DNA-Ligase Zn-finger region 0.0048 PF00042 Globin 0.0026 PF00091 Tubulin/FtsZ family, GTPase domain 0.0014 PF03953 Tubulin C-terminal domain SUB546 N-C:C-C 0.2756 PF00520 Ion transport protein 0.0605 PF00001 7 transmembrane receptor (rhodopsin family), SUB739 Cc1cc(Cl)ccc1 0.2754 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0196 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB659 C-C-S-C-C 0.2748 PF00001 7 transmembrane receptor (rhodopsin family), SUB446 C(-H)(-N)(=C) 0.2745 PF00107 Zinc-binding dehydrogenase 0.0753 PF08240 Alcohol dehydrogenase GroES-like domain SUB619 C:C-C-C:C 0.2738 PF00209 Sodium:neurotransmitter symporter family 0.0715 PF06512 Sodium ion transport-associated SUB634 N-C-C:C-C 0.2725 PF00702 haloacid dehalogenase-like hydrolase SUB328 C(~Br)(~C) 0.2709 PF00001 7 transmembrane receptor (rhodopsin family), SUB736 Cc1cc(O)ccc1 0.2692 PF00001 7 transmembrane receptor (rhodopsin family), 0.0093 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SUB616 N-C-C-O-C 0.2686 PF00067 Cytochrome P450 0.1162 PF01401 Angiotensin-converting enzyme SUB42 >= 1 K 0.2668 PF00324 Amino acid permease SUB275 B-C 0.2665 PF00227 Proteasome subunit SUB352 C(~C)(~N) 0.2612 PF00001 7 transmembrane receptor (rhodopsin family), 0.1673 PF00209 Sodium:neurotransmitter symporter family SUB462 O-C-C=N 0.2576 PF00155 Aminotransferase class I and II SUB528 C:C:N-[#1] 0.2551 PF00001 7 transmembrane receptor (rhodopsin family), SUB564 O-C-O-C 0.2549 PF02806 Alpha amylase, C-terminal all-beta domain 0.1561 PF07654 Immunoglobulin C1-set domain SUB785 OC1CCC(N)CC1 0.2547 PF07885 Ion channel SUB644 [#1]-C-C-N-[#1] 0.2529 PF00018 SH3 domain 0.2496 PF00069 Protein kinase domain 0.1953 PF00324 Amino acid permease 0.1371 PF00209 Sodium:neurotransmitter symporter family 0.1119 PF01536 Adenosylmethionine decarboxylase 0.0713 PF02166 Androgen receptor SUB179 >= 1 any ring size 6 0.2521 PF00089 Trypsin SUB627 C-O-C:C-C 0.2436 PF08441 Integrin alpha 0.2084 PF00664 ABC transporter transmembrane region SUB354 C(~C)(~S) 0.2436 PF00690 Cation transporter/ATPase, N-terminus 0.2371 PF02798 Glutathione S-transferase, N-terminal domain 0.2276 PF00689 Cation transporting ATPase, C-terminus 0.1576 PF01471 Putative peptidoglycan binding domain 0.1173 PF00045 Hemopexin 0.0346 PF00043 Glutathione S-transferase, C-terminal domain SUB620 O-C-C=C-C 0.2427 PF00702 haloacid dehalogenase-like hydrolase 0.1451 PF00822 PMP-22/EMP/MP20/Claudin family 0.1285 PF00001 7 transmembrane receptor (rhodopsin family), 0.0407 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB60 >= 1 Co 0.2390 PF01122 Eukaryotic cobalamin-binding protein SUB287 C-O 0.2335 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.1829 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.1504 PF00145 C-5 cytosine-specific DNA methylase 0.0249 PF00060 Ligand-gated ion channel SUB244 >= 1 saturated or aromatic nitrogen-containing ring size 9 0.2323 PF00001 7 transmembrane receptor (rhodopsin family), 0.1904 PF00069 Protein kinase domain 0.1038 PF00106 short chain dehydrogenase SUB44 >= 1 Br 0.2295 PF00001 7 transmembrane receptor (rhodopsin family), SUB573 N:C:N:C 0.2293 PF00067 Cytochrome P450 0.1130 PF00478 IMP dehydrogenase / GMP reductase domain 0.0196 PF00757 Furin-like cysteine rich region 0.0013 PF00821 Phosphoenolpyruvate carboxykinase SUB612 N-C-C-N-C 0.2274 PF08246 Cathepsin propeptide inhibitor domain (I29), 0.2125 PF03073 TspO/MBR family SUB632 O-C:C-O-[#1] 0.2259 PF00001 7 transmembrane receptor (rhodopsin family), 0.1084 PF01596 O-methyltransferase SUB386 C(:C)(:C)(:C) 0.2235 PF01582 TIR domain 0.0622 PF00001 7 transmembrane receptor (rhodopsin family), SUB338 C(~C)(~C)(~C)(~O) 0.2227 PF00001 7 transmembrane receptor (rhodopsin family), 0.1730 PF02161 Progesterone receptor 0.1293 PF08384 Pro-opiomelanocortin, N-terminal region 0.0426 PF00104 Ligand-binding domain of nuclear hormone receptor SUB504 Cl-C:C-[#1] 0.2187 PF00067 Cytochrome P450 SUB34 >= 1 S 0.2182 PF00167 Fibroblast growth factor SUB181 >= 1 saturated or aromatic nitrogen-containing ring size 6 0.2156 PF00001 7 transmembrane receptor (rhodopsin family), 0.2154 PF00106 short chain dehydrogenase 0.1256 PF06387 D1 dopamine receptor-interacting protein (calcyon), 0.0453 PF08246 Cathepsin propeptide inhibitor domain (I29), SUB597 N=C-N-C-C 0.2131 PF00233 3"5"-cyclic nucleotide phosphodiesterase 0.1324 PF01048 Phosphorylase superfamily SUB371 C(~H)(:C) 0.2008 PF00001 7 transmembrane receptor (rhodopsin family), 0.0644 PF06512 Sodium ion transport-associated SUB413 S(~C)(~C) 0.2007 PF02773 S-adenosylmethionine synthetase, C-terminal domain SUB256 >= 1 aromatic ring 0.1999 PF00001 7 transmembrane receptor (rhodopsin family), 0.1306 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB605 C-O-C-C:C 0.1963 PF00105 Zinc finger, C4 type (two domains), 0.1907 PF06512 Sodium ion transport-associated SUB834 NC1C(N)CCCC1 0.1933 PF00175 Oxidoreductase NAD-binding domain 0.0193 PF00001 7 transmembrane receptor (rhodopsin family), SUB298 C-Br 0.1878 PF00001 7 transmembrane receptor (rhodopsin family), SUB439 C(-C)(-N)(=N) 0.1828 PF00089 Trypsin 0.0978 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB376 C(~N)(~N) 0.1774 PF00051 Kringle domain 0.1305 PF00303 Thymidylate synthase 0.1070 PF00175 Oxidoreductase NAD-binding domain 0.0864 PF02867 Ribonucleotide reductase, barrel domain 0.0638 PF03477 ATP cone domain 0.0531 PF00317 Ribonucleotide reductase, all-alpha domain 0.0486 PF01007 Inward rectifier potassium channel SUB359 C(~C)(:N) 0.1713 PF00001 7 transmembrane receptor (rhodopsin family), SUB145 >= 1 saturated or aromatic carbon-only ring size 5 0.1699 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0083 PF02155 Glucocorticoid receptor SUB461 C-C-C#C 0.1677 PF00104 Ligand-binding domain of nuclear hormone receptor 0.1446 PF00105 Zinc finger, C4 type (two domains), SUB442 C(-C)(=C) 0.1604 PF00001 7 transmembrane receptor (rhodopsin family), SUB685 O=C-C-C-C-C 0.1541 PF00001 7 transmembrane receptor (rhodopsin family), SUB194 >= 3 saturated or aromatic carbon-only ring size 6 0.1539 PF00005 ABC transporter SUB798 CC1CC(C)CCC1 0.1538 PF00105 Zinc finger, C4 type (two domains), 0.0957 PF00104 Ligand-binding domain of nuclear hormone receptor SUB538 O=C-C-O 0.1538 PF00224 Pyruvate kinase, barrel domain 0.0276 PF00102 Protein-tyrosine phosphatase SUB412 P(~O)(~O) 0.1529 PF00074 Pancreatic ribonuclease 0.0996 PF00017 SH2 domain 0.0424 PF00018 SH3 domain 0.0053 PF02223 Thymidylate kinase SUB496 C-N-C:C 0.1512 PF00001 7 transmembrane receptor (rhodopsin family), 0.0570 PF00702 haloacid dehalogenase-like hydrolase SUB373 C(~H)(:C)(:N) 0.1509 PF00282 Pyridoxal-dependent decarboxylase conserved domain SUB404 N(:C)(:C) 0.1507 PF00067 Cytochrome P450 SUB557 C=C-C-C 0.1493 PF00067 Cytochrome P450 SUB435 C(-C)(-H)(=C) 0.1488 PF00067 Cytochrome P450 0.0668 PF03098 Animal haem peroxidase SUB566 C:C-O-C 0.1475 PF08441 Integrin alpha 0.0994 PF00664 ABC transporter transmembrane region SUB802 CC1CC(Cl)CCC1 0.1458 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0166 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB463 O-C-C=O 0.1432 PF02919 Eukaryotic DNA topoisomerase I, DNA binding fragment 0.0443 PF00102 Protein-tyrosine phosphatase SUB608 N-C-C-C:C 0.1408 PF00001 7 transmembrane receptor (rhodopsin family), 0.0084 PF00018 SH3 domain SUB583 C-C-C-C-C 0.1395 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB771 Nc1c(N)cccc1 0.1386 PF00175 Oxidoreductase NAD-binding domain 0.1147 PF01122 Eukaryotic cobalamin-binding protein 0.0038 PF00001 7 transmembrane receptor (rhodopsin family), SUB677 N#C-C-C-C 0.1279 PF00105 Zinc finger, C4 type (two domains), 0.0415 PF00625 Guanylate kinase SUB450 C(-N)(=C) 0.1269 PF03098 Animal haem peroxidase SUB189 >= 2 saturated or aromatic heteroatom-containing ring size 6 0.1265 PF00001 7 transmembrane receptor (rhodopsin family), SUB599 Cl-C:C:C-C 0.1263 PF03073 TspO/MBR family SUB570 N-C-C-N 0.1246 PF03073 TspO/MBR family SUB401 N(~H)(:C)(:C) 0.1231 PF00001 7 transmembrane receptor (rhodopsin family), SUB697 C-C-C-C-C-C-C-C 0.1210 PF00001 7 transmembrane receptor (rhodopsin family), 0.1137 PF00432 Prenyltransferase and squalene oxidase repeat 0.0735 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA), domain 0.0488 PF00209 Sodium:neurotransmitter symporter family SUB641 C=C-C-C-C 0.1155 PF00067 Cytochrome P450 SUB133 >= 1 saturated or aromatic heteroatom-containing ring size 4 0.1128 PF00854 POT family SUB576 O-C-C:C-O 0.1121 PF00171 Aldehyde dehydrogenase family SUB586 C-C:C-N-C 0.1100 PF00001 7 transmembrane receptor (rhodopsin family), 0.0360 PF00105 Zinc finger, C4 type (two domains), SUB642 O-C-C-C=C 0.1097 PF00001 7 transmembrane receptor (rhodopsin family), 0.0877 PF00989 PAS fold 0.0527 PF00069 Protein kinase domain SUB358 C(~C)(:C)(:N) 0.1093 PF00042 Globin 0.0120 PF00001 7 transmembrane receptor (rhodopsin family), SUB730 Nc1ccc(Cl)cc1 0.1072 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB589 O=C-C-C=O 0.1064 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB560 O-C-N-[#1] 0.1046 PF00001 7 transmembrane receptor (rhodopsin family), SUB804 OC1CC(O)CCC1 0.1040 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB783 OC1CCC(O)CC1 0.1006 PF00079 Serpin (serine protease inhibitor), SUB2 >= 8 H 0.0952 PF00089 Trypsin SUB614 C-N-C-C-C 0.0939 PF01007 Inward rectifier potassium channel 0.0121 PF00520 Ion transport protein 0.0033 PF00001 7 transmembrane receptor (rhodopsin family), SUB388 C(:C)(:N) 0.0933 PF00001 7 transmembrane receptor (rhodopsin family), SUB393 N(~C)(~C)(~H) 0.0932 PF00069 Protein kinase domain SUB525 C-C=C-C 0.0932 PF00061 Lipocalin / cytosolic fatty-acid binding protein family SUB137 >= 2 any ring size 4 0.0873 PF00069 Protein kinase domain SUB638 O-C-C-C-C 0.0859 PF00153 Mitochondrial carrier protein 0.0456 PF00001 7 transmembrane receptor (rhodopsin family), 0.0149 PF07686 Immunoglobulin V-set domain SUB380 C(~N)(:N) 0.0840 PF01030 Receptor L domain 0.0750 PF00069 Protein kinase domain 0.0109 PF00757 Furin-like cysteine rich region SUB604 C-C:C:C-C 0.0832 PF00209 Sodium:neurotransmitter symporter family SUB823 CC1C(Cl)CCCC1 0.0825 PF00069 Protein kinase domain SUB679 C-C-C=C-C 0.0805 PF00305 Lipoxygenase SUB654 O-C:C:C-O 0.0802 PF00069 Protein kinase domain SUB701 O-C-C-C-C-C-O-C 0.0801 PF02931 Neurotransmitter-gated ion-channel ligand binding domain 0.0145 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB710 C-C(C)-C-C-C 0.0800 PF02159 Oestrogen receptor 0.0020 PF00520 Ion transport protein SUB436 C(-C)(-H)(=N) 0.0796 PF00001 7 transmembrane receptor (rhodopsin family), SUB377 C(~N)(:C) 0.0788 PF00520 Ion transport protein SUB711 C-C-C(C)-C-C 0.0743 PF02159 Oestrogen receptor 0.0493 PF00305 Lipoxygenase SUB684 N-C-C-C-C-C 0.0727 PF00001 7 transmembrane receptor (rhodopsin family), SUB581 O=C-C-C-N 0.0681 PF02932 Neurotransmitter-gated ion-channel transmembrane region 0.0198 PF02931 Neurotransmitter-gated ion-channel ligand binding domain SUB658 C-N-C:C-C 0.0658 PF00001 7 transmembrane receptor (rhodopsin family), 0.0536 PF00105 Zinc finger, C4 type (two domains), SUB705 O=C-C-C-C-C-C-C 0.0607 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase SUB384 C(~S)(:C) 0.0569 PF08403 Amino acid permease N-terminal SUB299 C-I 0.0554 PF00233 3"5"-cyclic nucleotide phosphodiesterase SUB550 N-C-C:C 0.0519 PF00229 TNF(Tumour Necrosis Factor), family SUB507 C-C:N:C 0.0503 PF00571 CBS domain SUB532 S-C:C-C 0.0487 PF08403 Amino acid permease N-terminal SUB707 O=C-C-C-C-C(=O)-C 0.0440 PF00001 7 transmembrane receptor (rhodopsin family), SUB372 C(~H)(:C)(:C) 0.0434 PF00209 Sodium:neurotransmitter symporter family 0.0118 PF00001 7 transmembrane receptor (rhodopsin family), 0.0030 PF06512 Sodium ion transport-associated SUB861 CC1C(C)CCC1 0.0416 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0093 PF02155 Glucocorticoid receptor SUB722 Oc1ccc(N)cc1 0.0408 PF07885 Ion channel SUB491 C-C-C=C 0.0385 PF00067 Cytochrome P450 SUB473 C:N:C-C 0.0369 PF00571 CBS domain SUB251 >= 1 saturated or aromatic nitrogen-containing ring size 10 0.0316 PF00001 7 transmembrane receptor (rhodopsin family), 0.0157 PF01582 TIR domain SUB630 S-C:C:C-N 0.0314 PF00001 7 transmembrane receptor (rhodopsin family), SUB524 N:C:C-C 0.0290 PF00001 7 transmembrane receptor (rhodopsin family), SUB661 C-C=C-C-C 0.0288 PF00305 Lipoxygenase SUB609 C-C-C-C:C 0.0277 PF00209 Sodium:neurotransmitter symporter family 0.0100 PF00001 7 transmembrane receptor (rhodopsin family), SUB374 C(~H)(:N) 0.0232 PF02196 Raf-like Ras-binding domain SUB678 C-C=C-C:C 0.0183 PF00209 Sodium:neurotransmitter symporter family SUB334 C(~C)(~C)(~C) 0.0182 PF02932 Neurotransmitter-gated ion-channel transmembrane region SUB835 NC1C(Cl)CCCC1 0.0176 PF00001 7 transmembrane receptor (rhodopsin family), SUB471 C:C-C=C 0.0156 PF00209 Sodium:neurotransmitter symporter family SUB592 Cl-C-C-C-C 0.0111 PF03073 TspO/MBR family SUB382 C(~O)(:C) 0.0090 PF01477 PLAT/LH2 domain SUB385 C(:C)(:C) 0.0062 PF00005 ABC transporter SUB635 C-C-C:C-C 0.0056 PF00209 Sodium:neurotransmitter symporter family SUB294 C-S 0.0047 PF02798 Glutathione S-transferase, N-terminal domain SUB551 Cl-C-C-C 0.0046 PF03073 TspO/MBR family SUB741 Oc1cc(O)ccc1 0.0046 PF00069 Protein kinase domain SUB565 C=C-C=C 0.0018 PF00067 Cytochrome P450 SUB363 C(~Cl)(:C) 0.0010 PF03073 TspO/MBR family SUB607 O-C:C-C-C 0.0007 PF00001 7 transmembrane receptor (rhodopsin family), SUB571 C:C-C-C 0.0001 PF00001 7 transmembrane receptor (rhodopsin family),